6 research outputs found
Intraoperative Radiation Therapy in the Treatment of Cancer : 6th International IORT Symposium and 31st San Francisco Cancer Symposium, San Francisco, Calif., September 1996 /
No full textOver the past two decades, intraoperative radiotherapy (IORT) has been used for a variety of malignant tumors and has contributed significantly to improve local tumor control. Based on the 31st San Francisco Cancer Symposium and the 6th International Intraoperative Radiation Therapy Symposium in 1996, this book presents the most recent information available on the use of IORT in cancer treatment. A brief historical overview of the development of IORT is followed by discussions of its biological, physical and technical aspects. The main part of the book is devoted to the clinical applications of IORT and the results of its use in the management of cancers of the brain, head and neck, gastrointestinal tract, breast, bone, lung, urinary tract and gynecological region, and of sarcomas. A further topic considered is the quality of life of patients undergoing IORT. The findings presented indicate that IORT provides a major contribution to the control of locally advanced cancer and, in many instances, can improve long-term survival.This book is recommended reading for all clinical practitioners of oncology - surgeons, radiation oncologists and medical oncologists - as well as for radiobiologists, physicists and engineers interested in the technical development of this form of treatment.Over the past two decades, intraoperative radiotherapy (IORT) has been used for a variety of malignant tumors and has contributed significantly to improve local tumor control. Based on the 31st San Francisco Cancer Symposium and the 6th International Intraoperative Radiation Therapy Symposium in 1996, this book presents the most recent information available on the use of IORT in cancer treatment. A brief historical overview of the development of IORT is followed by discussions of its biological, physical and technical aspects. The main part of the book is devoted to the clinical applications of IORT and the results of its use in the management of cancers of the brain, head and neck, gastrointestinal tract, breast, bone, lung, urinary tract and gynecological region, and of sarcomas. A further topic considered is the quality of life of patients undergoing IORT. The findings presented indicate that IORT provides a major contribution to the control of locally advanced cancer and, in many instances, can improve long-term survival.This book is recommended reading for all clinical practitioners of oncology - surgeons, radiation oncologists and medical oncologists - as well as for radiobiologists, physicists and engineers interested in the technical development of this form of treatment.Print version recor
Expression Suppression and Activity Inhibition of TRPM7 Regulate Cytokine Production and Multiple Organ Dysfunction Syndrome During Endotoxemia: A New Target for Sepsis
No full textBackground: Main pathological features detected during sepsis and endotoxemia include over-secretion of pro-inflammatory cytokines and multiorgan dysfunction syndrome (MODS). Unfortunately, current clinical efforts to treat sepsis are unsatisfactory, and mortality remains high. Interestingly, transient receptor potential (TRP) melastatin 7 (TRPM7) ion channel controlling Ca2+ and Mg2+ permeability is involved in cytokine production and inflammatory response. Furthermore, TRPM7 downregulation has been shown to alleviate local symptoms in some models of sepsis, but its effects at a systemic level remain to be explored. Objective: To test whether TRPM7 mediates cytokine production and MODS during endotoxemia. Methods: Endotoxemic and sham-endotoxemic rats were subjected to pharmacological inhibition of TRPM7 using carvacrol, or to expression suppression by adenovirus delivery of shRNA (AdV(shTRPM7)). Then, cytokine and MODS levels in the blood were measured. Results: Inhibition of TRPM7 with carvacrol and suppression with AdV(shTRPM7 )were both efficient in inhibiting the over-secretion of pro-inflammatory cytokines TNF-alpha, IL-1 beta, IL-6, and IL-12 in endotoxemic rats, without inducing downregulation in blood levels of anti-inflammatory cytokines IL-10 and IL-4. Additionally, the use of carvacrol and AdV(shTRPM7) significantly prevented liver and pancreas dysfunction, altered metabolic function, and hypoglycemia, induced by endotoxemia. Furthermore, muscle mass wasting and cardiac muscle damage were also significantly reduced by the use of carvacrol and AdV(shTRPM7) in endotoxemic rats. Conclusion: Our results indicate TRPM7 ion channel as a key protein regulating inflammatory responses and MODS during sepsis. Moreover, TRPM7 appears as a novel molecular target for the management of sepsis
