Impact of asymptomatic urogenital tract infections on ejaculate parameters in infertile men with varicocele

Varicocele, a pathology developing in 15 % males, is associated with 30 % male infertility cases. The role of urogenital infections coinciding with varicocele in infertile men has not been studied in sufficient detail.Objective: to examine the effects of bacterial and viral infections on ejaculate parameters in infertile patients with varicocele. The study included 49 patients with infertility and varicocele and 26 healthy males undergoing prophylactic medical examination. Highlevel infection was recorded after examination of ejaculates and urethral scrapes of 49 patients: bacterial (30.6 %) and viral (14.3 %) pathogens. Quantitative analysis of viral DNA showed high contamination of ejaculates with herpes viruses (> 3 lg10/ml). Detailed analysis of spermatograms demonstrated a decrease in all basic parameters in patients with varicocele and infertility compared with those in healthy subjects. The presence of infectious agents had a statistically significant negative effect on ejaculate parameters. Spermiological examination revealed high level of sperm abnormalities (astenozoospermia, oligoteratozoospermia, and oligoastenoteratozoospermia) in patients with infertility, varicocele and bacterioviral infection of urogenital tract compared with uninfected infertile patients with varicocele. Laboratory tests for bacterial and viral infections should be recommended in infertility associated with varicocele even in the absence of clinical signs of these infections. Quantitative analysis of urogenital pathogens allows one to determine the necessity of etiotherapy of hidden infection and to monitor the effectiveness of treatment

CHARACTERISTICS OF MICROFLORA OF THE LARYNX MUCOUS MEMBRANE IN PATIENTS WITH HETEROSPECIFIC POSTINTUBATION GRANULOMS OF THE LARYNX

Actual problems of modern medicine is prevention and treatment of nonspecific laryngeal granulomas postintubation. One of the factors of this disease is inflammation in the throat after intubation performed caused by microorganisms. The latest in patients with nonspecific granuloma of the larynx has not been studied at all. The purpose of research – a comparative study of quantitative and qualitative common bacterial and fungal contamination laryngeal mucosa in healthy subjects and patients with nonspecific granuloma of the larynx. Materials and methods. Quantitative and qualitative characteristics of microbial associations and species composition of microflora laryngeal mucosa was studied in 40 healthy people and 72 patients with non-specific granuloma of the larynx. The identification of microorganisms were carried out according to classification schemes Bergey, using the test system "API Staph", "API Strep", "API 20 E", "API NH", "API Caryne", "API Candida". Antibiotiksь of each strain was examined under "Information letter №189». Discs were used with benzylpenicillin, amoksiklav, streptomycin, gentamicin, ofloxacin, levofloxacin, erythromycin, cefazolin, tsefuroksyn, ceftriaxone, tsefpirom. Results and discussion. Comparative analysis of the results reveals that, in patients with nonspecific postintubation granuloma of throat found all the same kinds of aerobic microorganisms in healthy people, but they were found more often. The total density of microbial populations on laryngeal mucosa in healthy subjects was (2672 ± 614) CFU / ml. In patients with nonspecific granuloma - (21514 ± 2382) cfu / ml. In both groups dominated coccal microflora. In patients with nonspecific granuloma of throat streptococcus was found in 56 (77.8%), Staphylococcus - in 60 (83.3%) and neyserias - in 65 (90.3%) patients. Analysis of antibiotikogram of the microorganisms isolated in patients with nonspecific granuloma of the larynx showed increasing their resistance to antibiotics, compared with microorganisms selected in healthy individuals. Conclusions. In the treatment of patients with nonspecific granuloma of the throat antibiotic selection can be representatives of cephalosporin (tsefuroksyn, ceftriaxone, сefpirome) and ftorhinolon (levofloxacin) series