Pharmacological management of immune and oxidative disturbances in patients with encephalopathy on the background of hypertension

Inclusion of a comprehensive drug treatment of patients with discirculatory encephalopathy cerebrolysin combination with meksidol normalizes the concentration of C3 and C4 components of the complement system, IgG, malondialdehyde, catalase activity, total antioxidant activity of blood serum, corrects, but not to the level of standards, the contents of cytokines (TNF, IL-1β, IL-6, IL-8, IL-18, IFγ, IL-2, IL-17), complement component C5, IgA, acylhydrohyperoxide, neopterin and increases anti-inflammatory cytokine

People's trust in the field of pensions: the sociological analysis

Авторы статьи анализируют такую характеристику социального взаимодействия органов власти граждан и предпринимателей как доверие. Ими обоснованы методологические подходы, применяемые при изучении доверия. Также они приводят результаты проведения фокус-групп, посвященных пенсионной реформе и действиям граждан относительно пенсионных накоплений.The authors analyze a characteristic of social interaction of citizens and government and business as a trust. They justifies the methodological approaches, used in the study of trust. They also report the results of the focus - groups, dealing with pension reform and citizens' actions with respect to pension savings

Peculiarities of sorption isotherm and sorption chemisms of caesium by mixed nickel-potassium ferrocyanide based on hydrated titanium dioxide

Sorption isotherm of caesium from tap water by mixed nickel-potassium ferrocyanide based on hydrated titanium dioxide is obtained for a wide range of concentrations of caesium. It is shown that there are three types of specificity to caesium sorption sites in this sorbent. Sorption chemisms of caesium are studied, factors conditioned high sorption capacity of the sorbent are revealed. It is shown that occupation of sorption sites I and II is well approximated by Langmuir equilibrium and this process can be described within the bounds of theory of ion exchange. The expected sorption chemism of caesium by sorption sites III at high concentrations of caesium (>50 mg L-1) is precipitation of mixed nickel-caesium ferrocyanide in pore space of the sorbent. © 2013 Akadémiai Kiadó, Budapest, Hungary

Статика и кинетика сорбции цезия из водных сред ферроцианидами никеля-калия на основе гидратированных диоксидов титана и циркония

Optimization of the synthesis of the mixed nickel-potassium ferrocyanide based on hydrated titanium dioxide has been realized. The influence of the conditions of synthesis of the sorbents on the elemental composition, surface texture, statics and kinetics has been shown. The synthetic technique was used to prepare sorbents based on hydrated titanium dioxide carrier. The influence of the chemical properties of the carrier on sorption behaviour of the ferrocyanides was determined.Описана оптимизация синтеза смешанного ферроцианида никеля-калия на основе гидратированного диоксида титана. Показано влияние условий синтеза сорбентов на их элементный состав, текстуру поверхности, статику и кинетику сорбции. Методика синтеза была использована для получения сорбента на основе гидратированного диоксида титана. Определено влияние химических свойств носителя на сорбционное поведение ферроцианидов

Approaches of Russian oil companies to optimal capital structure

Oil companies play a vital role in Russian economy. Demand for hydrocarbon products will be increasing for the nearest decades simultaneously with the population growth and social needs. Change of raw-material orientation of Russian economy and the transition to the innovative way of the development do not exclude the development of oil industry in future. Moreover, society believes that this sector must bring the Russian economy on to the road of innovative development due to neo-industrialization. To achieve this, the government power as well as capital management of companies are required. To make their optimal capital structure, it is necessary to minimize the capital cost, decrease definite risks under existing limits, and maximize profitability. The capital structure analysis of Russian and foreign oil companies shows different approaches, reasons, as well as conditions and, consequently, equity capital and debt capital relationship and their cost, which demands the effective capital management strategy

Characters of the lateral-line system and their use in taxonomy of Paralichthys, Hippoglossina and Lioglossina (Paralichthyidae, Pleuronectiformes)

A morphological study of eight species of Paralichthys, two species of Hippoglossina, and Lioglossina tetrophthalma, has revealed head lateral-line canal topography differences of taxonomic value. In species of Paralichthys, segment of the supraorbital canal in nasale of the blind side is connected with other canals and canaliculi are ramified, whereas in species of Hippoglossina this segment is not connected and canaliculi are not ramified. These different character states corroborate the generic distinction between Paralichthys and Hippoglossina. The connection of the supraorbital canal in nasale of the blind side with other canals and ramified canaliculi found in L. tetrophthalma and P. oblongus are against regarding them as Hippoglossina species. It appears necessary to restore the monotypic genus Lioglossina and to place P. oblongus in the genus Paralichthys until new morphological or molecular data are obtained. Paralichthys species vary in the degree of ramification of canaliculi, presence or absence of infraorbital canal segment in the lacrimale of the ocular side and posterior line of CST. Differences in lateral-line canal topography of H. macrops and H. bollmani were not found.Fil: Voronina, E. P.. Russian Academy of Sciences; RusiaFil: Díaz de Astarloa, Juan Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentin

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin