Clinical presentation, management and outcomes in the Acute Heart Failure Global Survey of Standard Treatment (ALARM-HF)

Purpose: We performed a survey on acute heart failure (AHF) in nine countries in four continents. We aimed to describe characteristics and management of AHF among various countries, to compare patients with de novo AHF versus patients with a pre-existing episode of AHF, and to describe subpopulations hospitalized in intensive care unit (ICU) versus cardiac care unit (CCU) versus ward. Methods and results: Data from 4,953 patients with AHF were collected via questionnaire from 666 hospitals. Clinical presentation included decompensated congestive HF (38.6%), pulmonary oedema (36.7%) and cardiogenic shock (11.7%). Patients with de novo episode of AHF (36.2%) were younger, had less comorbidities and lower blood pressure despite greater left ventricular ejection fraction (LVEF) and were more often admitted to ICU. Overall, intravenous (IV) diuretics were given in 89.7%, vasodilators in 41.1%, and inotropic agents (dobutamine, dopamine, adrenaline, noradrenaline and levosimendan) in 39% of cases. Overall hospital death rate was 12%, the majority due to cardiogenic shock (43%). More patients with de novo AHF (14.2%) than patients with a pre-existing episode of AHF (10.8%) (p=0.0007) died. There was graded mortality in ICU, CCU and ward patients with mortality in ICU patients being the highest (17.8%) (p<0.0001). Conclusions: Our data demonstrated the existence of different subgroups based on de novo or pre-existing episode(s) of AHF and the site of hospitalization. Recognition of these subgroups might improve management and outcome by defining specific therapeutic requirement

Seismostratigraphic and structural setting of the Malvinas Basin and its southern margin (Tierra del fuego Atlantic offshore)

New multichannel seismic reflection profiles acquired off the Tierra del Fuego Atlantic margin, from the southern part of the Malvinas foreland basin to the inner sector of the Magallanes fold and thrust belt, combined with available commercial profiles and exploration wells, allowed to outline the sedimentary architecture of the foreland basin and the structure of its deformed southern margin. Five major unconformities were differentiated within the sedimentary fill of the southern Malvinas basin, which neighbours the offshore extension of the Magallanes basin in Tierra del Fuego. The unconformity-bounded units record the corresponding major evolutionary tectonostratigraphic phases of the southern part of the Malvinas basin, and the development of the Magallanes fold-and thrust belt during Mesozoic and Cenozoic times: Unit 1 - Pre-Jurassic basement; Unit 2 - Rift phase (Middle - Upper Jurassic); Unit 3 - Sag phase (Lower – Upper Cretaceous); Unit 4 – Foredeep transitional phase (Upper Cretaceous - Middle Eocene); Unit 5 - Foreland phase (Middle Eocene - Pleistocene). The southern edge of the Malvinas basin corresponds to the imbricate basement wedges of the Fuegian Cordillera, which shows a thick-skin structural style developed as a consequence of the Middle Tertiary Andean compressional tectonic phase. Large folds, with low angle NE-verging thrusts propagated the shortening basin-ward at shallow structural levels. These structures are superimposed by an array of left-lateral strike-slip lineaments pertaining to the EW trending Magallanes-Fagnano fault system. In the Tierra del Fuego region these structures represent the western segment of the South America – Scotia plate boundary. Several Neogene pull-apart basins were formed along the principal deformation zone in correspondence of step-overs and releasing bends. These basins show an evident asymmetry in the sedimentary architecture, and are bounded by sub-vertical faults that in some cases reach the sea-floor. Other transtensional features were also recognized in the inner sector of the fold-and-thrust belt together with the formation of restricted pull-apart basins

Faciologia e análise tectônica de materiais de origem dos solos de Tabuleiros Costeiros no litoral Norte da Bahia.

O presente trabalho estudou os elementos faciológicos, arquiteturais, morfogenéticos e os reflexos da neotectônica no Grupo Barreiras, através de várias secções geológicas, análises de fotografias aéreas, imagens de satélite e de radar. O estudo mostra que os principais litofácies que compõem o Barreiras na região são os conglomerados maciços sustentados por lama (Cmf), conglomerados maciços sustentados por clastos (Cmc), arenitos lamosos conglomeráticos maciços (Alcm), arenitos lamosos conglomeráticos com estratificação cruzada (Alce), arenitos lamosos maciços (Alm) e argilitos maciços (Agm). A presença dos elementos arquiteturais fluviais canais (CH), finos de transbordamento (FF), fluxos gravitacionais de sedimentos (SG) e formas de leito arenosas (SB) indicam que os sedimentos do Grupo Barreiras são oriundos de sistemas fluviais entrelaçados e os depósitos ocorreram sob condições climáticas mais secas, em duas fases distintas, intercaladas por um clima úmido. Depois da deposição o Grupo Barreiras foi afetado por reflexos da tectônica, os quais podem ser inferidos pela direção preferencial das drenagens, anomalias das drenagens, padrão de drenagem dendrítico/paralelo, retangular e treliça, vales em forma de "U" com talvegues chatos, presença de basculamentos de blocos e vales dissimétricos. O trabalho desenvolvido dá subsídios para um melhor entendimento da gênese e evolução dos solos e do relevo na região, isto porque os litofácies e a neotectônica afetam a drenagem superficial e interna, condicionando processos intempéricos, pedológicos e morfodinâmicos

The Stellar Content of Obscured Galactic Giant HII Regions V: G333.1--0.4

We present high angular resolution near--infrared images of the obscured Galactic Giant HII (GHII) region G333.1--0.4 in which we detect an OB star cluster. For G333.1--0.4, we find OB stars and other massive objects in very early evolutionary stages, possibly still accreting. We obtained $K$--band spectra of three stars; two show O type photospheric features, while the third has no photospheric features but does show CO 2.3 $\mu$m band--head emission. This object is at least as hot as an early B type star based on its intrinsic luminosity and is surrounded by a circumstellar disc/envelope which produces near infrared excess emission. A number of other relatively bright cluster members also display excess emission in the $K$--band, indicative of disks/envelopes around young massive stars. Based upon the O star photometry and spectroscopy, the distance to the cluster is 2.6 $\pm$ 0.4 kpc, similar to a recently derived kinematic (near side) value. The slope of the $K$--band luminosity function is similar to those found in other young clusters. The mass function slope is more uncertain, and we find $-1.3 \pm 0.2 < \Gamma < -1.1 \pm 0.2$- for stars with M $> 5$ M$_\odot$ where the upper an lower limits are calculated independently for different assumptions regarding the excess emission of the individual massive stars. The number of Lyman continuum photons derived from the contribution of all massive stars in the cluster is 0.2 $\times$ $10^{50}$ $s^{-1}$ $< NLyc < 1.9$ $\times$ $10^{50}$ $s^{-1}$. The integrated cluster mass is 1.0 $\times$ $10^{3}$ $M_\odot < M_{cluster} < 1.3$ $\times$ $10^{3}$ $M_\odot$.Comment: 31 pages, including 12 figures and 3 tables. Accepted for publication in the A

Laser re-irradiation of palladium nanoparticles for antibacterial applications

Bacterial resistant infections represent the second leading cause of mortality worldwide, being responsible for almost the 14% of the global deaths according to figures of 2019. Nanoparticles of noble metals have received special attention because of their outstanding bactericidal activity, that is intrinsically linked to their physico-chemical properties, an asset that makes them an appealing alternative to combat resistant microorganisms. So as to optimize their applications within the biomedical field, it becomes relevant to develop and employ means to influence and act upon nanoparticles’ physico-chemical characteristics. In this research, palladium nanoparticles were synthesized via laser ablation. A nanosecond Nd:YVO4 laser operating at 532 nm was employed to ablate a palladium target immersed in deionized water in order to obtain the colloidal suspension. Then, the previous suspension was passed twice through a re-irradiation system to narrow the size and size distribution of palladium nanoparticles. Bacterial assays with Staphylococcus aureus revealed an effect of size on the bactericidal behaviour of palladium nanoparticles.This work was partially supported by the Government of Spain (PID2020-117900RB-I00 (MCI/AEI/FEDER, UE), EQC2018-004315-P (AEI/FEDER UE), FPU21/04488), Xunta de Galicia (ED431C 2019/23) and University of Vigo (Margarita Salas Postdoc Fellowship Program, M. Fernández Arias & P. Pou-Álvarez)

Methane and Nitrogen Abundances On Pluto and Eris

We present spectra of Eris from the MMT 6.5 meter telescope and Red Channel Spectrograph (5700-9800 angstroms; 5 angstroms per pix) on Mt. Hopkins, AZ, and of Pluto from the Steward Observatory 2.3 meter telescope and Boller and Chivens spectrograph (7100-9400 angstroms; 2 angstroms per pix) on Kitt Peak, AZ. In addition, we present laboratory transmission spectra of methane-nitrogen and methane-argon ice mixtures. By anchoring our analysis in methane and nitrogen solubilities in one another as expressed in the phase diagram of Prokhvatilov and Yantsevich (1983), and comparing methane bands in our Eris and Pluto spectra and methane bands in our laboratory spectra of methane and nitrogen ice mixtures, we find Eris' bulk methane and nitrogen abundances are about 10% and about 90%, and Pluto's bulk methane and nitrogen abundances are about 3% and about 97%. Such abundances for Pluto are consistent with values reported in the literature. It appears that the bulk volatile composition of Eris is similar to the bulk volatile composition of Pluto. Both objects appear to be dominated by nitrogen ice. Our analysis also suggests, unlike previous work reported in the literature, that the methane and nitrogen stoichiometry is constant with depth into the surface of Eris. Finally, we point out that our Eris spectrum is also consistent with a laboratory ice mixture consisting of 40% methane and 60% argon. Although we cannot rule out an argon rich surface, it seems more likely that nitrogen is the dominant species on Eris because the nitrogen ice 2.15 micron band is seen in spectra of Pluto and Triton.Comment: The manuscript has 44 pages, 15 figures, and four tables. It will appear in the Astrophysical Journa

Optical spectroscopy of the large Kuiper Belt objects 136472 (2005 FY9) and 136108 (2003 EL61).

We present high signal precision optical reflectance spectra of the large Kuiper Belt objects 2005 FY9 and 2003 EL61. The spectrum of 2005 FY9 exhibits strong CH4 ice bands. A comparison between the spectrum and a Hapke model indicates that the CH4 bands are shifted 3.25 ± 2.25 Å relative to pure CH4 ice, suggesting the presence of another ice component on the surface of 2005 FY9, possibly N2 ice, CO ice, or Ar. The spectrum of 2003 EL61 is remarkably featureless. There is a hint of an O2 ice band at 5773 Å; however, this feature needs to be confirmed by future spectroscopic observations of 2003 EL61 with a higher continuum signal precision sufficient to detect a second, weaker O2 ice band at 6275 Å. [on SciFinder(R)

Sexual dimorphism at different life stages: early life sexual differences in root growth in Silene latifolia

Male and female dioecious plants often show sexual dimorphism, differing in morphological, physiological and life-history traits. Most previous studies have focused on differences between males and females during or after reproduction, paying little attention to the pre-reproductive stages of the individuals. Here we assessed the response of male and female individuals of the dioecious plant Silene latifolia to abiotic stress at different life stages, including pre-reproductive (i.e. seedlings and young plants) and reproductive individuals. We measured growth, resource allocation and discrimination against 13C under nutrient deficiency, water stress, as well as their interaction. We observed sexual dimorphism in root growth, with female seedlings having longer main roots than male plants. Pre-reproductive male and female plants also responded differently, in terms of root allocation, to nutrient and water availability. At reproduction, females grew more roots than males when water was not limiting. These differences could help explain the female-skewed sex ratios found in natural populations of S. latifolia. We found no evidence of sexual dimorphism in aboveground dry mass, although females had longer leaves than males at the seedling stage. We conclude that sexual dimorphism in S. latifolia may occur not as a consequence of reproduction, but well before it