15,768 research outputs found
The RFOFO Ionization Cooling Ring for Muons
Practical ionization cooling rings could lead to lower cost or improved
performance in neutrino factory or muon collider designs. The ring modeled here
uses realistic three-dimensional fields. The performance of the ring compares
favorably with the linear cooling channel used in the second US Neutrino
Factory Study. The normalized 6D emittance of an ideal ring is decreased by a
factor of approximately 240, compared with a factor of only 15 for the linear
channel. We also examine such \textit{real-world} effects as windows on the
absorbers and rf cavities and leaving empty lattice cells for injection and
extraction. For realistic conditions the ring decreases the normalized 6D
emittance by a factor of 49.Comment: 27 pages, 18 figures and 5 tables. Submitted to Phys. Rev. ST-A
Theta dependence of CP^9 model
We apply to the model two recently proposed numerical techniques for
simulation of systems with a theta term. The algorithms, successfully tested in
the strong coupling limit, are applied to the weak coupling region. The results
agree and errors have been evaluated and are at % level. The results scale well
with the renormalization group equation and show that, for in presence
of a theta term, CP symmetry is spontaneously broken at in the
continuum limit.Comment: 4 pages, 4 figure
Gravitational diffraction radiation
We show that if the visible universe is a membrane embedded in a
higher-dimensional space, particles in uniform motion radiate gravitational
waves because of spacetime lumpiness. This phenomenon is analogous to the
electromagnetic diffraction radiation of a charge moving near to a metallic
grating. In the gravitational case, the role of the metallic grating is played
by the inhomogeneities of the extra-dimensional space, such as a hidden brane.
We derive a general formula for gravitational diffraction radiation and apply
it to a higher-dimensional scenario with flat compact extra dimensions.
Gravitational diffraction radiation may carry away a significant portion of the
particle's initial energy. This allows to set stringent limits on the scale of
brane perturbations. Physical effects of gravitational diffraction radiation
are briefly discussed.Comment: 5 pages, 2 figures, RevTeX4. v2: References added. Version to appear
in Phys. Rev.
Effects of thermal fluctuation and the receptor-receptor interaction in bacterial chemotactic signalling and adaptation
Bacterial chemotaxis is controlled by the conformational changes of the
receptors, in response to the change of the ambient chemical concentration. In
a statistical mechanical approach, the signalling due to the conformational
changes is a thermodynamic average quantity, dependent on the temperature and
the total energy of the system, including both ligand-receptor interaction and
receptor-receptor interaction. This physical theory suggests to biology a new
understanding of cooperation in ligand binding and receptor signalling
problems. How much experimental support of this approach can be obtained from
the currently available data? What are the parameter values? What is the
practical information for experiments? Here we make comparisons between the
theory and recent experimental results. Although currently comparisons can only
be semi-quantitative or qualitative, consistency is clearly shown. The theory
also helps to sort a variety of data.Comment: 26 pages, revtex. Journal version. Analysis on another set of data on
adaptation time is adde
Changes in the secretory profile of NSCLC-associated fibroblasts after ablative radiotherapy: potential impact on angiogenesis and tumor growth
In the context of radiotherapy, collateral effects of ablative ionizing radiation (AIR) on stromal components of tumors remains understudied. In this work, cancer-associated fibroblasts (CAFs) isolated from freshly resected human lung tumors were exposed to AIR (1x18Gy) and analyzed for their release of paracrine factors. Inflammatory mediators and regulators of angiogenesis and tumor growth were analyzed by multiplex protein assays in conditioned medium (CM) from irradiated and non-irradiated CAFs. Additionally, the profile of secreted proteins was examined by proteomics. In functional assays, effects of CAF-CM on proliferative and migratory capacity of lung tumor cells (H-520/H-522) and endothelial cells (HUVECs), and on the tube-forming capacity of endothelial cells was assessed. Our data show that exposure of CAFs to ablative doses of ionizing radiation results in a) down-regulated release of angiogenic factors SDF-1, angiopoietin and thrombospondin-2; b) up-regulated release of growth factor bFGF from most donors, and c) unaffected expression-levels of HGF and inflammatory mediators IL-6, IL-8, IL-1ƒÒ and TNF-£. Conditioned medium from irradiated and control CAFs did not affect differently the proliferative or migratory capacity of tumor cells (H-520/H-522), whereas migratory capacity of endothelial HUVEC cells was partially reduced in the presence of irradiated CAF conditioned medium. Overall we conclude that AIR mediates a transformation on the secretory profile of CAFs that could influence the behavior of other cells in the tumor tissue and hence guide to some extent therapeutic outcomes. The downstream consequences of the changes observed in this study merits further investigations
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