Utilization of malaria prophylaxes amongst Nigerian Urban antenatal population

Background: The recommendation of the World Health Organization (WHO) towards preventing malaria and its effects in pregnancy is the utilization of a combination of interventions such as sleeping under insecticide treated nets (ITNs), Intermittent Preventive Treatment in pregnancy (IPTp), insecticide room spraying (IRS) and effective case management and treatment. All these strategies have been adopted in Nigeria through a national policy on malaria treatment and prophylaxis. Despite these interventions, the high prevalence of malaria in pregnancy continues to rise in Nigeria, with the attendant cost in human lives and economic loss1,2. There is therefore need to determine the level of public awareness and utilization of these preventive measures. The objective of this study was to determine the knowledge and the use of known interventions towards preventing malaria in pregnancy prior to registration for antenatal care.Methods: Four hundred women were recruited by simple random sampling for this study. They were interviewed using a semistructured questionnaire to obtain information on their socio-demographic characteristics, their pregnancy, knowledge on malaria and its prophylaxis in pregnancy.Results: Many (51.6%) of the respondents registered for antenatal care after 20 weeks of gestation. Though majority (79.8%) rightly associated malaria with mosquito bite, only a few (15. 75%) of the respondents had ever used insecticide treated nets to prevent mosquito bites in their lifetime and only 1% used it the night before joining this study. About 27.5% of them were already on self-administered malaria chemoprophylaxis before registration.Conclusion: Over one half of these women register late for antenatal care. The attitude of the pregnant women towards malaria prevention prior to registration for antenatal care is poor even though they have adequate knowledge of the cause of malaria and its prevention.Keywords: Malaria Prophylaxis; Insecticide Treated Bed Nets; Antenatal Population; Sulphodoxine-Pyrimethamin

Ovulation Induction in Women with Polycystic Ovary Syndrome: What is the Optimal Option?

Infertility is a distressing medical and psychosocial problem afflicting about a quarter of all couples wanting to reproduce their offspring. Majority of the anovulatory problem in the female, as a cause of infertility, is due to polycystic ovary syndrome (PCOS). This condition is a complex interplay of factors, which affect women even beyond their fertility. It has been found to increase the risk of other adverse conditions such as the metabolic syndrome, cardiovascular diseases, type II diabetes mellitus, and endometrial cancer as well as infertility. Different groups have made diagnosis of PCOS with various diagnostic criteria. The Rotterdam criteria used in the diagnosis of PCOS mainly emphasize the reproductive malfunctions of this complex disease. The treatment of anovulatory infertility in PCOS is as enigmatic as the disease itself. Various methods have been deployed to treat the anovulation with variable success. Clomiphene citrate is a traditional first-line drug in treating anovulation in women with PCOS. Weight reduction, letrozole, metformin, follicle-stimulating hormone (FSH) and ovarian drilling are some of the other ways in which anovulation has been treated in these women. What method is more likely to succeed in treating the infertility from anovulation in PCOS and in what circumstance are the subject matters of this discussion

Live Birth After In-Vitro Fertilization (IVF) in a 53 Year Old Woman: A Case Report

Background Infertility is a global problem with high prevalence in low resource countries. As achieving  parenthood is a basic and desired goal in adulthood, infertility is more than a physical problem. It has  adverse social and psychological implications especially for women in developing countries. Age is no longer a barrier in assisted reproduction thanks to assisted reproductive techniques (ART) especially with the use of donor oocytes. The aim is to report a case of live birth in a 53 year old woman following ART.Case Report A 53-year-old civil servant who registered for antenatal care at the University of Port Harcourt Teaching Hospital (UPTH) in 2008 at 17 weeks gestation is presented. She had conceived after 4  years of infertility following treatment by intracytoplasmic sperm injection I embryo transfer (ICSI-ET) using her husband's sperm and donor eggs. The pregnancy was complicated by breech presentation at  term. She was delivered of a healthy live male infant by elective caesarean section at 38 weeks of  gestation. The puerperium was complicated by hypertension, which was managed appropriately.Conclusion Infertility in women of advanced reproductive age can be successfully treated with donor oocytes in Nigeria. Antenatal supervision and delivery by skilled attendants is key to achieving a favourable outcome.Keywords: Advanced maternal age; NF; ART; Live Birth; Port Harcourt

Hysterosalpingographic (HSG) pattern of infertility in women of reproductive age

Background: Infertility is a complex disorder with significant medical, psychological and economic problems. Aims: The aim of the study is to evaluate the structural abnormalities of the uterus and fallopian tubes in infertile women as elucidated by hysterosalpingography. Setting and Design: A retrospective study, conducted at the Radiology and Obstetric and Gynaecologic Departments of a tertiary health care institution. Materials and Methods: Evaluation of all consecutive patients in whom hysterosalpingographic (HSG) was performed for infertility between July 2013 and June 2015 in the Department of Radiology. For the biodata, indications for the investigation and the HSG findings were obtained. Statistical Analysis: The data were analyzed using IBM Statistical Package for the Social Sciences (SPSS Inc., Chicago, IL, USA) for Windows, version 20 software. Results: A total of 299 patients were evaluated. Of these, 250 were for infertility with primary and secondary infertility constituting 18.4 and 81.6%, respectively. Seventy percent of the cases for infertility had abnormalities on the HSG. Normal uterine cavity was found in 123 (49.2%) cases. Uterine filling defects were the most common uterine abnormality. Fallopian tube occlusion, loculated contrast material spillage and hydrosalpinx were more common on the right, and bilateral tubal occlusion was seen only in 11.2%. All cases of intravasation were associated with either unilateral or bilateral fallopian tube blockage or irregularity of the uterus. Conclusion: There was a high incidence of tubal disease in the women presenting with infertility. This was commonly as a result of infection and inflammatory process. This study showed that HSG is very vital in detecting birth canal pathologies; hence, the facility for this important procedure, especially fluoroscopy, should be made available in the health centres for adequate assessment of the women with infertility

Adaptation of the Wound Healing Questionnaire universal-reporter outcome measure for use in global surgery trials (TALON-1 study): mixed-methods study and Rasch analysis

BackgroundThe Bluebelle Wound Healing Questionnaire (WHQ) is a universal-reporter outcome measure developed in the UK for remote detection of surgical-site infection after abdominal surgery. This study aimed to explore cross-cultural equivalence, acceptability, and content validity of the WHQ for use across low- and middle-income countries, and to make recommendations for its adaptation.MethodsThis was a mixed-methods study within a trial (SWAT) embedded in an international randomized trial, conducted according to best practice guidelines, and co-produced with community and patient partners (TALON-1). Structured interviews and focus groups were used to gather data regarding cross-cultural, cross-contextual equivalence of the individual items and scale, and conduct a translatability assessment. Translation was completed into five languages in accordance with Mapi recommendations. Next, data from a prospective cohort (SWAT) were interpreted using Rasch analysis to explore scaling and measurement properties of the WHQ. Finally, qualitative and quantitative data were triangulated using a modified, exploratory, instrumental design model.ResultsIn the qualitative phase, 10 structured interviews and six focus groups took place with a total of 47 investigators across six countries. Themes related to comprehension, response mapping, retrieval, and judgement were identified with rich cross-cultural insights. In the quantitative phase, an exploratory Rasch model was fitted to data from 537 patients (369 excluding extremes). Owing to the number of extreme (floor) values, the overall level of power was low. The single WHQ scale satisfied tests of unidimensionality, indicating validity of the ordinal total WHQ score. There was significant overall model misfit of five items (5, 9, 14, 15, 16) and local dependency in 11 item pairs. The person separation index was estimated as 0.48 suggesting weak discrimination between classes, whereas Cronbach's α was high at 0.86. Triangulation of qualitative data with the Rasch analysis supported recommendations for cross-cultural adaptation of the WHQ items 1 (redness), 3 (clear fluid), 7 (deep wound opening), 10 (pain), 11 (fever), 15 (antibiotics), 16 (debridement), 18 (drainage), and 19 (reoperation). Changes to three item response categories (1, not at all; 2, a little; 3, a lot) were adopted for symptom items 1 to 10, and two categories (0, no; 1, yes) for item 11 (fever).ConclusionThis study made recommendations for cross-cultural adaptation of the WHQ for use in global surgical research and practice, using co-produced mixed-methods data from three continents. Translations are now available for implementation into remote wound assessment pathways