195 research outputs found

    Fatigue life prediction of high strength steel welded joints by Energy Approach

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    AbstractTwo full-field techniques were applied for the study of the base material and welded specimens, made of S690QL steel: digital image correlation and thermographic techniques. Static and fatigue tests were carried out. The thermographic measurements can be used to predict the fatigue, with a great saving in time and effort. Fatigue tests at increasing loads were carried out by a stepwise succession, applied to the same specimen, for applying an energy-based approach. The predictions of the fatigue life, obtained by means of the Energy Approach, were compared with the values obtained by the traditional procedure

    Lifestyle interventions and prevention of suicide

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    Over the past years, there has been a growing interest in the association between lifestyle psychosocial interventions, severe mental illness, and suicide risk. Patients with severe mental disorders have higher mortality rates, poor health states, and higher suicide risk compared to the general population. Lifestyle behaviors are amenable to change through the adoption of specific psychosocial interventions, and several approaches have been promoted. The current article provides a comprehensive review of the literature on lifestyle interventions, mental health, and suicide risk in the general population and in patients with psychiatric disorders. For this purpose, we investigated lifestyle behaviors and lifestyle interventions in three different age groups: adolescents, young adults, and the elderly. Several lifestyle behaviors including cigarette smoking, alcohol use, and sedentary lifestyle are associated with suicide risk in all age groups. In adolescents, growing attention has emerged on the association between suicide risk and internet addiction, cyberbullying and scholastic and family difficulties. In adults, psychiatric symptoms, substance and alcohol abuse, weight, and occupational difficulties seems to have a significant role in suicide risk. Finally, in the elderly, the presence of an organic disease and poor social support are associated with an increased risk of suicide attempt. Several factors may explain the association between lifestyle behaviors and suicide. First, many studies have reported that some lifestyle behaviors and its consequences (sedentary lifestyle, cigarette smoking underweight, obesity) are associated with cardiometabolic risk factors and with poor mental health. Second, several lifestyle behaviors may encourage social isolation, limiting the development of social networks, and remove individuals from social interactions; increasing their risk of mental health problems and suicide

    Experimental investigation on Iroko wood used in shipbuilding

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    The paper deals with investigations about mechanical properties of Iroko, a hardwood species used for structures in shipbuilding as glued laminated timber. Experimental tests have been carried out to assess strength, stiffness and density of Iroko in accordance with current EN Standards. All the results obtained by tensile and three-point bending tests, along with the statistical analyses performed to define the characteristics values of some mechanical properties, are reported in the paper. These values allowed to assign the strength class, reported in EN 338 Standard, to the investigated Iroko wood population. The experiments have taken into account both solid timber strips and scarf-jointed strips, in order to evaluate the influence of such a type of joint, which is widely used in wooden shipbuilding on strength and stiffness. Eventually, peculiar investigations have been carried out to analyse the failure mode of some test pieces through special experimental techniques: three-dimensional computed tomography and infrared thermography

    Fatigue assessment of Ti-6Al-4V titanium alloy laser welded joints in absence of filler material by means of full-field techniques

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    The aim of this research activity was to study the fatigue behavior of laser welded joints of titanium alloy, in which the welding was performed using a laser source and in the absence of filler material, by means of unconventional full field techniques: Digital Image Correlation (DIC), and Infrared Thermography (IRT). The DIC technique allowed evaluating the strain gradients around the welded zone. The IRT technique allowed analyzing the thermal evolution of the welded surface during all the fatigue tests. The fatigue limit estimated using the Thermographic Method corresponds with good approximation to the value obtained from the experimental fatigue tests. The obtained results provided useful information for the development of methods and models to predict the fatigue behavior of welded T-joints in titanium alloy

    Tailored Topological Edge Waves via Chiral Hierarchical Metamaterials

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    Precise manipulation of the direction and re-direction of vibrational wave energy is a key demand in wave physics and engineering. We consider the paradigm of a finite frame-like structure and the requirement to channel energy away from critical regions, leaving them vibration-free, and redirect energy along edges towards energy concentrators for damping or energy harvesting. We design an exemplar frame metamaterial, combining two distinct areas of wave physics. Firstly, topological edge states taking an unconventional tetrachiral lattice. We control these highly localised protected edge states leveraging a hierarchy of scales through the addition of micro-resonators that impose tuneable symmetry breaking and reconfigurable mass. This allows us to achieve precise positional control in the macro-scale frame lattice, thereby opening opportunities for robust signal transport and vibration control. Experiments, theory, simulation are all utilised to provide a comprehensive analysis and interpretation of the physics

    Integrated structure for a resonant micro-gyroscope and accelerometer

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    This paper presents the study of the mechanical behavior of a microstructure designed to detect acceleration and angular velocity simultaneously. The new resonant micro-sensor proposed, fabricated by the ThELMA© surface-micromachining technique, bases detection of two components of external acceleration (one in-plane component and one out-of plane component) and two components of angular velocity (roll and yaw) on the variation of frequency of several elements set in resonance. The device, despite its small dimensions, provides a differential decoupled detection of four external quantities thanks to the presence of four slender beams resonating in bending and four torsional resonators

    Modeling and experimental verification of an ultra-wide bandgap in 3D phononic crystal

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    This paper reports a comprehensive modeling and experimental characterization of a three-dimensional phononic crystal composed of a single material, endowed with an ultra-wide complete bandgap. The phononic band structure shows a gap-mid gap ratio of 132% that is by far the greatest full 3D bandgap in literature for any kind of phononic crystals. A prototype of the finite crystal structure has been manufactured in polyamide by means of additive manufacturing technology and tested to assess the transmission spectrum of the crystal. The transmission spectrum has been numerically calculated taking into account a frequency-dependent elastic modulus and a Rayleigh model for damping. The measured and numerical transmission spectra are in good agreement and present up to 75 dB of attenuation for a three-layer crystal

    Experimental and theoretical analyses of Iroko wood laminates

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    This paper reports the experimental tests, which have been carried out to assess the mechanical properties of Iroko wood laminates used for the construction of a large wooden sailing ship. Three-point bending tests have been carried out on different types of specimens: laminates with 3 layers @ 0\ub0 and without scarf joints, laminates with 3 layers @ 0\ub0 having the outer layers with scarf joints, and laminates with 4 layers @ 0\ub0/\ub145\ub0/0\ub0 and no scarf joints. The tests have been performed in compliance with the current EN Standards. The analyses of the experimental data allowed the assessment of the mechanical properties of the laminated Iroko wood as well as the influence of scarf joints. The experimental results demonstrated that the presence of scarf joints only affect the strength of the glued laminate, while the stiffness properties in terms of Young modulus in bending and shear modulus, obtained applying the \u201cmethod of variable support span\u201d, remain essentially the same. The investigated laminates have been also analysed using a 3D computed tomography and an ultrasonic phased array equipment in order to assess the dimensions of possible defects or voids in the adhesive and the dynamic modulus of elasticity. The tomographic measurements of the glue thickness explained the reason of the reduced strength of the scarf joints, due to the inhomogeneity of the glue bond-line. The value of the dynamic modulus of elasticity, obtained by the ultrasonic technique, is slightly higher than the value of the modulus of elasticity obtained by the bending tests. Finally, the experimental findings have been compared with those drawn from both Classical Lamination Theory and Dietz approach, obtaining a good agreement and confirming that the Dietz approach is a fast and easy way to assess the elastic properties of a laminated structure

    Indole and 2,4-Thiazolidinedione conjugates as potential anticancer modulators

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    Background. Thiazolidinediones (TZDs), also called glitazones, are five-membered carbon ring molecules commonly used for the management of insulin resistance and type 2 diabetes. Recently, many prospective studies have also documented the impact of these compounds as anti-proliferative agents, though several negative side effects such as hepatotoxicity, water retention and cardiac issues have been reported. In this work, we synthesized twenty-six new TZD analogues where the thiazolidinone moiety is directly connected to an N-heterocyclic ring in order to lower their toxic effects. Methods. By adopting a widely applicable synthetic method, twenty-sixTZDderivatives were synthesized and tested for their antiproliferative activity in MTT and Wound healing assays with PC3 (prostate cancer) and MCF-7 (breast cancer) cells. Results. Three compounds, out of twenty-six, significantly decreased cellular viability and migration, and these effects were even more pronounced when compared with rosiglitazone, a well-known member of the TZD class of antidiabetic agents. As revealed by Western blot analysis, part of this antiproliferative effect was supported by apoptosis studies evaluating BCL-xL and C-PARP protein expression. Conclusion. Our data highlight the promising potential of these TZD derivatives as anti-proliferative agents for the treatment of prostate and breast cancer
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