VARIATION OF PEAK EXPIRATORY FLOW RATE WITH BODY MASS INDEX IN THE FIRST YEAR MALE MEDICAL STUDENTS OF VISWABHARATHI MEDICAL COLLEGE, KURNOOL

Background: Obesity has become one of the major health issues in India. WHO defines obesity as “A condition with excessive fat accumulation in the body to the extent that the health and wellbeing are adversely affectedâ€. Obesity results from a complex interaction of genetic, behavioral, environmental and socioeconomic factors causing an imbalance in energy production and expenditure. Peak expiratory flow rate is the maximum rate of airflow that can be generated during forced expiratory maneuver starting from total lung capacity. The simplicity of the method is its main advantage. It is measured by using a standard Wright Peak Flow Meter or mini Wright Meter. The pulmonary disorders due to obesity results in increased mortality and morbidity. Aims: To study the effect of Body Mass Index on Peak Expiratory Flow Rate in Medical students. Methods & Methods: study was performed on 60 Male age group of 17-22 Years, categorized as normal Weight BMI= 18.5-24.99kg/m2 and overweight BMI= 25-29.99 Kg/m2. There were 30 students with normal Weight BMI and 30 students with overweight BMI. Normal weight BMI subjects acted as control group to compare the Peak Expiratory Flow Rate with over weight. The parameters studied were weight, height, age, body mass index and Peak expiratory flow rate (PEFR). Student’s unpaired t-test was used for two group’s comparison. Results: The results of the investigation revealed a significantly lower Peak expiratory flow rate (PEFR) among the overweight BMI subjects compared to normal weight BMI subjects. Conclusion: Thus it is evident from the present study that obesity significantly affects the pulmonary functions which may give rise to long term complications and may lead to early morbidity and mortality.Key words: Peak Expiratory Flow Rate; Body Mass Index; Obesity

VARIATION OF PEAK EXPIRATORY FLOW RATE WITH BODY MASS INDEX IN THE FIRST YEAR MALE MEDICAL STUDENTS OF VISWABHARATHI MEDICAL COLLEGE, KURNOOL

Background: Obesity has become one of the major health issues in India. WHO defines obesity as “A condition with excessive fat accumulation in the body to the extent that the health and wellbeing are adversely affectedâ€. Obesity results from a complex interaction of genetic, behavioral, environmental and socioeconomic factors causing an imbalance in energy production and expenditure. Peak expiratory flow rate is the maximum rate of airflow that can be generated during forced expiratory maneuver starting from total lung capacity. The simplicity of the method is its main advantage. It is measured by using a standard Wright Peak Flow Meter or mini Wright Meter. The pulmonary disorders due to obesity results in increased mortality and morbidity. Aims: To study the effect of Body Mass Index on Peak Expiratory Flow Rate in Medical students. Methods & Methods: study was performed on 60 Male age group of 17-22 Years, categorized as normal Weight BMI= 18.5-24.99kg/m2 and overweight BMI= 25-29.99 Kg/m2. There were 30 students with normal Weight BMI and 30 students with overweight BMI. Normal weight BMI subjects acted as control group to compare the Peak Expiratory Flow Rate with over weight. The parameters studied were weight, height, age, body mass index and Peak expiratory flow rate (PEFR). Student’s unpaired t-test was used for two group’s comparison. Results: The results of the investigation revealed a significantly lower Peak expiratory flow rate (PEFR) among the overweight BMI subjects compared to normal weight BMI subjects. Conclusion: Thus it is evident from the present study that obesity significantly affects the pulmonary functions which may give rise to long term complications and may lead to early morbidity and mortality.Key words: Peak Expiratory Flow Rate; Body Mass Index; Obesity

A Study of Challenges and Recommendations for Teaching: DevOps Education

DevOps has gained significant popularity in the software industry due to its ability to enhance collaboration, improve software delivery, and drive organizational agility. However, providing effective education and training in DevOps poses several Issue. This research paper presents an interview study conducted with a seasoned DevOps professional to explore the challenges faced in DevOps education and provide recommendations for addressing these challenges. The study highlights the evolving nature of the DevOps landscape, the interdisciplinary nature of DevOps, and the need for hands-on learning experiences. Additionally, the study emphasizes the importance of continuous curriculum updates, practical exercises, cross-functional collaboration, industry partnerships, and fostering a continuous learning mindset. The findings from this study contribute to the understanding of the unique challenges and recommendations for improving DevOps education

Research for practice in small human service organisations: doing and disseminating smallscale research

A series of novel alkynyl substituted 3,4-dihydropyrimidin-2(1H)-one (DHPM) derivatives were designed, synthesized and evaluated in vitro as potential inhibitors of chorismate mutase (CM). All these compounds were prepared via a multi-component reaction (MCR) involving sequential I2-mediated Biginelli reaction followed by Cu-free Sonogashira coupling. Some of them showed promising inhibitory activities when tested at 30 μM. One compound showed dose dependent inhibition of CM with IC50 value of 14.76 ± 0.54 μM indicating o-alkynylphenyl substituted DHPM as a new scaffold for the discovery of promising inhibitors of CM

Improvement of two traditional Basmati rice varieties for bacterial blight resistance and plant stature through morphological and marker-assisted selection

Bacterial blight (BB) is a major production threat to Basmati, the aromatic rice prized for its unique quality. In order to improve the BB resistance of two elite, traditional BB-susceptible Basmati varieties (Taraori Basmati and Basmati 386), we utilized the strategy of limited marker-assisted backcrossing for introgression of two major BB resistance genes, Xa21 and xa13, coupled with phenotype-based selection for improvement of their plant type and yield. Improved Samba Mahsuri, an elite high-yielding, fine-grain-type BB-resistant rice variety served as donor for BB resistance. Backcross-derived improved Basmati lines at BC1F5 possessing a single resistance gene (i.e. either Xa21 or xa13) displayed moderate resistance to BB, while lines possessing both Xa21 and xa13 showed significantly higher levels of resistance. Two-gene pyramid lines (Xa21 + xa13) possessing good grain and cooking quality similar to their respective traditional Basmati parents, short plant stature (<110 cm plant height) and higher grain yield than the recurrent parent(s) were identified and advanced. This work demonstrates the successful application of marker-assisted selection in conjunction with phenotype-based selection for targeted introgression of multiple resistance genes into traditional Basmati varieties along with improvement of their plant stature and yield

VARIATION OF PEAK EXPIRATORY FLOW RATE WITH BODY MASS INDEX IN THE FIRST YEAR MALE MEDICAL STUDENTS OF VISWABHARATHI MEDICAL COLLEGE, KURNOOL

Background: Obesity has become one of the major health issues in India. WHO defines obesity as “A condition with excessive fat accumulation in the body to the extent that the health and wellbeing are adversely affectedâ€. Obesity results from a complex interaction of genetic, behavioral, environmental and socioeconomic factors causing an imbalance in energy production and expenditure. Peak expiratory flow rate is the maximum rate of airflow that can be generated during forced expiratory maneuver starting from total lung capacity. The simplicity of the method is its main advantage. It is measured by using a standard Wright Peak Flow Meter or mini Wright Meter. The pulmonary disorders due to obesity results in increased mortality and morbidity. Aims: To study the effect of Body Mass Index on Peak Expiratory Flow Rate in Medical students. Methods &amp; Methods: study was performed on 60 Male age group of 17-22 Years, categorized as normal Weight BMI= 18.5-24.99kg/m2 and overweight BMI= 25-29.99 Kg/m2. There were 30 students with normal Weight BMI and 30 students with overweight BMI. Normal weight BMI subjects acted as control group to compare the Peak Expiratory Flow Rate with over weight. The parameters studied were weight, height, age, body mass index and Peak expiratory flow rate (PEFR). Student’s unpaired t-test was used for two group’s comparison. Results: The results of the investigation revealed a significantly lower Peak expiratory flow rate (PEFR) among the overweight BMI subjects compared to normal weight BMI subjects. Conclusion: Thus it is evident from the present study that obesity significantly affects the pulmonary functions which may give rise to long term complications and may lead to early morbidity and mortality.Key words: Peak Expiratory Flow Rate; Body Mass Index; Obesity

EFFECT OF DIABETES MELLITUS ON RIFAMPICIN PEAK SERUM CONCENTRATION

Objective: To comparatively analyze the peak serum concentration (Cmax) of rifampicin and to determine the incidence of decreased Cmax between diabetic and non-diabetic adult pulmonary tuberculosis patients.Methods: A cross-sectional observational study was carried out in the chest and tuberculosis (TB) department of a tertiary care hospital after the approval of the institutional ethics committee. Five millilitre (ml) of blood was withdrawn by venipuncture from each patient at a time point of 2 h post dose administration at steady state concentration (Css). The separated serum was centrifuged at a rate of 3500 rotations per minute (rpm) for a period of fifteen minutes and the resultant serum was stored at-70 ° C until analysis. Estimation of rifampicin concentration was carried out in Thermo TSQ Ultra (MS/MS) with Shimadzu 20 AD UFLC LC-MS.Results: The mean (Standard Deviation (SD)) age of the study population was 46.8 (14.2) years. The mean serum Cmax of rifampicin was significantly less in diabetic patients with pulmonary tuberculosis (p=0.0305). Statistically, a significant difference in the incidence of a decrease in Cmax was found between diabetic and non-diabetic patients (p=0.0335). Diabetes mellitus was found to be the predominant factor that affects rifampicin Cmax.Conclusion: In this study, an effect of diabetes mellitus (DM) on the peak serum concentration of rifampicin was observed. Patients with hyperglycemia levels had significantly reduced levels of rifampicin serum concentrations, thus showing an inversely proportional relationship between blood glucose and rifampicin serum levels