Simulation of Transcendental Deformation Mode of Interchamber Pillars and Ore Deposit in the Course of Development of Bauxite Resources at Great Depth on the Example of Mine "Sevuralboksitruda"

The publication describes the problem of transcendental deformation mode of interchamber pillar and ore deposit associated with the formation of hazardous zones in the rock mass in process of development of rockburst-hazardous rock masses at the great depth. Geomechanical software PRESS 3D URAL is used to assess the impact of the range of geological and technological factors on the mode of interchamber pillars deformation and ore deposit. The software allows to solve spatial problems in the elastic-plastic formulation. The results of step-by-step modeling of different mining and technical situations with a test of the bearing capacity of interchamber pillars showed that some of them can't withstand the mountain pressure and go to the transcendental mode of deformation with subsequent destruction. Identification of the destroyed pillars allows to adjust the boundary conditions of loading the ore mass. At the same time the neglect of transcendental mode of deformation of interchamber pillars can lead to an undervaluation of the stress level in the ore mass by 1.5 or more times. This can lead to an error in predicting the parameters of zones dangerous due to rock bumps

The Trade-Economic Component of the Regional Economic Processes in the Context of Globalization

The article is concerned with analyzing and defining the structure of the tradeeconomic component of the regional economic processes on example of the EU, ASEAN, BRICS, SCO and NAFTA in the context of globalization. Based on analysis and generalization of numerous scientific works by various authors, a block of theoretical and statistical data on the contemporary regional integration associations has been considered and systematized. The article carries out an analysis of the trade-economic relations by the objectively leading and indicative, as to the current global economic processes, regional integration associations, namely the EU, SCO, BRIC, ASEAN and NAFTA, determines their impact on development of the international economic relations. The structure has been studied, as well as a comparative characterization of the data of regional economic integration associations in the context of global economy has been accomplished. Prospect for further research on this issue is determining the involvement of an individual integration association in the system of contemporary global economic relations

Assessment of Stress-Strain and Shock Bump Hazard of Rock Mass in the Zones of High-Amplitude Tectonic Dislocations

The paper analyses geodynamic processes in the development of the Talnakh and Oktyabrsk deposits, which have complex geological structure. It demonstrates the results of the forecast estimation of seismic energy released on the contact surface of the fault plane of type I and II tectonic dislocations when stoping approaches. The article discusses the geodynamic processes occurring during the mining of the Talnakh and Oktyabrsky deposits of complex geological structure. The results of predictive assessments of seismic energy released at the contact surface displacement of a tectonic disturbance type I and II at the approach of remediation. For practical use of the obtained graph of the dependence of critical distance from the front of the treatment works to a tectonic disturbance on the magnitude of the angle of internal friction

Liver regeneration is associated with lipid reorganization in membranes of the endoplasmic reticulum

BACKGROUND:In recent years, an adaptive endoplasmic reticulum (ER) stress response has been actively investigated. The ER membrane, isolated from the intact and regenerating liver, may be an appropriate model for investigating the association between structural and functional characteristics of ER in vivo and their corresponding behavioral characteristics in vitro. The rate of lipid synthesis and that of intracellular lipid exchange between the ER and cytosol were investigated in the intact and regenerating liver (13 h after partial hepatectomy). Particularly, membrane characteristics, surface potential, and glucose 6-phosphatase (G6Pase) activity were investigated, along with the degradation rate of G6Pase in vitro, which was estimated by the loss of G6Pase activity, formation of lipid peroxides, and size of excreted membrane vesicles. METHODS:The rate of lipid synthesis was determined by measuring the intensity of radioactive precursor (C14 - sodium acetate) in different fractions of lipids (phospholipids, non-esterified fatty acids, and triacylglycerides) after 30 min exposure. The rate of lipid metabolism was assessed by measuring the quantity of lipids with radioactive labels emerging in the cytosol of hepatocytes (CPM). Viscosity and surface potential were determined by fluorescent probes. RESULTS:It was observed that after 13 h of partial hepatectomy, the rate of lipid synthesis in the ER of hepatocytes in the regenerating liver was 3 times lower than that in ER of hepatocytes in the intact liver, wherein the rate of incorporation of newly synthesized lipids in cytosol was several times higher in the regenerating liver. Increase in the rate of exchange of neutral lipids in cells of the regenerating liver was accompanied by lipid reconstruction in the ER, changing the structural and functional characteristics of the membrane. Such membrane rebuilding also contributed to the rate of degradation of the ER in vitro,which that must be taken into account during development of systems for in vitro assessment of xenobiotic metabolism. CONCLUSIONS:An increase in the rate of direct (microsomes---cytosol) and reverse transport of lipids (cytosol --- microsomes) was observed in the regenerating liver. Microsomes, isolated from the regenerating liver, were degraded in the in vitro system at a higher rate

Detection of angiospastic disorders in the microcirculatory bed using laser diagnostics technologies

The evaluation of the microcirculatory bed functional state and the identification of angiospastic disorders with related complications, when the pathological changes are reversible, have an important role in medical practice. The aim of this study was to evaluate the possibility of using optical noninvasive methods and the cold pressor test to solve this problem. A total of 33 patients with rheumatological diseases and 32 healthy volunteers were included in the study. Laser Doppler flowmetry, tissue reflectance oximetry and pulse oximetry were used as optical noninvasive methods. The parameters were recorded before, immediately after and 20(Formula presented.)min after the cold pressor test. Based on the measured parameters, the complex parameters of the microcirculatory bed were calculated. A detailed statistical analysis of the parameter changes for each individual in the two groups displayed diverse microcirculatory bed parameter responses upon cold exposure, with differing recovery of parameters after CPT. New diagnostic criteria were proposed for the identification of angiospastic disorders. According to the proposed criteria, 27 people of the volunteers group were confirmed to not display any disorders. In the patient group, however, 18 people were observed to have a relatively normal functional state of the microcirculatory bed, while 15 people were observed to have a possible tendency to angiospasm. To highlight the differences between a relatively normal state and presence of angiospastic disorders, statistical analysis of experimental data was carried out, which revealed significant differences. Further analysis of data with angiospastic disorders identified a relationship between their diagnoses and the results of laboratory studies. Thus, the evaluation of combined noninvasive optical diagnostic method use, the cold pressor test and proposed diagnostic criteria showed a positive result. This approach can be used to detect the presence of possible angiospastic disorders and related complications, as well as microcirculatory bed disorders against the background of other diseases

The Influence of Globalization on the Synchronism of Development of Economic Processes within the Terms of World Economy (p. 16 - 20)

The article is aimed at analyzing the degree of dependence of national economies at the present stage of development of the world economy. Both the dynamics and the nature of development of the economic globalization were analyzed on the example of various areas of world economy. The key tendencies of the economic globalization have been identified and described, the key indicators of participation of countries in the economic globalization have been analyzed as well. Dynamics of the key stock indices of the developed and developing countries (G7 and BRICS) were researched for synchronism of reaction to positive and negative economic events. Using the results of the research, the degree of dependence of the largest stock indices during 2001-2015 has been estimated by means of correlation analysis and the analysis of critical dimensions, also the fact has been empirically proved, that the dynamics of growth of national economies have more synchronous nature during the period of economic shocks, rather than during the periods of their normal functioning

Liver regeneration is associated with lipid reorganization in membranes of the endoplasmic reticulum

BACKGROUND:In recent years, an adaptive endoplasmic reticulum (ER) stress response has been actively investigated. The ER membrane, isolated from the intact and regenerating liver, may be an appropriate model for investigating the association between structural and functional characteristics of ER in vivo and their corresponding behavioral characteristics in vitro. The rate of lipid synthesis and that of intracellular lipid exchange between the ER and cytosol were investigated in the intact and regenerating liver (13 h after partial hepatectomy). Particularly, membrane characteristics, surface potential, and glucose 6-phosphatase (G6Pase) activity were investigated, along with the degradation rate of G6Pase in vitro, which was estimated by the loss of G6Pase activity, formation of lipid peroxides, and size of excreted membrane vesicles. METHODS:The rate of lipid synthesis was determined by measuring the intensity of radioactive precursor (C14 - sodium acetate) in different fractions of lipids (phospholipids, non-esterified fatty acids, and triacylglycerides) after 30 min exposure. The rate of lipid metabolism was assessed by measuring the quantity of lipids with radioactive labels emerging in the cytosol of hepatocytes (CPM). Viscosity and surface potential were determined by fluorescent probes. RESULTS:It was observed that after 13 h of partial hepatectomy, the rate of lipid synthesis in the ER of hepatocytes in the regenerating liver was 3 times lower than that in ER of hepatocytes in the intact liver, wherein the rate of incorporation of newly synthesized lipids in cytosol was several times higher in the regenerating liver. Increase in the rate of exchange of neutral lipids in cells of the regenerating liver was accompanied by lipid reconstruction in the ER, changing the structural and functional characteristics of the membrane. Such membrane rebuilding also contributed to the rate of degradation of the ER in vitro,which that must be taken into account during development of systems for in vitro assessment of xenobiotic metabolism. CONCLUSIONS:An increase in the rate of direct (microsomes---cytosol) and reverse transport of lipids (cytosol --- microsomes) was observed in the regenerating liver. Microsomes, isolated from the regenerating liver, were degraded in the in vitro system at a higher rate

Measurements of the Total and Differential Higgs Boson Production Cross Sections Combining the H??????? and H???ZZ*???4??? Decay Channels at s\sqrt{s}=8??????TeV with the ATLAS Detector

Measurements of the total and differential cross sections of Higgs boson production are performed using 20.3~fb$^{-1}$ of $pp$ collisions produced by the Large Hadron Collider at a center-of-mass energy of $\sqrt{s} = 8$ TeV and recorded by the ATLAS detector. Cross sections are obtained from measured $H \rightarrow \gamma \gamma$ and $H \rightarrow ZZ ^{*}\rightarrow 4\ell$ event yields, which are combined accounting for detector efficiencies, fiducial acceptances and branching fractions. Differential cross sections are reported as a function of Higgs boson transverse momentum, Higgs boson rapidity, number of jets in the event, and transverse momentum of the leading jet. The total production cross section is determined to be $\sigma_{pp \to H} = 33.0 \pm 5.3 \, ({\rm stat}) \pm 1.6 \, ({\rm sys}) \mathrm{pb}$. The measurements are compared to state-of-the-art predictions.Measurements of the total and differential cross sections of Higgs boson production are performed using 20.3  fb-1 of pp collisions produced by the Large Hadron Collider at a center-of-mass energy of s=8  TeV and recorded by the ATLAS detector. Cross sections are obtained from measured H→γγ and H→ZZ*→4ℓ event yields, which are combined accounting for detector efficiencies, fiducial acceptances, and branching fractions. Differential cross sections are reported as a function of Higgs boson transverse momentum, Higgs boson rapidity, number of jets in the event, and transverse momentum of the leading jet. The total production cross section is determined to be σpp→H=33.0±5.3 (stat)±1.6 (syst)  pb. The measurements are compared to state-of-the-art predictions.Measurements of the total and differential cross sections of Higgs boson production are performed using 20.3 fb$^{-1}$ of $pp$ collisions produced by the Large Hadron Collider at a center-of-mass energy of $\sqrt{s} = 8$ TeV and recorded by the ATLAS detector. Cross sections are obtained from measured $H \rightarrow \gamma \gamma$ and $H \rightarrow ZZ ^{*}\rightarrow 4\ell$ event yields, which are combined accounting for detector efficiencies, fiducial acceptances and branching fractions. Differential cross sections are reported as a function of Higgs boson transverse momentum, Higgs boson rapidity, number of jets in the event, and transverse momentum of the leading jet. The total production cross section is determined to be $\sigma_{pp \to H} = 33.0 \pm 5.3 \, ({\rm stat}) \pm 1.6 \, ({\rm sys}) \mathrm{pb}$. The measurements are compared to state-of-the-art predictions