1,294 research outputs found
Beam Dynamics Studies for SRF Photoinjectors
The SRF photoinjector combines the advantages of photo assisted production of high brightness, short electron pulses and high gradient, low loss continuous wave CW operation of a superconducting radiofrequency SRF cavity. The paper discusses beam dynamics considerations for ERL class applications of SRF photoinjectors. One case of particular interest is the design of the SRF photoinjector for BERLinPro, an ERL test facility demanding a high brightness beam with an emittance better than 1 mm mrad at 77 pC and average current of 100 m
Wigner Glass, Spin-liquids, and the Metal-Insulator Transition
Recent experiments on the two dimensional electron gas in various
semiconductor devices have revealed an unexpected metal-insulator transition
and have challenged the previously held assumption that there is no such
transition in two dimensions. While the experiments are still at the stage of
rapid development, it is becoming evident that they cannot be understood from
the conventional perspective of weak interactions. In the present paper, we
propose the following. (1) The low-density insulating state is the Wigner
Glass, a phase with quasi-long-range translational order and competing
ferromagnetic and antiferromagnetic spin-exchange interactions. (2) The
transition is the melting of this Wigner Glass, disorder being the agent
allowing the transition to be second order. (3) Within the Wigner Glass phase,
there are at least two, distinct magnetic ground-states, a ferromagnetic state
at very low electron density and a spin-liquid state with a spin pseudo-gap at
higher densities. (4) The metallic side of the transition is a non-Fermi
liquid. These conclusions are encapsulated in Figure 1 which presents the
proposed phase diagram as a function of disorder strength and density; we also
suggest experimental signatures of the various phases and transitions.Comment: Revised manuscript 6 pages, 1 figure redrawn for clarity; discussion
of experiments expande
Upper water column structure during marine isotope stage 11.3 and the Holocene on the portuguese margin
Effects of Elevated Sucrose-Phosphate Synthase Activity on Photosynthesis, Assimilate Partitioning, and Growth in Tomato (Lycopersicon esculentum var UC82B)
Molecular Electroporation and the Transduction of Oligoarginines
Certain short polycations, such as TAT and polyarginine, rapidly pass through
the plasma membranes of mammalian cells by an unknown mechanism called
transduction as well as by endocytosis and macropinocytosis. These
cell-penetrating peptides (CPPs) promise to be medically useful when fused to
biologically active peptides. I offer a simple model in which one or more CPPs
and the phosphatidylserines of the inner leaflet form a kind of capacitor with
a voltage in excess of 180 mV, high enough to create a molecular electropore.
The model is consistent with an empirical upper limit on the cargo peptide of
40--60 amino acids and with experimental data on how the transduction of a
polyarginine-fluorophore into mouse C2C12 myoblasts depends on the number of
arginines in the CPP and on the CPP concentration. The model makes three
testable predictions.Comment: 15 pages, 5 figure
Data report: IODP Site U1387: the revised splice between Sections U1387B-18X-3 and U1387C-8R-3 (>171.6 mcd)
The Expedition 339 shipboard splice of Integrated Ocean Drilling
Program (IODP) Site U1387 deeper than ~155 meters composite
depth (mcd) is based on a composite of the magnetic susceptibility and natural gamma radiation data. When generating high-resolution paleoceanographic reconstructions for the Mid-Pleistocene Transition and early Pleistocene sections of Site U1387, it
quickly became obvious that proxy data misfits existed at several
splice transitions. Thus, a revised splice was generated for Site
U1387 below Core 339-U1387B-18X based on X-ray fluorescence–
derived element records (e.g., ln[Fe/Ca]) and the stable isotope records obtained for planktonic and benthic foraminifers. Corrections were needed at most of the splice transitions below Core
339-U1387A-19X, with adjustments ranging from a few centimeters to several meters. In addition, Core 339-U1387A-33X and sections of Core 36X were integrated into the revised splice to replace Core 339-U1387C-2R and sections of Core 5R, respectively.
The replacement of Core 339-U1387C-2R with Core 339-U1387A33X is an option for the intended paleoceanographic research and
not essential for lower resolution studies. The splice tie point table, therefore, also includes an option for a splice that retains
Core 339-U1387C-2R. The extensive revision of the shipboard
splice reveals that making a splice for sediment sequences rich in
contourite layers and coring disturbances (biscuiting in the extended core barrel cores) can be tricky and that data misfits at
splice transitions are not necessarily a data problem but could indicate a splice problem.SFRH/BPD/111433/2015info:eu-repo/semantics/publishedVersio
The transcriptome of utricle hair cell regeneration in the avian inner ear
Sensory hair cell loss is the major cause of hearing and balance disorders. Mammals are incapable of sustained hair cell regeneration, but lower vertebrates can regenerate these mechano-electrical transducers. We present the first comprehensive transcriptome (by mRNA-Seq) of hair cell regeneration in the chick utricle. We provide pathway and pattern annotations and correlate these with the phenotypic events that occur during regeneration. These patterns are surprisingly synchronous and highly punctuated. We show how these patterns are a new resource for identifying components of the hair cell transcriptome and identify 494 new putative hair-cell-specific genes and validate three of these (of three tested) by immunohistochemical staining. We describe many surprising new components and dynamic expression patterns, particularly within NOTCH signaling. For example, we show that HES7 is specifically expressed during utricle hair cell regeneration and closely parallels the expression of HES5. Likewise, the expression of ATOH1 is closely correlated with HEYL and the HLH inhibitory transcription factors ID1, ID2, and ID4. We investigate the correlation between fibroblast growth factor signaling and supporting cell proliferation and show that FGF20 inhibits supporting cell proliferation. We also present an analysis of 212 differentially expressed transcription factor genes in the regenerative time course that fall into nine distinct gene expression patterns, many of which correlate with phenotypic events during regeneration and represent attractive candidates for future analysis and manipulation of the regenerative program in sensory epithelia and other vertebrate neuroepithelia
Nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats
We evaluated the effects of sustained perinatal inhibition of NO synthase (NOS) on hyperoxia induced lung injury in newborn rats. NG-nitro-Larginine-methyl-ester (L-NAME) or untreated water was administered to pregnant rats for the final 7 days of gestation and during lactation; followed by postnatal exposure to hyperoxia (>95% O2) or room air. The survival rate of L-NAME treated pups when placed in > 95% O2 at birth was significantly lower than controls from day 4 (L-NAME, 87%; control pups, 100%, p < 0.05) to 14 (L-NAME, 0%; control pups, 53%, p < 0.05). Foetal pulmonary artery vasoconstriction was induced by L-NAME with a decrease in internal diameter from 0.88 ± 0.03 mm to 0.64 ± 0.01 mm in control vs. L-NAME groups (p < 0.05), respectively. We conclude that perinatal NOS inhibition results in pulmonary artery vasoconstriction and a decreased tolerance to hyperoxia induced lung injury in newborn rats
Palaeoclimatic events, dispersal and migratory losses along the Afro-European axis as drivers of biogeographic distribution in Sylvia warblers
<p>Abstract</p> <p>Background</p> <p>The Old World warbler genus <it>Sylvia </it>has been used extensively as a model system in a variety of ecological, genetic, and morphological studies. The genus is comprised of about 25 species, and 70% of these species have distributions at or near the Mediterranean Sea. This distribution pattern suggests a possible role for the Messinian Salinity Crisis (from 5.96-5.33 Ma) as a driving force in lineage diversification. Other species distributions suggest that Late Miocene to Pliocene Afro-tropical forest dynamics have also been important in the evolution of <it>Sylvia </it>lineages. Using a molecular phylogenetic hypothesis and other methods, we seek to develop a biogeographic hypothesis for <it>Sylvia </it>and to explicitly assess the roles of these climate-driven events.</p> <p>Results</p> <p>We present the first strongly supported molecular phylogeny for <it>Sylvia</it>. With one exception, species fall into one of three strongly supported clades: one small clade of species distributed mainly in Africa and Europe, one large clade of species distributed mainly in Africa and Asia, and another large clade with primarily a circum-Mediterranean distribution. Asia is reconstructed as the ancestral area for <it>Sylvia</it>. Long-distance migration is reconstructed as the ancestral character state for the genus, and sedentary behavior subsequently evolved seven times.</p> <p>Conclusion</p> <p>Molecular clock calibration suggests that <it>Sylvia </it>arose in the early Miocene and diverged into three main clades by 12.6 Ma. Divergence estimates indicate that the Messinian Salinity Crisis had a minor impact on <it>Sylvia</it>. Instead, over-water dispersals, repeated loss of long-distance migration, and palaeo-climatic events in Africa played primary roles in <it>Sylvia </it>divergence and distribution.</p
Theory of d-density wave viewed from a vertex model and its implications
The thermal disordering of the -density wave, proposed to be the origin of
the pseudogap state of high temperature superconductors, is suggested to be the
same as that of the statistical mechanical model known as the 6-vertex model.
The low temperature phase consists of a staggered order parameter of
circulating currents, while the disordered high temperature phase is a
power-law phase with no order. A special feature of this transition is the
complete lack of an observable specific heat anomaly at the transition. There
is also a transition at a even higher temperature at which the magnitude of the
order parameter collapses. These results are due to classical thermal
fluctuations and are entirely unrelated to a quantum critical point in the
ground state. The quantum mechanical ground state can be explored by
incorporating processes that causes transitions between the vertices, allowing
us to discuss quantum phase transition in the ground state as well as the
effect of quantum criticality at a finite temperature as distinct from the
power-law fluctuations in the classical regime. A generalization of the model
on a triangular lattice that leads to a 20-vertex model may shed light on the
Wigner glass picture of the metal-insulator transition in two-dimensional
electron gas. The power-law ordered high temperature phase may be generic to a
class of constrained systems and its relation to recent advances in the quantum
dimer models is noted.Comment: RevTex4, 10 pages, 11 figure
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