Very Large Array Detection of the 36 GHz Zeeman Effect in DR21W Revisited

We report on the observation of the 36 GHz methanol maser line in the star forming region DR21W to accurately measure the Zeeman effect. The reported Zeeman signature by Fish et al. (2011) became suspicious after an instrumental effect was discovered in the early days of the Very Large Array Wide-band Digital Architecture (WIDAR) correlator commissioning. We conclude that the previously reported magnetic field strength of 58 mG ((1.7 Hz/mG)/z) is instrumental in nature and thus incorrect. With the improved performance of the array, we now deduce a 3 sigma limit of -4.7 to +0.4 mG ((1.7 Hz/mG)/z) for the line-of-sight component of the magnetic field strength in DR21W.Comment: 6 pages, 1 figure, accepted for publication in Ap

The Effect of Oral and Intraperitoneal Administration of Alcohol upon the Concentration of Alcohol in the Blood of the Rat

A number of experiments were made in this laboratory to determine the rate of absorption of alcohol into the blood of rats after the administration of alcohol both orally and by intraperitoneal injection. Both fasted and unfasted rats were used in these experiments

A Micro Method for the Determination of Ethyl Alcohol in Blood

In connection with some work on the physiological effects of ethyl alcohol on rats being done in this laboratory, it was essential to have a rapid and accurate method for the determination of ethyl alcohol in small samples of bloo

Control surfaces of aquatic vertebrates: active and passive design and function

Aquatic vertebrates display a variety of control surfaces that are used for propulsion, stabilization, trim and maneuvering. Control surfaces include paired and median fins in fishes, and flippers and flukes in secondarily aquatic tetrapods. These structures initially evolved from embryonic fin folds in fishes and have been modified into complex control surfaces in derived aquatic tetrapods. Control surfaces function both actively and passively to produce torque about the center of mass by the generation of either lift or drag, or both, and thus produce vector forces to effect rectilinear locomotion, trim control and maneuvers. In addition to fins and flippers, there are other structures that act as control surfaces and enhance functionality. The entire body can act as a control surface and generate lift for stability in destabilizing flow regimes. Furthermore, control surfaces can undergo active shape change to enhance their performance, and a number of features act as secondary control structures: leading edge tubercles, wing-like canards, multiple fins in series, finlets, keels and trailing edge structures. These modifications to control surface design can alter flow to increase lift, reduce drag and enhance thrust in the case of propulsive fin-based systems in fishes and marine mammals, and are particularly interesting subjects for future research and application to engineered systems. Here, we review how modifications to control surfaces can alter flow and increase hydrodynamic performance

Biomarkers for Radiation Pneumonitis Using Noninvasive Molecular Imaging

Our goal is to develop minimally invasive biomarkers for predicting radiation-induced lung injury before symptoms develop. Currently, there are no biomarkers that can predict radiation pneumonitis. Radiation damage to the whole lung is a serious risk in nuclear accidents or in radiologic terrorism. Our previous studies have shown that a single dose of 15 Gy of x-rays to the thorax causes severe pneumonitis in rats by 6–8 wk. We have also developed a mitigator for radiation pneumonitis and fibrosis that can be started as late as 5 wk after radiation. Methods: We used 2 functional SPECT probes in vivo in irradiated rat lungs. Regional pulmonary perfusion was measured by injection of 99mTc-macroaggregated albumin. Perfused volume was determined by comparing the volume of distribution of 99mTc-macroaggregated albumin to the anatomic lung volume obtained by small-animal CT. A second probe, 99mTc-labeled Duramycin, which binds to apoptotic cells, was used to measure pulmonary cell death in the same rat model. Results: The perfused volume of lung was decreased by about 25% at 1, 2, and 3 wk after receipt of 15 Gy, and 99mTc-Duramycin uptake was more than doubled at 2 and 3 wk. There was no change in body weight, breathing rate, or lung histology between irradiated and nonirradiated rats at these times. Pulmonary vascular resistance and vascular permeability measured in isolated perfused lungs ex vivo increased at 2 wk after 15 Gy of irradiation. Conclusion: Our results suggest that SPECT biomarkers have the potential to predict radiation injury to the lungs before substantial functional or histologic damage is observed. Early prediction of radiation pneumonitis in time to initiate mitigation will benefit those exposed to radiation in the context of therapy, accidents, or terrorism

Developing workplace menopause policies: four reasons why, and how

Menopause is increasingly – if finally – being acknowledged as an important workplace issue. Five experts from different fields discuss the social, business, legal and ethical cases for improving support at work for women transitioning through the menopause, and explain how to start and sustain the conversation with employers. Menopause – when a woman stops having periods for good – is currently receiving an increasing amount of attention. Celebrities including Kirsty Wark, Davina McCall, Gillian Anderson, Jenny Eclair, Meg Mathews, Carol Vorderman and Cynthia Nixon have shared their experiences of this natural, and yet often taboo, mid-life transition with the wider world. Also noticeable is a groundswell among employers across a variety of sectors that are acknowledging the significant effects menopause symptoms

The Role of Extracellular Vesicles in β-Cell Function and Viability: A Scoping Review

Extracellular vesicles (EVs) released by cells throughout the body have been implicated in diabetes pathogenesis. Understanding the role of EVs in regulation of β-cell function and viability may provide insights into diabetes etiology and may lead to the development of more effective screening and diagnostic tools to detect diabetes earlier and prevent disease progression. This review was conducted to determine what is known from the literature about the effect of EV crosstalk on pancreatic β-cell function and viability in the pathogenesis of diabetes mellitus, to perform a gap analysis for future research directions, and to discuss implications of available evidence for diabetes care. The literature search yielded 380 studies from which 31 studies were determined to meet eligibility criteria. The majority of studies had the disease context of autoimmunity in T1DM. The most commonly studied EV crosstalk dynamics involved localized EV-mediated communication between β-cells and other islet cells, or between β-cells and immune cells. Other organs and tissues secreting EVs that affect β-cells include skeletal muscle, hepatocytes, adipocytes, immune cells, bone marrow, vascular endothelium, and mesenchymal stem cells. Characterization of EV cargo molecules with regulatory effects in β-cells was conducted in 24 studies, with primary focus on microRNA cargo. Gaps identified included scarcity of evidence for the effect on β-cell function and viability of EVs from major metabolic organs/tissues such as muscle, liver, and adipose depots. Future research should address these gaps as well as characterize a broader range of EV cargo molecules and their activity in β-cells

The Distribution of Alcohol in the Tissues of the Rat

In order to determine the distribution of alcohol in the tissues, we have devised a method which is quite simple and accurate. The animal is killed and the tissues removed as rapidly as possible. The tissues are placed in weighed 150 ml. extraction flasks immersed in solid carbon dioxide. The flasks and tissues are weighed and the tissues covered with a solution of picric and tartaric acids. The samples are then placed in a refrigerator until the analysis can be made