Human capital as a key factor of economic growth in crisis

The purpose of the article is to determine the role of human capital in overcoming of crisis phenomena in economy by the example of modern Russia. During the research, the authors use such scientific methods as modeling of development of socio-economic systems, factor analysis, analysis of causal connections, systemic and problem analysis, correlation analysis, synthesis, and graphic representation of information. The authors analyze dynamics and connection between Russian economy and innovational activity of Russian enterprises before, during, and after the recent financial crisis and develop an anti-crisis strategy of development of human capital, depending on the phase of economic cycle. As a result, the authors come to the conclusion that overcoming of crisis phenomena in economy is done by innovational activity of enterprises, which is ensured by their human capital.peer-reviewe

Peculiarity of Embodiment of Literary Text by N. Leskov in Libretto of Opera by R. Shchedrin “The Enchanted Wanderer”

On the example of reading two texts the story of N. Leskov “The Enchanted Wanderer” and the libretto of “opera for a concert stage” by R. Shchedrin the mechanism of transformation of a literary text into an opera libretto text is described in the article. The principles of elimination, intensification and re-emphasis are described as basic principles of such a transformation. It is shown how their implementation affects the concept of the main character, genre features and the architectonics of the libretto. Particular attention is paid to the concept of the main character. It is concluded that, working with Leskov’s text, reducing and supplementing it, shifting individual accents, R. Shchedrin as a whole does not deviate from the narrative in the interpretation of the concept of the main character, does not violate the genre specificity of the work, the general drawing of its plot and plot canvas. The relevance of the article is due to the fact that Shchedrin’s opera “The Enchanted Wanderer” (last production - New York, 2015) still causes a considerable research reaction both in Russia and abroad. The novelty of the article is due to the fact that there is no literary study on the comparative analysis of two texts: the story of Leskov and the opera libretto by Shchedrin. Meanwhile, the consideration of the ways and methods that artists went to implement the main idea of the work seems important and interesting

CONCERNING CHAIN GROWTH SPECIFIC REACTION RATE AS A PART OF THE PROCESS OF METHYL METHACRYLATE MASS RADICAL POLYMERIZATION

It is the chain growth specific reaction rate that was determined for the process of methyl methacrylate mass radical polymerization within the temperature range of 40–900 С in quasi-steady approximation by means of Monte Carlo method. The theoretical model of radical polymerization was developed taking the gel effect into account. Computer software was developed that enables to imitate radical polymerization process taking gel effect into account within the minimum run time. The programme was tested on asymptotic examples as well as was applied for methyl methacrylate mass radical polymerization. The programme makes it possible to calculate monomer conversion, molecular mass variation, molecular-mass distribution, etc

Probenecid slows disease progression in a murine model of autosomal dominant polycystic kidney disease

Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst-lining cells, and thus results in cystic fluid accumulation. Earlier, we demonstrated that Pkd1(RC/RC) mice, a hypomorphic model of ADPKD, exhibit increased expression of pannexin-1, a membrane channel capable of ATP release. In the current study, we found that human ADPKD cystic epithelia have higher pannexin-1 abundance than normal collecting ducts. We hypothesized that inhibition of pannexin-1 function with probenecid can be used to attenuate ADPKD development. Renal function in male and female Pkd1(RC/RC) and control mice was monitored between 9 and 20 months of age. To test the therapeutic effects of probenecid (a uricosuric agent and a pannexin-1 blocker), osmotic minipumps were implanted in male and female Pkd1(RC/RC) mice, and probenecid or vehicle was administered for 42 days until 1 year of age. Probenecid treatment improved glomerular filtration rates and slowed renal cyst formation in male mice (as shown in histopathology). The mechanistic effects of probenecid on sodium reabsorption and fluid transport were tested on polarized mpkCCD(cl4) cells subjected to short-circuit current measurements, and in 3D cysts grown in Matrigel. In the mpkCCD(cl4) epithelial cell line, probenecid elicited higher ENaC currents and attenuated in vitro cyst formation, indicating lower sodium and less fluid retention in the cysts. Our studies open new avenues of research into targeting pannexin-1 in ADPKD pathology

Infrastructural development of agricultural products in the republic of Kazakhstan

This article explores the dependence of the agro-industrial products of the Republic of Kazakhstan on the development level of rural production, social and transport infrastructure. The paper presents main trend of the indices of the agribusiness infrastructural development in the Republic of Kazakhstan according to the time series based on the statistical data of Kazakhstan. The study revealed that the level of endowment in social and industrial infrastructure of agriculture in Kazakhstan remains extremely unstable. This circumstance can consequently form a tendency for a decline and even degradation of the Kazakh villages. As a result, it can lead to a violation and decline of the reproductive processes in the agribusiness, which, in turn, will negatively affect the endowment in products from agricultural raw materials. Hence, the formation and development of the agribusiness infrastructure is seen as an indispensable condition for the effective interaction of the actors of the main and auxiliary production, contributing to the development of general prerequisites for the growth and development of agricultural products. The results of the research can be used by the state in investing social, transport and production development of the village to ensure food security. Agricultural development of rural areas in Kazakhstan based on improving the infrastructure will increase the welfare of rural workers, solve the problem of quality food for the population of the country, and take an active part in the global task of eradicating hunger on the planet. © 2019 Stukach V. F., Saparova G. K., Sultanova G. T., Saginova S. A. Text

Macro-microscopic study of posterior vitreous detachment variants in an ex vivo experiment

Purpose. The key to understanding the development of any vitreoretinal pathology is a presence of a clear conception to possible variants of changes in the anatomical and topographic relationships of the posterior cortical layers of the vitreous body and the retinal internal limiting membrane (ILM) in a formation of posterior vitreous detachment (PVD).An original method of macro-microscopic examinations of anatomical objects proposed by professor V.P. Vorobyov, which includes investigations of morphological objects whose dimensions lie in the boundary area between macroscopic parameters studied by anatomists and microstructures studied by histologists, discover a new boundary area for the study of anatom ical structures.However, it has not been practically used in ophthalmology until now. The study of a process for changes in the vitreoretinal interface during the PVD occurrence is difficult due to a complexity of simulation, a possibility of visualization, and an absence of approved protocols for macro-microscopic research.Purpose. To study variants of anatomical and topographical changes in the vitreoretinal interface during the formation of induced PVD in ex vivo experiments using the method of macro-microscopic examination.Material and methods. The study was performed in 24 eyeballs of cadaver donors. To assess changes in the vitreoretinal interface in the process of PVD induction, an original method of dissection was used, that allows to isolate layer-by-layer the cortical layers of the vitreous body and the retinal ILM, with a possibility of further evaluation of changes in the vitreoretinal interface by the macro-microscopic examination. Salt barium sulfate suspension Video-contrast was used with the purpose to contrast vitreous fibers. Macroscopic investigation was carried out using the Topcon OMS-800 operating microscope with an indication from x8 to x21 magnification, microscopic changes were evaluated by the light microscopy method with x50, x100, x200, x400 x630 magnification using the Leica DM LB2 microscope with the subsequent photo r egistration.Results. During the macro-microscopic study, three variants of possible changes in the vitreoretinal interface during the development of induced PVD were revealed, which were interpreted as the normal (true) PVD and abnormal PVD, which occurred both with the formation (the variant A) of vitreoschisis zones (exfoliation of the cortical layers of the vitreous body) and with the zones of retinal ILM exfoliation (the variant B).Conclusion. The proposed method of macro-microscopic investigation of the vitreoretinal interface allows to dissect isolated sequentially layerby- layer the cortical layers of the vitreous body and the retinal ILM with subsequent fixation on a special substrate according to the original method and the possibility to carry out a histological section and its evaluation by the light m icroscopy method. The application of the developed method allows to accurately assess changes in the vitreoretinal interface on any isolated site of the vitreoretinal surface. The presented work demonstrates possibilities for the application of the method to detect variants of changes in the vitreoretinal interface within the formation of i nduced PVD

Image of Your Own Body, Sense of Isolation and Quality of Life in Patients with Gynecological Cancers

Aim: to study mental state of gynecological oncological patients, their attitude to the existing disease and quality of life.Material and methods. The study was conducted on the basis of the City Clinical Hospital No. 1 of Novosibirsk. The main group (17women aged 29 to 60 years) included patients with ovarian cancer, cancer of the external female genital organs, and uterine cancer; the comparison group was comprised of 20 people aged 29 to 63 years without a history of cancer.Results. In gynecological oncological patients, dissatisfaction with their own bodies is more pronounced; they perceive their body distorted, which may be due to the characteristics of the disease and the specifics of treatment. Patients with gynecological cancers have a more pronounced subjective feeling of loneliness, but it is at the upper limit of the norm, which may mean the fact that these patients turn in upon themselves, in their experiences, as well as the feeling of something lost in their inner world. Patients with gynecological cancers showed an average level of quality of life and low indicators of the mental component of health, which indicates reduced functioning and a significant effect of the patient’s physical and emotional state on daily activities.Conclusion. The mental state of the cancer patient, his ability to withstand stress, his attitude to the existing disease affect the treatment process and further quality of life

Investigation of Biological and Photocatalytic Activity of Nanopowders Metal Oxides with Nanosized Silver Coating

Was carried out the assessment of photocatalytic, cytotoxic properties on cells and antibacterial properties against E. coli and Staphylococcus of oxides nanopowders with nanoscale silver coating. Is shown the promising use of such composites as a photocatalytic agent, as well as in medicine. © Published under licence by IOP Publishing Ltd.The reported study was funded partially by RFBR and Sverdlovsk region, project 20-48-660019 р_а

Searching for novel antagonists of adenosine A1 receptors among azolo [1,5-a] pyrimidine nitro derivatives

Ligands of adenosine A1Rs are potential candidates for the development of drugs for the treatment of paroxysmal supraventricular tachycardia, angina pectoris, hypertriglyceridemia, type 2 diabetes mellitus, neuropathic pain, and heart failure. At the same time, there is a deficiency of drugs that can regulate the functions of A1 receptor

Analysis of the quality of inter-hospital transportation patients in critical condition in Tyumen and the south of the Tyumen region

Patients in critical condition during inter-hospital transportation are at the highest risk of morbidity and deterioration of the severity of the condition. When analyzing the call cards of the teams of the disaster medicine center, it was revealed that the mortality during the first 24 hours in the hospital was 3%, which is 9 times less than the global indicators. This study found that the age of patients, distance and duration of transportation, type of vehicle and transfer at night can be predictors of adverse events in this category of patients. The work aroused interest in identifying factors that predict the risk of adverse events and thus improve the quality of inter-hospital transportation.Пациенты в критическом состоянии во время межгоспитальной транспортировки подвергаются наиболее повышенному риску заболеваемости и ухудшению тяжести состояния. При анализе карт вызова бригад центра медицины катастроф выявлено, что смертность в течение первых 24 часов в стационаре составила 3%, что в 9 раз меньше общемировых показателей. В данном исследовании установлено, что возраст пациентов, расстояние и длительность транспортировки, вид транспортного средства и перевод в ночное время суток могут быть предикторами неблагоприятных событий у данной категории пациентов. Работа вызвала интерес к выявлению факторов, прогнозирующих риск возникновения неблагоприятных событий и, тем самым, улучшить качество межгоспитальной транспортировк