Analysis of Vaccinal Process Peculiarities in Persons Immunized with Smallpox Live Vaccine in Case of Primary Vaccination and Revaccination

Immunization against smallpox may be attended by serious complications. The premises for the differences in postvaccinal reaction intensity are underexplored. In this paper presented is the review of peculiarities of postvaccinal manifestations in members of the Russian population primarily immunized against smallpox as compared to the revaccinated ones. Examined has been the cohort of 217 people, of whom 82 are vaccinated initially, and 135 - repeatedly within the period from 2000 to 2013. Average age of the vaccinated is 40.0 years (ranged 20 to 40). Studied has been severity of vaccine-challenged condition and cutaneous inflammatory vaccinal elements. In case of initial vaccination medium severity has been observed 2.1 times oftener than low one. In case of revaccination - low level of severity has been registered 17.7 times more frequently than the medium one. Hyperemia zone is 2.2 times greater as regards primary vaccination compared to revaccination, zone of induration - 1.9 times. The diameter of the sore is 1.3 and its shedding time is 1.4 times greater and longer, respectively. Thus, initial vaccination follows more severe course and is attended by expressed response in comparison to booster one

A single blind, placebo-controlled randomized study of the safety, reactogenicity and immunogenicity of the “EpiVacCorona” Vaccine for the prevention of COVID-19, in volunteers aged 18–60 years (phase I–II)

Vaccination of the population is one of the most effective countermeasures in responding to the pandemic caused by novel coronavirus infection. Therefore, scientists all over the world have been working to develop effective and safe vaccines. We have developed a synthetic peptide vaccine, EpiVacCorona, against novel SARS-CoV-2 coronavirus, which is a suspension for intramuscular administration containing a composition of chemically synthesized peptide immunogens of the S protein of SARS-CoV-2 coronavirus conjugated to a carrier protein and adsorbed on aluminum hydroxide. Phase I–II clinical trials of the vaccine have started that consist of two stages: Stage 1 is an open study of the safety, reactogenicity, and immunological activity of the vaccine with the involvement of 14 volunteers aged 18–30 years; Stage 2 is a single blind, comparative, randomized placebo-controlled study with the involvement of 86 volunteers. The study involved volunteers aged 18–60 years; the vaccine was injected intramuscularly twice, spaced 21 days apart between injections. All local reactions in response to vaccine administration were mild, such as a short-term pain at the injection site. There were no signs of development of local or systemic adverse reactions. The two-dose vaccination scheme induced the production of antibodies, specific to the antigens that make up the vaccine, in 100% of the volunteers. Seroconversion with a neutralizing antibody titer ≥ 1:20 was reported in 100% of the volunteers 21 days following the second immunization dose. No seroconversion was reported in the groups of volunteers vaccinated with a placebo. The peptide-based EpiVacCorona Vaccine has low reactogenicity and is a safe, immunogenic product. Clinical Trials Identifier: NCT04527575

Комплекс цефтриаксона с Mg(II): синтез, структура, спектральные и антибактериальные свойства

Magnesium complex of ceftriaxone was obtained and characterized by atomic-emission and elemental analysis, TGA, FTIR and Raman spectroscopy, X‑ray diffraction and density functional theory calculations. Ceftriaxone was coordinated to the magnesium ion by the oxygen of the triazine cycle in the 6th position, the nitrogen of the amine group of the thiazole ring, and oxygen atoms of the lactam carbonyl and carboxylate groups. The disodium salt of ceftriaxone and magnesium complex were screened for antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosaПолучен и охарактеризован магниевый комплекс цефтриаксона методами атомно-эмиссионного и элементного анализов, ТГА, ИК- и КР‑спектроскопии, РФА и расчетов теории функционала плотности. Цефтриаксон координируется к иону магния через кислород триазинового цикла в шестом положении, азот аминогруппы тиазольного цикла и атомы кислорода карбоксильной и лактамной групп. Динатриевая соль цефтриаксона и комплекс магния были исследованы на антибактериальную активность в отношении Staphylococcus aureus, Escherichia coli и Pseudomonas aeruginos

The influence of size effect on the electronic and elastic properties of diamond films with nanometer thickness

The atomic structure and physical properties of few-layered oriented diamond nanocrystals (diamanes), covered by hydrogen atoms from both sides are studied using electronic band structure calculations. It was shown that energy stability linear increases upon increasing of the thickness of proposed structures. All 2D carbon films display direct dielectric band gaps with nonlinear quantum confinement response upon the thickness. Elastic properties of diamanes reveal complex dependence upon increasing of the number of layers. All theoretical results were compared with available experimental data.Comment: 16 pages, 5 figures, 3 table

Relative Stability of Different Fullerenes Formed in Plasma

Предложен метод, объясняющий относительную стабильность наноструктур, образующихся при плазменно-химическом синтезе. Метод основан на вычислении вероятности развала моле- кулы. Данная вероятность определялась по вероятностям разрыва среди всех химических свя- зей молекулы при растяжении их до критической величины благодаря тепловым колебаниям. Для этого, путем вычисления собственных частот и векторов всех колебаний и предполагая некореллированность фаз всех колебаний, определялась вероятность развала каждой химической связи. Выбор максимальной вероятности, соответствующей разрыву самой слабой связи, опре- делял вероятность разрушения молекулы при данной температуре. Применяя данный метод для некоторых фуллеренов и углеродных нанотрубок, показано, что он дает качественное согласие с экспериментальными данными. Благодаря общей формулировке метода, можно ожидать, что он может использоваться и для объяснения образования других наноструктур.A method explaining the relative yield of nanostructures during the plasma chemical synthesis is proposed. The method is based on calculation of probability of molecule destruction. This probability is considered as the maximal probability among all chemical bonds in the molecule to stretch upon the critical distance due to molecule thermal vibrations. By calculations of vibration eigenfrequencies and eigenvectors and suppose that all vibrations are independent and their phases are random, it is possible to calculate the probability of every bond destruction. Choosing the maximal one, corresponding the weakest bond destroying, it is possible to calculate probability of the molecule destroying. Using this method for yield of some fullerenes and single wall carbon nanotubes, it is shown that it can qualitatively explain the data of experimental yield. Because of general treatment of the method, one can expect that this method can provide an explanation of other nanostructures yield

A complex of ceftriaxone with Pb(II): synthesis, characterization, and antibacterial activity study

<div><p>A Pb(II) complex with ceftriaxone (H₂Ceftria) antibiotic was synthesized by reaction of ceftriaxone disodium salt (hemi)heptahydrate with lead nitrate in water–ethanol medium. The complex was characterized on the basis of complexometric titration, spectrophotometric and thermogravimetric analyses, capillary electrophoresis, IR, Raman and UV–vis spectroscopies, and density functional theory calculations. Pb(II) is five-coordinate with distorted square pyramidal geometry. The coordination of Ceftria²⁻ to Pb(II) occurs through N and O of the triazine, lactam carbonyl, carboxylate, and amine groups. The antibacterial activity study showed that <i>Klebsiella pneumoniae</i> is resistant to [Pb(Ceftria)]·3H₂O. The antibacterial activity of [Pb(Ceftria)]·3H₂O against <i>Staphylococcus aureus</i> is reduced compared with ceftriaxone. In contrast, the antibacterial activity of [Pb(Ceftria)]·3H₂O against <i>Escherichia coli</i> is 28% higher than that of ceftriaxone antibiotic.</p></div

Relative Stability of Different Fullerenes Formed in Plasma

Предложен метод, объясняющий относительную стабильность наноструктур, образующихся при плазменно-химическом синтезе. Метод основан на вычислении вероятности развала моле- кулы. Данная вероятность определялась по вероятностям разрыва среди всех химических свя- зей молекулы при растяжении их до критической величины благодаря тепловым колебаниям. Для этого, путем вычисления собственных частот и векторов всех колебаний и предполагая некореллированность фаз всех колебаний, определялась вероятность развала каждой химической связи. Выбор максимальной вероятности, соответствующей разрыву самой слабой связи, опре- делял вероятность разрушения молекулы при данной температуре. Применяя данный метод для некоторых фуллеренов и углеродных нанотрубок, показано, что он дает качественное согласие с экспериментальными данными. Благодаря общей формулировке метода, можно ожидать, что он может использоваться и для объяснения образования других наноструктур.A method explaining the relative yield of nanostructures during the plasma chemical synthesis is proposed. The method is based on calculation of probability of molecule destruction. This probability is considered as the maximal probability among all chemical bonds in the molecule to stretch upon the critical distance due to molecule thermal vibrations. By calculations of vibration eigenfrequencies and eigenvectors and suppose that all vibrations are independent and their phases are random, it is possible to calculate the probability of every bond destruction. Choosing the maximal one, corresponding the weakest bond destroying, it is possible to calculate probability of the molecule destroying. Using this method for yield of some fullerenes and single wall carbon nanotubes, it is shown that it can qualitatively explain the data of experimental yield. Because of general treatment of the method, one can expect that this method can provide an explanation of other nanostructures yield