Mosca-negra-dos-citros Aleurocanthus woglumi Ashby (Hemiptera: Aleyrodidae) em culturas de citros e de mangueira no estado de São Paulo e observações de sua biologia e controle.

Resumo: O principal objetivo deste trabalho foi avaliar a infestação da mosca-negra-dos-citros, A. woglumi, observada em janeiro de 2008, em pomar comercial de laranja Pêra-Rio porta enxerto de Limão-Cravo, de nove anos de idade, e em árvo- res isoladas de mangueira variedades Haden e Palmer, de sete a oito anos de idade, no município de Artur Nogueira, estado de São Paulo. Outros objetivos foram relatar a sua biologia, os níveis de danos e o controle biológico dessa praga.bitstream/CNPMA/7710/1/comunicado_46.pd

Níveis De Estresse Oxidativo Ao Diagnóstico E Sua Associação Com O Perfil De Sobrevida Em Pacientes Portadoras De Câncer De Mama Operáveis Em Estadios Iniciais: Um Estudo Piloto

AAltos níveis de estresse oxidativo têm sido associados pior prognóstico do câncer de mama, mas não se sabe sua relação como possível preditor de sobrevida. Neste estudo investigamos a associação entre os níveis circulantes de estresse oxidativo no momento do diagnóstico e o perfil de sobrevida de pacientes portadoras de tumores de mama operáveis. Foi realizado um estudo prospectivo em uma população de 606 pacientes do sexo feminino com tumores de mama em estadios iniciais entre os anos de 2015-2020. Dentre essas pacientes, 18 vieram a óbito no seguimento do estudo, sendo pareadas com 36 pacientes que permaneceram vivas no período do estudo. Amostras de sangue foram coletadas ao diagnóstico, e os níveis de estresse quantificados por meio da dosagem dos metabólitos do óxido nítrico (NO) e perfil de peroxidação lipídicaplasmática. No grupo óbito, observou-se perfil de lipoperoxidação plasmática e níveis de NO elevados ao diagnóstico, quando comparado ao grupo de pacientes vivas. Altos níveis de lipoperoxidação plasmática foram diretamente relacionados com o desenvolvimento de metástases no grupo de pacientes vivas. Os resultados sugerem que o perfil oxidativo sistêmico aumentado ao diagnóstico observado em portadoras de câncer de mama está diretamente relacionado ao desfecho óbito em 5 anos.

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): study protocol for a randomized controlled trial

BACKGROUND: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). METHODS/DESIGN: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH2O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure 6430 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. DISCUSSION: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration metho

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt