11 research outputs found
HTP kinetics studies of the reactions of O(2β 3
Article on HTP kinetics studies of the reaction of O(2(3)Pj) atoms with H2 and D2 over wide temperature ranges
ΠΠ΅ΠΎΠΏΠ΅ΡΠ°Π±Π΅Π»ΡΠ½ΡΠΉ Π³Π΅ΠΏΠ°ΡΠΎΡΠ΅Π»Π»ΡΠ»ΡΡΠ½ΡΠΉ ΡΠ°ΠΊ β ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π»Π΅Π½Π²Π°ΡΠΈΠ½ΠΈΠ±ΠΎΠΌ
There is a number of unresolved issues regarding the systemic therapy administration for hepatocellular carcinoma (HCC). Their solution is facilitated by accumulating realβworld study results. Lenvatinib therapy is a recognized drug with a good efficacy and safety profile for the treatment of HCC. Subanalyses of the REFLECT study showed that the absence of stratification by baseline AFP and baseline liver function, as well as the lack of options for subsequent drug therapy after lenvatinib, also affects the outcomes. Once these factors are taken into account, the hypothesis of superiority of lenvatinib to sorafenib and other drugs can be tested. Realβworld clinical studies have demonstrated positive results of lenvatinib therapy in patients with ChildβPugh class B liver function, provided recommendations on the sequence of systemic therapy after lenvatinib and on the use of lenvatinib in patients with BCLC stage B, along with considering the possibility of lenvatinib monotherapy and the prospects for its use in patients with nHCC. Further realβworld studies of lenvatinib for HCC in the Russian population are required.Π ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π°Ρ
ΠΊ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π³Π΅ΠΏΠ°ΡΠΎΡΠ΅Π»Π»ΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° (ΠΠ¦Π ) Π΅ΡΡΡ ΡΡΠ΄ Π΅ΡΠ΅ Π½Π΅ΡΠ΅ΡΠ΅Π½Π½ΡΡ
Π²ΠΎΠΏΡΠΎΡΠΎΠ². ΠΡ
ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π² ΡΠ΅Π°Π»ΡΠ½ΠΎΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅. ΠΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½ΡΠΎΠ·Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΠ¦Π Ρ Ρ
ΠΎΡΠΎΡΠΈΠΌ ΠΏΡΠΎΡΠΈΠ»Π΅ΠΌ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΈΠ·Π½Π°Π½Π° ΡΠ΅ΡΠ°ΠΏΠΈΡ Π»Π΅Π½Π²Π°ΡΠΈΠ½ΠΈΠ±ΠΎΠΌ. Π ΡΡΠ±Π°Π½Π°Π»ΠΈΠ·Π°Ρ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ REFLECT ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΡΡΡΠ°ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΠΎ ΠΈΡΡ
ΠΎΠ΄Π½ΠΎΠΌΡ ΡΡΠΎΠ²Π½Ρ Π°Π»ΡΡΠ°-ΡΠ΅ΡΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½Π° ΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΈΡΡ
ΠΎΠ΄Π½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ Π΄Π΅ΡΠΈΡΠΈΡ ΠΎΠΏΡΠΈΠΉ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ ΠΏΠΎΡΠ»Π΅ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΡ Π»Π΅Π½Π²Π°ΡΠΈΠ½ΠΈΠ±Π° ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½ΡΠΎΠ·Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ΡΠ΅Ρ ΡΡΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π΄Π°ΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ²Π΅ΡΠΈΡΡ Π³ΠΈΠΏΠΎΡΠ΅Π·Ρ ΠΏΡΠ΅Π²ΠΎΡΡ
ΠΎΠ΄ΡΡΠ²Π° ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π»Π΅Π½Π²Π°ΡΠΈΠ½ΠΈΠ±ΠΎΠΌ Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ ΡΠΎΡΠ°ΡΠ΅Π½ΠΈΠ±ΠΎΠΌ ΠΈ Π΄ΡΡΠ³ΠΈΠΌΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌΠΈ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
ΡΠ΅Π°Π»ΡΠ½ΠΎΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠΈ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Ρ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π»Π΅Π½Π²Π°ΡΠΈΠ½ΠΈΠ±Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΊΠ»Π°ΡΡΠ° B ΠΏΠΎ ΡΠΊΠ°Π»Π΅ Π§Π°ΠΉΠ»Π΄-ΠΡΡ, Π΄Π°Π½Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΠΎΡΠ»Π΅ Π»Π΅Π½Π²Π°ΡΠΈΠ½ΠΈΠ±Π°, ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π»Π΅Π½Π²Π°ΡΠΈΠ½ΠΈΠ±Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΡΠ°Π΄ΠΈΠΈ BCLC B, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΌΠΎΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π»Π΅Π½Π²Π°ΡΠΈΠ½ΠΈΠ±ΠΎΠΌ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ Π΅Π³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½ΠΠ¦Π. ΠΠ΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π»Π΅Π½Π²Π°ΡΠΈΠ½ΠΈΠ±Π° ΠΏΡΠΈ ΠΠ¦Π Π² ΡΠ΅Π°Π»ΡΠ½ΠΎΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ Π½Π° ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ
2-ΡΠΈΠΊΠ»ΠΎΠ°Π»ΠΊΠΈΠ»ΠΈΠΌΠΈΠ½ΠΎ-5-(4-Π½ΠΈΡΡΠΎΡΠ΅Π½ΠΈΠ»)-1,3,4-ΡΠΈΠ°Π΄ΠΈΠ°Π·ΠΈΠ½Ρ, ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΠ΅ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΏΡΠΎΡΠΈΠ² Π²ΠΈΡΡΡΠΎΠ² ΠΎΡΠΏΡ
ΠΠ·ΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΎΡΠ½ΠΎΡΠΈΡΡΡ ΠΊ Π½ΠΎΠ²ΡΠΌ 2-ΡΠΈΠΊΠ»ΠΎΠ°Π»ΠΊΠΈΠ»ΠΈΠΌΠΈΠ½ΠΎ-5-(4-Π½ΠΈΡΡΠΎΡΠ΅Π½ΠΈΠ»)-1,3,4-ΡΠΈΠ°Π΄ΠΈΠ°Π·ΠΈΠ½Π°ΠΌ ΠΎΠ±ΡΠ΅ΠΉ ΡΠΎΡΠΌΡΠ»Ρ I: Π³Π΄Π΅ ΠΏΠΈΠΏΠ΅ΡΠΈΠ΄ΠΈΠ½ΠΎ; ΠΏΠΈΡΡΠΎΠ»ΠΈΠ΄ΠΈΠ½ΠΎ; ΠΌΠ΅ΡΠΈΠ»ΠΏΠΈΠΏΠ΅ΡΠ°Π·ΠΈΠ½ΠΎ; Π³Π΅ΠΊΡΠ°ΠΌΠ΅ΡΠΈΠ»Π΅Π½ΠΈΠΌΠΈΠ½ΠΎ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΎΠ±Π»Π°Π΄Π°ΡΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΏΡΠΎΡΠΈΠ² Π²ΠΈΡΡΡΠΎΠ² ΠΎΡΠΏΡ. Π’Π΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ΅Π·ΡΠ»ΡΡΠ°Ρ - ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ Π½ΠΎΠ²ΡΠ΅ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ, ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½ΡΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ Π²ΠΈΡΡΡΠΎΠ² ΠΎΡΠΏΡ. 1 Π½.ΠΏ. Ρ-Π»Ρ, 1 ΡΠ°Π±Π». ΠΠ·ΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΎΡΠ½ΠΎΡΠΈΡΡΡ ΠΊ ΠΎΠ±Π»Π°ΡΡΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ, ΠΊΠ°ΡΠ°Π΅ΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ Π½ΠΎΠ²ΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
1,3,4-ΡΠΈΠ°Π΄ΠΈΠ°Π·ΠΈΠ½ΠΎΠ², ΠΈ ΠΏΡΠ΅Π΄Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΎ Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΈ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, Π²ΡΠ·ΡΠ²Π°Π΅ΠΌΡΡ
ΠΏΠ°ΡΠΎΠ³Π΅Π½Π½ΡΠΌΠΈ Π΄Π»Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π²ΠΈΡΡΡΠ°ΠΌΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΠΈΡΡΡΠΎΠΌ ΠΎΡΠΏΠ°Π²Π°ΠΊΡΠΈΠ½Ρ (Π»Π΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΡΡΠ²Π°ΠΊΡΠΈΠ½Π°Π»ΡΠ½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ)
FUNCTIONAL AND MORPHOMETRIC EVALUATION OF PROSTATE MICROCIRCULATION FOLLOWING HIGH-INTENSITY FOCUSED ULTRASOUND THERAPY WITH ANDROGEN DEPRIVATION FOR PROSTATIC ADENOCARCINOMA
Objective. To evaluate morphometric and hemodynamic changes in the prostate microcirculation under high-intensity focused ultrasound therapy (HIFU) combining with androgen deprivation in prostate cancer patients with a focus on the treatment effect assessment. Material and methods. 119 patients with localized adenocarcinoma of the prostate (Π’2Π°-ΡN0M0) were examined prior to HIFU ablation and 3 to 36 months following the treatment. Microvascular density in the prostate tissue and hemodynamic parameters recorded by laser Doppler flowmetry at the prostate projection area (PPA) of the skin were analyzed comparatively. Results and discussion. Successful HIFU ablation (recurrence free survival at 3-year follow-up period) was associated with higher pretreatment microvascular density in the prostate tumor tissue and with a marked reduction of this parameter in the areas of residual non-neoplastic parenchyma after the ablation, which was accompanied by a significant decrease in PPA microhemodynamics. A course of androgen deprivation administered 1-3 months prior to ablation contributed to a moderate pre-HIFU reduction of tumor vascularization and PPA microcirculation index. As compared to HIFU monotherapy, cooperative use of HIFU and androgen blockade was associated with a relative decrease in the number of microvessels in the areas of residual neoplastic and non-neoplastic parenchyma in cases with local recurrence. A substantial increase of PPA microcirculation indices 6 or more months after HIFU ablation was found to be strongly associated with prostate cancer local recurrence which suggests that laser Doppler flowmetry could be used in the complex monitoring of the outcome from HIFU therapy for prostatic adenocarcinoma