Influence irradiation argon ion SnO[2] on optical and electrical characteristics

Tin oxide in the form of films has been deposited by reactive magnetron sputtering on glass substrates a room temperature. Process was carried out in such mode when the deposited films were conductive. The deposited films were irradiated with argon ions. Have been studied happening at that the changes optical and electric properties of films. Have been investigated optical properties of films in the range of 300-1100 nanometers by means of photometry. For research structure of films was used the x-ray diffractometry. Diffractometric researches have shown that the films deposited on a substrate have crystal structure from shares of a quasicrystal phase and after influence of argon ions she completely became quasicrystal. It is established that change transmission of a film correlates with change her electric resistance. Average value transmission in the range of 380-1100 nanometers as well as the electric resistance of a film with growth of irradiation time increases to the values exceeding initial. At the same time at irradiation time ~ 13,2 sec. are observed their slight decrease. To this value of irradiation time there corresponds the minimum value of electric resistance and transmission films. Change of transmission coefficient correlates with change of surface resistance

Radiation-induced deposition of transparent conductive tin oxide coatings

The study of tin oxide films is stimulated by the search for an alternative replacement of indium-tin oxide (ITO) films used as transparent conductors, oxidation catalysts, material gas sensors, etc. This work was aimed at studying the influence of argon ions irradiation on optical and electrical characteristics of tin oxide films. Thin films of tin oxide (without dopants) were deposited on glass substrates at room temperature using reactive magnetron sputtering. After deposition, the films were irradiated with an argon ion beam. The current density of the beam was (were) 2.5 mA/cm{2}, and the particles energy was 300-400 eV. The change of the optical and electrical properties of the films depending on the irradiation time was studied. Films optical properties were investigated by photometry in the range of 300-1100 nm. Films structural properties were studied using X-ray diffraction. The diffractometric research showed that the films, deposited on a substrate, had a crystal structure, and after argon ions irradiation they became quasi-crystalline (amorphous). It has been found that the transmission increases proportionally with the irradiation time, however the sheet resistance increases disproportionally. Tin oxide films (thickness ~30 nm) with ~100% transmittance and sheet resistance of ~100 kOhm/sq. were obtained. The study has proved to be prospective in the use of ion beams to improve the properties of transparent conducting oxides

Cardiofaciocutaneus syndrome: literature review and case report

The cardiofaciocutaneous syndrome is a condition of sporadic occurrence, with patients showing multiple congenital anomalies and mental retardation. The syndrome is caused by molecular disturbances in the RAS/MAPK pathway. We report on the girl, 9 year-old, with the cardiofaciocutaneous syndrome presenting with typical craniofacial appearance, heart defects, ectodermal abnormalities, neglected orthopedic pathology, developmental delay and spasticity, which rare in this syndrome

Modification of optical and electrical properties of SnO[2] under the influence of argon ion beam

Thin films of tin oxide were deposited on the glass substrates at a room temperature using reactive magnetron sputtering. The ratio between O[2]/Ar and the discharge voltage is maintained in such a mode when the deposited films are dielectrics. After the deposition, the films were irradiated with an argon ions beam. The modification of the optical and electrical properties of the films depending on the irradiation time was studied. Optical properties of the films were analyzed in the range of 300-1100 nm using photometry and structural X-ray diffraction. The diffractometric research showed that the films, deposited on a substrate, had a crystal structure, and after argon ions irradiation they became quasi-crystalline (amorphous). It was found that the modification in the transmittance was correlated with modifications in the meaning of surface resistance. The dielectrics films SnO[2] with increasing exposure time became conductive and then the electrical resistance decreased and reached a minimum at 13.2 seconds. Then resistance films began to increase

Peptide KED: molecular-genetic aspects of neurogenesis regulation in Alzheimer’s disease

Neuroprotective peptides are promising candidate molecules for the treatment of Alzheimer’s disease (AD). Oral application of KED (Lys-Glu-Asp) improved memory and attention in elderly individuals with functional CNS disorders. Peptide KED also restores synaptic plasticity in in vitro model of AD. This review is focused on the analysis of the influence of KED peptide on the expression of genes and synthesis of proteins regulating apoptosis, aging, neurogenesis, and involved in AD pathogenesi

Peptides: Prospects for use in the treatment of COVID-19

There is a vast practice of using antimalarial drugs, RAS inhibitors, serine protease inhibitors, inhibitors of the RNA-dependent RNA polymerase of the virus and immunosuppressants for the treatment of the severe form of COVID-19, which often occurs in patients with chronic diseases and older persons. Currently, the clinical efficacy of these drugs for COVID-19 has not been proven yet. Side effects of antimalarial drugs can worsen the condition of patients and increase the likelihood of death. Peptides, given their physiological mechanism of action, have virtually no side effect

Сердечно-кожно-лицевой синдром: обзор литературы и описание клинического случая

The cardiofaciocutaneous syndrome is a condition of sporadic occurrence, with patients showing multiple congenital anomalies and mental retardation. The syndrome is caused by molecular disturbances in the RAS/MAPK pathway. We report on the girl, 9 year-old, with the cardiofaciocutaneous syndrome presenting with typical craniofacial appearance, heart defects, ectodermal abnormalities, neglected orthopedic pathology, developmental delay and spasticity, which rare in this syndrome.Сердечно-кожно-лицевой синдром возникает спорадически, проявляется множественными пороками развития и умственной отсталостью. Причиной развития данного синдрома являются молекулярные нарушения в каскаде RAS/MAPK-сигнального пути. Представляем клиническое наблюдение девочки 9 лет с характерными для сердечно-кожно-лицевого синдрома черепно-лицевыми нарушениями, пороком сердца, эктодермальными аномалиями, грубой ортопедической патологией, задержкой психомоторного развития и спастикой, редко встречающейся при данном синдроме

Results of Many Years’ Measurements Conducted at the Czech State Long Distances Measuring Standard Koštice

Currently, electronic total stations based on the principles of laser long-range distance measurement are used for collecting geospatial information. As time goes, in the process of using the electronic total stations, their technical parameters vary, necessitating periodic calibration of the instruments. Calibration of the long-range distance measurement laser component of the electronic total stations is carried out at specialized baselines and consists in testing the constant component of an electronic total station, determining the scale error and determining the cyclic error. In the territory of the Czech Republic, two geodetic baselines are operated, the National Calibration Baseline Hvězda and Koštice. Koštice is the Czech State Long Distances Measuring Standard, where electronic total stations are calibrated. From 2017 to 2020, about 600 electronic total stations by different manufacturers Leica Geosystems, Trimble, Topcon, Sokkia, Nikon, Pentax, South and Geomax were calibrated. The total number of measurements performed under the program in all combinations has equaled about 40000. In this paper, results of analysis many years’ measurements performed at the geodetic baseline Koštice from 2017 to 2020 with electronic total stations manufactured by Leica Geosystems are presented. In total, 9186 measurements between the baseline sections 1–2, 1–3, 1–4, 1–5, 1–6, 1–7 and 1–8 have been analyzed. For each section, measurements have been detected which did not pass the Grubbs test criterion (the Smirnov – Grubbs test). Altogether, 261 outliers have been detected, totaling 3 % of the total number of measurements. After excluding the detected outliers with the algorithm of the parametric version of least squares optimization, the length of each section of the baseline was found, and the accuracy of the results obtained was evaluted. The calculated values of the length of the baseline sections are in generally good agreement with the results of the measurements performed at the geodetic baseline Koštice by the specialists from the laboratory of the Bundeswehr University in Munich (Germany) and the results of similar measurements conducted at the same baseline by the specialists from the Research Institute of Geodesy, Topography and Cartography (Czech Republic). For section 1–5, based on the results of both verifications, differences have been obtained exceeding the permissible values of the accuracy of determining baseline characteristics. This may be related to the fact that there are displacements of certain pillars, which mainly have a periodic character and depend on the season. To allow more specific assumptions regarding instability of certain pillars, it is recommended to verify the lengths of the baseline sections once in three months, according to the program in all combinations, which will allow comparison of the values of the confidence limits of the baseline section lengths and putting forward hypotheses regarding variations in the position of individual centers, so that the deviations revealed should be included into the residual uncertainty of length measurement

Результаты многолетних измерений на линейном базисе Коштице

Currently, electronic total stations based on the principles of laser long-range distance measurement are used for collecting geospatial information. As time goes, in the process of using the electronic total stations, their technical parameters vary, necessitating periodic calibration of the instruments. Calibration of the long-range distance measurement laser component of the electronic total stations is carried out at specialized baselines and consists in testing the constant component of an electronic total station, determining the scale error and determining the cyclic error. In the territory of the Czech Republic, two geodetic baselines are operated, the National Calibration Baseline Hvězda and Koštice. Koštice is the Czech State Long Distances Measuring Standard, where electronic total stations are calibrated. From 2017 to 2020, about 600 electronic total stations by different manufacturers Leica Geosystems, Trimble, Topcon, Sokkia, Nikon, Pentax, South and Geomax were calibrated. The total number of measurements performed under the program in all combinations has equaled about 40000. In this paper, results of analysis many years’ measurements performed at the geodetic baseline Koštice from 2017 to 2020 with electronic total stations manufactured by Leica Geosystems are presented. In total, 9186 measurements between the baseline sections 1–2, 1–3, 1–4, 1–5, 1–6, 1–7 and 1–8 have been analyzed. For each section, measurements have been detected which did not pass the Grubbs test criterion (the Smirnov – Grubbs test). Altogether, 261 outliers have been detected, totaling 3 % of the total number of measurements. After excluding the detected outliers with the algorithm of the parametric version of least squares optimization, the length of each section of the baseline was found, and the accuracy of the results obtained was evaluated. The calculated values of the length of the baseline sections are in generally good agreement with the results of the measurements performed at the geodetic baseline Koštice by the specialists from the laboratory of the Bundeswehr University in Munich (Germany) and the results of similar measurements conducted at the same baseline by the specialists from the Research Institute of Geodesy, Topography and Cartography (Czech Republic). For section 1–5, based on the results of both verifications, differences have been obtained exceeding the permissible values of the accuracy of determining baseline characteristics. This may be related to the fact that there are displacements of certain pillars, which mainly have a periodic character and depend on the season. To allow more specific assumptions regarding instability of certain pillars, it is recommended to verify the lengths of the baseline sections once in three months, according to the program in all combinations, which will allow comparison of the values of the confidence limits of the baseline section lengths and putting forward hypotheses regarding variations in the position of individual centers, so that the deviations revealed should be included into the residual uncertainty of length measurement.В настоящее время для сбора геопространственной информации широко используются электронные тахеометры, основанные на принципах лазерной дальнометрии. В процессе эксплуатации изменяются их технические параметры и возникает необходимость периодической калибровки. Она осуществляется на специальных линейных базисах и состоит в поверке постоянной cоставляющей электронного тахеометра, определении ошибки масштаба и циклической ошибки. На территории Чешской Республики действуют два линейных базиса – Гвезда и Коштице. Последний является национальным государственным эталоном длины дальних расстояний, на котором осуществляются поверки электронных тахеометров. С 2017 по 2020 год здесь выполнена калибровка порядка 600 тахеометров различных фирм (Leica Geosystems, Trimble, Topcon, Sokkia, Nikon, Pentax, South и Geomax), общее количество измерений во всех комбинациях около 40000. В статье представлены результаты анализа многолетних измерений, проведенных на линейном базисе Коштице тахеометрами фирмы Leica Geosystems. Исследованы 9186 измерений между секциями базиса 1–2, 1–3, 1–4, 1–5, 1–6, 1–7 и 1–8. По каждой секции выявлялись измерения, которые не прошли заданный критерий Смирнова – Граббса, обнаружен 261 выброс, что составляет 3 % всех измерений. После исключения выбросов с помощью алгоритма параметрической версии МНК-оптимизации определена длина каждой секции базиса и выполнена оценка точности полученных результатов. Вычисленные значения длин секций в целом хорошо согласуются с результатами измерений, проведенных на линейном базисе Коштице Лабораторией геодезии Военного университета Мюнхена (Германия) и Научно-исследовательского института геодезии, топографии и картографии. По секции 1–5 в ходе обоих сравнений получены разности, превышающие допустимые значения точности определения характеристик базиса. Это может быть связано с тем, что по отдельным пунктам наблюдаются смещения, которые носят в основном периодический характер и зависят от времени года. Для более конкретных предположений о нестабильности отдельных пунктов рекомендуется проводить поверку длин секций базиса один раз в три месяца по программе во всех комбинациях, что позволит сопоставлять значения доверительных границ длин секций базиса и выдвигать гипотезы о колебаниях положения отдельных центров. В дальнейшем это позволит включать полученные смещения в остаточную неопределенность измерения длины.