BN Doping in the Realm of Two-Dimensional Fullerene Network for Unparalleled Structural, Electronic, Optical, and HER Advancements: A Cutting-Edge DFT Investigation

The doping of lighter non-metals like boron and nitrogen into graphene represents a promising advancement in the field of nano-electronic devices, particularly in the development of field-effect transistors (FETs). These doped two-dimensional (2D) materials offer improved stability and enhanced adsorption characteristics compared to pure graphene. Notably, It displays semiconducting behavior, resulting in higher conductivity and carrier mobility. In this study, we investigate the structural, electronic, optical, and conductivity/carrier transport properties of 2D polymer sheets made of fullerene, both with and without boron and nitrogen doping. We employ density functional theory (DFT) with PBE and HSE functionals, considering the inclusion of van der Waals (vdW) interactions. The research findings indicate that the 2D sheets of C60, C58B1N1, and C54B3N3 exhibit band gaps of approximately 0.97 eV (1.5 eV), 1.08 eV (1.9 eV), and 1.05 eV (1.6 eV), respectively, as obtained from PBE (HSE) calculations. Moreover, according to the deformation potential theory, both doped sheets exhibit ultra-high conductivity at elevated temperature). These results are highly promising and underscore the significance of a single pair of BN dopants in fullerene (C58B1N1) monolayers for the advancement of next-generation 2D nanoelectronic and photonics applications

Screening natural product database for identification of potential inhibitors of beta Secretase; a key enzyme of Alzheimer’s disease

Alzheimer¡¦s disease is a most common amyloid-associated disorder, irreversible, progressive brain disorders that leads to change in nerve cells destroying the thinking, memory, remembering, reasoning and skills of individuals. The symptom of Alzheimer¡¦s, disease generally appears in the individuals having age more than 65 years. The neuropathological hallmarks of AD include presence of senile plaques (NP) and neurofibrillary tangles (NFT). Amyloid Beta precursor protein cleaving enzyme (BACE-1) or Memapsin-2 is a single-membrane protein belongs to the Aspartyl protease family, responsible for the processing of the amyloid Precursor protein (APP). The cleavage of APP by BACE-1 leads to production of two peptide fragments Amyloid beta peptide (AƒÒ) 40 and 42. AƒÒ42 is thought to be responsible for the neurotoxicity and amyloid plaque formation in Alzheimer¡¦s disease (AD). Thus BACE-1 will be an important drug target for the generation of inhibitors that lower A£]. We aim to identify potential natural product inhibitors of beta secretase which can be further developed as drug to treat Alzheimer¡¦s disease. Here, we have performed in silico virtual screening approach of a natural product database consists of 800 different chemical molecules. Beta secretase (PDB ID: 1FKN) was used in screening process, and docking studies to identify potential lead compounds. The sorting of compound were done based upon their binding energy and top 50 ranked protein- inhibitor complexes were selected. We have reported some compound like Spermine, Netilmicinsulfate, and Spermidine Trihydrochloride molecule which could be potential inhibitors of beta secretase. The ligplot image also provided some idea about the inhibitors that they can attain at the active site of beta secretase

Overview of Cancers and Impact of Music Therapy in Intervention: A Literature Review

Cancer is taken under consideration as a fatal disease. It’s caused by a spread of things including unhealthy lifestyles, pollution, stress, radiation exposure, infection, tobacco consumption, and unhealthy food choices. There are several varieties of cancer that affect the chassis and their growth varies depending on the type. Cancer could be a major reason for death after a heart condition. There are 10 million new cases of cancer and approximately 5 million deaths in 2020 were caused by cancer (World Health Organization, 2018)1, and deaths from cancer worldwide are projected to still rise to over 20 million by 2025 (Stewart and Wild. 2014)2. There are several intervention modes to treat cancer patients. Besides medical intervention, there are prominent psychosocial concerns that have a very noticeable impact on intervention in the case of cancer patients. Cancer treatment facilities in India have incorporated psychosocial services into cancer care by routinely assessing patients’ levels of distress. For that Music therapy can improve their quality of life by addressing the emotional, spiritual, and physical needs that will arise during this point. Furthermore, music therapy also can be applied to assist relationships throughout the grieving process by providing comfort, continuity, and opportunities for specific feelings of loss (Rossetti et al., 2017)3. Hence, there’s a greater need and justification for exploring the scope of using music therapy with cancer patients, especially in low-income countries, including Indi

Hearing Loss in Stroke Cases: A Literature Review

Stroke is the most common cause of neurological disability (MacDonald, Cockerell, Sander, & Shorvon, 2000) and about 1 in 3 stroke life survivors are functionally reliant on it after one year (Murray and Lopez 1996). The majority of stroke survivors need restoration (MacDonald et al., 2000), requiring them to be adequately informed of the prognosis, nature, and proposed treatment of their illness. Hearing plays an important role in effective communication between healthcare professionals and patients (Bensing, 2000), therefore hearing loss may restrict contribution in recuperation programs, leading to an inferior level of bodily performance (Landi et al., 2006). Both hemorrhagic and ischemic strokes may interrupt all stages of the hearing path and lead to hearing shortages that start acutely previously, throughout, or shortly after the occurrence of the stroke. Yet, hearing shortfalls after stroke have not been as lengthily investigated as visual shortfalls, possibly due to the potentially “invisible” nature of this loss compared to more noticeable symptoms (e.g., dysphasia or motor loss). Hearing impairment after stroke may be a vital unmet need for stroke patients and additional research into patterns, detection, prevalence, and treatment are compulsory. In SCA infarction, the ischemic lesion happens in the area where threads from the nucleus have already traversed, and therefore sensory hearing impairment is noticed in the contralateral sideways. There is clear evidence that PICA and AICA territory strokes may result in mixed cochlear/retro­ cochlear, and less frequently retro cochlear-only patterns of hearing impairment (H. Lee et al., 2002). Hearing impairment for both AICA and PICA infarcts is mostly one-sided. Stroke may affect all levels of the auditory pathway and lead to hearing reception and/or perception deficits. Sudden-onset hearing loss after stroke of the vertebra-basilar territory and/or low brainstem is one of the less frequent neurologic impairments, while cortical or central deafness is even rarer. However, studies of populations with stroke indicate that hearing loss is very common, while in the general population, a past history of stroke increases the likelihood of having hearing loss. Auditory-processing deficits after stroke are less well studied than hearing loss and possibly under documented. Auditory dysfunction may impact on patient communication and may even predict long-term patient outcome after stroke. Despite this, clinical guidelines for auditory assessments after stroke are rudimentary. This study reviews the available information of auditory function in patients with stroke. On the basis of the information available, it is suggested that screening the patient's hearing before the patient leaves the stroke ward with a short test and a minimum set of hearing-related questions and subsequently screening the patient's hearing needs with targeted questions at the chronic stage of stroke may be a cost-effective bare minimum assessment approach to addressing the hearing needs of this complex population

Oral and maxillofacial surgery in patients on anticoagulant/antiplatelet therapy- a review

Objective: To review the antiplatelet and anticoagulant drugs currently used and to highlight the management of patients with anticoagulant therapy undergoing minor and invasive oral and maxillofacial surgical procedures. Materials and methods: A systematic review of the literature on PubMed, Science Direct, Springer regarding anticoagulation therapy during oral surgery procedures from 1996 to 2020 was done. Data on the indications for anticoagulant treatment, the regimen of anticoagulation, bridging used, the procedure done, local hemostatic agents used, thromboembolic outcome, follow-up period and bleeding characteristics were collected. Results: The thromboembolic risk due to withdrawal of oral anticoagulants outweighs the risk of bleeding and thus in majority of minor oral surgical procedures discontinuing the regimen is not recommended. Most of the bleeding complications can be controlled with local hemostatic measures. Major invasive oral and maxillofacial procedures with high risk patients warrants cessation of anticoagulant drugs with bridging therapy. The novel oral anticoagulants and newer antiplatelet agents has definite advantages over older main stay drugs especially warfarin and aspirin

Physicochemical Characterisation of Commercially Available Prussian Blue Insoluble Samples and Its Comparison with Radiogardase Cs

The physicochemical properties of insoluble Prussian blue (PB) play an important role in its thallium binding ability. Therefore, the present study aimed to characterise various physicochemical parameters of PB available commercially and compare them with the USFDA-approved Radiogardase ® -Cs. In addition, PB was synthesised by indirect and direct methods. PB samples and Radiogardase®-Cs were analysed for various parameters like particle size, moisture content, and thermogravimetric analysis (TGA) and correlated with its Maximum Binding Capacity (MBC) for thallium. Radiogardase ® -Cs showed the highest MBC of 238 mg/g for thallium with D 90 of 785 μm and moisture content of 23.24 %. The MBC of other PB samples was found to be significantly lower than Radiogardase ® -Cs which was found to be directly proportional to the moisture content. However, other parameters like particle size, and iron content vary significantly but no correlation was observed with MBC for thallium. This finding suggests that moisture content and MBC are extremely important parameters for optimising the PB to achieve desirable pharmacological efficacy for removing thallium in vivo

Traumatic Diaphragmatic Hernia: An Uncommon Entity

Traumatic Diaphragmatic hernia is secondary to penetrating injuries and blunt abdominal and thoracic trauma. It is an uncommon entity. Early diagnosis is necessary to decrease morbidity and mortality. Here we report a case of 22-year-old male with diagnosis of traumatic diaphragmatic hernia. On examination abdomen was distended, guarding present, tender present and bowel sound not appreciated with decreased air entry over left side. CT Scan showed left sided diaphragmatic defect with intrathoracic herniation of abdominal viscera. Laparotomy and exploration revealed a diaphragmatic tear of size 7.5cm X 5cm, with herniation of stomach, spleen, splenic flexure of colon, distal pancreas through diaphragmatic tear

Traumatic Diaphragmatic Hernia: An Uncommon Entity

Traumatic Diaphragmatic hernia is secondary to penetrating injuries and blunt abdominal and thoracic trauma. It is an uncommon entity. Early diagnosis is necessary to decrease morbidity and mortality. Here we report a case of 22-year-old male with diagnosis of traumatic diaphragmatic hernia. On examination abdomen was distended, guarding present, tender present and bowel sound not appreciated with decreased air entry over left side. CT Scan showed left sided diaphragmatic defect with intrathoracic herniation of abdominal viscera. Laparotomy and exploration revealed a diaphragmatic tear of size 7.5cm X 5cm, with herniation of stomach, spleen, splenic flexure of colon, distal pancreas through diaphragmatic tear

In-group and out-group behavior in Indian multinational corporations: An analysis of its implications on organizational performance

The purpose of this study is to investigate in-group and out-group dynamics within multinational corporations in India and their influence on organizational performance. The paper uses concurrent triangulation. Primary data were gathered via a purposive sample of 500 employees across various demographic backgrounds, ensuring diversity. Respondents participated in an online survey and a few in-depth interviews, administered in-person or online, capturing their experiences of group dynamics. Survey data were analyzed using R, SPSS, and SAS, while thematic analysis was applied to in-depth interview transcripts using NVivo software. The study also employed descriptive statistics, ANOVA, MANOVA for the survey and thematic analysis for interviews, revealing the depth and complexity of in-group favoritism. In-group members have reported significantly higher levels of communication, trust, cooperation, conflict management, and innovation, indicating the impact of group dynamics on organizational performance. The outcome of the multivariate analysis of variance (MANOVA) demonstrates a substantial impact of in-group/out-group categorization on the amalgamated dependent variables (evidenced by a Wilks’ Lambda value of 0.68, F (5,94) = 4.17, p < .001). This suggests a noteworthy influence of in-group/out-group affinities on overall team efficacy. The insights offer concrete strategies to enhance inclusivity amid diversity within multinational corporations, thereby mitigating group bias and promoting organizational performance. This study not only expands the understanding of group dynamics in Indian multinational corporations but also offers valuable guidance for managerial practices