64 research outputs found

    Solution of Euler-Type Non-Homogeneous Differential Equations with Three Fractional Derivatives

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    The linear non-homogeneous ordinary differential equations with three left-hand sided Lioville derivatives of fractional order are considered. Using the direct and inverse Mellin transforms and the residue theory, explicit solutions of such equations are established in terms of the generalized hypergeometric Wright functions, of the generalized hypergeometric functions and of the Euler psi function. The corresponding results are deduced for ordinary differential equations of Euler type. Examples are given. Mathematics Subject Classification: 34A05, 26A33, 44A99, 33C20, 33C99. Key Words and Phrases: linear differential equations with Liouville fractional derivatives, ordinary differential equations, explicit solutions, Mellin transforms, generalized Wright function, generalized hypergeometric function, Euler psi function

    Antiplatelet activity of new derivatives of benzimidazole containing sterically hindered phenolic group in their structure

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    The chemical class of benzimidazole derivatives with a hindered phenolic substituent in their structure is promising for the search for new antiaggregant and antioxidant drug

    ΠšΠΎΠΌΠΏΠ΅Ρ‚Π΅Π½Ρ‚Π½ΠΎΡΡ‚Π½Ρ‹ΠΉ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ ΠΊ ΠΏΡ€ΠΎΡ„Π΅ΡΡΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ ΠΏΠΎΠ΄Π³ΠΎΡ‚ΠΎΠ²ΠΊΠ΅ Π² условиях экспансии Ρ†ΠΈΡ„Ρ€ΠΎΠ²ΠΎΠΉ Π³Π»ΠΎΠ±Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ

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    Introduction. Based on the analysis of changes in the educational environment described in the pedagogical, sociological, and philosophical literature, the authors of the article seek to identify the determinants and possibilities of a competency-based approach to vocational training. Purpose setting. The tasks of modernizing vocational education in the context of digital globalization come into view. The breadth of the research fi in which digital globalization is determined, its tendencies, essential features have led the authors to the need for methodological research. The inconsistency, thematic scattering of studies that have the object of digitalization in all its manifestations predetermined the interest in professionalism, where the synthesizing origins of modern universalism are found. Under the influence of informatization and digitalization, a special sphere is emerging, which becomes the foundation of professional activity. Methodology of the study. The article proves that the competency-based approach, which has repeatedly demonstrated its heuristic significance, is clearly not used enough when implementing the tasks of digitalization, minimizing its negative consequences, and enhancing the potential of information culture. It is shown that basic competencies, professional competencies and basic qualifications have a complex, including hierarchical structure. The comprehension of the competency-based approach is proposed in connection with the post-non-classical model of vocational education and the paradigms of pedagogical influence and personal social activity.Results. Increasing the openness and flexibility of the educational process makes new demands on its organizers. The transition from empirical research to theoretical rethinking of specific tasks should be based on methodologically verified guidelines. Scientific research is based on philosophical, general scientific ideas and reflexive-methodological analysis. Reflexive practice at the same time affects all levels of professional training and its origins at the general educational level.Conclusion. The competency-based approach opens up new opportunities for practice-oriented education, and the open nature of the paradigms applied in this case will allow us to see the prospects for digitalization., социологичСской, философской Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Π΅, Π°Π²Ρ‚ΠΎΡ€Ρ‹ ΡΡ‚Π°Ρ‚ΡŒΠΈ стрСмятся Π²Ρ‹ΡΠ²ΠΈΡ‚ΡŒ Π΄Π΅Ρ‚Π΅Ρ€ΠΌΠΈΠ½Π°Π½Ρ‚Ρ‹ ΠΈ возмоТности компСтСнтностного ΠΏΠΎΠ΄Ρ…ΠΎΠ΄Π° ΠΊ ΠΏΡ€ΠΎΡ„Π΅ΡΡΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ ΠΏΠΎΠ΄Π³ΠΎΡ‚ΠΎΠ²ΠΊΠ΅. ΠŸΠΎΡΡ‚Π°Π½ΠΎΠ²ΠΊΠ° Π·Π°Π΄Π°Ρ‡ΠΈ. Π’ ΠΏΠΎΠ»Π΅ зрСния оказались Π·Π°Π΄Π°Ρ‡ΠΈ ΠΌΠΎΠ΄Π΅Ρ€Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΏΡ€ΠΎΡ„Π΅ΡΡΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ образования Π² условиях Ρ†ΠΈΡ„Ρ€ΠΎΠ²ΠΎΠΉ Π³Π»ΠΎΠ±Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ. Π¨ΠΈΡ€ΠΎΡ‚Π° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΡΠΊΠΎΠ³ΠΎ поля, Π² ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠΌ опрСдСляСтся цифровая глобализация, Π΅Π΅ Ρ‚Π΅Π½Π΄Π΅Π½Ρ†ΠΈΠΈ, сущностныС Ρ‡Π΅Ρ€Ρ‚Ρ‹ ΠΏΠΎΠ΄Π²Π΅Π»ΠΈ Π°Π²Ρ‚ΠΎΡ€ΠΎΠ² ΠΊ нСобходимости мСтодологичСских изысканий. ΠΠ΅ΡΠΎΠΎΡ‚Π½Π΅ΡΠ΅Π½Π½ΠΎΡΡ‚ΡŒ, тСматичСская Ρ€Π°Π·Π±Ρ€ΠΎΡΠ°Π½Π½ΠΎΡΡ‚ΡŒ исслСдований, ΠΈΠΌΠ΅ΡŽΡ‰ΠΈΡ… ΠΎΠ±ΡŠΠ΅ΠΊΡ‚ΠΎΠΌ Ρ†ΠΈΡ„Ρ€ΠΎΠ²ΠΈΠ·Π°Ρ†ΠΈΡŽ Π²ΠΎ всСх Π΅Π΅ проявлСниях ΠΏΡ€Π΅Π΄ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΠΈΠ»ΠΈ интСрСс ΠΊ профСссионализму, Π³Π΄Π΅ ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠΈΠ²Π°ΡŽΡ‚ΡΡ ΡΠΈΠ½Ρ‚Π΅Π·ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠ΅ истоки соврСмСнного унивСрсализма. Под влияниСм ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΈ Ρ†ΠΈΡ„Ρ€ΠΎΠ²ΠΈΠ·Π°Ρ†ΠΈΠΈ складываСтся особая сфСра, которая становится Ρ„ΡƒΠ½Π΄Π°ΠΌΠ΅Π½Ρ‚ΠΎΠΌ ΠΏΡ€ΠΎΡ„Π΅ΡΡΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ. ΠœΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠ° ΠΈ мСтодология исслСдования. Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ доказываСтся, Ρ‡Ρ‚ΠΎ компСтСнтностный ΠΏΠΎΠ΄Ρ…ΠΎΠ΄, Π½Π΅ Ρ€Π°Π· Π΄Π΅ΠΌΠΎΠ½ΡΡ‚Ρ€ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠΉ свою ΡΠ²Ρ€ΠΈΡΡ‚ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ Π·Π½Π°Ρ‡ΠΈΠΌΠΎΡΡ‚ΡŒ, явно нСдостаточно ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΠ΅Ρ‚ΡΡ ΠΏΡ€ΠΈ Ρ€Π΅Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ Π·Π°Π΄Π°Ρ‡ Ρ†ΠΈΡ„Ρ€ΠΎΠ²ΠΈΠ·Π°Ρ†ΠΈΠΈ, ΠΌΠΈΠ½ΠΈΠΌΠΈΠ·Π°Ρ†ΠΈΠΈ Π΅Π΅ Π½Π΅Π³Π°Ρ‚ΠΈΠ²Π½Ρ‹Ρ… послСдствий, Π°ΠΊΡ‚ΠΈΠ²ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»Π° ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Ρ‹. Показано, Ρ‡Ρ‚ΠΎ Π±Π°Π·ΠΎΠ²Ρ‹Π΅ компСтСнтности, ΠΏΡ€ΠΎΡ„Π΅ΡΡΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Π΅ ΠΊΠΎΠΌΠΏΠ΅Ρ‚Π΅Π½Ρ†ΠΈΠΈ ΠΈ Π±Π°Π·ΠΎΠ²Ρ‹Π΅ ΠΊΠ²Π°Π»ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ ΠΈΠΌΠ΅ΡŽΡ‚ ΡΠ»ΠΎΠΆΠ½ΡƒΡŽ, Π² Ρ‚ΠΎΠΌ числС ΠΈΠ΅Ρ€Π°Ρ€Ρ…ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ структуру. ΠžΡΠΌΡ‹ΡΠ»Π΅Π½ΠΈΠ΅ компСтСнтностного ΠΏΠΎΠ΄Ρ…ΠΎΠ΄Π° прСдлагаСтся Π² связи с постнСклассичСской модСлью ΠΏΡ€ΠΎΡ„Π΅ΡΡΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ образования ΠΈ ΠΏΠ°Ρ€Π°Π΄ΠΈΠ³ΠΌΠ°ΠΌΠΈ пСдагогичСского воздСйствия ΠΈ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠΉ активности личности. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ΠŸΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ открытости, гибкости ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ процСсса ΠΏΡ€Π΅Π΄ΡŠΡΠ²Π»ΡΠ΅Ρ‚ ΠΊ Π΅Π³ΠΎ ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ‚ΠΎΡ€Π°ΠΌ Π½ΠΎΠ²Ρ‹Π΅ трСбования. ΠŸΠ΅Ρ€Π΅Ρ…ΠΎΠ΄ ΠΎΡ‚ эмпиричСских исслСдований ΠΊ тСорСтичСскому ΠΏΠ΅Ρ€Π΅ΠΎΡΠΌΡ‹ΡΠ»Π΅Π½ΠΈΡŽ ΠΊΠΎΠ½ΠΊΡ€Π΅Ρ‚Π½Ρ‹Ρ… Π·Π°Π΄Π°Ρ‡ Π΄ΠΎΠ»ΠΆΠ΅Π½ Π±Π°Π·ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒΡΡ Π½Π° мСтодологичСски Π²Ρ‹Π²Π΅Ρ€Π΅Π½Π½Ρ‹Ρ… ΠΎΡ€ΠΈΠ΅Π½Ρ‚ΠΈΡ€Π°Ρ…. Научный поиск опираСтся Π½Π° философскиС, ΠΎΠ±Ρ‰Π΅Π½Π°ΡƒΡ‡Π½Ρ‹Π΅ ΠΈΠ΄Π΅ΠΈ ΠΈ рСфлСксивно-мСтодологичСский Π°Π½Π°Π»ΠΈΠ·. РСфлСксивная ΠΏΡ€Π°ΠΊΡ‚ΠΈΠΊΠ° ΠΏΡ€ΠΈ этом Π·Π°Ρ‚Ρ€Π°Π³ΠΈΠ²Π°Π΅Ρ‚ всС ΡƒΡ€ΠΎΠ²Π½ΠΈ ΠΏΡ€ΠΎΡ„Π΅ΡΡΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ ΠΏΠΎΠ΄Π³ΠΎΡ‚ΠΎΠ²ΠΊΠΈ ΠΈ Π΅Π΅ истоки Π½Π° ΠΎΠ±Ρ‰Π΅ΠΎΠ±Ρ€Π°Π·ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΌ ΡƒΡ€ΠΎΠ²Π½Π΅. Π’Ρ‹Π²ΠΎΠ΄Ρ‹. ΠšΠΎΠΌΠΏΠ΅Ρ‚Π΅Π½Ρ‚Π½ΠΎΡΡ‚Π½Ρ‹ΠΉ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ ΠΎΡ‚ΠΊΡ€Ρ‹Π²Π°Π΅Ρ‚ Π½ΠΎΠ²Ρ‹Π΅ возмоТности для ΠΏΡ€Π°ΠΊΡ‚ΠΈΠΊΠΎ-ΠΎΡ€ΠΈΠ΅Π½Ρ‚ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ образования, Π° ΠΎΡ‚ΠΊΡ€Ρ‹Ρ‚Ρ‹ΠΉ Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ примСняСмых ΠΏΡ€ΠΈ этом ΠΏΠ°Ρ€Π°Π΄ΠΈΠ³ΠΌ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ‚ ΡƒΠ²ΠΈΠ΄Π΅Ρ‚ΡŒ пСрспСктивы Ρ†ΠΈΡ„Ρ€ΠΎΠ²ΠΈΠ·Π°Ρ†ΠΈΠΈ

    Technology Platforms as an Efficient Tool to Modernize Russia's Economy

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    There is an urgent need to consider the dynamicΒ developmentΒ of theΒ globalΒ economy from the point of view of its positive impact on competitiveness improvement in national manufacturing industries, andΒ the bestΒ waysΒ toΒ modernize the country economy. The purposeΒ of the paper is to provide with perspectives for development of instruments related to technologyΒ platformsΒ within the framework of innovation management and adaptedΒ to the conditionsΒ of Russia's economicΒ reality.Β The major method in studying thisΒ issueΒ is mathematical economic modelingΒ which has made it possibleΒ to facilitate expediencyΒ in determining aΒ technology platformΒ asΒ anΒ effective innovation controlΒ instrument.Β  The paper considers European and Russian experience in deploying technology platforms, and identifies national features characteristic to the performance of the innovation management instrument.Β  A mathematical economic model is used for justifying the efficiency of introducing technology platforms into Russian institutional innovation system. TheΒ practicalΒ significanceΒ ofΒ resultsΒ and conclusions is in its ability to improveΒ theΒ mechanismsΒ ofΒ developingΒ and implementing federalΒ andΒ regional innovation development programs, developmentΒ of the innovationΒ infrastructure, stimulationΒ ofΒ the innovationΒ activity,Β useΒ of aΒ set of technologyΒ platformΒ instrumentsΒ by public authorities.Β  Keywords: technology platforms, innovative development, modernization, triple helix. JEL Classifications: C02, C18, O2

    Π€ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎ Π·Π°ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Π΅ слоТныС эфиры ΠΈ диэфиры - ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄Π½Ρ‹Π΅ сСлСктивно восстановлСнных бСзальдСгидов Π²Π°Π½ΠΈΠ»ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ряда

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    By selective reduction of vanillin-related benzaldehydes, using NaBH4 and Na [BH(OAc)3], the corresponding alcohols and diols have been synthesized. Their esterification by acyl chlorides in the presence of Et3N afforded functionally substituted esters and diesters containing fragments of heterocyclic compounds.Π‘Π΅Π»Π΅ΠΊΡ‚ΠΈΠ²Π½Ρ‹ΠΌ восстановлСниСм Π·Π°ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Ρ… бСнзальдСгидов Π²Π°Π½ΠΈΠ»ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ряда с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ NaBH4 ΠΈΠ»ΠΈ Na[BH(OAc)3] синтСзированы спирты ΠΈ Π΄ΠΈΠΎΠ»Ρ‹, ΠΈΡ… этСрификациСй Ρ…Π»ΠΎΡ€Π°Π½Π³ΠΈΠ΄Ρ€ΠΈΠ΄Π°ΠΌΠΈ ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΎΠ²Ρ‹Ρ… кислот Π² присутствии Et3N ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Ρ‹ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎ Π·Π°ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Π΅ слоТныС эфиры ΠΈ диэфиры, содСрТащиС Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚Ρ‹ гСтСроцикличСских соСдинСний

    Π—Π°ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Π΅ N-[изоксазол(ΠΈΠ·ΠΎΡ‚ΠΈΠ°Π·ΠΎΠ»)-3-ΠΈΠ»(ΠΌΠ΅Ρ‚ΠΈΠ»Π΅Π½)ΠΌΠ΅Ρ‚ΠΈΠ»]Π°Ρ€ΠΈΠ»Π°ΠΌΠΈΠ½Ρ‹: синтСз, комплСксы с ΠΏΠ°Π»Π»Π°Π΄ΠΈΠ΅ΠΌ ΠΈ ΠΈΡ… каталитичСская Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ Π² Π²ΠΎΠ΄Π½Ρ‹Ρ… срСдах

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    Schiff bases have been synthesized from substituted isoxazol- and isothiazol-3-carbaldehydes by condensation with biphenyl- and naphthyl amines. Reduction of azomethines obtained affords the corresponding amines. It has been shown that synthesized N-ligands form the palladium complexes possessing high catalytic activity in Suzuki reaction in aqueous and aqueous-alcohol media.ΠžΡΡƒΡ‰Π΅ΡΡ‚Π²Π»Π΅Π½ молСкулярный Π΄ΠΈΠ·Π°ΠΉΠ½ ΠΈ Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½ синтСз Π°Π·ΠΎΠΌΠ΅Ρ‚ΠΈΠ½ΠΎΠ² Π½Π° основС Π·Π°ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Ρ… изоксазол- ΠΈ ΠΈΠ·ΠΎΡ‚ΠΈΠ°Π·ΠΎΠ»-3-ΠΊΠ°Ρ€Π±Π°Π»ΡŒΠ΄Π΅Π³ΠΈΠ΄ΠΎΠ² ΠΏΠΎ Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ с Π±ΠΈΡ„Π΅Π½ΠΈΠ»- ΠΈ Π½Π°Ρ„Ρ‚ΠΈΠ»Π°ΠΌΠΈΠ½Π°ΠΌΠΈ. УстановлСно, Ρ‡Ρ‚ΠΎ Π°Π·ΠΎΠΌΠ΅Ρ‚ΠΈΠ½Ρ‹ ΠΎΠ±Ρ€Π°Π·ΡƒΡŽΡ‚ΡΡ Π² Π²ΠΈΠ΄Π΅ Π•-ΠΈΠ·ΠΎΠΌΠ΅Ρ€Π°. ВосстановлСниС ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… Π°Π·ΠΎΠΌΠ΅Ρ‚ΠΈΠ½ΠΎΠ² ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠΌ Π°ΠΌΠΈΠ½Π°ΠΌ. Показано, Ρ‡Ρ‚ΠΎ синтСзированныС N-Π»ΠΈΠ³Π°Π½Π΄Ρ‹ ΠΎΠ±Ρ€Π°Π·ΡƒΡŽΡ‚ с Ρ…Π»ΠΎΡ€ΠΈΠ΄ΠΎΠΌ палладия комплСксы, ΠΎΠ±Π»Π°Π΄Π°ΡŽΡ‰ΠΈΠ΅ высокой каталитичСской Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΡŽ Π² Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ Π‘ΡƒΠ·ΡƒΠΊΠΈ Π² Π²ΠΎΠ΄Π½ΠΎΠΉ ΠΈ Π²ΠΎΠ΄Π½ΠΎ-спиртовой срСдах. Π Π΅Π°ΠΊΡ†ΠΈΠΈ ΠΏΡ€ΠΎΡ‚Π΅ΠΊΠ°ΡŽΡ‚ с практичСски количСствСнными Π²Ρ‹Ρ…ΠΎΠ΄Π°ΠΌΠΈ, Ρ‡Ρ‚ΠΎ позволяСт максимально ΡƒΠΏΡ€ΠΎΡΡ‚ΠΈΡ‚ΡŒ ΠΏΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Ρƒ выдСлСния Ρ†Π΅Π»Π΅Π²Ρ‹Ρ… соСдинСний. Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΊΠ°Ρ€Π±ΠΎΠΊΡΠΈΠ»ΡŒΠ½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΡ‹ Π² ароматичСский Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚ для ΠΈΠ·ΠΎΠΊΡΠ°Π·ΠΎΠ»ΡŒΠ½Ρ‹Ρ… комплСксов ΠΏΠΎΡ‡Ρ‚ΠΈ Π½Π΅ влияСт Π½Π° ΠΊΠ°Ρ‚Π°Π»ΠΈΡ‚ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ. Π’ случаС ΠΈΠ·ΠΎΡ‚ΠΈΠ°Π·ΠΎΠ»ΡŒΠ½Ρ‹Ρ… комплСксов, каталитичСская Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ возрастаСт, ΠΏΡ€ΠΈΡ‡Π΅ΠΌ эффСкт особСнно Ρ…ΠΎΡ€ΠΎΡˆΠΎ Π·Π°ΠΌΠ΅Ρ‚Π΅Π½ ΠΏΡ€ΠΈ 20ΠΎΠ‘

    Π‘ΠΈΠ½Ρ‚Π΅Π· ΠΌΠ΅Ρ‚ΠΈΠ»ΠΎΠ²Ρ‹Ρ… эфиров ( E, S)-2-Π°Ρ€ΠΈΠ»ΠΈΠ΄Π΅Π½Π°ΠΌΠΈΠ½ΠΎ-4-ΠΌΠ΅Ρ‚ΠΈΠ»Π²Π°Π»Π΅Ρ€ΠΈΠ°Π½ΠΎΠ²Ρ‹Ρ… кислот

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    By the reaction of L-leucine methyl ester hydrochloride with vanniline and vanillale ethers or esters, corresponding methyl esters of (Π•,S)-2-arylidenamino-4-methylpentanoic acids have been synthesised.ΠšΠΎΠ½Π΄Π΅Π½ΡΠ°Ρ†ΠΈΠ΅ΠΉ Π·Π°ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Ρ… бСнзальдСгидов Π²Π°Π½ΠΈΠ»ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ряда с Π³ΠΈΠ΄Ρ€ΠΎΡ…Π»ΠΎΡ€ΠΈΠ΄ΠΎΠΌ ΠΌΠ΅Ρ‚ΠΈΠ»ΠΎΠ²ΠΎΠ³ΠΎ эфира L-Π»Π΅ΠΉΡ†ΠΈΠ½Π° Π² присутствии Π³ΠΈΠ΄Ρ€ΠΎΠΊΠ°Ρ€Π±ΠΎΠ½Π°Ρ‚Π° натрия (ΠΏΡ€ΠΈ ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΈ Ρ€Π΅Π°Π³Π΅Π½Ρ‚ΠΎΠ², Ρ€Π°Π²Π½ΠΎΠΌ 1:1:1) Π±Ρ‹Π»ΠΈ синтСзированы Ρ…ΠΈΡ€Π°Π»ΡŒΠ½Ρ‹Π΅ (Π•,S)-алкилароматичСскиС Π°Π·ΠΎΠΌΠ΅Ρ‚ΠΈΠ½Ρ‹ (основания Π¨ΠΈΡ„Ρ„Π°), содСрТащиС простыС ΠΈ слоТноэфирныС Π³Ρ€ΡƒΠΏΠΏΡ‹

    Russian consensus statement on the diagnosis and treatment of patients with carotid stenosis

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    Carotid stenosis is a multidisciplinary problem that requires the involvement of a specialists’ team, including cardiovascular surgeons, neurosurgeons, endovascular surgeons, cardiologists, neurologists, and internists. In this consensus statement, a group of experts considered the main stages of diagnosing carotid stenosis, as well as discussed, the necessary prevention methods and features of choosing the optimal treatment approach. The aim was to provide concise and structured information on the management of patients with carotid stenosis. This document was developed based on the updated clinical guidelines of the European Society for Vascular Surgery and the American Association for Vascular Surgery, taking into account the consensus opinion of Russian experts

    The effects of culture, attitudes and perceptions on industrial cluster policy – the case of Russia

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    Culture, attitudes and perceptions have an underappreciated effect on industrial cluster policies particularly in transition economies, where long-established local social norms are confronted with hard-pressed external imperatives. This paper examines the impact of cultural and governmental peculiarities in the Russian context on the development of Special Economic Zones and Industrial Parks. Based on some stylised facts about the Russian context, in-depth interviews and surveys of the managing companies and tenants of all industrial clusters in Russia, we find cultural and governmental characteristics emerge as major influences on the effective development of industrial cluster policies. We develop an adapted industrial cluster model that accommodates these factors and suggests a policy pathway for mitigation

    Distribution of the Octopamine Receptor AmOA1 in the Honey Bee Brain

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    Octopamine plays an important role in many behaviors in invertebrates. It acts via binding to G protein coupled receptors located on the plasma membrane of responsive cells. Several distinct subtypes of octopamine receptors have been found in invertebrates, yet little is known about the expression pattern of these different receptor subtypes and how each subtype may contribute to different behaviors. One honey bee (Apis mellifera) octopamine receptor, AmOA1, was recently cloned and characterized. Here we continue to characterize the AmOA1 receptor by investigating its distribution in the honey bee brain. We used two independent antibodies produced against two distinct peptides in the carboxyl-terminus to study the distribution of the AmOA1 receptor in the honey bee brain. We found that both anti-AmOA1 antibodies revealed labeling of cell body clusters throughout the brain and within the following brain neuropils: the antennal lobes; the calyces, pedunculus, vertical (alpha, gamma) and medial (beta) lobes of the mushroom body; the optic lobes; the subesophageal ganglion; and the central complex. Double immunofluorescence staining using anti-GABA and anti-AmOA1 receptor antibodies revealed that a population of inhibitory GABAergic local interneurons in the antennal lobes express the AmOA1 receptor in the cell bodies, axons and their endings in the glomeruli. In the mushroom bodies, AmOA1 receptors are expressed in a subpopulation of inhibitory GABAergic feedback neurons that ends in the visual (outer half of basal ring and collar regions) and olfactory (lip and inner basal ring region) calyx neuropils, as well as in the collar and lip zones of the vertical and medial lobes. The data suggest that one effect of octopamine via AmOA1 in the antennal lobe and mushroom body is to modulate inhibitory neurons
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