82 research outputs found
Elimination of biliary stones through the urinary tract: a complication of the laparoscopic cholecystectomy
Epidemiological Surveillance of Birth Defects Compatible with Thalidomide Embryopathy in Brazil
The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive surveillance to identify birth defects compatible with TE. Along one year, newborns with LRD were assessed in the Brazilian hospitals participating in the Latin-American Collaborative Study of Congenital Malformations (ECLAMC). A phenotype of LRD called thalidomide embryopathy phenotype (TEP) was established for surveillance. Children with TEP born between the years 2000â2008 were monitored, and during the 2007â2008 period we clinically investigated in greater detail all cases with TEP (proactive period). The period from 1982 to 1999 was defined as the baseline period for the cumulative sum statistics. The frequency of TEP during the surveillance period, at 3.10/10,000 births (CI 95%: 2.50â3.70), was significantly higher than that observed in the baseline period (1.92/10,000 births; CI 95%: 1.60â2.20), and not uniformly distributed across different Brazilian regions. During the proactive surveillance (2007â2008), two cases of suspected TE were identified, although the two mothers had denied the use of the drug during pregnancy. Our results suggest that TEP has probably increased in recent years, which coincides with the period of greater thalidomide availability. Our proactive surveillance identified two newborns with suspected TE, proving to be a sensitive tool to detect TE. The high frequency of leprosy and the large use of thalidomide reinforce the need for a continuous monitoring of TEP across Brazil
Biological characteristics of Trichogramma pretiosum and Trichogramma acacioi (Hym.: Trichogrammatidae), parasitoids of the avocado defoliator Nipteria panacea (Lep.: Geometridae), on eggs of Anagasta kuehniella (Lep.: Pyralidae)
Characterization of the Brazilian continental shelf adjacent to Rio Grande do Norte state, NE Brazil
Os partidos dentro e fora do poder: a judicialização como resultado contingente da estratĂ©gia polĂtica
O âPACTO PELA EDUCAĂĂOâ E O MISTĂRIO DO âTODOSâ: ESTADO SOCIAL E CONTRARREFORMA BURGUESA NO BRASIL
O lobby da indĂșstria no Congresso Nacional: empresariado e polĂtica no Brasil contemporĂąneo
Uma utopia brasileira: Vargas e a construção do estado de bem-estar numa sociedade estruturalmente desigual
Globalização e poder de estado: circulação internacional de elites e hierarquias do campo jurĂdico brasileiro
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