382 research outputs found
Não compactação do VentrÃculo Esquerdo. Revisão da Literatura a Propósito de um Caso ClÃnico
A não compactação isolada do ventrÃculo
esquerdo (NCIVE) constitui uma etiologia rara de miocardiopatia dilatada, caracterizando-se do ponto de vista morfológico por apresentar dilatação do ventrÃculo esquerdo, com exuberante padrão trabecular. Embora não esteja claramente demonstrado, é geralmente aceite que a NCIVE resulta da paragem do processo de compactação miocárdica durante a
embriogénese. Têm sido descritas formas
familiares, estando identificadas alterações de genes que codificam proteÃnas de ligação entre a matriz extra-celular e o citoesqueleto. O quadro clÃnico é frequentemente dominado por sintomas e manifestações de insuficiência cardÃaca, sendo as complicações cardio-embólicas e disrÃtmicas, causa frequente de morbilidade e mortalidade. O diagnóstico tem por base critérios clÃnicos e ecocardiográficos, e a estratégia terapêutica assenta nas recomendações estabelecidas para o tratamento da insuficiência cardÃaca,
destacando-se a importância da hipocoagulação e prevenção de disrtimias malignas. Os autores descrevem o caso clÃnico de um homem de 29 anos, internado por um quadro de insuficiência cardÃaca congestiva em classe IV da NYHA, com dilatação do ventrÃculo esquerdo, acompanhada de exuberante trabeculação das paredes, disfunção sistólica grave e volumoso trombo apical. A evolução clÃnica foi favorável após terapêutica farmacológica convencional e perfusão de
levosimendan, tendo tido alta melhorado, em
classe I-II da NYHA. Cerca de 18 meses após
alta hospitalar, faleceu subitamente no
domicÃlio. A propósito do caso, foi feita uma revisão da literatura actual sobre a NCIVE, no que se refere à etiopatogenia, critérios de diagnóstico e orientação terapêutica
Collider Phenomenology with Split-UED
We investigate the collider implications of Split Universal Extra Dimensions.
The non-vanishing fermion mass in the bulk, which is consistent with the
KK-parity, largely modifies the phenomenology of Minimal Universal Exta
Dimensions. We scrutinize the behavior of couplings and study the discovery
reach of the Tevatron and the LHC for level-2 Kaluza-Klein modes in the
dilepton channel, which would indicates the presence of the extra dimensions.
Observation of large event rates for dilepton resonances can result from a
nontrivial fermion mass profile along the extra dimensions, which, in turn, may
corroborate extra dimensional explanation for the observation of the positron
excess in cosmic rays.Comment: 23 pages, 15 figure
Multi-Photon Signals from Composite Models at LHC
We analyze the collider signals of composite scalars that emerge in certain
little Higgs models and models of vectorlike confinement. Similar to the decay
of the pion into photon pairs, these scalars mainly decay through
anomaly-induced interactions into electroweak gauge bosons, leading to a
distinct signal with three or more photons in the final state. We study the
standard model backgrounds for these signals, and find that the LHC can
discover these models over a large range of parameter space with 30 fb
at 14 TeV. An early discovery at the current 7 TeV run is possible in some
regions of parameter space. We also discuss possibilities to measure the spin
of the particles in the and decay channels.Comment: 18 pages, LaTe
SÃndrome coronária aguda de origem paradoxal
We describe a rare case of acute myocardial infarction secondary to paradoxical embolism complicating acute pulmonary embolism. A 44-year-old woman presented to the emergency department with chest pain. The physical examination was unremarkable except for oxygen saturation of 75%, and the electrocardiogram showed ST-segment elevation in the inferior leads. Urgent coronary angiography showed a distal occlusion of the right coronary artery and multiple thrombi were aspirated. Despite relief of chest pain and electrocardiogram normalization, her oxygen saturation remained low (90%) with high-flow oxygen by mask. The transthoracic echocardiogram showed a mass in the left atrium and dilatation of the right chambers, while the transesophageal echocardiogram showed a thrombus attached to the interatrial septum in the region of the foramen ovale. Color flow imaging was consistent with a patent foramen ovale. Thoracic computed tomography angiography documented thrombi in both branches of the pulmonary trunk. After five days on anticoagulation, the patient underwent surgical foramen ovale closure
General analysis of signals with two leptons and missing energy at the Large Hadron Collider
A signal of two leptons and missing energy is challenging to analyze at the
Large Hadron Collider (LHC) since it offers only few kinematical handles. This
signature generally arises from pair production of heavy charged particles
which each decay into a lepton and a weakly interacting stable particle. Here
this class of processes is analyzed with minimal model assumptions by
considering all possible combinations of spin 0, 1/2 or 1, and of weak
iso-singlets, -doublets or -triplets for the new particles. Adding to existing
work on mass and spin measurements, two new variables for spin determination
and an asymmetry for the determination of the couplings of the new particles
are introduced. It is shown that these observables allow one to independently
determine the spin and the couplings of the new particles, except for a few
cases that turn out to be indistinguishable at the LHC. These findings are
corroborated by results of an alternative analysis strategy based on an
automated likelihood test.Comment: 18 pages, 3 figures, LaTe
Significados da alimentação escolar segundo alunos atendidos pelo Programa Nacional de Alimentação Escolar
Candida albicans repetitive elements display epigenetic diversity and plasticity
Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here, we address this question by analysing the chromatin state associated with DNA repeats in the human fungal pathogen Candida albicans. Our analyses indicate that, contrary to model systems, each type of repetitive element is assembled into a distinct chromatin state. Classical Sir2-dependent hypoacetylated and hypomethylated chromatin is associated with the rDNA locus while telomeric regions are assembled into a weak heterochromatin that is only mildly hypoacetylated and hypomethylated. Major Repeat Sequences, a class of tandem repeats, are assembled into an intermediate chromatin state bearing features of both euchromatin and heterochromatin. Marker gene silencing assays and genome-wide RNA sequencing reveals that C. albicans heterochromatin represses expression of repeat-associated coding and non-coding RNAs. We find that telomeric heterochromatin is dynamic and remodelled upon an environmental change. Weak heterochromatin is associated with telomeres at 30?°C, while robust heterochromatin is assembled over these regions at 39?°C, a temperature mimicking moderate fever in the host. Thus in C. albicans, differential chromatin states controls gene expression and epigenetic plasticity is linked to adaptation
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