Confinement of two-dimensional excitons in a non-homogeneous magnetic field

The effective Hamiltonian describing the motion of an exciton in an external non-homogeneous magnetic field is derived. The magnetic field plays the role of an effective potential for the exciton motion, results into an increment of the exciton mass and modifies the exciton kinetic energy operator. In contrast to the homogeneous field case, the exciton in a non-homogeneous magnetic field can also be trapped in the low field region and the field gradient increases the exciton confinement. The trapping energy and wave function of the exciton in a GaAs two-dimensional electron gas for specific circular magnetic field configurations are calculated. The results show than excitons can be trapped by non-homogeneous magnetic fields, and that the trapping energy is strongly correlated with the shape and strength of the non-homogeneous magnetic field profile.Comment: 9 pages, 12 figure

Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets.

BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF). Following ligand binding, EGFR heterodimerizes with other HER family members, such as HER2 (human epidermal growth factor receptor-2). Previously, we showed that the EGFR is upregulated in trastuzumab resistant HER2 positive (HER2+) breast cancer cells. This study is aimed to determine the downstream effects on transcription following EGFR upregulation in HER2+ breast cancer cells. METHODS:RNA-sequence and ChIP-sequence for H3K18ac and H3K27ac (Histone H3 lysine K18 and K27 acetylation) were conducted following an Epidermal Growth Factor (EGF) treatment time course in HER2+ breast cancer cells, SKBR3. The levels of several proteins of interest were confirmed by western blot analysis. The cellular localization of proteins of interest was examined using biochemically fractionated lysates followed by western blot analysis. RESULTS:Over the course of 24 h, EGFR stimulation resulted in the modulation of over 4000 transcripts. Moreover, our data demonstrates that EGFR/HER2 signaling regulates the epigenome, with global H3K18ac and H3K27ac oscillating as a function of time following EGF treatment. RNA-sequence data demonstrates the activation of immediate early genes (IEGs) and delayed early genes (DEGs) within 1 h of EGF treatment. More importantly, we have identified members of the S100 (S100 Calcium Binding Protein) gene family as likely direct targets of EGFR signaling as H3K18ac, H3K27ac and pol2 (RNA polymerase II) increase near the transcription start sites of some of these genes. CONCLUSIONS:Our data suggests that S100 proteins, which act as Ca2+ sensors, could play a role in EGF induced tumor cell growth and metastasis, contribute to trastuzumab resistance and cell migration and that they are likely drug targets in HER2+ breast cancer

Transition from single-file to two-dimensional diffusion of interacting particles in a quasi-one-dimensional channel

Diffusive properties of a monodisperse system of interacting particles confined to a \textit{quasi}-one-dimensional (Q1D) channel are studied using molecular dynamics (MD) simulations. We calculate numerically the mean-squared displacement (MSD) and investigate the influence of the width of the channel (or the strength of the confinement potential) on diffusion in finite-size channels of different shapes (i.e., straight and circular). The transition from single-file diffusion (SFD) to the two-dimensional diffusion regime is investigated. This transition (regarding the calculation of the scaling exponent ($\alpha$) of the MSD $$ $\propto t^{\alpha}$) as a function of the width of the channel, is shown to change depending on the channel's confinement profile. In particular the transition can be either smooth (i.e., for a parabolic confinement potential) or rather sharp/stepwise (i.e., for a hard-wall potential), as distinct from infinite channels where this transition is abrupt. This result can be explained by qualitatively different distributions of the particle density for the different confinement potentials.Comment: 13 pages, 11 figure

Understanding tribological behavior of complex gel systems for personal care applications using surrogate skin and their bulk rheology

Creams and lotions based on oil-in-water emulsions with polymers are commonly used to treat dry skin conditions. Since the accumulation of traditional surfactants on the skin can promote irritation, an alternative is the use of hydrogenated phosphatidylcholine (HPC), a type of phospholipid that can form a lipid lamellar structure similar to the stratum corneum, the outermost layer of the epidermis which acts as a skin barrier. This research aims to investigate the effect of composition on the rheological and tribological characteristics in systems with HPC as surfactant and to find relationships between rheological and tribological properties to help predicting sensory perception of emulsions for skincare applications. For tribology experiments we used a ball-on-disk configuration to obtain friction curves using different disk materials to mimic the skin surface (PDMS and artificial skin, Bioskin™), while for bulk rheology studies we used dynamic and steady shear experiments. We examine how the addition of different amounts of HPC and polymers with different hydrophobicity affects friction and lubrication regimes from the tribological standpoint and the viscoelasticity, yield stress, and gel formation from the rheological standpoint. The bulk rheology shows that the studied systems are shear thinning and have gel-like behavior. The effect of each component was investigated by going from a simple system (polymer and water) to the more complex system. Systems containing a hydrophobically modified polyacrylic acid lightly crosslinked showed lower yield stresses and lower moduli than systems with carbomer type polymer. Analogous experiments were carried out in tribology. In the range of entrainment speed investigated, the friction coefficients in the boundary regime were lower for diluted systems containing the hydrophobically modified polymer than for systems containing the carbomer type polymer. The Stribeck curves obtained for each of the systems are compared for different polymer types and related to the bulk rheology results to obtain physical insights into these complex systems

Conditions for non-monotonic vortex interaction in two-band superconductors

We describe a semi-analytic approach to the two-band Ginzburg-Landau theory, which predicts the behavior of vortices in two-band superconductors. We show that the character of the short-range vortex-vortex interaction is determined by the sign of the normal domain - superconductor interface energy, in analogy with the conventional differentiation between type-I and type-II superconductors. However, we also show that the long-range interaction is determined by a modified Ginzburg-Landau parameter $\kappa^*$, different from the standard $\kappa$ of a bulk superconductor. This opens the possibility for non-monotonic vortex-vortex interaction, which is temperature-dependent, and can be further tuned by alterations of the material on the microscopic scale

Bound vortex states and exotic lattices in multi-component Bose-Einstein condensates: The role of vortex-vortex interaction

We numerically study the vortex-vortex interaction in multi-component homogeneous Bose-Einstein condensates within the realm of the Gross-Pitaevskii theory. We provide strong evidences that pairwise vortex interaction captures the underlying mechanisms which determine the geometric configuration of the vortices, such as different lattices in many-vortex states, as well as the bound vortex states with two (dimer) or three (trimer) vortices. Specifically, we discuss and apply our theoretical approach to investigate intra- and inter-component vortex-vortex interactions in two- and three-component Bose-Einstein condensates, thereby shedding light on the formation of the exotic vortex configurations. These results correlate with current experimental efforts in multi-component Bose-Einstein condensates, and the understanding of the role of vortex interactions in multiband superconductors.Comment: Published in PR

Hysteresis and re-entrant melting of a self-organized system of classical particles confined in a parabolic trap

A self-organized system composed of classical particles confined in a two-dimensional parabolic trap and interacting through a potential with a short-range attractive part and long-range repulsive part is studied as function of temperature. The influence of the competition between the short-range attractive part of the inter-particle potential and its long-range repulsive part on the melting temperature is studied. Different behaviors of the melting temperature are found depending on the screening length ($\kappa$) and the strength ($B$) of the attractive part of the inter-particle potential. A re-entrant behavior and a thermal induced phase transition is observed in a small region of ($\kappa,B$)-space. A structural hysteresis effect is observed as a function of temperature and physically understood as due to the presence of a potential barrier between different configurations of the system.Comment: 8 pages, 6 figure

Divergência genética multivariada entre genótipos de mandioca coletados em área indígena do Amapá.

O trabalho teve como objetivo estimar a diversidade genetica multivariada entre 31 genotipos de mandioca coletados em área indigena do município de Oiapoque-AP