DANSSino: a pilot version of the DANSS neutrino detector

DANSSino is a reduced pilot version of a solid-state detector of reactor antineutrinos (to be created within the DANSS project and installed under the industrial 3 GW(th) reactor of the Kalinin Nuclear Power Plant -- KNPP). Numerous tests performed at a distance of 11 m from the reactor core demonstrate operability of the chosen design and reveal the main sources of the background. In spite of its small size (20x20x100 ccm), the pilot detector turned out to be quite sensitive to reactor antineutrinos, detecting about 70 IBD events per day with the signal-to-background ratio about unity.Comment: 16 pages, 11 figures, 3 tables. arXiv admin note: substantial text overlap with arXiv:1304.369

Search for sterile neutrinos at the DANSS experiment

DANSS is a highly segmented 1~m${}^3$ plastic scintillator detector. Its 2500 one meter long scintillator strips have a Gd-loaded reflective cover. The DANSS detector is placed under an industrial 3.1~$\mathrm{GW_{th}}$ reactor of the Kalinin Nuclear Power Plant 350~km NW from Moscow. The distance to the core is varied on-line from 10.7~m to 12.7~m. The reactor building provides about 50~m water-equivalent shielding against the cosmic background. DANSS detects almost 5000 $\widetilde\nu_e$ per day at the closest position with the cosmic background less than 3$\%$. The inverse beta decay process is used to detect $\widetilde\nu_e$. Sterile neutrinos are searched for assuming the $4\nu$ model (3 active and 1 sterile $\nu$). The exclusion area in the $\Delta m_{14}^2,\sin^22\theta_{14}$ plane is obtained using a ratio of positron energy spectra collected at different distances. Therefore results do not depend on the shape and normalization of the reactor $\widetilde\nu_e$ spectrum, as well as on the detector efficiency. Results are based on 966 thousand antineutrino events collected at 3 distances from the reactor core. The excluded area covers a wide range of the sterile neutrino parameters up to $\sin^22\theta_{14}<0.01$ in the most sensitive region.Comment: 10 pages, 13 figures, version accepted for publicatio

О ТЕРМИЧЕСКОЙ УСТОЙЧИВОСТИ КОМПЛЕКСА ВИСМУТ(III) ЙОД ЭТИОПОРФИРИН II

For the first time, a complex of bismuth(III) with iodine and etioporphyrin II is reported. It was prepared by reacting etioporphyrin II and bismuth(III) iodide in pyridine in Ar atmosphere. The prepared compound was characterized by FT-IR, 1H-NMR, UV-VIS spectroscopy and mass spectrometry. One intense line at m/z 684.990 attributed to the complex without the iodine atom is observed in the mass spectrum. This is in agreement with the data indicating that bismuthporphyrin complexes generally have low stability. Analysis of FT-IR spectra obtained at room temperature and at 145°С is reported. Priroda15 DFT package was used for optimization of complex geometry and calculation of the IR spectrum. Calculations were done using BPE functional and L1 basis set under relativistic approximation of Dyall Modified Dirac. Assignment of the vibrational frequencies is reported. Collected data indicate that the complex of bismuth(III) with iodine and etioporphyrin II is not stable and easily hydrolyses when exposed to air forming the corresponding hydroxocomplex. This transformation does not change significantly the dynamics of the porphyrin ring.Впервые получен комплекс висмут(III) йод этиопорфирин II. Реакция этиопорфирина II с йодидом висмута(III) проведена при кипячении в пиридине в токе аргона. Соединение охарактеризовано методами ИК-, 1Н-ЯМР-, электронной спектроскопии и масс-спектрометрии. Масс-спектр представлен одной интенсивной линией m/z 684.990, соответствующей комплексному иону без атома йода. Последнее согласуется с данными, свидетельствующими о низкой устойчивости комплексов висмута с порфиринами. Выполнен анализ ИК-спектров поглощения полученного комплекса при комнатной температуре и 145°С. Оптимизация геометрии и расчет частот поглощения выполнены в программе Priroda15 методом DFT с использованием функционала PBE в базисе L1 в полноэлектронном скалярно-релятивистском приближении Dyall Modified Dirac. Проведено отнесение колебательных частот. Полученные результаты позволяют заключить, что комплекс висмут(III) йод этиопорфирин II представляет собой крайне неустойчивое соединение, которое легко гидролизуется на воздухе молекулами атмосферной воды с образованием гидроксокомплекса. При этом динамика порфиринового кольца не претерпевает заметных изменений

Clinical Experience of Luminescent Diagnostics of Precancerous Diseases and Cervical Cancer

The article summarizes the experience of using luminescent diagnostics with the use of ytterbium porphyrin complexes in gynecology and oncology. A pharmaceutical composition based on the Yb complex of 2,4-dimethoxyhematoporphyrin IX was used as the luminescent markers within the infrared range. The determination of luminescence characteristics (luminescence intensity) was carried out using a laserfiber fluorimeter in the range of 900-1100 nm. A new method for diagnosis of cervical disease has been proposed. The method of luminescent diagnostics allows to conduct a survey of a large number of patients in a short time. The method of luminescent diagnostics using the ytterbium complexes of porphyrins is not invasive. The method can be used as a screening. Differences between normal and pathologically altered cervical tissue have been identified and differences between pathological changes in the cervix HSIL (CIN II, CIN III) and cervical cancer are reliable. Keywords: Cervical cancer, squamous cell carcinoma, diagnosis of cervical cancer, squamous intraepithelial lesions of high grade – HSIL, luminescent diagnostics, luminescing in the near infrared (NIR) spectral region, porphyrins, ytterbium complexes of porphyrins

FEATURES OF THE OIL AND GAS POLICY OF THE UNITED STATES OF AMERICA

The scientific article is devoted to the study of the features of the oil and gas policy of the United States of America. The authors considered the organizational and economic structure of the oil and gas industry, state policy and taxation in the oil and gas complex, problems and prospects for its development

Формилирование металлокомплексов м- и п-изомеров тетраaнизилпорфиринов

The Vilsmeyer formylation reaction a of metallocomplexes of m- and p- methoxy-substituted tetraphenylporphyrins was investigated. Formyl derivatives of m-isomers were shown to form cyclization products not only in solutions but in solid state. Ability to such transformations decreases in a number Co&gt;Cu&gt;Ni&gt;Pd&gt;Pt.Исследована реакция формилирования по Вильсмейеру металлокомплексов изомерных м- и п-метоксизамещенных тетрафенилпорфиринов. Показано, что формилпроизводные м-изомеров образуют продукты циклизации не только в растворах, но и в твердом состоянии. Способность к подобным превращениям уменьшается в ряду Co&gt;Cu&gt;Ni&gt;Pd&gt;Pt

СОЕДИНЕНИЯ ВИСМУТА И ЕГО КОМПЛЕКСЫ С ПОРФИРИНАМИ: ПРИМЕНЕНИЕ, СТРУКТУРА И СВОЙСТВА

Bismuth and its compounds have been known since ancient times and now are widely used in practice in various fields. Bismuth use in medicine can be traced back to the Middle Ages, and its wide application is due to its very low toxicity - for most bismuth compounds it is less than for sodium chloride. Bismuth and its compounds, in particular salts, are used in medical practice in the treatment of diseases such as spirochetosis, gastric and duodenal ulcer, leishmaniasis and coronaviral infection, as well as in cancer therapy. In addition to solid preparations liquid peroral pharmaceutical forms have been developed for the treatment of diarrhea, colitis, ulcers etc. Bismuth preparations are used in stomatology for the treatment of inflammatory diseases of paradontium. The review considers the syntheses and properties of bismuth complexes with natural and synthetic porphyrins, which are used in medicine and other fields of science and technology. Considerable attention is paid to the structure features of bismuth porphyrins complexes, their dimeric structures, and the influence of various extra ligands. The counterion nature and structure make a substantial contribution in solving the problem of complexes stability. The central bismuth atom in these complexes extends far above the plane of the macrocycle due to the large ionic radius. Thus, the counterions action on the conformation, physicochemical properties and stability of metal porphyrins complexes is shown. A separate section is devoted to unique and interesting properties of bismuth porphyrins complexes, such as fluorescence and color variation of crystals.Обзор посвящен использованию висмута и его соединений, в частности солей, в медицинской практике при лечении таких заболеваний, как спирохетозы, язвенная болезнь желудка и двенадцатиперстной кишки, а также в терапии рака. Наряду с твердыми препаратами разработаны жидкие пероральные лекарственные формы для лечения диареи, колитов, язв и др. Препараты висмута используются в стоматологии для лечения воспалительных заболеваний пародонта. Рассмотрены синтезы и свойства висмутовых комплексов с природными и синтетическими порфиринами, которые находят применение в медицине и иных областях науки и техники. Значительное внимание уделено особенностям строения висмутовых комплексов порфиринов, их пространственной структуре, влиянию стерических и электронодонорных эффектов, образованию димеров и влиянию различных экстралигандов. Так, показано действие противоионов на конформацию, физико-химические свойства и устойчивость висмутовых металлокомплексов порфирино

Иттербий и его комплексы с порфиринами

The present review is devoted to the 70th element of the Periodic system and its complexes with natural and synthetic porphyrins. The ytterbium combination with porphyrin compounds, which are able to accumulate selectively in malignant tumors, led to the creation of a new class of diagnostic compounds fluorescing in the NIRregion in a "window of tissues transparency". Syntheses of Yb-complexes of various porphyrins with the use of Yb(acac)3 in several solvents and microwave radiation are considered. Electronic absorption spectra, fluorescence spectra and luminescence decay curves are given, the lifetimes of excited Yb-complexes state are measured, and the influence of chromophore aromatic fragments in macrocycle meso-positions on quantum exits values is considered. The carried out screening of more than 20 compounds allowed to choose the most perspective substance for early luminescent diagnostics – dipotassium salt of Yb(acac)-dimethoxyhematoporphyrin IX. Biological tests on tumor-carrier mice are carried out, and primary preparation accumulation in malignant tumors is shown. This compound was used also for the functionalization of composite nanoparticles consisting of gold-silver nanocages covered with mesoporous silicon dioxide. Syntheses of bis-porphyrins with different elements, application of ytterbium compounds in biomedicine, technics, chemical reactions and etc. are considered.О бзор посвящен одному из элементов группы лантанидов - иттербию, некоторым его физико-химическим свойствам, применению различных соединений иттербия в химических реакциях, медицине и технике. Основное внимание уделено применению иттербиевых комплексов порфиринов в качестве чувствительных ИК-флуоресцентных зондов для диагностики злокачественных новообразований

High resolution manometry and new classification of esophageal motility disorders

Purpose of the review. To present application of Chicago classification criteria of esophageal motility disorders defined in high resolution manometry in clinical practice. Basic provisions. High-resolution manometry is the most exact hi-tech diagnostic method for esophageal motor function disorders according to Chicago classification v3.0. Uniqueness of the method consists in capacity to define integrated quantitative and qualitative metrics of esophageal contractile function and to establish their specific disorders e.g.: change of intrabolus pressure at disorders of esophagogastric junction (EGj) outflow, hypercontractile esophagus, fragmented contractions and weak or failed peristalsis, distal esophageal spasm. Assessment of the type of achalasia subtypes has significant impact on the patients’ treatment choice. According to anatomical location of the lower esophageal sphincter and crural diaphragm several morphological types of gastro-esophageal junction are defined that determine severity of gastroesophageal reflux disease. Multiple rapid swallow responses during esophageal high-resolution manometry reflect esophageal body peristaltic reserve and is a predictor of postoperative complications. Differential diagnosis of belching type became possible at combined application of high-resolution manometry and impedance measurement. Conclusion. High-resolution manometry is a fundamental diagnostic test of esophageal motor function disorders. Clinical application of this method significantly expands diagnostic potential and allows to carry out personalized treatment that increases treatment quality