Thoracic duct fistula and renal transplantation

Thoracic duct drainage (TDD) was established for 21-115 days in 40 kidney recipients with an average removal per patient day of 4.7 1 lymph and 1.88 billion cells. Cellular and humoral immunity were depressed. TDD and immunosuppressive drugs were started at transplantation in 35 recipients of cross-match negative grafts. Although the results were better than in precedent non-TDD controls, eight patients rejected their grafts before a full TDD effect, and three of the eight developed predominantly anti-B lymphocyte cytotoxic antibodies which were probably responsible for positive cross-matches with their next donors. With continuing TDD, all eight patients had good initial function after early retransplantation. In five more 'nontransplantable' patients with performed cytotoxic antibodies, TDD was started 30-56 days before transplantation. In these five pretreated patients, antibodies persisted with positive antidonor cross-matches. Hyperacute rejection occurred repeatedly in two patients with high anti-T (and anti-B) titers, but was surmounted in three patients with lower titers. From the clinical and immunologic data, we have concluded that TDD should be used for pretreatment of all cases with or without prior antibodies, and have suggested an adjustable management plan that takes into account new developments in antibody monitoring

Exploring Potential Modifiers of the Association between Neurodevelopmental Disorders and Risk of Bullying Exposure

This survey study examines data from the National Survey of Children’s Health to determine which sociodemographic factors might modify the association between neurodevelopmental disorders and being bullied

Statistics of Lyapunov exponent in one-dimensional layered systems

Localization of acoustic waves in a one dimensional water duct containing many randomly distributed air filled blocks is studied. Both the Lyapunov exponent and its variance are computed. Their statistical properties are also explored extensively. The results reveal that in this system the single parameter scaling is generally inadequate no matter whether the frequency we consider is located in a pass band or in a band gap. This contradicts the earlier observations in an optical case. We compare the results with two optical cases and give a possible explanation of the origin of the different behaviors.Comment: 6 pages revtex file, 6 eps figure

Funkcional za tvorbu vezanih stanja u QED

The manifestly Lorentz covariant formulation of quantum electrodynamics disregards Coulomb instantaneous interaction and its consequence - instantaneous bound states (IBS\u27s). In this article we consider the way of construction the IBS generating functional using the operator generalization of the initial data in the Dirac Hamiltonian approach to QED.Očito Lorentz-kovariantna formulacija kvantne elektrodinamike zanemaruje trenutno Coulombovo međudjelovanje i njegovu posljedicu – trenutna vezana stanja. U ovom se radu razmatra postavljanje tvorbenog funkcionala za trenutno vezana stanja primjenom operatora poopćenih početnih stanja u Dirac-Hamiltonovom pristupu QED

Funkcional za tvorbu vezanih stanja u QED

The manifestly Lorentz covariant formulation of quantum electrodynamics disregards Coulomb instantaneous interaction and its consequence - instantaneous bound states (IBS\u27s). In this article we consider the way of construction the IBS generating functional using the operator generalization of the initial data in the Dirac Hamiltonian approach to QED.Očito Lorentz-kovariantna formulacija kvantne elektrodinamike zanemaruje trenutno Coulombovo međudjelovanje i njegovu posljedicu – trenutna vezana stanja. U ovom se radu razmatra postavljanje tvorbenog funkcionala za trenutno vezana stanja primjenom operatora poopćenih početnih stanja u Dirac-Hamiltonovom pristupu QED

Exploring polygenic contributors to subgroups of comorbid conditions in autism spectrum disorder

Individuals with autism spectrum disorder (ASD) have heterogeneous comorbid conditions. This study examined whether comorbid conditions in ASD are associated with polygenic risk scores (PRS) of ASD or PRS of comorbid conditions in non-ASD specific populations. Genome-wide single nucleotide polymorphism (SNP) data were obtained from 1386 patients with ASD from the Autism Genetic Resource Exchange (AGRE) study. After excluding individuals with missing clinical information concerning comorbid conditions, a total of 707 patients were included in the study. A total of 18 subgroups of comorbid conditions (‘topics’) were identified using a machine learning algorithm, topic modeling. PRS for ASD were computed using a genome-wide association meta-analysis of 18,381 cases and 27,969 controls. From these 18 topics, Topic 6 (over-represented by allergies) (p = 1.72 × 10−3) and Topic 17 (over-represented by sensory processing issues such as low pain tolerance) (p = 0.037) were associated with PRS of ASD. The associations between these two topics and the multi-locus contributors to their corresponding comorbid conditions based on non-ASD specific populations were further explored. The results suggest that these two topics were not associated with the PRS of allergies and chronic pain disorder, respectively. Note that characteristics of the present AGRE sample and those samples used in the original GWAS for ASD, allergies, and chronic pain disorder, may differ due to significant clinical heterogeneity that exists in the ASD population. Additionally, the AGRE sample may be underpowered and therefore insensitive to weak PRS associations due to a relatively small sample size. Findings imply that susceptibility genes of ASD may contribute more to the occurrence of allergies and sensory processing issues in individuals with ASD, compared with the susceptibility genes for their corresponding phenotypes in non-ASD individuals. Since these comorbid conditions (i.e., allergies and pain sensory issues) may not be attributable to the corresponding comorbidity-specific biological factors in non-ASD individuals, clinical management for these comorbid conditions may still depend on treatments for core symptoms of ASD

Enhancing high-order harmonic generation by sculpting waveforms with chirp

We present a theoretical analysis showing how chirp can be used to sculpt two-color driving laser field waveforms in order to enhance high-order harmonic generation (HHG) and/or extend HHG cutoff energies. Specifically, we consider driving laser field waveforms composed of two ultrashort pulses having different carrier frequencies in each of which a linear chirp is introduced. Two pairs of carrier frequencies of the component pulses are considered: (ω, 2ω) and (ω, 3ω). Our results show how changing the signs of the chirps in each of the two component pulses leads to drastic changes in the HHG spectra. Our theoretical analysis is based on numerical solutions of the time-dependent Schrödinger equation and on a semiclassical analytical approach that affords a clear physical interpretation of how our optimized waveforms lead to enhanced HHG spectra

Enhancing high-order-harmonic generation by time delays between two-color, few-cycle pulses

Use of time delays in high-order-harmonic generation (HHG) driven by intense two-color, few-cycle pulses is investigated in order to determine means of optimizing HHG intensities and plateau cutoff energies. Based upon numerical solutions of the time-dependent Schrõdinger equation for the H atom as well as analytical analyses, we show that introducing a time delay between the two-color, few-cycle pulses can result in an enhancement of the intensity of the HHG spectrum by an order of magnitude (or more) at the cost of a reduction in the HHG plateau cutoff energy. Results for both positive and negative time delays as well as various pulse carrier-envelope phases are investigated and discussed

Enhancing high-order-harmonic generation by time delays between two-color, few-cycle pulses

Use of time delays in high-order-harmonic generation (HHG) driven by intense two-color, few-cycle pulses is investigated in order to determine means of optimizing HHG intensities and plateau cutoff energies. Based upon numerical solutions of the time-dependent Schrõdinger equation for the H atom as well as analytical analyses, we show that introducing a time delay between the two-color, few-cycle pulses can result in an enhancement of the intensity of the HHG spectrum by an order of magnitude (or more) at the cost of a reduction in the HHG plateau cutoff energy. Results for both positive and negative time delays as well as various pulse carrier-envelope phases are investigated and discussed