Mediators of mechanotransduction between bone cells

Mechanical forces are known to regulate the function of tissues in the body, including bone. Bone adapts to its mechanical environment by altering its shape and increasing its size in response to increases in mechanical load associated with exercise, and by decreasing its size in response to decreases in mechanical load associated with microgravity or prolonged bed rest. Changes in bone size and shape are produced by a cooperative action of two main types of the bone cells - osteoclasts that destroy bone and osteoblasts that build bone. These cell types come from different developmental origins, and vary greatly in their characteristics, such as size, shape, and expression of receptor subtypes, which potentially may affect their responses to mechanical stimuli. The objective of this study is to compare the responses of osteoclasts and osteoblasts to mechanical stimulation. This study has allowed us to conclude the following: 1. A mediator is released from a single source cell. 2. The response to the mediator changes with distance. 3. The value of the apparent diffusion coeficient increases with distance. 4. A plausible proposed mechanism is that ATP is released and degrades to ADP. 5. Future experiments are required to confim that ATP is the mediator as suggested

The earliest spectroscopy of the GRB 030329 afterglow with 6-m telescope

The earliest BTA (SAO RAS 6-m telescope) spectroscopic observations of the GRB 030329 optical transient (OT) are presented, which almost coincide in time with the "first break" ($t\sim 0.5$ day after the GRB) of the OT light curve. The beginning of spectral changes are seen as early as $\sim 10-12$ hours after the GRB. So, the onset of the spectral changes for $t<1$ day indicates that the contribution from Type Ic supernova (SN) into the OT optical flux can be detected earlier. The properties of early spectra of GRB 030329/SN 2003dh can be consistent with a shock moving into a stellar wind formed from the pre-SN. Such a behavior (similar to that near the UV shock breakout in SNe) can be explained by the existence of a dense matter in the immediate surroundings of massive stellar GRB/SN progenitor). The urgency is emphasized of observation of early GRB/SN spectra for solving a question that is essential for understanding GRB physical mechanism: {\it Do all} long-duration gamma-ray bursts are caused by (or physically connected to) {\it ordinary} core-collapse supernovae? If clear association of normal/ordinary core-collapse SNe (SN Ib/c, and others SN types) and GRBs would be revealed in numbers of cases, we may have strong observational limits for gamma-ray beaming and for real energetics of the GRB sources.Comment: 4 pages, 5 figures. Proceedings of the 4th Workshop "Gamma-Ray Bursts in the Afterglow Era", Roma, 2004 October 18-22, eds. L. Piro, L. Amati, S. Covino, and B. Gendre. Il Nuovo Cimento, in pres

Kraichnan model of passive scalar advection

A simple model of a passive scalar quantity advected by a Gaussian non-solenoidal ("compressible") velocity field is considered. Large order asymptotes of quantum-field expansions are investigated by instanton approach. The existence of finite convergence radius of the series is proved, a position and a type of the corresponding singularity of the series in the regularization parameter are determined. Anomalous exponents of the main contributions to the structural functions are resummed using new information about the series convergence and two known orders of the expansion.Comment: 21 page

The Multiband Photometry of GRB Host Galaxies: Comparison with the Spectral Energy Distributions of Nearby and Theoretical Modeling Galaxies

We present one of the results of $BVRI$ photometry of the hosts of GRB for the host galaxy of GRB 970508 and the theoretical modeling of its continuum spectral energy distribution (SED) to show that it is important to take into account internal extinction in the host galaxies. We compared the BVRI broad-band flux spectrum of the host to template SEDs of local starburst galaxies and found that there is a significant internal extintion in this host. Moreover, this comparison allows us to derive the absolute magnitude (M_{B_{rest}}) and rouhgly estimate reddening (A_V). Population synthesis modeling of the continuum SED for different reddening laws demostrates that the observational data of the host galaxy of GRB 970508 are best fitted by the spectral properties of a model SED with extinction of A_V\approx 2.Comment: 3 pages, 2 figures, poster presentation on 2nd Rome Workshop on Gamma-Ray Bursts in the Afterglow Er

Problems and prospects of development of ecological tourism in Ireland

The paper presents the research on the development of ecological tourism in Ireland. The basic directions and problems of development of ecotourism. Income from ecotourism in the country was analyzed in the article, as well as the model for the attraction of tourists to Irelan