Evaluation of Topical Therapies in the Treatment of Hyposalivation

ABSTRACT Although being a frequent condition in the oral cavity, still no adequate therapeutic possibilities for the treatment of hyposalivation exist. The aim of this review article was to summarize knowledge already published on the Pubmed evaluating the topical therapeutic possibilities with regard to the hyposalivation. The results of this review have shown that every topical treatment applied in patients with dry mouth alleviates symptoms of hyposalivation. However, it is still inconclusive which topical treatment is the best option for patients dry mouth symptoms

Extramedullary myeloma in an HIV-seropositive subject. Literature review and report of an unusual case

Myeloma is characterized by monoclonal bone marrow plasmacytosis, the presence of M-protein in serum and/or in urine and osteolytic bone lesions. HIV-seropositive subjects with myeloma are younger at the time of diagnosis of the tumour and usually the myeloma has a more aggressive clinical course than it does in HIV-seronegative subjects

Unilateral Intraparotid Swelling: A Case Report of Kimura’s Disease and Review of Differential Diagnosis

An interesting case of Kimura's disease was described in the 42-year-old patient manifesting itself as a unilateral parotid swelling, albeit the disease usually affects both parotid glands. Furthermore, first pathohistological finding was not suggestive of the disease, revealing only fatty tissue, but on the repeated biopsy together with CT the correct diagnosis was established. It should be emphasized that Kimura's disease has to be taken into account while making differential diagnosis in parotid gland swellings, especially in people of Oriental origin

Oral aphthous-like ulceration due to tiotropium bromide

Unwanted side-effects of a drug therapy are well known to oral medicine specialists and other colleagues. Usually they manifest itself as dry mouth, taste disturbances, various allergic or toxic reactions on the lips and/or in the oral cavity. However, the list of the drugs which might induce unwanted reactions is everyday becoming longer as more and more drugs are introduced on the market. Certain problems when diagnosing and reporting unwanted side effects of the drugs exist as only accurate method of diagnosis is repeated drug use in controlled clinical setting where fatal consequences due to the anaphilactic shock could be avoided. We report a side effect reaction to tiotropium bromide (Spiriva(R)) cap used with HandiHaler manifesting itself as an oral ulceration in a 65 yrs old male. On the third day of drug intake the patient developed oral ulceration two times in a period of few months. Other medications he has been using for several years. To our knowledge this is a first report as an oral side-effect of this drug used for treatment of chronic obstructive pulmonary disease (COPD)

Oral squamous cell carcinoma with discoid lupus erythematosus

Summary This paper reports an interesting development in a 64 year old female originally referred for evaluation of oral lichenoid lesions. The patient had a previous diagnosis of discoid lupus erythematosus of the skin. The presenting oral clinical appearance varied between lichenoid areas and ectopic erythema migrans. At initial presentation the patient had an exophytic lesion on the vermilion of the lower lip and biopsy confirmed the clinical diagnosis of oral squamous cell carcinoma. She subsequently developed multiple lesions involving isolated oral sites as well as the lip. Crow

Unrecognized oral manifestations of Langerhans cell histiocytosis which progressed to systemic disease

SummaryA 2.5 years old boy was referred to the Department of oral medicine because of substantial erythema and ulcerations on palatal, buccal and alveolar regions. Unfortunately, it took two subsequent visits to our Department in six-months intervals, and re-evaluation at Pediatric oncology clinic where diagnosis of Langerhans cell histiocytosis (LCH) was finally established. At that stage, disease already progressed to multisystem life-threatening presentation, requiring aggressive treatment. Therefore, this case is a reminder of the possibility of occurrence of this rare disease in the oral cavity which might manifest itself in multiple presentations thus easily leading to the misdiagnosis and therefore it could be easily overlooked by dentists