Ultrasonic Vibroacoustic Processes, Excited By Heating By Impulse Currents of Metals

When passing impulse currents through a conductor, powerful vibro-acoustic oscillations are generated in it. The parameters of these oscillations are easy to control. Changing the duty cycle of pulses allows for such equipment as welding with the allocation of a large amount of heat, and regimes of controlled cooling and ultrasonic quality control of the welded joint. Keywords: welding, vibration, pulse current, diagnostics, ultrasoun

Analysis of the Relationships for the Vibrational Response to the Excitation of Vibro-acoustic Processes in Conductors from the Action of a Pulsed Current

Evaluation of the mechanisms of formation of mechanical deformations is of great importance for the practical application of the electroplastic effect. Estimations of the efficiency of conversion of the energy of the electric pulse in the energy of the magnetic field and mechanical oscillations are obtained. Keywords: pulse current, metal, vibroacoustic, magnetic field, vibration sensors

Electroplastic Processing of Titanium Implants

The results of experimental studies of samples of titanium for implants when exposed to pulsed electric currents. Excitation of longitudinal and transverse vibrations to the sample under these influences can be used in their electroplastic processing and introduction into the bone tissue. When exposed to pulses of surface layers of titanium sample are experiencing significant dynamic load. The possibility of increasing amplitudes with decreasing duration of pulses of electric current was shown. This allows to exclude the heating of implants during such impacts. The peculiarities of ponderomotive effects in titanium samples related to its uniqueelectrical and mechanical properties, precluding the practical manifestation of the classic skin-effect and its impact on the generation of oscillatory processes in the moments of passage of the leading and trailing edges of current pulse. Keywords: titanium, implant, vibration, acceleration, magnetic field, skin effect

Тhe effect of Cr substitution for Fe on ferroelectric and magnetic properties of PbFe0.5Nb0.5O3, PbFe0.5Sb0.5O3 and BiFeO3 multiferroics

Проведены диэлектрические и мессбауэровские исследования сегнетоэлектрических и магнитных фазовых переходов в твердых растворах PbFe0.5-xCrxNb0.5O3, BiFe1-xCrxO3, PbFe0.5-xCrxSb0.5O3. Во всех этих системах замещение железа хромом разрушает как сегнетоэлектрический, так и магнитный дальний порядок.PbFe0.5-xCrxNb0.5O3, BiFe1-xCrxO3, PbFe0.5-xCrxSb0.5O3 solid solutions have been carried out. In all the systems studied Cr substitution for Fe destroys both ferroelectric and magnetic long-range order.Работа выполнена при поддержке Российского Фонда Фундаментальных Исследований (грант 16-52-0072 Бел_a) и Белорусского Республиканского Фонда Фундаментальных Исследований (грант T16R-079)

Molecular imaging of rheumatoid arthritis by radiolabelled monoclonal antibodies: new imaging strategies to guide molecular therapies

The closing of the last century opened a wide variety of approaches for inflammation imaging and treatment of patients with rheumatoid arthritis (RA). The introduction of biological therapies for the management of RA started a revolution in the therapeutic armamentarium with the development of several novel monoclonal antibodies (mAbs), which can be murine, chimeric, humanised and fully human antibodies. Monoclonal antibodies specifically bind to their target, which could be adhesion molecules, activation markers, antigens or receptors, to interfere with specific inflammation pathways at the molecular level, leading to immune-modulation of the underlying pathogenic process. These new generation of mAbs can also be radiolabelled by using direct or indirect method, with a variety of nuclides, depending upon the specific diagnostic application. For studying rheumatoid arthritis patients, several monoclonal antibodies and their fragments, including anti-TNF-α, anti-CD20, anti-CD3, anti-CD4 and anti-E-selectin antibody, have been radiolabelled mainly with 99mTc or 111In. Scintigraphy with these radiolabelled antibodies may offer an exciting possibility for the study of RA patients and holds two types of information: (1) it allows better staging of the disease and diagnosis of the state of activity by early detection of inflamed joints that might be difficult to assess; (2) it might provide a possibility to perform ‘evidence-based biological therapy’ of arthritis with a view to assessing whether an antibody will localise in an inflamed joint before using the same unlabelled antibody therapeutically. This might prove particularly important for the selection of patients to be treated since biological therapies can be associated with severe side-effects and are considerably expensive. This article reviews the use of radiolabelled mAbs in the study of RA with particular emphasis on the use of different radiolabelled monoclonal antibodies for therapy decision-making and follow-up