Testicular diffuse large B-cell lymphoma. Clinical lecture and case report

Lymphoma is a heterogeneous group of lymphocyte malignancies that may involve lymphatic tissue, bone marrow, or extranodal sites. The lecture provides a  brief overview of the current state of the problem of diagnosis and treatment of primary testicular lymphoma. Primary testicular lymphoma (PTL) is a rare lymphoid malignancy. Though it is rare, PTL is the most common type of testicular tumor in men over 60 years of age. The most common histological type is diffuse large B-cell lymphoma. To date, there are no well-documented etiological or risk factors for PTL. In contrast to other common testicular neoplasms, there was no statistically significant association of PTL with cryptorchidism, trauma, chronic orchitis, or infertility. Ultrasound is generally the first-line imaging method used to characterize testicular lesions. PTL manifests itself in the form of a hypoechoic formation, which can take the form of either a single large formation or multiple small formations that occupy most of the testicular parenchyma or completely replace it. Systemic treatment, including orchiectomy, chemotherapy, radiation therapy, and intrathecal prophylaxis, is necessary for all patients with PTL. In addition to achieving complete remission, the goal of PTL treatment is to prevent recurrences in the contralateral testis and central nervous system. The presented information is supplemented by our own observation and images. Personal medical data is published with the written consent of the patient. In our case, the patient’s age was 38 years, which does not fall into the specified age group for primary testicular lymphoma. In our opinion, the publication of this clinical case and analysis of scientific literature on this topic are relevant

METHOD OF DIAGNOSTICS OF STENOSING PROCESSES OF VERTEBRAL CANAL AND DURAL SACK ON LUMBAR LEVEL

On the basis of commonly used morphometric and additional new indices at the research, of vertebromotor segment, dural sack and vertebral canal in 48 patients Zn coefficient was calculated mathematically. Its value corresponds to the degree of stenosing process of vertebral canal and. defines the degree of gravity of clinical and. neurological disorders in studied patients

Polarization lidars with conical scanning for retrieving the microphysical characteristics of cirrus clouds

The paper presents the first results of observations of cirrus clouds by polarization lidars with conical scanning, which were developed in Hefei (China) and in Tomsk (Russia). The light scattering matrix of ice crystal particles of cirrus clouds has been calculated for the first by the authors within the framework of the physical optics approximations in the case of conical scanning lidar. It is found that in this case the Mueller matrix consists of ten non-zero elements, four of which are small and can’t be applied to interpret the azimuthal distribution of particle orientation. All the diagonal elements have a strong azimuthal dependence. Among the off-diagonal elements only one element M34 carries additional information for interpreting the azimuthal distribution. © (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only

ACTIVITY OF FREE RADICAL OXIDATION AND CYCLOOXYGENASE EXPRESSION IN RATS KIDNEYS UNDER EXPERIMENTAL THERAPY OF OXALATE NEPHROLITHIASIS WITH TETRAPEPTIDE Leu-Ile-Lys-Met

The aim of the study was to investigate the effect of Leu-Ile-Lys-Met tetrapeptide on the activity of free radical oxidation (FRO) and the level of cyclooxygenase-1 (COX-1) and COX-2 expression in rat kidney with experimental oxalate nephrolithiasis. Material and methods. The experiments were carried out on 30 male rats Wistar runoff, divided into 3 groups: the comparison group (10 intact rats), the control group (6 weeks of experimental oxalate nephrolithiasis simulation, n = 10), the experimental group (6 weeks of experimental simulation oxalate nephrolithiasis + oral administration of Leu-Ile-Lys-Met tetrapeptide at a dose of 12 mg/kg from the 3rd to the 6th week, n = 10). The oxalate nephrolithiasis was simulated according to conventional ethylene glycol model. COX-1 and COX-2 concentration in rat urine at baseline and after 6 weeks of experimental nephrolithiasis was determined by enzyme immunoassay using the prostaglandin-endoperoxide synthase 1 and 2 (PTGS 1, 2) kit from «Cloud-Clone Corp.». In rat kidney homogenate, the activity indicators of FRO processes were determined by common methods. Results and discussion. At the background of the Leu-Ile-Lys-Met tetrapeptide, free radical kidney damage was weakened, which was manifested in the complete absence of morphological signs of nephrolithiasis, decrease of thiobarbituric acid-reactive product concentration and overall prooxidant activity as compared to the control group; glutathione peroxidase activity, on the contrary, increased by 1.5 times

The Period Changes of the Cepheid RT Aurigae

Observations of the light curve for the 3.7-day Cepheid RT Aur both before and since 1980 indicate that the variable is undergoing an overall period increase, amounting to +0.082 +-0.012 s/yr, rather than a period decrease, as implied by all observations prior to 1980. Superposed on the star's O-C variations is a sinusoidal trend that cannot be attributed to random fluctuations in pulsation period. Rather, it appears to arise from light travel time effects in a binary system. The derived orbital period for the system is P = 26,429 +-89 days (72.36 +-0.24 years). The inferred orbital parameters from the O-C residuals differ from those indicated by existing radial velocity data. The latter imply the most reasonable results, namely a1 sin i = 9.09 (+-1.81) x 10^8 km and a minimum secondary mass of M2 = 1.15 +-0.25 Msun. Continued monitoring of the brightness and radial velocity changes in the Cepheid are necessary to confirm the long-term trend and to provide data for a proper spectroscopic solution to the orbit.Comment: Accepted for publication in PASP (November 2007

Морфологические свидетельства анаболического действия препарата «Гистохром» у крыс

The aim of the investigation was to assess histochrome’s anabolic effect as a consequence of treatment of various doses in rats in conditions of prolonged physical training.Materials and methods. The experiments were performed on the Wistar’s rats. Experimental Group 1 was subcutaneously injected with histochrome in a dose of 1 mg/kg (n = 20) within 10 days, experimental group 2 was treated subcutaneously at a dose of 10 mg/kg (n = 20), and control group 3 received equivolume injections of isotonic sodium chloride (n = 20). Rat musclehypertrophy was induced using the method of forced swimming. A piece ofmuscle  was takenfor morphological examination a day after the first and last period of swimming. Hypertrophy of muscle fibers was evaluated by the cross-sectional diameter of muscle fibers, the average quantity of argyrophilic nucleolar organizer region (AgNOR) proteins and the percentage of nuclei with 1, 2, 3 or more AgNOR compared to intact (control) animals.Results. Microscopic morphological examination of M. gastrocnemius registered increase in diameter of muscle fiber by 19,4% (1 mg/kg) and by 60% (10 mg/kg). In the control group of rats an increase in a transverse section of muscle fibers was not found to be statistically significant.The study of biosynthetic nuclei activity of myosimplastus registered increase the AgNOR proteins in both examines groups of animals in comparison the less dynamics in control one. By 10th day of observation the quantity of myosimplastus with two AgNOR increased in a control group of rats by 10%. The maximum AgNOR proteins gained was marked in case of the prolonged use of histochrome in a dose 1 mg/kg.Conclusion. Histochrome enables the increase in dose-dependent biosynthetic processes in skeletal muscles of rats, providing the development of anabolic effect.Цель. Изучить анаболическое действие различных доз гистохрома у крыс в условиях длительных физических тренировок.Материалы и методы. Эксперименты выполнены на аутбредных крысах сток Вистар обоего пола в возрасте 2–3 мес и весом 200–300 Крысам группы 1 (n = 20) в течение 10 сут подкожно вводили гистохром в дозе 1 мг/кг, группы 2 (n = 20) – 10 мг/кг, группы 3 (n = 20) – эквиобъемные инъекции изотонического раствора натрия хлорида (контроль). Гипертрофические процессы в мускулатуре крыс индуцировали, используя модель принудительного плавания. Тренировки проводили через 1 сут. Забор материала для морфологического исследования осуществляли через 1 сут после первого и последнего плавания. Гипертрофию мышечных волокон оценивали по диаметру поперечного сечения мышечных волокон, среднему количеству гранул серебра на одно ядро миосимпласта и процентному содержанию ядер с 1–3 и более гранулами в сравнении с интактными (контрольными) животными.Результаты. При морфологическом исследовании микропрепарата m. gastrocnemius зарегистрировано увеличение диаметра мышечного волокна на 19,4% в группе 1 и на 60% в группе 2. В контрольной группе крыс не обнаруживалось статистически значимого увеличения поперечного сечения мышечных волокон.Изучение биосинтетической активности ядер миосимпластов выявило увеличение аргирофильных белков (AgNORs) в обеих испытуемых группах животных при менее яркой динамике в контроле.  К 10-м сут наблюдения в контрольной группе крыс на 10% возросло количество миосимпластов с двумя ядрышковыми организаторами. Максимальный прирост аргирофильных гранул отмечался при длительном применении препарата «Гистохром» в дозе 1 мг/кг.Заключение. Гистохром дозозависимо повышает биосинтетические процессы в скелетной мускулатуре крыс, обеспечивая развитие анаболического эффекта

Применение викасола как перспективного средства фармакологической коррекции экспериментального нефролитиаза

The aim of the investigation was studying vicasole’s effect on experimental oxalate nephrolithiasis.Experimental nephrolithiasis was being modeled by using of 1% ethylenglycole’s solution as a drink for rats during 6 weeks. First group was control. In the second group since the third week was being administrated vicasole in dose 500 mkg/kg. Was being detected parameters of kidney’s function, markers enzymes activity and free oxygen’s radicals activity, was carried out morphological researches.It was concluded that vicasole’s therapy reduce experimental oxalate nephrolithiasisПроведено исследование влияния викасола на течение экспериментального оксалатного нефролитиаза.Экспериментальный нефролитиаз моделировали у двух групп крыс путем потребления в течение 6 нед 1%-го раствора этиленгликоля в виде питья. Первая группа являлась контрольной. Во второй группе начиная с 3-й нед ежедневно вводили подкожно викасол в дозе 500 мкг/кг массы тела. Определяли показатели экскреторной функции почек, измеряли активность маркерных ферментов и процесса свободнорадикального окисления, а также проводили морфометрическое исследование почечных срезов.Установлено, что викасол существенно облегчает течение экспериментального нефролитиаза