Linear IgA bullous dermatosis

Aim: to present a clinical case of linear IgA bullous dermatosis.Materials and methods. A 44 years old patient complaining of skin rashes on the trunk and extremities, accompanied by severe itching was examined. We carried out a morphological investigation of biopsy samples derived from the lesion and apparently unaffected skin areas using the method of indirect immunofluorescence.Results. The patient having rashes in the form of multiple vesicles and small bubbles with a tight cover, which had been grouped into figures resembling pearl necklaces, demonstrated the presence of focal subepidermal cracks (subepidermal bubble in one location), as well as a linear deposition of IgA along the epidermal basement membrane. According to the clinical picture and following the histological and immunofluorescent investigation of skin biopsies, the patient was diagnosed with linear IgA bullous dermatosis. Lesion regression was achieved as a result of systemic therapy with prednisolone at a dose of 50 mg per day.Conclusion. The diagnosis of linear IgA bullous dermatosis should be made on the basis of skin biopsy investigation by the method of indirect immunofluorescence. Systemic glucocorticosteroids are seen as an effective approach to the treatment of such patients

Художественное образование: к взаимосвязи литературного текста и графического образа

Discusses the role of art education in the process of development of creative potential of personality, grounded interrelationship of the literary text and the graphic imageРассмотрена роль художественного образования в процессе развития творческого потенциала личности, обоснована взаимосвязь литературного текста и графического образ

Нелинейность и интерсубъективность как основания гуманитарного образования

Disclosed is the synthesis of individual and social based on the nonlinearity of intersubjectivity and Humanities educationРаскрыт синтез индивидуального и общественного, основанного на нелинейности интерсубъективности и гуманитарного образовани

Narrow-band UVB phototherapy in patients with atopic dermatitis: analysis of the factors determining treatment efficacy

Background. Efficacy the narrow-band UVB phototherapy in patients with atopic dermatitis varies greatly. An important condition for achieving optimal therapeutic effect is the identification of factors that can impact on the efficacy of therapy and considering their influence when prescribing treatment. Aims. The present study aimed to identify the factors which affect the efficacy of narrow-band phototherapy in patients with atopic dermatitis Methods. A prospective, open-label trial was conducted to evaluate the efficacy and safety of narrow-band UVB phototherapy for patients with moderate-to-severe atopic dermatitis. All patients were treated with narrow-band UVB phototherapy four times weekly for 5 weeks. Disease severity was evaluated by SCORing of the Atopic Dermatitis Index (SCORAD) and Eczema Area and Severity Index (EASI). Distribution of patients by the severity of therapeutic effect was evaluated. To compare the efficacy of therapy depending on initial atopic dermatitis severity, initial and cumulative irradiation doses, skin phototype, and smoking status patients were divided into subgroups. Results. 40 patients with moderate-to-severe atopic dermatitis received course of narrow-band UVB phototherapy. After NB-UVB therapy SCORAD and EASI scores reduced from 45.6 ± 11.4 at baseline to 22.6 ± 12.4 (p 0,05) and from 14.4 ± 7.2 at baseline to 4.1 ± 3.9 (p 0,05) respectively demonstrating the efficacy of narrow-band UVB phototherapy in patients with atopic dermatitis. Our investigation showed that tobacco smokers had definitely lower efficacy of NB-UVB phototherapy in comparison with non-smokers. Narrow-band UVB phototherapy had definitely higher efficacy when it is started with an initial dose 0.2–0.3 J/cm2 chosen in compliance with results of MED determing in comparison with an initial dose 0.05–0.15 J/cm2 selected according to skin phototype. Conclusions. Factors that impact on the efficacy of narrow-band UVB phototherapy in patients with atopic dermatitis were identified. It was determined that using higher initial dose is associated with higher efficacy of therapy. The obtained data suggest the opportunity of decrease in efficacy of therapy in smokers with atopic dermatitis

EFFECT OF CHROMIUM CONCENTRATION ON THE IMPULSE CATHODOLUMINESCENCE OF ALUMINA CERAMIC

Parameters that affect the luminescent properties of the material are its chemical composition and structure. One way to change these characteristics is to dope the original sample with solutions with different impurity concentrations. In connection with this, the purpose of this paper is to estimate the effect of the concentration of a solution of the chromium-containing dopant on the luminescence of nano-sized alumina

DOPING NANOSTRUCTURED ALUMINA BY MANGANESE AND INVESTIGATION OF ITS LUMINESCENT PROPERTIES

The nanostructured aluminium oxide doped manganese are synthesized at different annealing temperature and concentration of impurity. Pulse cathodoluminescence of obtained samples are measured. An increase in the concentration of dopant causes quenching of the luminescence of chromium ions

Течение Covid-19 у вакцинированных пациентов

Aim of study. To conduct a retrospective analysis of treatment outcomes for COVID-19 in unvaccinated and vaccinated patients.Material and methods. The present retrospective single-center study included 209 patients who were vaccinated in history and hospitalized at the City Aleksandrovskaya Hospital for infection with COVID-19 in the period from April 5, 2020 to July 9, 2021. The average period between vaccine administration and hospitalization was 18.0 ± 11.0 days. In all cases, a positive result of the polymerase chain reaction (PCR) for the presence of SARS-CoV-2 was obtained. These patients were included in Group 1. The comparison group included 475 unvaccinated patients with comparable lung tissue damage according to multispiral computed tomography of the chest (MSCT) and a positive PCR result for the presence of SARS-CoV-2, selected randomly over the same observation period.Results. The lesions of the lung tissue according to the results of chest MSCT upon admission of the group were comparable (p=0.55). All deaths were observed in the group of unvaccinated patients (n=46; 9.7%; p<0.0001). In all cases, the cause was an increase in multiple organ failure. In the same cohort of patients, there was a statistically significantly greater number of deep vein thrombosis of the upper and lower extremities (p=0.02). In the group of vaccinated patients (1st), arterial thrombosis of various location was not diagnosed, while in the 2nd group (comparison), this pathology was detected in every 10th patient. At the same time, thrombosis of the arteries of the lower extremities developed statistically more often (n=52; 10.9%; p><0.0001). This condition was accompanied by an increase in laboratory parameters of the inflammatory reaction and coagulopathy with the progression of lung tissue damage to the 3–4th degree according to the results of MSCT. However, in 37 (7.8%) cases, open thrombectomy was not possible, and on the first day after the operation, repeated thrombosis developed, followed by amputation of the limb. In 23 (4.8%) cases, a fatal outcome was observed. Conclusion Vaccination prevents the severe course of covid-19: the progression of pneumonia, coagulopathy, and inflammatory syndrome. In vaccinated patients, no deaths, pulmonary embolism were observed, which demonstrates the absence of a severe course of the disease. All arterial thrombosis associated with covid-19 develops in unvaccinated patients and is accompanied by a high incidence of repeated thrombosis, requiring subsequent amputation of the limb. The widespread introduction of vaccination will help reduce the severity of the course and prevent complications of the new coronavirus infection. Key words: COVID-19, novel coronavirus infection, thrombosis, SARS-CoV-2, vaccine>˂0.0001). In all cases, the cause was an increase in multiple organ failure. In the same cohort of patients, there was a statistically significantly greater number of deep vein thrombosis of the upper and lower extremities (p=0.02). In the group of vaccinated patients (1st), arterial thrombosis of various location was not diagnosed, while in the 2nd group (comparison), this pathology was detected in every 10th patient. At the same time, thrombosis of the arteries of the lower extremities developed statistically more often (n=52; 10.9%; p˂0.0001). This condition was accompanied by an increase in laboratory parameters of the inflammatory reaction and coagulopathy with the progression of lung tissue damage to the 3–4th degree according to the results of MSCT. However, in 37 (7.8%) cases, open thrombectomy was not possible, and on the first day after the operation, repeated thrombosis developed, followed by amputation of the limb. In 23 (4.8%) cases, a fatal outcome was observed.Conclusion. Vaccination prevents the severe course of covid-19: the progression of pneumonia, coagulopathy, and inflammatory syndrome. In vaccinated patients, no deaths, pulmonary embolism were observed, which demonstrates the absence of a severe course of the disease. All arterial thrombosis associated with covid-19 develops in unvaccinated patients and is accompanied by a high incidence of repeated thrombosis, requiring subsequent amputation of the limb. The widespread introduction of vaccination will help reduce the severity of the course and prevent complications of the new coronavirus infection. Цель. Провести ретроспективный анализ исходов лечения COVID-19 у невакцинированных и вакцинированных пациентов.Материал и методы. В настоящее ретроспективное одноцентровое исследование вошли 209 пациентов, вакцинированных и госпитализированных в СПб ГБУЗ «Городская Александровская больница» по поводу заражения COVID-19 в период с 5 апреля 2021 по 9 июля 2021 г. Средний период между введением вакцины и госпитализацией составил 18,0±11,0 суток. Во всех случаях был получен положительный результат полимеразной цепной реакции (ПЦР) на наличие SARS-CoV-2. Данные пациенты были включены в 1-ю (основную) группу. В группу сравнения вошли 475 невакцинированных больных с сопоставимым поражением легочной ткани по данным мультиспиральной компьютерной томографии органов грудной клетки (МСКТ ОГК) и положительным результатом ПЦР на наличие SARS-CoV-2, подобранных рандомизированным способом за тот же период наблюдения.Результаты. Поражения легочной ткани согласно результатам МСКТ ОГК на момент поступления группы были сопоставимы (р=0,55). Все смертельные исходы были зафиксированы в группе невакцинированных пациентов (n=46; 9,7%; р<0,0001, статистически значимо). Во всех случаях причиной стало нарастание полиорганной недостаточности. В этой же когорте больных отмечалось статистически значимо большее количество тромбозов глубоких вен верхних и нижних конечностей (р=0,02). В группе вакцинированных пациентов (1-я) артериальные тромбозы разной локализации не диагностировались, тогда как во 2-й группе (сравнения) данная патология была выявлена у каждого 10-го больного. При этом статистически значимо чаще развивался тромбоз артерий нижних конечностей (n=52; 10,9%; р><0,0001). Данное состояние сопровождалось нарастанием лабораторных показателей воспалительной реакции и коагулопатией с прогрессированием поражения легочной ткани до 3–4-й степени по результатам МСКТ. Однако в 37 случаях (7,8%) открытая тромбэктомия оказалась невозможной, и в первые сутки после операции развился повторный тромбоз с последующей ампутацией конечности. В 23 случаях (4,8%) был зафиксирован смертельный исход. Заключение Вакцинация предупреждает тяжелое течение COVID-19: прогрессирование пневмонии, коагулопатии и воспалительного синдрома. У вакцинированных пациентов не наблюдалось смертельных исходов, тромбоэмболии легочной артерии, что демонстрирует отсутствие тяжелого течения заболевания. Все артериальные тромбозы на фоне COVID-19 развиваются у невакцинированных пациентов и сопровождаются высокой частотой повторных тромбозов, требующих последующей ампутации конечности. Широкое внедрение вакцинации будет способствовать уменьшению тяжести течения и профилактике осложнений новой коронавирусной инфекции. Ключевые слова: COVID-19, новая коронавирусная инфекция, тромбоз, SARS-CoV-2, вакцина >˂ 0,0001, статистически значимо). Во всех случаях причиной стало нарастание полиорганной недостаточности. В этой же когорте больных отмечалось статистически значимо большее количество тромбозов глубоких вен верхних и нижних конечностей (р=0,02). В группе вакцинированных пациентов (1-я) артериальные тромбозы разной локализации не диагностировались, тогда как во 2-й группе (сравнения) данная патология была выявлена у каждого 10-го больного. При этом статистически значимо чаще развивался тромбоз артерий нижних конечностей (n=52; 10,9%; р˂ 0,0001). Данное состояние сопровождалось нарастанием лабораторных показателей воспалительной реакции и коагулопатией с прогрессированием поражения легочной ткани до 3–4-й степени по результатам МСКТ. Однако в 37 случаях (7,8%) открытая тромбэктомия оказалась невозможной, и в первые сутки после операции развился повторный тромбоз с последующей ампутацией конечности. В 23 случаях (4,8%) был зафиксирован смертельный исход.Заключение. Вакцинация предупреждает тяжелое течение COVID-19: прогрессирование пневмонии, коагулопатии и воспалительного синдрома. У вакцинированных пациентов не наблюдалось смертельных исходов, тромбоэмболии легочной артерии, что демонстрирует отсутствие тяжелого течения заболевания. Все артериальные тромбозы на фоне COVID-19 развиваются у невакцинированных пациентов и сопровождаются высокой частотой повторных тромбозов, требующих последующей ампутации конечности. Широкое внедрение вакцинации будет способствовать уменьшению тяжести течения и профилактике осложнений новой коронавирусной инфекции.

Inclusive meson production in peripheral collisions of ultrarelativistic heavy ions

There exist several proposals to use Weizs\"{a}cker-Williams photons generated by ultrarelativistic heavy ions to produce exotic particles in $\gamma\gamma$ fusion reactions. To estimate the background conditions for such reactions we analyze various mechanisms of meson production in very peripheral collisions of ultrarelativistic heavy ions at RHIC and LHC energies. Besides $\gamma\gamma$ fusion they include also electromagnetic $\gamma A$ interactions and strong nucleon-nucleon interactions in grazing $AA$ collisions. All these processes are characterised by low multiplicities of produced particles. $\gamma A$ and $AA$ events are simulated by corresponding Monte Carlo codes, RELDIS and FRITIOF. In each of these processes a certain fraction of pions is produced close to the mid-rapidity region that gives a background for the $\gamma\gamma$ events. The possibility of selecting mesons produced in $\gamma\gamma$ fusion events via different $p_t$ cut procedures is demonstrated.Comment: 27 pages with 4 eps-figures included, uses axodraw.sty Tab.2 and 3 correcte

Methods of carotid endarterectomy

This literature review is devoted to various carotid endarterectomy (CE) methods that exist today in Russia. The pros and cons of conventional and eversion technique of the operation are given. It is indicated that the former is associated with higher long-term rate of restenosis, aneurysm and patch infection. The second is associated with higher prevalence of intraoperative internal carotid artery (ICA) thrombosis due to intimal detachment distal to endarterectomy area. The following CE methods for patients with prolonged ICA involvement are described: neo bifurcation formation, autoarterial reconstruction, ICA autotransplantation, plastic using an occipital artery flap. The methods of CE with carotid body saving have been demonstrated: 1. Swallow tail type patch repair proposed by R.I. Izhbuldin; 2. S-shaped arteriotomy proposed by K. A. Antsupov; 3. Two types of operations proposed by R. А. Vinogradov; 4. Сutting off the ICA with sections of common and external carotid artery proposed by A. N. Kazantsev; 5. Glomus-saving ICA autotransplantation in patients with prolonged atherosclerotic involvement. The role of ICA transposition over the hypoglossal nerve in eversion CE is presented. The glomus-saving CE with ICA transposition, called Chik-Chirik CE, is described. Conclusions are drawn on the need to demonstrate all CE types in the novel Russian guidelines for the management of patients with of head and neck arterial diseases