Antiviral Therapy for Acute Respiratory Infections in Children

It is shown that administration of inosine pranobex reduces the symptoms of acute respiratory viral infection, duration of the disease, prevents complications and restores compromised immunity. The drug is effective not only in the first hours of the disease, but also in the subsequent period

IMMUNO-PHARMACOTHERAPY OF CHILDREN WITH ALLERGIC DISEASES

The literature overview is dedicated to the application experience of immune response modifiers of various classes in treatment of allergic diseases among children. the authors of the article justify the prescription of immune response modifiers by frequent inter current acute respiratory diseases and complications of allergic pathology connected therewith on one hand and by the capability of immune response modifiers to change the activity of tymphocytes and inhibit the reproduction of Ige, thus, increasing the effectiveness of therapy in treatment of allergic diseases among children on the other hand.Key words: children, allergic diseases, respiratory infections, immunity, prevention, treatment, vaccines, immune response modifiers

IMMUNO-PHARMACOTHERAPY OF CHILDREN WITH ALLERGIC DISEASES

The literature overview is dedicated to the application experience of immune response modifiers of various classes in treatment of allergic diseases among children. the authors of the article justify the prescription of immune response modifiers by frequent inter current acute respiratory diseases and complications of allergic pathology connected therewith on one hand and by the capability of immune response modifiers to change the activity of tymphocytes and inhibit the reproduction of Ige, thus, increasing the effectiveness of therapy in treatment of allergic diseases among children on the other hand.Key words: children, allergic diseases, respiratory infections, immunity, prevention, treatment, vaccines, immune response modifiers

CURRENT STATUS OF PROBLEM: CHILDREN WITH RECURRENT RESPIRATORY INFECTIONS

The article deals with children suffered from recurrent respiraatory infections. The authors attempted to summarize the literature data on the research findings of inosine pranobex application (Isoa prinosine, Teva, Israel) in complex therapy against virulent and inflammatory diseases. Within recent years, many experts emphaasize the persistence of viruses and other pathogenic microorganaisms in the human body, which leads to changes in reactivity and emergence of the chronic diseases. These disorders are especially urgent for sickly children, suffering from respiratory infections, what well justifies the application of bacteriogenic immunomodulaa tors, interferon synthesis inductors, expediency for incorporating immunomodulators with antiviral action into complex therapy along with special vaccination against flu, pneumococcus and etc.Key words: sickly children, acute respiratory infections, immunomodulators, inosine pranobex

CURRENT STATUS OF PROBLEM: CHILDREN WITH RECURRENT RESPIRATORY INFECTIONS

The article deals with children suffered from recurrent respiraatory infections. The authors attempted to summarize the literature data on the research findings of inosine pranobex application (Isoa prinosine, Teva, Israel) in complex therapy against virulent and inflammatory diseases. Within recent years, many experts emphaasize the persistence of viruses and other pathogenic microorganaisms in the human body, which leads to changes in reactivity and emergence of the chronic diseases. These disorders are especially urgent for sickly children, suffering from respiratory infections, what well justifies the application of bacteriogenic immunomodulaa tors, interferon synthesis inductors, expediency for incorporating immunomodulators with antiviral action into complex therapy along with special vaccination against flu, pneumococcus and etc.Key words: sickly children, acute respiratory infections, immunomodulators, inosine pranobex

Characteristics of cadmium ion sorption from aqueous solutions on copper(II) sulfide at different temperatures and pH

Characteristics of cadmium ion sorption from aqueous solutions on copper(II) sulfide at different temperatures and pH were investigated. The sorption process obeys to the Langmuir equation, which is used to calculate the sorption capacities of copper(II) sulfide. It is shown that the sorption capacity increases with increase of pH and decrease of temperature. The sorption capacity changes from 5.6 mg/g at pH 5 and 308 K to 15.2 mg/g at pH 7 and 288 K. Optimization of the conditions permits to improve the copper(II) sulfide sorption capacity. The pH changes during the sorption obey to the Kurbatov equation with the sorption process being the ion exchange reaction

ИММУНОФАРМАКОТЕРПИЯ ДЕТЕЙ С АЛЛЕРГИЧЕСКИМИ БОЛЕЗНЯМИ

The literature overview is dedicated to the application experience of immune response modifiers of various classes in treatment of allergic diseases among children. the authors of the article justify the prescription of immune response modifiers by frequent inter current acute respiratory diseases and complications of allergic pathology connected therewith on one hand and by the capability of immune response modifiers to change the activity of tymphocytes and inhibit the reproduction of Ige, thus, increasing the effectiveness of therapy in treatment of allergic diseases among children on the other hand.Key words: children, allergic diseases, respiratory infections, immunity, prevention, treatment, vaccines, immune response modifiers.Обзор литературы посвящён опыту применения иммуномодуляторов различных классов при аллергических болезнях у детей. Целесообразность назначения иммуномодуляторов авторами статьи обосновывается с одной стороны частыми интеркуррентными острыми респираторными заболеваниями и связанными с ними обострениями аллергической патологии, с другой стороны — наличием у иммуномодуляторов способности изменять активность Т лимфоцитов и тормозить продукцию IgE, повышая тем самым эффективность терапии аллергических болезней у детей.Ключевые слова: дети, аллергические болезни, респираторные инфекции, иммунитет, профилактика, лечение, вакцины, иммуномодуляторы.(Педиатрическая фармакология. – 2006; 3(5):22-28

ASSESSMENT OF THE EFFICACY OF COMBINED EFFECT IMMUNOMODULATOR INOSINE PRANOBEX IN PREVENTING RESPIRATORY INFECTIONS IN CHILDREN WITH ALLERGIES

Among children with allergies, particularly with bronchial asthma, patients susceptible to frequent acute respiratory infections make up a large group. In recent years, a strong focus has been on persistency of viruses and other pathogenic microorganisms in various areas of the respiratory tract, which leads to change in responsiveness of the organism and warrants the practicability of applying agents with a combined immunomodulating and antiviral effect. The purpose of this study was to assess the clinical and immunological efficacy of inosine pranobex in children with bronchial asthma and frequent respiratory infections. 37 children with atopic persistent moderate asthma at ages 4 to 15 were examined, 26 of which were administered inosine pranobex orally in prevention dosages at 50 mg/kg twice a day over 14 days. The control group was made up of 11 children who were on no immunopharmacological prevention course. Virus antigens in nasopharyngeal smear samples were identified, cytokine status and antibody immune response were studied. In the main group, 23 children (88,5%) were found to have the frequency and length of intercurrent acute respiratory viral infections decreased 1,5 times (p < 0,05) and the number of asthma attacks decreased 1,7 times (p < 0,05). The obtained results demonstrate the efficacy of preventing respiratory infections with inosine pranobex in children with bronchial asthma and other allergic diseases. Key words: acute respiratory infections, allergy, bronchial asthma, children, prevention, immunomodulators, inosine pranobex. (Pediatric Pharmacology. – 2010; 7(5):30-37

CLINICAL AND IMMUNOLOGICAL EFFICACY OF INOSINE PRANOBEX FOR ACUTE RESPIRATORY INFECTIONS IN CHILDREN WITH ATOPIC ASTHMA

The prevalence rate of atopic asthma in children remains high. One of the reasons for lack of control over asthma symptoms is repeated infection. The article describes results from the study of immunomodulating medication inosine pranobex used in treatment of acute respiratory infections in children with atopic asthma. The results obtained prove the efficacy and safety of this medication. The use of this immunomodifier with antiviral activity during the period of acute respiratory infection in children with atopic asthma contributes to shortening of intoxication and catarrhal signs duration, elimination of viral agents. Key words: asthma, acute respiratory infections, immunomodifiers, inosine pranobex, children. (Pediatric Pharmacology. – 2010; 7(3):98-105