666 research outputs found
Grasping the semantic of actions: a combined behavioral and MEG study
There is experimental evidence that the brain systems involved in action execution also play a role in action observation and understanding. Recently, it has been suggested that the sensorimotor system is also involved in language processing. Supporting results are slower response times and weaker motor-related MEG Beta band power suppression in semantic decision tasks on single action verbs labels when the stimulus and the motor response involve the same effector. Attenuated power suppression indicates decreased cortical excitability and consequent decreased readiness to act. The embodied approach forwards that the simultaneous involvement of the sensorimotor system in the processing of the linguistic content and in the planning of the response determines this language-motor interference effect. Here, in a combined behavioral and MEG study we investigated to what extent the processing of actions visually presented (i.e., pictures of actions) and verbally described (i.e., verbs in written words) share common neural mechanisms. The findings demonstrated that, whether an action is experienced visually or verbally, its processing engages the sensorimotor system in a comparable way. These results provide further support to the embodied view of semantic processing, suggesting that this process is independent from the modality of presentation of the stimulus, including language
Magnetic breakdown in a normal-metal - superconductor proximity sandwich
We study the magnetic response of a clean normal-metal slab of finite
thickness in proximity with a bulk superconductor. We determine its free energy
and identify two (meta-)stable states, a diamagnetic one where the applied
field is effectively screened, and a second state, where the field penetrates
the normal-metal layer. We present a complete characterization of the first
order transition between the two states which occurs at the breakdown field,
including its spinodals, the jump in the magnetization, and the latent heat.
The bistable regime terminates at a critical temperature above which the sharp
transition is replaced by a continuous cross-over. We compare the theory with
experiments on normal-superconducting cylinders.Comment: 7 pages Revtex, 3 Postscript figures, needs psfig.te
INFLUENCE OF AGE AND HAND GRIP STRENGTH ON FREESTYLE PERFORMANCES IN MASTER SWIMMERS
The aim of our work was to examine whether age and hand grip strength are correlated with 50m, 100m, 200m, 400m, 800m swimming performance times in Master swimmers and how correlation varies considering short, middle or long distances. The main finding of this work was that hand grip strength and age correlated significantly at each distance. Hand grip strength showed a relevant influence on performance time and explained 52% of variance of performance time in 50m race freestyle and only 15% in 800m race. Increasing age was a disadvantageous factor for performance time, and explained 45% of variance of performance time in 800m race freestyle and only 20% in 50 m race
Prevalence of the single-nucleotide polymorphism rs11554137 (IDH1105GGT) in brain tumors of a cohort of Italian patients
IDH mutational status is required for proper diagnosis according to the WHO criteria revised in 2016. The single nucleotide polymorphism (SNP) rs11554137 (IDH1105GGT) at codon 105 of IDH1 has been reported in patients with several tumor types, including those with glioma. The aim of this study is to investigate the prevalence of IDH1105GGTin a cohort of brain tumors, and its association with clinicopathologic features and IDH1 and IDH2 missense mutations. Exon 4 of IDH1 and IDH2 was analyzed in a series of brain tumors classified according to current WHO criteria. DNA from control individuals was analyzed to infer the prevalence of IDH1105GGTin the reference population. Analysis was performed using next generation sequencing. IDH1105GGTwas three times more frequent in patients with tumors (44/293 cases, 15.0%) vs. population controls (6/109, 5.5%) (p = 0.0102). IDH1105GGTwas more frequent in grade III tumors (26.1%) compared to grade II (10.9%, p = 0.038) and grade IV tumors (13.7%, p = 0.041). IDH1105GGTwas more frequent in grade II and III tumors without an IDH tumor missense mutation (43.8%) than in those with (11.5%, p = 0.005). The IDH1105GGTSNP likely represents an important genetic marker, worthy of additional investigation to better understand the clinical and biological features of IDH-WT infiltrating gliomas
Transcriptional Analysis of Lennert Lymphoma Reveals a Unique Profile and Identifies Novel Therapeutic Targets
Lennert lymphoma (LL) is a lymphoepithelioid morphological variant of peripheral T-cell lymphoma—not otherwise specified (PTCL/NOS), clinically characterized by better prognosis if compared with other PTCL/NOS. Although well characterized as far as morphology and phenotype are concerned, very little is known regarding its molecular features. In this study, we investigated the transcriptional profile of this tumor aiming 1) to identify its cellular counterparts; 2) to better define its relation with other PTCLs—and, therefore, its possible position in lymphoma classification; and 3) to define pathogenetic mechanisms, possibly unveiling novel therapeutic targets. To address these issues, we performed gene and microRNA expression profiling on LL and other PTCL/NOS cases; we identified different genes and microRNAs that discriminated LL from other PTCL/NOS. Particularly, LL revealed a molecular signature significantly enriched in helper function and clearly distinguishable from other PTCL/NOS. Furthermore, PI3K/Akt/mTOR pathway emerged as novel potential therapeutic target. In conclusion, based on the already known particular morphological and clinical features, the new molecular findings support the hypothesis that LL might be classified as a separate entity. Preclinical and clinical studies testing the efficacy of PI3K/MTOR inhibitors in this setting are warranted
Low-dose lenalidomide plus cytarabine induce complete remission that can be predicted by genetic profiling in elderly acute myeloid leukemia patients
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Diamagnetic response of cylindrical normal metal - superconductor proximity structures with low concentration of scattering centers
We have investigated the diamagnetic response of composite NS proximity
wires, consisting of a clean silver or copper coating, in good electrical
contact to a superconducting niobium or tantalum core. The samples show strong
induced diamagnetism in the normal layer, resulting in a nearly complete
Meissner screening at low temperatures. The temperature dependence of the
linear diamagnetic susceptibility data is successfully described by the
quasiclassical Eilenberger theory including elastic scattering characterised by
a mean free path l. Using the mean free path as the only fit parameter we found
values of l in the range 0.1-1 of the normal metal layer thickness d_N, which
are in rough agreement with the ones obtained from residual resistivity
measurements. The fits are satisfactory over the whole temperature range
between 5 mK and 7 K for values of d_N varying between 1.6 my m and 30 my m.
Although a finite mean free path is necessary to correctly describe the
temperature dependence of the linear response diamagnetic susceptibility, the
measured breakdown fields in the nonlinear regime follow the temperature and
thickness dependence given by the clean limit theory. However, there is a
discrepancy in the absolute values. We argue that in order to reach
quantitative agreement one needs to take into account the mean free path from
the fits of the linear response. [PACS numbers: 74.50.+r, 74.80.-g]Comment: 10 pages, 9 figure
Inter- and Intragranular Effects in Superconducting Compacted Platinum Powders
Compacted platinum powders exhibit a sharp onset of diamagnetic screening at
mK in zero magnetic field in all samples investigated. This
sharp onset is interpreted in terms of the intragranular transition into the
superconducting state. At lower temperatures, the magnetic ac susceptibility
strongly depends on the ac field amplitude and reflects the small intergranular
critical current density . This critical current density shows a strong
dependence on the packing fraction f of the granular samples. Surprisingly,
increases significantly with decreasing f ( A/cm for f = 0.67 and A/cm for f
= 0.50). The temperature dependence of shows strong positive curvature
over a wide temperature range for both samples. The phase diagrams of inter-
and intragranular superconductivity for different samples indicate that the
granular structure might play the key role for an understanding of the origin
of superconductivity in the platinum compacts.Comment: 11 pages including 9 figures. To appear in Phys. Rev. B in Nov. 0
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