The '39 steps' : an algorithm for performing statistical analysis of data on energy intake and expenditure

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.Peer reviewedPublisher PD

Partitioning the variance in calorie restriction-induced weight and fat loss in outbred mice

Funding agencies: LMV was funded by a Rubicon grant from the Netherlands Organisation for Scientific Research (NWO, 825.08.014). This work was supported by BBSRC grant BB/G009953/1.Peer reviewedPostprin

Are component endpoints equal?:A preference study into the practice of composite endpoints in clinical trials

Objectives: To examine patients’ perspectives regarding composite endpoints and the utility patients put on possible adverse outcomes of revascularization procedures. Design: In the PRECORE study, a stated preference elicitation method Best-Worst Scaling (BWS) was used to determine patient preference for 8 component endpoints (CEs): need for redo percutaneous coronary intervention (PCI) within 1 year, minor stroke with symptoms <24 hours, minor myocardial infarction (MI) with symptoms <3 months, recurrent angina pectoris, need for redo coronary artery bypass grafting (CABG) within 1 year, major MI causing permanent disability, major stroke causing permanent disability and death within 24 hours. Setting: A tertiary PCI/CABG centre. Participants: One hundred and sixty patients with coronary artery disease who underwent PCI or CABG. Main outcome measures: Importance weights (IWs). Results: Patients considered need for redo PCI within 1 year (IW: 0.008), minor stroke with symptoms <24 hours (IW: 0.017), minor MI with symptoms <3 months (IW: 0.027), need for redo CABG within 1 year (IW: 0.119), recurrent angina pectoris (IW: 0.300) and major MI causing permanent disability (IW: 0.726) less severe than death within 24 hours (IW: 1.000). Major stroke causing permanent disability was considered worse than death within 24 hours (IW: 1.209). Ranking of CEs and the relative values attributed to the CEs differed among subgroups based on gender, age and educational level. Conclusion: Patients attribute different weight to individual CEs. This has significant implications for the interpretation of clinical trial data

The relationship of female physical attractiveness to body fatness

Funding This work was supported by NSFC grant 91431102 from the National Science Foundation of China. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgements We are grateful to all the participants from all the countries and all the members of Molecular Energetics Group for their help on the investigation and discussion of the results.Peer reviewedPublisher PD

Limits to sustained energy intake XXVII : trade-offs between first and second litters in lactating mice support the ecological context hypothesis

Osei Duah Agemang was supported by a scholarship from the Cape University, Ghana. Lobke Maria Vaanholt was supported by a Rubicon grant from the Netherlands Organisation for Scientific Research (NWO).Peer reviewedPublisher PD