129 research outputs found
Occupational and anthropogenic environmental exposure during asbestos-cement production by FIBRONIT in Broni (Pavia): assessment of asbestos lung burden by SEM-EDS
Tectonometamorphic discontinuities within the Greater Himalayan Sequence in Western Nepal (Central Himalaya): Insights on the exhumation of crystalline rocks
Microparticles Carrying Sonic Hedgehog Are Increased in Humans with Peripheral Artery Disease.
Sonic hedgehog (Shh) is a prototypical angiogenic agent with a crucial role in the regulation of angiogenesis. Experimental studies have shown that Shh is upregulated in response to ischemia. Also, Shh may be found on the surface of circulating microparticles (MPs) and MPs bearing Shh (Shh + MPs) have shown the ability to contribute to reparative neovascularization after ischemic injury in mice. The goal of this study was to test the hypothesis that, in humans with peripheral artery disease (PAD), there is increased number of circulating Shh + MPs. This was done by assessing the number of Shh + MPs in plasma of patients with PAD and control subjects without PAD. We found significantly higher number of Shh + MPs in plasma of subjects with PAD, compared to controls, while the global number of MPs\u2014produced either by endothelial cells, platelets, leukocytes, and erythrocytes\u2014was not different between PAD patients and controls. We also found a significant association between the number of Shh + MPs and the number of collateral vessels in the ischemic limbs of PAD patients. Interestingly, the concentration of Shh protein unbound to MPs\u2014which was measured in MP-depleted plasma\u2014was not different between subjects with PAD and the controls, indicating that, in the setting of PAD, the call for Shh recapitulation does not lead to secretion of protein into the blood but to binding of the protein to the membrane of MPs. These findings provide novel information on Shh signaling during ischemia in humans, with potentially important biological and clinical implications
Pressure Temperature time path of the Col dei Bovi metamorphic unit (Eastern Southalpine basement, South Tyrol)
Coupling of variscan metamorphic units characterised by contrasting thermomechanical evolutions in the eastern southalpine basement (Brixen area, NE Italy)
The Funes/Villn\uf6ss basin: an example of Early Permian tectonics, magmatism and sedimentation in the Eastern Southern Alps
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