Colposcopic evaluation and papanicolaou smear in high risk groups and its correlation with histology

Background: Cervical cancer is one of the most common gynaecologic neoplasms. PAP smear and colposcopy are used for its early detection. This study aims to find the correlation of colposcopic evaluation with Pap smear in cervical cancer screening and with histology. Methods: All women attending the OPD with unhealthy cervix and abnormal symptoms, who gave written informed consent were included in the study. Pap smear cytological grading, colposcopic findings were recorded. Pap smear and colposcopy findings was compared with histopathology. Results: The study included 73 patients. Pap smear was negative in more than half of the patients (56.2%), followed by atypical squamous cells of undetermined significance in 12 (16.4%), low-grade squamous intraepithelial lesion in 17 (23.3%), high-grade squamous intraepithelial lesion in 2 (2.7%) and squamous cell carcinoma in 1 patient (1.4%).  The histopathology showed normal findings in 46 patients (63%), followed by CIN 1 in 11 (15.1%), CIN 2 in 6 patients (8.2%), CIN 3 and squamous cell carcinoma in 5 patients each (6.8%). Pap smear’s predictability of cervical malignancy showed that it had a sensitivity of 48.15, it’s specificity for identifying patients without cervical malignancy was 84.78%. Colposcopy’s predictability of cervical malignancy showed that it had a sensitivity of 88.89%, it’s specificity for identifying patients without cervical malignancy was 95.65%. Conclusions: Colposcopy does seem to be better than Pap smear in diagnosing cervical carcinoma and also identifying patients without it

Laparoscopic cervicopexy in uterine prolapse, a prospective study

Background: Pelvic organ prolapse is a common condition and a major cause of gynecological surgery. The lifetime risk of having an operation for prolapse may be 11%. Uterine conserving surgeries using synthetic mesh, especially in younger age group can restore normal anatomy relieving their pelvic symptoms. To evaluate the safety, intra operative and postoperative complications and efficacy of the laparoscopic cervicopexy.Methods: This Prospective observational study was carried out on women aged below 45 years attending gynaecology outpatient department with uterine prolapse at MES Medical College, Perinthalmanna between January 1st and December 31st, 2015. 39 women underwent laparoscopic cervicopexy and follow up assessments was done among them at 2 weeks, 3 months and 6 months. Results: The mean operative time was 27.6 minutes and blood loss was 0.4 gm/dl. No intraoperative and postoperative complications occurred. Short duration of hospital stay with mean of 1.4 days. 7.7% patients and 5.5% had mersilene tape reaction at 3 months and 6 months. The POP Q score C was significantly away from hymen at 2 weeks,3 months and 6 months (+4.4 - -4.3). 7.7% and 2.6% had recurrence at 3 month and 6 months. 5.1% underwent vaginal hysterectomy to get relieved from symptom.Conclusion: Laparoscopic cervicopexy is an effective option for women with pelvic organ prolapse who desire uterine preservation

MC-DS-CDMA System based on DWT and STBC in ITU Multipath Fading Channels Model

 في هذه الورقة، تم تحسين أداء النفوذ المتعدد بالتقسيم لرمز السلسلة المباشر متعدد الموجات (MC-DS-CDMA) في تطبيقات MC-DS-CDMA الثابتة والتطبيقات MC-DS-CDMA  المتنقلة باستعمال تعويضات التشفير الزمنية الفضائية وتحويل فورير السريعة المنفصلة (FFT) أو تحويل المويجات المنفصلة DWT. وقد تمت محاكاة أنظمة MC-DS-CDMA  باستخدام ماتلاب 2015a. من خلال محاكاة النظام المقترح، يمكن تغيير المعالم المختلفة واختبارها. ويتم الحصول على معدل خطأ البيانات (BER) لهذه الأنظمة على مدى واسع من نسبة الإشارة إلى الضوضاء. وقد قورنت جميع نتائج المحاكاة مع بعضها البعض باستخدام حجم الموجة الحاملة الفرعية المختلفة FFT أو DWT مع ل STBC 1،2،3 و 4 هوائيات في المرسل وفي مختلف قنوات الخبو في متعددة الممرات ITU ومختلف ترددات دوبلر (fd).In this paper, the performance of multicarrier direct sequence code division multiple access (MC-DS-CDMA) in fixed MC-DS-CDMA and Mobile MC-DS-CDMA applications have been improved by using the compensations of space time block coding and Discrete Fast Fourier transforms (FFT) or Discrete Wavelets transform DWT. These MC-DS-CDMA systems had been simulated using MATLAB 2015a. Through simulation of the proposed system, various parameters can be changed and tested. The Bit Error Rate (BERs) of these systems are obtained over wide range of signal to noise ratio. All simulation results had been compared with each other using different subcarrier size of FFT or DWT with STBC for 1,2,3 and 4 antennas in transmitter and under different ITU multipath fading channels and different Doppler frequencies (fd). The proposed structures of STBC-MC-DS-CDMA system based on (DWT) batter than based on (FFT) in varies Doppler frequencies and subcarrier size. Also, proposed system with STBC based on 4 transmitters better than other systems based on 1 or 2 or 3 transmitters in all Doppler frequencies and subcarrier size in all simulation results

Online signature verification using neural network and Pearson correlation features

In this paper, we proposed a method for feature extraction in online signature verification. We first used signature coordinate points and pen pressure of all signatures, which are available in the SIGMA database. Then, Pearson correlation coefficients were selected for feature extraction. The obtained features were used in back-propagation neural network for verification. The results indicate an accuracy of 82.42%

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Expectant management of incomplete miscarriage, anembryonic pregnancy and early fetal demise: a comparative study

Background: Expectant management as first line management of early pregnancy miscarriages is less accepted due to failure and increased complications reported in few studies. Proper selection of cases improves outcome of expectant management. Aim of this study was to compare success rate and complications in expectant management in three groups of early pregnancy miscarriages- Incomplete miscarriage, anembryonic pregnancy and early fetal demise.Methods: Prospective observational study conducted in tertiary care centre for 3 years, including 107 patients with USG confirmed pregnancy miscarriage <13 weeks. Patients preferring expectant management were managed as outpatient without intervention for 2 weeks after which repeat USG was done to ascertain complete miscarriage. Failed expectant management patients underwent planned surgical uterine evacuation. Emergency admission and evacuation was done, if symptomatic during waiting period. Success rate and complications like emergency evacuation, vaginal bleeding, abdominal pain, limitation of physical activity and patient satisfaction were assessed and compared in subgroups of anembryonic pregnancy, early fetal demise and incomplete miscarriage. Statistical analysis was done by chi-square test.Results: Incomplete miscarriage group had highest success rate of 88.46%. followed by anembryonic pregnancy (72.5%) and EFD (47.83%) p value = 0.007. Complication rate was highest in EFD, followed by anembryonic and the least in incomplete miscarriage all of which was statistically significant except vaginal bleeding.Conclusions: Expectant management should be offered as first line choice for all types of early pregnancy miscarriages. Proper selection of case as to type of miscarriage especially incomplete miscarriage and selected cases of anembryonic pregnancy and EFD ensures higher success rate with lesser complications. Reserving medical and surgical management for unsuitable/failed cases

Allele, genotype, and composite genotype effects of IL-1A +4845 and IL-1B +3954 polymorphisms for chronic periodontitis in an Indian population

Introduction: The pro-inflammatory cytokine interleukin-1 (IL-1) is a key modulator of host responses to microbial infection and a major modulator of extracellular matrix catabolism and bone resorption, and polymorphisms in the IL-1 gene cluster have been associated with an increased risk of developing severe adult periodontitis. A case control study was performed to determine the role of IL-1A+4845 and IL-1B+3954 polymorphisms in the predisposition to chronic periodontitis. Materials and Methods: The study was conducted with 103 unrelated participants recruited from Manipal College of Dental Sciences, Manipal, which included 51 chronic periodontitis patients and 52 normal periodontally healthy individuals. Extensive clinical data were collected, bone loss was the major outcome variable and smokers and diabetics were excluded from the study to eliminate the influence of these risk factors. Genomic DNA was isolated from the blood samples of participants for genotyping IL-1A+4845 and IL-1B+3954 polymorphisms by polymerase chain reaction-restriction fragment length polymorphism and the data statistically analyzed. Results: Allele 2 of the IL-1A+4845 polymorphism was carried by 38% of all participants; of these only 6 were homozygous for the allele. Allele 2 of the IL-1B+3954 was carried by 21% of the subjects; only 1 was homozygous for allele 2. The composite genotype was carried by 31% of the cases and by 38% of the controls. Overall, 35% participants carried the composite IL-1 genotype. No statistically significant association was found for the distributions. Conclusions: The distribution of the IL-1 positive composite genotype is in concordance with the frequencies reported in the Caucasians. Association was not found for the effect of allele, genotype, composite genotype, and haplotypes of IL-1A+4845 and IL-1B+3954 polymorphisms with periodontitis. Its utility as a risk marker in this population was not borne out by the study