Cardiovascular effects of an arginase II selective inhibitor

For the first time in vitro experiments there were studied the inhibitory activity and safety of potential molecules arginase II selective inhibitors from the group of norleucine derivatives. Also first the substance under the code ZB49-0010C from the group of norleucine derivatives showed the greatest selectivity and inhibitory activity against arginase II in experiments in vitro. However, this substance in vivo exerts dose-dependent hypotensive action and cardioprotective and endothelial protective effects on the L-NAME induced and homocysteine-induced endothelial dysfunction (ED), which are most pronounced at a dose of 10 mg/kg in intragastric administratio

Contributions of spontaneous phase slippage to linear and non-linear conduction near the Peierls transition in thin samples of o-TaS_3

In the Peierls state very thin samples of TaS_3 (cross-section area \sim 10^{-3} mkm^2) are found to demonstrate smearing of the I-V curves near the threshold field. With approaching the Peierls transition temperature, T_P, the smearing evolves into smooth growth of conductance from zero voltage interpreted by us as the contribution of fluctuations to the non--linear conductance. We identify independently the fluctuation contribution to the linear conductance near T_P. Both linear and non-linear contributions depend on temperature with close activation energies \sim (2 - 4) x 10^3 K and apparently reveal the same process. We reject creep of the {\it continuous} charge-density waves (CDWs) as the origin of this effect and show that it is spontaneous phase slippage that results in creep of the CDW. A model is proposed accounting for both the linear and non-linear parts of the fluctuation conduction up to T_P.Comment: 6 pages, 5 Postscript figure, RevTeX, accepted for publication in PR

Mott Insulators of Ultracold Fermionic Alkaline Earth Atoms: Underconstrained Magnetism and Chiral Spin Liquid

We study Mott insulators of fermionic alkaline earth atoms, described by Heisenberg spin models with enhanced SU(N) symmetry. In dramatic contrast to SU(2) magnetism, more than two spins are required to form a singlet. On the square lattice, the classical ground state is highly degenerate and magnetic order is thus unlikely. In a large-N limit, we find a chiral spin liquid ground state with topological order and Abelian fractional statistics. We discuss its experimental detection. Chiral spin liquids with non-Abelian anyons may also be realizable with alkaline earth atoms.Comment: 4 pages, 2 figures, 1 table. Minor changes from v2. Final published versio

Boundary information inflow enhances correlation in flocking

The most conspicuous trait of collective animal behaviour is the emergence of highly ordered structures. Less obvious to the eye, but perhaps more profound a signature of self-organization, is the presence of long-range spatial correlations. Experimental data on starling flocks in 3d show that the exponent ruling the decay of the velocity correlation function, C(r) ~ 1/r^\gamma, is extremely small, \gamma << 1. This result can neither be explained by equilibrium field theory, nor by off-equilibrium theories and simulations of active systems. Here, by means of numerical simulations and theoretical calculations, we show that a dynamical field applied to the boundary of a set of Heisemberg spins on a 3d lattice, gives rise to a vanishing exponent \gamma, as in starling flocks. The effect of the dynamical field is to create an information inflow from border to bulk that triggers long range spin wave modes, thus giving rise to an anomalously long-ranged correlation. The biological origin of this phenomenon can be either exogenous - information produced by environmental perturbations is transferred from boundary to bulk of the flock - or endogenous - the flock keeps itself in a constant state of dynamical excitation that is beneficial to correlation and collective response