BP Reduction, Kidney Function Decline, and Cardiovascular Events in Patients without CKD.

BACKGROUND AND OBJECTIVES: In the Systolic Blood Pressure Intervention Trial (SPRINT), intensive systolic BP treatment (target <120 mm Hg) was associated with fewer cardiovascular events and higher incidence of kidney function decline compared with standard treatment (target <140 mm Hg). We evaluated the association between mean arterial pressure reduction, kidney function decline, and cardiovascular events in patients without CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We categorized patients in the intensive treatment group of the SPRINT according to mean arterial pressure reduction throughout follow-up: <20, 20 to <40, and ≥40 mm Hg. We defined the primary outcome as kidney function decline (≥30% reduction in eGFR to <60 ml/min per 1.73 m2 on two consecutive determinations at 3-month intervals), and we defined the secondary outcome as cardiovascular events. In a propensity score analysis, patients in each mean arterial pressure reduction category from the intensive treatment group were matched with patients from the standard treatment group to calculate the number needed to treat regarding cardiovascular events and the number needed to harm regarding kidney function decline. RESULTS: In the intensive treatment group, 1138 (34%) patients attained mean arterial pressure reduction <20 mm Hg, 1857 (56%) attained 20 to <40 mm Hg, and 309 (9%) attained ≥40 mm Hg. Adjusted hazard ratios for kidney function decline were 2.10 (95% confidence interval, 1.22 to 3.59) for mean arterial pressure reduction between 20 and 40 mm Hg and 6.22 (95% confidence interval, 2.75 to 14.08) for mean arterial pressure reduction ≥40 mm Hg. In propensity score analysis, mean arterial pressure reduction <20 mm Hg presented a number needed to treat of 44 and a number needed to harm of 65, reduction between 20 and <40 mm Hg presented a number needed to treat of 42 and a number needed to harm of 35, and reduction ≥40 mm Hg presented a number needed to treat of 95 and a number needed to harm of 16. CONCLUSIONS: In the intensive treatment group of SPRINT, larger declines in mean arterial pressure were associated with higher incidence of kidney function decline. Intensive treatment seemed to be less favorable when a larger reduction in mean arterial pressure was needed to attain the BP target.info:eu-repo/semantics/publishedVersio

A Measurement of Secondary Cosmic Microwave Background Anisotropies with Two Years of South Pole Telescope Observations

We present the first three-frequency South Pole Telescope (SPT) cosmic microwave background (CMB) power spectra. The band powers presented here cover angular scales 2000 < ℓ < 9400 in frequency bands centered at 95, 150, and 220 GHz. At these frequencies and angular scales, a combination of the primary CMB anisotropy, thermal and kinetic Sunyaev-Zel'dovich (SZ) effects, radio galaxies, and cosmic infrared background (CIB) contributes to the signal. We combine Planck/HFI and SPT data at 220 GHz to constrain the amplitude and shape of the CIB power spectrum and find strong evidence for nonlinear clustering. We explore the SZ results using a variety of cosmological models for the CMB and CIB anisotropies and find them to be robust with one exception: allowing for spatial correlations between the thermal SZ effect and CIB significantly degrades the SZ constraints. Neglecting this potential correlation, we find the thermal SZ power at 150 GHz and ℓ = 3000 to be 3.65 ± 0.69 μK^2, and set an upper limit on the kinetic SZ power to be less than 2.8 μK^2 at 95% confidence. When a correlation between the thermal SZ and CIB is allowed, we constrain a linear combination of thermal and kinetic SZ power: D^(tSZ)_(3000) + 0.5D^(kSZ)_(3000) = 4.60 ± 0.63 μK^2, consistent with earlier measurements. We use the measured thermal SZ power and an analytic, thermal SZ model calibrated with simulations to determine σ_8 = 0.807 ± 0.016. Modeling uncertainties involving the astrophysics of the intracluster medium rather than the statistical uncertainty in the measured band powers are the dominant source of uncertainty on σ_8. We also place an upper limit on the kinetic SZ power produced by patchy reionization; a companion paper uses these limits to constrain the reionization history of the universe

Modelling radiation emission in the transition from the classical to the quantum regime

An emissivity formula is derived using the generalised Fermi-Weizacker-Williams method of virtual photons which accounts for the recoil the charged particle experiences as it emits radiation. It is found that through this derivation the formula obtained by Sokolov et al using QED perturbation theory is recovered. The corrected emissivity formula is applied to nonlinear Thomson scattering scenarios in the transition from the classical to the quantum regime, for small values of the nonlinear quantum parameter \chi. Good agreement is found between this method and a QED probabilistic approach for scenarios where both are valid. In addition, signatures of the quantum corrections are identified and explored.Comment: 11 pages, 4 figures, submitted for publicatio

Ion motion in the wake driven by long particle bunches in plasmas

We explore the role of the background plasma ion motion in self-modulated plasma wakefield accelerators. We employ J. Dawson's plasma sheet model to derive expressions for the transverse plasma electric field and ponderomotive force in the narrow bunch limit. We use these results to determine the on-set of the ion dynamics, and demonstrate that the ion motion could occur in self-modulated plasma wakefield accelerators. Simulations show the motion of the plasma ions can lead to the early suppression of the self-modulation instability and of the accelerating fields. The background plasma ion motion can nevertheless be fully mitigated by using plasmas with heavier plasmas.Comment: 23 pages, 6 figure

Fractal analysis of weld defect patterns obtained by radiographic tests

This paper presents a fractal analysis of radiographic patterns obtained from specimens with three types of inserted welding defects: lack of fusion, lack of penetration, and porosity. The study focused on patterns of carbon steel beads from radiographs of the International Institute of Welding (IIW). The radiographs were scanned using a greyscale with 256 levels, and the fractal features of the surfaces constructed from the radiographic images were characterized by means of Hurst, detrended-fluctuation, and minimal-cover analyses. A Karhunen-Loeve transformation was then used to classify the curves obtained from the fractal analyses of the various images, and a study of the classification errors was performed. The obtained results indicate that fractal analyses can be an effective additional tool for pattern recognition of weld defects in radiographic tests.Comment: 7 pages, 2 figures. To appear AIP Conference Proceedings - QNDE 200

Magnetically assisted self-injection and radiation generation for plasma based acceleration

It is shown through analytical modeling and numerical simulations that external magnetic fields can relax the self-trapping thresholds in plasma based accelerators. In addition, the transverse location where self-trapping occurs can be selected by adequate choice of the spatial profile of the external magnetic field. We also find that magnetic-field assisted self-injection can lead to the emission of betatron radiation at well defined frequencies. This controlled injection technique could be explored using state-of-the-art magnetic fields in current/next generation plasma/laser wakefield accelerator experiments.Comment: 7 pages, 4 figures, accepted for publication in Plasma Physics and Controlled Fusio