116 research outputs found
The Occupational Vision of Information Technology Job Markets
This study introduces the IT Occupation Vision, a new conceptual and methodological framework, to examine structural changes in IT occupations. It also highlights the role of industry discourse in shaping those changes. The approach suggests that these occupations are shaped by a latent collective consensus that influences labor market categories. Adapting Relational Class Analysis (RCA), a type of Schematic Class Analysis, the study leverages textual signals from online job advertisements to scrutinize structural changes in IT roles and skill sets. This work bridges Organizing Vision and diffusion literature with the IT workforce, providing insights into the interaction between innovation, skills, and emerging technologies. Unlike the Organizing Vision theory, which is artifact-centric, the IT Occupational Vision focuses on the labor aspects associated with these technological innovations. The study addresses gaps in our understanding of the socio-cognitive aspects of IT occupations, providing valuable insights for policies and practices in evolving labor markets
Building Grounded Theory with Social Media Data
The growing popularity and constant innovations of social media platforms and applications have transformed ways of interacting, working, creating value and innovating. We elaborate upon how building theory from case studies may be adapted to the opportunities and challenges of social media environments. We delve into key challenges of the research process: case study design, data analysis, and engaging in multi methods
Towards an ecology of collective innovation: Human variome project (HVP), rare disease consortium for autosomal loci (RADical) and data-enabled life sciences alliance (DELSA)
Antiferromagnetic ordering in a 90 K copper oxide superconductor
Using elastic neutron scattering, we evidence a commensurate
antiferromagnetic Cu(2) order (AF) in the superconducting (SC) high-
cuprate (y=0.013, =93 K). As
in the Co-free system, the spin excitation spectrum is dominated by a magnetic
resonance peak at 41 meV but with a reduced spectral weight. The substitution
of Co thus leads to a state where AF and SC cohabit showing that the CuO
plane is a highly antiferromagnetically polarizable medium even for a sample
where T remains optimum.Comment: 3 figure
Local tree knowledge can fast-track agroforestry recommendations for coffee smallholders along a climate gradient in Mount Elgon, Uganda
K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport
<p>Abstract</p> <p>Background</p> <p>Lung epithelial Na<sup>+ </sup>channels (ENaC) are regulated by cell Ca<sup>2+ </sup>signal, which may contribute to calcium antagonist-induced noncardiogenic lung edema. Although K<sup>+ </sup>channel modulators regulate ENaC activity in normal lungs, the therapeutical relevance and the underlying mechanisms have not been completely explored. We hypothesized that K<sup>+ </sup>channel openers may restore calcium channel blocker-inhibited alveolar fluid clearance (AFC) by up-regulating both apical and basolateral ion transport.</p> <p>Methods</p> <p>Verapamil-induced depression of heterologously expressed human αβγ ENaC in <it>Xenopus </it>oocytes, apical and basolateral ion transport in monolayers of human lung epithelial cells (H441), and <it>in vivo </it>alveolar fluid clearance were measured, respectively, using the two-electrode voltage clamp, Ussing chamber, and BSA protein assays. Ca<sup>2+ </sup>signal in H441 cells was analyzed using Fluo 4AM.</p> <p>Results</p> <p>The rate of <it>in vivo </it>AFC was reduced significantly (40.6 ± 6.3% of control, <it>P </it>< 0.05, n = 12) in mice intratracheally administrated verapamil. K<sub>Ca3.1 </sub>(1-EBIO) and K<sub>ATP </sub>(minoxidil) channel openers significantly recovered AFC. In addition to short-circuit current (Isc) in intact H441 monolayers, both apical and basolateral Isc levels were reduced by verapamil in permeabilized monolayers. Moreover, verapamil significantly altered Ca<sup>2+ </sup>signal evoked by ionomycin in H441 cells. Depletion of cytosolic Ca<sup>2+ </sup>in αβγ ENaC-expressing oocytes completely abolished verapamil-induced inhibition. Intriguingly, K<sub>V </sub>(pyrithione-Na), K <sub>Ca3.1 </sub>(1-EBIO), and K<sub>ATP </sub>(minoxidil) channel openers almost completely restored the verapamil-induced decrease in Isc levels by diversely up-regulating apical and basolateral Na<sup>+ </sup>and K<sup>+ </sup>transport pathways.</p> <p>Conclusions</p> <p>Our observations demonstrate that K<sup>+ </sup>channel openers are capable of rescuing reduced vectorial Na<sup>+ </sup>transport across lung epithelial cells with impaired Ca<sup>2+ </sup>signal.</p
We All Know How, Don’t We? On the Role of Scrum in IT-Offshoring
Part 2: Creating Value through Software DevelopmentInternational audienceOffshoring in the IT-industry involves dual interactions between a mother company and an external supplier, often viewed with an implicit perspective from the mother company. This article review general off shoring and IT offshoring literature, focusing on the proliferation of a globally available set of routines; Scrum and Agile. Two cases are studied; a small company and short process and a large mother company with a long process. The interactions of the set ups shows that global concepts like Scrum and Agile are far from a common platform. The “well known” concepts are locally shaped and the enterprises have mixed experiences
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