The effect of dry extract of Geranium Palustre herb on coagulation system = Вплив сухого екстракту трави герані болотної на систему зсідання крові

Ostapets M. O., Shevtsov I. I., Karabut L. V., Bereznyakova M. E. The effect of dry extract of Geranium Palustre herb on coagulation system = Вплив сухого екстракту трави герані болотної на систему зсідання крові. Journal of Education, Health and Sport. 2015;5(8):119-125. ISSN 2391-8306. DOI 10.5281/zenodo.27484http://dx.doi.org/10.5281/zenodo.27484http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%288%29%3A119-125https://pbn.nauka.gov.pl/works/605723Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 05.06.2015. Revised 15.07.2015. Accepted: 25.07.2015. UDC 615.322:582.751:615.273 THE EFFECT OF DRY EXTRACT OF GERANIUM PALUSTRE HERB ON COAGULATION SYSTEMВПЛИВ СУХОГО ЕКСТРАКТУ ТРАВИ ГЕРАНІ БОЛОТНОЇ НА СИСТЕМУ ЗСІДАННЯ КРОВІ M. O. Ostapets, I. I. Shevtsov, L. V. Karabut, M. E. BereznyakovaМ. О. Остапець, І. І. Шевцов, Л. В. Карабут, М. Є. Березнякова National University of Pharmacy, Kharkiv, UkraineНаціональний фармацевтичний університет, Харків, Україна[email protected] AbstractThe article is devoted to the studying of mechanism action on coagulation system the dry extract of Geranium Palustre herb. Established, those during 20-ty days of introduction the investigation extract increasing the activity of platelet’s mechanism of hemostasis (increasing platelet’s amount, their aggregation activity and retraction of blood clotting). On the background of introduction the investigation extract decreasing indicators of I and III phase of coagulation cascade (activated partial thromboplastin time, thrombin time), increasing prothrombin time and level of fibrinogen. Obtaining result suggest about active action the dry extract of Geranium Palustre herb on «external» way activation of hemocoagulation by possibility effect of accelerate the formation of thromboplastin, causing the hypercoagulation.The mechanism of antihemmorhagic action of dry extract of Geranium Palustre herb due to the presence in the composition biological active substances (such as tannins, flavonoids, elagic, galic and ascorbinic organic acids) that acting complex on vascular-platelet and coagulation hemostasis at the expense of increasing the strength and sealing vascular-tissue barriers, P-vitamin activity – it is ability to reduce capillary fragility and permeability and increasing their resistance.Key words: dry extract of Geranium Palustre herb, platelets, coagulation, phenolic compounds.  РефератСтаття присвячена дослідженню механізму дії сухого екстракту трави герані болотної на систему зсідання крові. Встановлено, що протягом 20-ти денного введення досліджуваного екстракту підвищувалася активність тромбоцитарної ланки гемостазу (підвищувалася кількість тромбоцитів, їх агрегаційна здатність та ретракція кров’яного згустку). На фоні введення сухого екстракту трави герані болотної знижувалися показники I та III фази коагуляційного гемостазу (активований частковий тромбопластиновий час, тромбіновий час), підвищувався протромбіновий час та рівень фібриногену. Отримані дані свідчать про вплив сухого екстракту трави герані болотної на «внутрішній» шлях активації зсідання крові за рахунок прискорення формування тромбопластину, що призводить до гіперкоагуляції.Механізм антигеморагічної дії сухого екстракту трави герані болотної обумовлений наявністю у складі біологічно активних речовин (дубильних речовин, флавоноїдів, елагової, галової та аскорбінової органічних кислот), які діють комплексно як на судинно-тромбоцитарний, так і на коагуляційний гемостаз за рахунок ущільнення та збільшення міцності судинно-тканинних бар’єрів, Р-вітамінної активності – здатності зменшувати проникність та ламкість капілярів, підвищувати їх резистентність.Ключові слова: сухий екстракт трави герані болотної, тромбоцити, зсідання крові, фенольні сполуки. РефератВЛИЯНИЕ СУХОГО ЭКСТРАКТА ТРАВЫ ГЕРАНИ БОЛОТНОЙ НА СИСТЕМУ СВЕРТЫВАНИЯ КРОВИ. Статья посвящена исследованию механизма действия сухого экстракта травы герани болотной на систему свертывания крови. Установлено, что на протяжении 20-ти дневного введения исследуемого экстракта повышалась активность тромбоцитарного звена гемостаза (увеличивалось количество тромбоцитов, их агрегационная способность и ретракция кровяного сгустка). На фоне введения сухого экстракта травы герани болотной снижались показатели I и III фазы коагуляционного гемостаза (активированное частичное тромбопластиновое время, тромбиновое время), повышалось  протромбиновое время и уровень фибриногена. Полученные данные свидетельствуют о влиянии сухого экстракта травы герани болотной на «внутренний» путь активации свертывания крови за счет ускорения формирования тромбопластина, что приводит к гиперкоагуляции.Механизм антигеморрагического действия сухого экстракта травы герани болотной обусловлен наличием в составе биологически активных соединений (дубильных веществ, флавоноидов, эллаговой, галловой и аскорбиновой органических кислот), которые действуют комплексно как на сосудисто-тромбоцитарный, так и на коагуляционный гемостаз за счет уплотнения и увеличения прочности сосудисто-тканевых барьеров, Р-витаминной активности – способности уменьшать проницаемость и ломкость капилляров, повышать их резистентность.Ключевые слова: сухой экстракт травы герани болотной, тромбоциты, свертывание крови, фенольные соединения

Defects of long bones — a brief history of the development of technology of their compensation

The Ilizarov bone reconstruction method involves bone reconstruction and the formation of new bone. It is based on the biological phenomenon of distraction osteogenesis, which is used to lengthen bone and correct deformities. Ilizarov bone grafting is a lifesaving procedure for a number of conditions, including large bone defects and orthopedic infection complications. The method has given rise to new developments in bone reconstruction surgery based on the regenerative potential of bone tissue. The acceleration of distraction regenerate consolidation is one of the objectives of modern research in the field of new bone formation.Метод реконструкции кости по Илизарову включает в себя восстановление кости и образование новой кости. Он основан на биологическом явлении дистракционного остеогенеза, который используется для удлинения кости и коррекции деформации. Костная пластика по Илизарову является спасительной процедурой при ряде состояний, включая большие костные дефекты и ортопедические инфекционные осложнения. Метод дал толчок новым разработкам в хирургии реконструкции костей, основанным на регенерационном потенциале костной ткани. Ускорение консолидации дистракционного регенерата является одной из задач современных исследований в области формирования новой кости

Mathematical support of the drying process as a pre – stage of the new generation CAD dryers design

Objective. The aim of the study is the mathematical support of the vacuum microwave process, the design of the installation in CAD, the manufacture of a prototype, the modeling of temperature and moisture content fields.Method. The mathematical model was implemented numerically by the finite element method in the Comsol Multiphysics environment on a grid of 3678 elements, using its deformation to change the height.Result. Experimental data were obtained on a laboratory vacuum microwave installation, which made it possible to identify patterns in the drying of foamed materials. The drying parameters, as well as the properties of the initial and dried material, were analyzed. A pilot-type vacuum plant was designed using CAD and a working prototype was made. The modeling of the temperature field and moisture content zones in the dynamics of the process has been carried out.Conclusion. Mathematical modeling of the drying process makes it possible to determine the temperature fields and moisture content of the material with a high accuracy with a relatively small amount of necessary experimental data

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The purpose of this Note is to describe the optical assembly procedure called here Optical Instrumentation and the quality tests conducted on the assembled units. Altogether, 65 Barrel (or LB) modules were constructed - including one spare - together with 129 Extended Barrel (EB) modules (including one spare). The LB modules were mechanically assembled at JINR (Dubna, Russia) and transported to CERN, where the optical instrumentation was performed with personnel contributed by several Institutes. The modules composing one of the two Extended Barrels (known as EBA) were mechanically assembled in the USA, and instrumented in two US locations (ANL, U. of Michigan), while the modules of the other Extended barrel (EBC) were assembled in Spain and instrumented at IFAE (Barcelona). Each of the EB modules includes a subassembly known as ITC that contributes to the hermeticity of the calorimeter; all ITCs were assembled at UTA (Texas), and mounted onto the module mechanical structures at the EB mechanical assembly locations.The Tile Calorimeter, covering the central region of the ATLAS experiment up to pseudorapidities of ±1.7, is a sampling device built with scintillating tiles that alternate with iron plates. The light is collected in wave-length shifting (WLS) fibers and is read out with photomultipliers. In the characteristic geometry of this calorimeter the tiles lie in planes perpendicular to the beams, resulting in a very simple and modular mechanical and optical layout. This paper focuses on the procedures applied in the optical instrumentation of the calorimeter, which involved the assembly of about 460,000 scintillator tiles and 550,000 WLS fibers. The outcome is a hadronic calorimeter that meets the ATLAS performance requirements, as shown in this paper

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The paper contains solution of the problem concerning heating of multi-layer materials. Method of finite elements has been used to solve the problem.On the basis of numerical experiments plots of temperature fields have been constructed and optimum operating conditions of heating processes of multi-layer structures of materials having special properties have been determined.Приведено решение задачи нагревания многослойных материалов. При решении задачи использован метод конечных элементов.По результатам численного эксперимента построены графики температурных полей и определены оптимальные режимные параметры процессов нагревания многослойных структур материалов, обладающих специальными свойствами

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