Generation and Collection of Biological Nanoaerosols

The report describes new technologies in generation and collection of biological nanoaerosol (NA) developed in the laboratory of Nanostructures and Nanotechnologies, ITEB RAS. NA generator to be used for pulmonary delivery of antibiotics, anti-inflammatory and other drugs and vaccines employs a new atomization principle based on a gas-phase neutralization of electrospray-generated drug nanoclusters with small counter-ions produced by electrospraying of a volatile solvent like ethanol. It was demonstrated that a variety of biological substances including proteins can be atomized into NA of 20-100 nm in size, using this generator without affecting functional properties of the atomized substance. Several approaches have been developed to measure doses of inhaled NA including standard condensation particle counter, quartz resonator and filters from polyvinylpirrolidone nanofibers. It was demonstrated that water-soluble electrospun nanofilters may also be employed to capture pathogens and pathogen biomarkers for analysis of nosocomial infections in clinics wards, in collection of non-volatile biomarkers in the exhaled breath, in testing working places for NA pollution and in other applications. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3543

Comment on "Quantum diffusion of 3-He impurities in solid 4- He"

In this comment I show that the experimental data on quantum diffusion of 3-He impurities in solid 4-He can be explained using the adopted quasiparticle theory. The contention by E.G. Kisvarsanyi and N.S. Sullivan (KS) in Phys.Rev.B v. 48, 16557 (1993) as well as in their Reply (ibid. v. 55, 3989 (1997)) to the Grigor'ev's Comment (Phys.Rev. B v. 55, 3987 (1997)) that "Pushkarov's theory of phonon scattering fails to fit the data by very large factors" is groundless and may result from their bad arithmetical error. This means that the phonon-impurity scattering mechanism of diffusion is consistent with experiment and its neglecting by KS makes their results questionable.Comment: RevTex, 5 pages, no figures, to be published in Phys.Rev.

Light during embryonic development modulates patterns of lateralization strongly and similarly in both zebrafish and chick

Some aspects of lateralization are widespread. This is clear for the association between left-eye (LE) use and readiness to respond intensely to releasing stimuli presented by others, which has been found in representatives of all major groups of tetrapods and in fishes. In the chick, this behavioural asymmetry is linked developmentally to greater ability to sustain response against distracting stimuli with right-eye (RE) use, in that both reverse with the reversal of the normal RE exposure to light. In the zebrafish, the same two asymmetries (normally) have similar associations with the LE and the RE, and both also reverse together (owing to epithalamic reversal). Here, we show that light exposure early in development is needed in zebrafish to generate both asymmetries. Dark development largely abolishes both the enhanced abilities, confirming their linkage. Resemblance to the chick is increased by the survival in the chick, after dark development, of higher ability to assess familiarity of complex stimuli when using the LE. A somewhat similar ability survives in dark-developed zebrafish. Here, LE use causes lesser reliance on a single recent experience than on longer term past experience in the assessment of novelty. Such resemblances between a fish and a bird suggest that we should look not only for resemblances between different groups of vertebrates in the most common overall pattern of lateralization, but also for possible resemblances in the nature of inter-individual variation and in the way in which it is generated during development

Fast Diffusion Process in Quenched hcp Dilute Solid 3^3He-4^4He Mixture

The study of phase structure of dilute $^3$He - $^4$He solid mixture of different quality is performed by spin echo NMR technique. The diffusion coefficient is determined for each coexistent phase. Two diffusion processes are observed in rapidly quenched (non-equilibrium) hcp samples: the first process has a diffusion coefficient corresponding to hcp phase, the second one has huge diffusion coefficient corresponding to liquid phase. That is evidence of liquid-like inclusions formation during fast crystal growing. It is established that these inclusions disappear in equilibrium crystals after careful annealing.Comment: 7 pages, 3 figures, QFS200

Solar neutrino oscillations and indications of matter effects in the Sun

Assuming the current best-fit solutions to the solar neutrino problem at large mixing angle, we briefly illustrate how prospective data from the Sudbury Neutrino Observatory (SNO) and from the Kamioka Liquid scintillator Anti-Neutrino Detector (KamLAND) can increase our confidence in the occurrence of standard matter effects on active neutrino flavor oscillations in the Sun, which are starting to emerge from current data.Comment: Updated to include the first KamLAND data. One figure adde

Model Independent Information On Solar Neutrino Oscillations

We present the results of a Bayesian analysis of solar neutrino data in terms of nu_e->nu_{mu,tau} oscillations, independent from the Standard Solar Model predictions for the solar neutrino fluxes. We show that such a model independent analysis allows to constraint the values of the neutrino mixing parameters in limited regions around the usual SMA, LMA, LOW and VO regions. Furthermore, there is a strong indication in favor of large neutrino mixing and large values of Delta m^2 (LMA region). We calculate also the allowed ranges of the neutrino fluxes and we show that they are in good agreement with the Standard Solar Model prediction. In particular, the ratio of the 8B flux with its Standard Solar Model prediction is constrained in the interval [0.45,1.42] with 99.73% probability. Finally, we show that the hypothesis of no neutrino oscillations is strongly disfavored in a model independent way with respect to the hypothesis of neutrino oscillations.Comment: 40 pages, 20 figures. Added references and improved figure

Индивидуальность поведения рыб влияет на риск заражения паразитами [Personality influences risk of parasitism in fish]

Influence of fish personality on infection rate is almost not studied. In the experiments on the young-of-the-year Oncorhynchus mykiss and cercariae of a trematode Diplostomum pseudospathaceum we tested the hypothesis that infection rate differs between more and less active (“bold” and “shy”) fish. Will individual differences in infection persist upon re-infection? Fish serve as a second intermediate host for this trematode. A positive correlation was found between the results of consecutive infections. Accumulation of parasites with successive infections leads to an aggregated distribution of D. pseudospathaceum among the hosts, affecting individual fitness and polymorphism in fish populations. Persistent individual differences in parasite burden among fish and, as a result, vulnerability for predators confirms the role of parasites as an important factor of natural selection.peerReviewe