191 research outputs found
ΠΠΎΡΡΠ΅ΠΊΡΠΈΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΉ Π³Π΅ΠΏΠ°ΡΠΎΠ±ΠΈΠ»ΠΈΠ°ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΡΠΌ ΡΠ°ΡΡΠΈΡΠ΅Π»ΡΠ½ΡΠΌ ΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ
The influence of complex herbal remedy on the secretary and metabolic functions of a liver was investigated in rates with experimental toxic hepatitis and hypercholesterolemia. The result obtained have shown that complex herbal remedy shortened the time of evolution and decreased hepatic enzymes (AST, ALT, and GGT), alkaline phosphates, total bilirubin, and cholesterol. It has also been shown that complex herbal remedy increased the protein synthesis of hepatocyte and hampered lipolysis processes. On the other hand, the active components of this remedy regulated the excessive bile production. During complex herbal remedy administration, the rheologycal properties of bile are normalized, bile acid pool extends, and total cholesterol in bile reduces. Along with hepatoprotective properties, remedy has the expressive choleretic and cholekinetic effects.ΠΠ·ΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ΅Π΄ΡΡΠ²Π° Π½Π° ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΡΡ ΠΈ ΡΠ΅ΠΊΡΠ΅ΡΠΎΡΠ½ΡΡ ΡΡΠ½ΠΊΡΠΈΡ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΊΡΡΡ Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌΠΈ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΌ Π³Π΅ΠΏΠ°ΡΠΈΡΠΎΠΌ ΠΈ Π³ΠΈΠΏΠ΅ΡΡ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π΅ΠΌΠΈΠ΅ΠΉ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΠΊΡΡΡΠ°ΠΊΡΠΈΠ²Π½ΡΠΉ ΡΠ°ΡΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΠΎΠ³ΡΠ°Π½ΠΈΡΠΈΠ²Π°Π΅Ρ Π²ΡΡ
ΠΎΠ΄ Π² ΠΊΡΠΎΠ²Ρ ΡΠΈΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Ρ
ΠΎΠ»Π΅ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΡΠΌΠ΅Π½ΡΠΎΠ², ΡΡΠΈΠΌΡΠ»ΠΈΡΡΠ΅Ρ ΡΠΈΠ½ΡΠ΅Π· Π±Π΅Π»ΠΊΠ°, ΡΠΎΡΠΌΠΎΠ·ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΡ Π»ΠΈΠΏΠΎΠ»ΠΈΠ·Π°, Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·ΡΠ΅Ρ ΠΏΠΈΠ³ΠΌΠ΅Π½ΡΠ½ΡΠΉ ΠΎΠ±ΠΌΠ΅Π½ ΠΏΠ΅ΡΠ΅Π½ΠΈ. ΠΠ° ΡΠΎΠ½Π΅ ΠΏΡΠΈΠ΅ΠΌΠ° ΡΠΊΡΡΡΠ°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·ΡΠ΅ΡΡΡ ΠΊΠΎΠ»Π»ΠΎΠΈΠ΄Π½ΠΎΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΆΠ΅Π»ΡΠΈ, ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅ΡΡΡ ΠΏΡΠ» ΠΆΠ΅Π»ΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ, ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ ΡΡΠΎΠ²Π΅Π½Ρ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° Π² ΠΆΠ΅Π»ΡΠΈ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠ΅ Ρ
ΠΎΠ»Π΅ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈ Ρ
ΠΎΠ»Π΅ΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡΡ
ΠΠΎΡΡΠ΅ΠΊΡΠΈΡ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ ΡΠΈΠΊΠ»ΠΎΡΠΎΡΡΠ°Π½Π° Π³Π΅ΠΏΠ°ΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠ°ΠΌΠΈ ΠΏΠΎΠ»ΠΈΡΠ΅Π½ΠΎΠ»ΡΠ½ΠΎΠΉ ΠΏΡΠΈΡΠΎΠ΄Ρ
Efficiency of lokhein, maksar and karsil hepatoprotectors in the treatment of cyclophosphan damaged liver has been investigated. Hepatoprotectors decrease the overall cytostatic toxicity, reduce the hepatocyte necrosis and the cell infiltration of liver parenchyma, cause the hyperaminotransferase and hyperbilirubin regression, stimulate the bilirubin conjugation and normalize the protein content in blood. Lokhein prevents most efficiently the development of morphologic disturbances in liver and recovers most of biochemical abnormalities at cyclophosphan intoxication.Π ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Ρ
Π½Π° ΠΊΡΡΡΠ°Ρ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π³Π΅ΠΏΠ°ΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠΎΠ² Π»ΠΎΡ
Π΅ΠΈΠ½Π°, ΠΌΠ°ΠΊΡΠ°ΡΠ° ΠΈ ΠΊΠ°ΡΡΠΈΠ»Π° ΠΏΡΠΈ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΡΠΈΠΊΠ»ΠΎΡΠΎΡΡΠ°Π½ΠΎΠΌ. ΠΠ΅ΠΏΠ°ΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΡ ΡΠ½ΠΈΠΆΠ°ΡΡ ΠΎΠ±ΡΡΡ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡ ΡΠΈΡΠΎΡΡΠ°ΡΠΈΠΊΠ°, ΡΠΌΠ΅Π½ΡΡΠ°ΡΡ Π½Π΅ΠΊΡΠΎΠ· Π³Π΅ΠΏΠ°ΡΠΎΡΠΈΡΠΎΠ² ΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΈΠ½ΡΠΈΠ»ΡΡΡΠ°ΡΠΈΡ ΠΏΠ°ΡΠ΅Π½Ρ
ΠΈΠΌΡ ΠΏΠ΅ΡΠ΅Π½ΠΈ, Π²ΡΠ·ΡΠ²Π°ΡΡ ΡΠ΅Π³ΡΠ΅ΡΡ Π³ΠΈΠΏΠ΅ΡΠ°ΠΌΠΈΠ½ΠΎΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Π΅ΠΌΠΈΠΈ, Π³ΠΈΠΏΠ΅ΡΠ±ΠΈΠ»ΠΈΡΡΠ±ΠΈΠ½Π΅ΠΌΠΈΠΈ, ΡΡΠΈΠΌΡΠ»ΠΈΡΡΡΡ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΈΡ Π±ΠΈΠ»ΠΈΡΡΠ±ΠΈΠ½Π°, Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·ΡΡΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π±Π΅Π»ΠΊΠ° Π² ΠΊΡΠΎΠ²ΠΈ. ΠΠΎΡ
Π΅ΠΈΠ½ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΡΠ΅Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ Π² ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΈ Π²ΠΎΡΡΡΠ°Π½Π°Π²Π»ΠΈΠ²Π°Π΅Ρ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ ΠΏΡΠΈ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΡΠΈΠΊΠ»ΠΎΡΠΎΡΡΠ°Π½ΠΎΠΌ
ΠΠ΅Π½Π°ΠΊΠΎΡΡ Π² Π°ΠΌΠ±ΡΠ»Π°ΡΠΎΡΠ½ΠΎΠΌ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ Π±ΡΠΎΠ½Ρ ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ
A cost-effectiveness analysis of supporting therapy was carried out in 30 various severity asthmatic patients against the background of use foreign anti-asthmatic drugs in 1997-1998 and the home inhaled glucocorticosteroid Benacort in 1999-2000. The patients at the exacerbation applied Benacort 800 meg daily and then the dose was reduced up to 4 0 0 -6 0 0 meg daily in mild and moderate asthmatic patients if the stable state was achieved, but not less than in 3 months.The therapy efficiency was estimated by clinical symptoms dynamics, the daily need in Ξ²2-agonists, a lung function dynamics before and in 1, 3 and 5 months of the treatment. The night asthmatic attacks disappeared in all the patients within 2 -3 weeks, the need in inhaled bronchodilators decreased sharply over a month, and a frequency of daytime asthma and cough attacks also decreased. Lung function parameters became normal in the mild asthma patients in 3 months and improved significantly in the moderate and severe asthma patients over 3 and 5 months accordingly, though the severe asthma patients did not reach the norm al lung function values. We did not reveal undesirable local effects of Benacort but we had to abolish the drug in one patient after 4 days o f the treatment because of severe cough. Generally, the out-patient application of Benacort as the basic therapy in various severity asthmatic patients was shown to control the disease course, to improve the quality of life and to reduce the yearly cost of supporting therapy for mild, moderate and severe bronchial asthma in 2.2, 1.48 and 1.71 times accordingly.ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΡΡΠΎΠΈΠΌΠΎΡΡΠΈ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°ΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Ρ 30 Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ Π² 1997-1998 Π³Π³. Π½Π° ΡΠΎΠ½Π΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΠ°ΡΡΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ² ΠΈ Π² 19 99 -200 0 Π³Π³., ΠΊΠΎΠ³Π΄Π° Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π±Π°Π·ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΡΡ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΈΠ½Π³Π°Π»ΡΡΠΈΠΎΠ½Π½ΡΠΉ ΠΠΠ‘ Π±Π΅Π½Π°ΠΊΠΎΡΡ. ΠΠ»Ρ ΠΊΡΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±ΠΎΡΡΡΠ΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ ΡΠ½Π°ΡΠ°Π»Π° ΠΈΠ½Π³Π°Π»ΠΈΡΠΎΠ²Π°Π»ΠΈ Π±Π΅Π½Π°ΠΊΠΎΡΡ Π² ΡΡΡΠΎΡΠ½ΠΎΠΉ Π΄ΠΎΠ·Π΅ 800 ΠΌ ΠΊΠ³, ΠΏΠΎΡΠ»Π΅ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΠΌΠΈΡΡΠΈΠΈ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ ΡΠ΅ΠΌ ΡΠ΅ΡΠ΅Π· 3 ΠΌΠ΅Ρ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠ Π»Π΅Π³ΠΊΠΎΠΉ ΠΈ ΡΡΠ΅Π΄Π½Π΅ΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ ΡΡΡΠΎΡΠ½Π°Ρ Π΄ΠΎΠ·Π° Π±Π΅Π½Π°ΠΊΠΎΡΡΠ° ΡΠ½ΠΈΠΆΠ°Π»Π°ΡΡ Π΄ΠΎ 4 0 0 -6 0 0 ΠΌΠΊΠ³. ΠΡΠ΅Π½ΠΊΠ° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΠΏΠΎ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ², ΡΡΡΠΎΡΠ½ΠΎΠΉ ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΠΈ Π² Ξ²2-Π°Π΄ΡΠ΅Π½ΠΎΡΡΠΈΠΌΡΠ»ΡΡΠΎΡΠ°Ρ
, Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ Π€ Π Π Π΄ΠΎ Π½Π°ΡΠ°Π»Π° Π»Π΅ΡΠ΅Π½ΠΈΡ, ΡΠ΅ΡΠ΅Π· 1, 3 ΠΈ 5 ΠΌΠ΅Ρ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 2 -3 Π½Π΅Π΄ Ρ Π²ΡΠ΅Ρ
Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΏΡΠ΅ΠΊΡΠ°ΡΠΈΠ»ΠΈΡΡ Π½ΠΎΡΠ½ΡΠ΅ ΠΏΡΠΈΡΡΡΠΏΡ ΡΠ΄ΡΡΡΡ, ΡΠ΅ΡΠ΅Π· ΠΌΠ΅ΡΡΡ ΡΠ΅Π·ΠΊΠΎ ΡΠ½ΠΈΠ·ΠΈΠ»Π°ΡΡ ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΡ Π² ΠΈΠ½Π³Π°Π»ΡΡΠΈΠΎΠ½Π½ΡΡ
Π±ΡΠΎΠ½Ρ
ΠΎΠ»ΠΈΡΠΈΠΊΠ°Ρ
, ΡΠΌΠ΅Π½ΡΡΠΈΠ»Π°ΡΡ ΡΠ°ΡΡΠΎΡΠ° ΠΏΡΠΈΡΡΡΠΏΠΎΠ² ΡΠ΄ΡΡΡΡ ΠΈ ΠΊΠ°ΡΠ»Ρ Π΄Π½Π΅ΠΌ . Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠ Π»Π΅Π³ΠΊΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ Π€ Π Π Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π»ΠΈΡΡ ΡΠ΅ΡΠ΅Π· 3 ΠΌΠ΅Ρ, Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠ ΡΡΠ΅Π΄Π½Π΅ΠΉ ΠΈ ΡΡΠΆΠ΅Π»ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠ΅ ΡΠ»ΡΡΡΠ΅Π½ΠΈΠ΅ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² Π€ Π Π ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΡΠ΅ΡΠ΅Π· 3 ΠΈ 5 ΠΌΠ΅Ρ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ, Ρ
ΠΎΡΡ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΡΠΆΠ΅Π»ΠΎΠΉ ΠΠ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π½Π΅ Π΄ΠΎΡΡΠΈΠ³Π»ΠΈ Π΄ΠΎΠ»ΠΆΠ½ΡΡ
Π²Π΅Π»ΠΈΡΠΈΠ½. ΠΠ°ΠΌΠΈ Π½Π΅ Π²ΡΡΠ²Π»Π΅Π½Ρ Π½Π΅ΠΆΠ΅Π»Π°ΡΠ΅Π»ΡΠ½ΡΠ΅ ΠΌΠ΅ΡΡΠ½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ Π±Π΅Π½Π°ΠΊΠΎΡΡΠ°. Π£ 1 Π±ΠΎΠ»ΡΠ½ΠΎΠΉ ΠΈΠ·-Π·Π° Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠ°ΡΠ»Ρ ΠΏΡΠΈΡΠ»ΠΎΡΡ ΠΏΡΠ΅ΠΊΡΠ°ΡΠΈΡΡ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΡΠ΅Π· 4 Π΄Π½Ρ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π±Π΅Π½Π°ΠΊΠΎΡΡΠ° Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π±Π°Π·ΠΈΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Ρ Π°ΠΌΠ±ΡΠ»Π°ΡΠΎΡΠ½ΡΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π΄ΠΎΠ±ΠΈΡΡΡΡ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΠΏΠΎΠ²ΡΡΠΈΡΡ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΆΠΈΠ·Π½ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈ ΡΠ½ΠΈΠ·ΠΈΡΡ ΡΡΠΎΠΈΠΌΠΎΡΡΡ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°ΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π² Π³ΠΎΠ΄ Π΄Π»Ρ 1-Π³ΠΎ Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ ΠΠ Π»Π΅Π³ΠΊΠΎΠΉ, ΡΡΠ΅Π΄Π½Π΅ΠΉ ΠΈ ΡΡΠΆΠ΅Π»ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ Π² 2,2, 1,48, 1,71 ΡΠ°Π·Π° ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ
Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients
Β© 2017 Nailya Kubysheva et al. The definition of new markers of local and systemic inflammation of chronic obstructive pulmonary disease (COPD) is one of the priority directions in the study of pathogenesis and diagnostic methods improvement for this disease. We investigated 91 patients with COPD and 21 healthy nonsmokers. The levels of soluble CD25, CD38, CD8, and HLA-I-CD8 molecules in the blood serum and exhaled breath condensate (EBC) in moderate-to-severe COPD patients during exacerbation and stable phase were studied. An unidirectional change in the content of sCD25, sCD38, and sCD8 molecules with increasing severity of COPD was detected. The correlations between the parameters of lung function and sCD8, sCD25, and sHLA-I-CD8 levels in the blood serum and EBC were discovered in patients with severe COPD. The findings suggest a pathogenetic role of the investigated soluble molecules of the COPD development and allow considering the content of sCD8, sCD25, and sHLA-I-CD8 molecules as additional novel systemic and endobronchial markers of the progression of chronic inflammation of this disease
Π€Π°ΡΠΌΠ°ΠΊΠΎΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ°ΡΡΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΡΠ΅Π΄ΡΡΠ²
The problems of the clinical and economic efficiency of the bronchial asthma treatment with salben, saltos and benacort are considered. It is shown that the Russian anti-asthmatic preparations are not inferior to the foreign analogs as for the therapy efficiency. Introduction of these preparations into a large-scale clinical practice can provide for a considerable economic and social effect.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ Π²ΠΎΠΏΡΠΎΡΡ, ΠΊΠ°ΡΠ°ΡΡΠΈΠ΅ΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ°Π»ΡΠ±Π΅Π½Π°, ΡΠ°Π»ΡΡΠΎΡΠ° ΠΈ Π±Π΅Π½Π°ΠΊΠΎΡΡΠ° Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ°ΡΡΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ Π½Π΅ ΡΡΡΡΠΏΠ°ΡΡ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΠΌ Π°Π½Π°Π»ΠΎΠ³Π°ΠΌ. ΠΠ½Π΅Π΄ΡΠ΅Π½ΠΈΠ΅ ΡΡΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π² ΡΠΈΡΠΎΠΊΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΡΡ ΠΏΡΠ°ΠΊΡΠΈΠΊΡ ΠΌΠΎΠΆΠ΅Ρ Π΄Π°ΡΡ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΠΉ ΡΡΡΠ΅ΠΊΡ
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΡΠ΅Π½ΠΎΠ»ΡΠ½ΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² ΡΠ΄ΡΠΎΠ²ΠΎΠΉ Π΄ΡΠ΅Π²Π΅ΡΠΈΠ½Ρ ΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ ΠΌΠ°Π°ΠΊΠΈΠΈ Π°ΠΌΡΡΡΠΊΠΎΠΉ Π½Π° ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎ-ΡΠ΅Π·ΠΎΠ½Π°Π½ΡΠ½ΡΠ΅ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ
Comparative evaluation of hepatoprotective properties of polyphenolic fraction from wood (Maksar) and a polyphenolic complex of cell culture of Maakia amurensis.Therapeutic efficacy of the objects was assessed by their effect on the MR tomographic performance of the liver of rats with experimental Π‘Cl4-hepatitis. Hepatoprotective activity of polyphenol complex cell culture Maakia amurensis is not inferior to the original effect of the drug Maksar.ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½Π°Ρ ΠΎΡΠ΅Π½ΠΊΠ° Π³Π΅ΠΏΠ°ΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΏΠΎΠ»ΠΈΡΠ΅Π½ΠΎΠ»ΡΠ½ΠΎΠΉ ΡΡΠ°ΠΊΡΠΈΠΈ ΡΠ΄ΡΠΎΠ²ΠΎΠΉ Π΄ΡΠ΅Π²Π΅ΡΠΈΠ½Ρ ΠΌΠ°Π°ΠΊΠΈΠΈ Π°ΠΌΡΡΡΠΊΠΎΠΉ (ΠΌΠ°ΠΊΡΠ°Ρ) ΠΈ ΠΏΠΎΠ»ΠΈΡΠ΅Π½ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ ΠΌΠ°Π°ΠΊΠΈΠΈ Π°ΠΌΡΡΡΠΊΠΎΠΉ.Π’Π΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ² ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΏΠΎ ΠΈΡ
Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎ-ΡΠ΅Π·ΠΎΠ½Π°Π½ΡΠ½ΡΠ΅ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΊΡΡΡ Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌ Π‘Cl4-Π³Π΅ΠΏΠ°ΡΠΈΡΠΎΠΌ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π³Π΅ΠΏΠ°ΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠΎΠ»ΠΈΡΠ΅Π½ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ ΠΌΠ°Π°ΠΊΠΈΠΈ Π°ΠΌΡΡΡΠΊΠΎΠΉ Π½Π΅ ΡΡΡΡΠΏΠ°Π΅Ρ ΡΡΡΠ΅ΠΊΡΡ ΠΎΡΠΈΠ³ΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Β«ΠΠ°ΠΊΡΠ°ΡΒ»
Π Π°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΡ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π°Π»Π»Π΅ΡΠ³ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° Π±ΡΠΎΠ½Ρ ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΡ Π² ΠΠΎΡΡΠΎΡΠ½ΠΎΠΉ Π‘ΠΈΠ±ΠΈΡΠΈ
The paper reports the data of a two-stage research conducted in random groups of schoolchildren (n=8247) aged 7β8 and 13β14 years and adults (n=5395) aged 20β59 years living at an industrial city (Irkutsk) and in a rural area. The first stage included a questionnaire screening (using the ISAAC and ECRHS questionnaires). During the second stage clinical and allergological as well as functional examinations were carried out in the subjects who reported asthma-like symptoms. The BA prevalence was 4.6β8.3% for children and teenagers and 3.1β5.6% for adults according to the investigation results. These results are considerably higher than statistical data given by medical institutions. The highest prevalence index was registered among the population of the industrial city, that is likely to be connected with a high level of industrial air pollution. An atopic type of the disease predominates in the etiological structure of BA and constitutes 68β73% and 89β92% among adults and children respectively. The analysis of the obtained results evidences that late diagnostics of BA takes place at the region, that is the reason of high proportion of patients with severe and complicated course of the disease.ΠΡΠΈΠ²ΠΎΠ΄ΡΡΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π΄Π²ΡΡ
ΡΡΠ°ΠΏΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π² ΡΠ»ΡΡΠ°ΠΉΠ½ΡΡ
Π²ΡΠ±ΠΎΡΠΊΠ°Ρ
ΡΠΊΠΎΠ»ΡΠ½ΠΈΠΊΠΎΠ² 7β8 ΠΈ 13β14 Π»Π΅ΡΠ½Π΅Π³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° (8247 ΡΠ΅Π».) ΠΈ Π²Π·ΡΠΎΡΠ»ΡΡ
20β59 Π»Π΅Ρ (5395 ΡΠ΅Π».) Π² ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎ ΡΠ°Π·Π²ΠΈΡΠΎΠΌ Π³ΠΎΡΠΎΠ΄Π΅ ΠΡΠΊΡΡΡΠΊΠ΅ ΠΈ Π² ΡΠ΅Π»ΡΡΠΊΠΎΠΌ ΡΠ°ΠΉΠΎΠ½Π΅. ΠΠ΅ΡΠ²ΡΠΉ ΡΡΠ°ΠΏ Π²ΠΊΠ»ΡΡΠ°Π» Π² ΡΠ΅Π±Ρ Π°Π½ΠΊΠ΅ΡΠ½ΡΠΉ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³ (Π²ΠΎΠΏΡΠΎΡΠ½ΠΈΠΊΠΈ ISAAC ΠΈ ECRHS). ΠΠ° Π²ΡΠΎΡΠΎΠΌ ΡΡΠ°ΠΏΠ΅ Π»ΠΈΡΠ°ΠΌ Ρ Π°ΡΡΠΌΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΡΠΌΠΈ ΡΠΈΠΌΠΏΡΠΎΠΌΠ°ΠΌΠΈ (1753 ΡΠ΅Π».) ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π°Π»Π»Π΅ΡΠ³ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅. ΠΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΡ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΡ (ΠΠ) ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° ΡΡΠ΅Π΄ΠΈ Π΄Π΅ΡΠ΅ΠΉ 4,6β8,3% ΠΈ ΡΡΠ΅Π΄ΠΈ Π²Π·ΡΠΎΡΠ»ΡΡ
β 3,1β5,6%, ΡΡΠΎ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΡΠ΅Π²ΡΡΠ°Π΅Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΡΡΠ΅ΡΠ½ΠΎΡΡΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ
ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ. ΠΠ°ΠΈΠ±ΠΎΠ»ΡΡΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΠΈ ΠΠ ΠΎΡΠΌΠ΅ΡΠ΅Π½Ρ ΡΡΠ΅Π΄ΠΈ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎ ΡΠ°Π·Π²ΠΈΡΠΎΠ³ΠΎ Π³ΠΎΡΠΎΠ΄Π°, ΡΡΠΎ ΡΠ²ΡΠ·ΡΠ²Π°Π΅ΡΡΡ Ρ Π²ΡΡΠΎΠΊΠΈΠΌ ΡΡΠΎΠ²Π½Π΅ΠΌ ΡΠ΅Ρ
Π½ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΡ Π΅Π³ΠΎ Π²ΠΎΠ·Π΄ΡΡΠ½ΠΎΠΉ ΡΡΠ΅Π΄Ρ. Π ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΡΠΊΡΡΡΠ΅ ΠΠ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΎΡΠΌΠ° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠ°Ρ ΡΡΠ΅Π΄ΠΈ Π²Π·ΡΠΎΡΠ»ΡΡ
Β Π±ΠΎΠ»ΡΠ½ΡΡ
68β73% ΠΈ ΡΡΠ΅Π΄ΠΈ Π΄Π΅ΡΠ΅ΠΉ β 89β92%. ΠΠ½Π°Π»ΠΈΠ· ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠ΄Π΅Π»Π°ΡΡ Π²ΡΠ²ΠΎΠ΄ ΠΎ ΠΏΠΎΠ·Π΄Π½Π΅ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π² ΡΠ΅Π³ΠΈΠΎΠ½Π΅, ΡΡΠΎ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»ΠΈΠ²Π°Π΅Ρ Π²ΡΡΠΎΠΊΠΈΠΉ ΡΠ΄Π΅Π»ΡΠ½ΡΠΉ Π²Π΅Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΡΡΠΆΠ΅Π»ΡΠΌ ΠΈ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΡΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΠ
ΠΠ΅ΠΏΠ°ΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΏΠΎΠ»ΠΈΡΠ΅Π½ΠΎΠ»ΡΠ½ΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² ΠΈΠ· Π΄ΡΠ΅Π²Π΅ΡΠΈΠ½Ρ ΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ ΠΌΠ°Π°ΠΊΠΈΠΈ Π°ΠΌΡΡΡΠΊΠΎΠΉ
Annot For finding-out of a role of separate groups of polyphenols in realization hepatoprotective properties of maksar we investigate activity of polyphenolic complexes (PPC) from duramen and cellular culture of maakia amur. Experiments are carried out on 40 not purebred white rats with an experimental Π‘Cl4-hepatites. Therapeutic efficiency of researched objects estimated on their influence on survival rate of animals, morphological and biochemical parameters of a liver and wheys of blood. In rat's CCl4-hepatitis PPC from duramen and cellular culture of maakia amur reduce the acute toxity of tetrachloromethane, decrease the necrosis of hepatocytes and cellural infiltration of liver's parenchyma, prevent from development of fatty and protein dystrophy of a liver, normalize the activity of amino transferase, -glutamyltransferase in blood, the concentration of proteins and lipids, stimulate conjugation of bilirubin. The therapeutic effect of PPC of cellular culture is more evident. The hepatoprotective action is caused by a presence of isoflavonoids daidzein, retuzin, genistein, afromozin, formononetin, orobol, tektorigenin, maakiain and medicarpin. PPC from a culture of cells doesn't influence on a level of cholesterol in blood, that apparently is caused by an absence of mono- and dimeric stilbenes in its structure.ΠΠ»Ρ Π²ΡΡΡΠ½Π΅Π½ΠΈΡ ΡΠΎΠ»ΠΈ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ
Π³ΡΡΠΏΠΏ ΠΏΠΎΠ»ΠΈΡΠ΅Π½ΠΎΠ»ΠΎΠ² Π² ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π³Π΅ΠΏΠ°ΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΌΠ°ΠΊΡΠ°ΡΠ° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠΎΠ»ΠΈΡΠ΅Π½ΠΎΠ»ΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² (ΠΠ€Π) ΠΈΠ· ΡΠ΄ΡΠΎΠ²ΠΎΠΉ Π΄ΡΠ΅Π²Π΅ΡΠΈΠ½Ρ ΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ ΠΌΠ°Π°ΠΊΠΈΠΈ Π°ΠΌΡΡΡΠΊΠΎΠΉ. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π½Π° 40 Π±Π΅ΡΠΏΠΎΡΠΎΠ΄Π½ΡΡ
Π±Π΅Π»ΡΡ
ΠΊΡΡΡΠ°Ρ
-ΡΠ°ΠΌΡΠ°Ρ
Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌ Π‘Cl4-Π³Π΅ΠΏΠ°ΡΠΈΡΠΎΠΌ. Π’Π΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ² ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΏΠΎ ΠΈΡ
Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΈ ΡΡΠ²ΠΎΡΠΎΡΠΊΠΈ ΠΊΡΠΎΠ²ΠΈ. ΠΡΠΈ CCl4-Π³Π΅ΠΏΠ°ΡΠΈΡΠ΅ Ρ ΠΊΡΡΡ ΠΠ€Π ΠΈΠ· ΡΠ΄ΡΠΎΠ²ΠΎΠΉ Π΄ΡΠ΅Π²Π΅ΡΠΈΠ½Ρ ΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ ΠΌΠ°Π°ΠΊΠΈΠΈ Π°ΠΌΡΡΡΠΊΠΎΠΉ ΡΠ½ΠΈΠΆΠ°ΡΡ ΠΎΡΡΡΡΡ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½Π°, ΡΠΌΠ΅Π½ΡΡΠ°ΡΡ Π½Π΅ΠΊΡΠΎΠ· Π³Π΅ΠΏΠ°ΡΠΎΡΠΈΡΠΎΠ² ΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΈΠ½ΡΠΈΠ»ΡΡΡΠ°ΡΠΈΡ ΠΏΠ°ΡΠ΅Π½Ρ
ΠΈΠΌΡ ΠΏΠ΅ΡΠ΅Π½ΠΈ, ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΡΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π² ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΆΠΈΡΠΎΠ²ΠΎΠΉ ΠΈ Π±Π΅Π»ΠΊΠΎΠ²ΠΎΠΉ Π΄ΠΈΡΡΡΠΎΡΠΈΠΈ, Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·ΡΡΡ Π² ΠΊΡΠΎΠ²ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π°ΠΌΠΈΠ½ΠΎΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·, Ξ³-Π³Π»ΡΡΠ°ΠΌΠΈΠ»ΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Ρ, ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π±Π΅Π»ΠΊΠ° ΠΈ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², ΡΡΠΈΠΌΡΠ»ΠΈΡΡΡΡ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΈΡ Π±ΠΈΠ»ΠΈΡΡΠ±ΠΈΠ½Π°. ΠΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ ΠΠ€Π ΠΈΠ· ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ. ΠΠ΅ΠΏΠ°ΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ Π² ΠΠ€Π ΠΈΠ·ΠΎΡΠ»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ² Π΄Π°ΠΈΠ΄Π·Π΅ΠΈΠ½Π°, ΡΠ΅ΡΡΠ·ΠΈΠ½Π°, Π³Π΅Π½ΠΈΡΡΠ΅ΠΈΠ½Π°, Π°ΡΡΠΎΠΌΠΎΠ·ΠΈΠ½Π°, ΡΠΎΡΠΌΠΎΠ½ΠΎΠ½Π΅ΡΠΈΠ½Π°, ΠΎΡΠΎΠ±ΠΎΠ»Π°, ΡΠ΅ΠΊΡΠΎΡΠΈΠ³Π΅Π½ΠΈΠ½Π°, ΠΌΠ°Π°ΠΊΠΈΠ°ΠΈΠ½Π° ΠΈ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΡΠΏΠΈΠ½Π°. ΠΠ€Π ΠΈΠ· ΠΊΡΠ»ΡΡΡΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π½Π΅ Π²Π»ΠΈΡΠ΅Ρ Π½Π° ΡΡΠΎΠ²Π΅Π½Ρ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° Π² ΠΊΡΠΎΠ²ΠΈ, ΡΡΠΎ, ΠΏΠΎ-Π²ΠΈΠ΄ΠΈΠΌΠΎΠΌΡ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ΠΌ Π² Π΅Π³ΠΎ ΡΠΎΡΡΠ°Π²Π΅ ΠΌΠΎΠ½ΠΎ- ΠΈ Π΄ΠΈΠΌΠ΅ΡΠ½ΡΡ
ΡΡΠΈΠ»ΡΠ±Π΅Π½ΠΎΠ²
ΠΠ€Π€ΠΠΠ’Π« ΠΠ ΠΠ‘Π‘ΠΠΠΠΠΠ Π ΠΠ ΠΠ‘Π‘ΠΠΠΠΠΠ ΠΠ Π ΠΠΠΠΠΠ ΠΠ‘Π’Π ΠΠ ΠΠΠΠΠ ΠΠΠΠΠΠΠΠΠ, ΠΠΠΠ£Π¦ΠΠ ΠΠΠΠΠΠΠ ΠΠ’ΠΠΠΠΠΠ
Objective: study sesquiterpene lactones grosshemin and grossmisin lipid-lowering properties on the model of acute hyperlipidemia induced by ethanol in rats.Materials and methods. Rats during 7 days injected into the stomach grosshemin and grossmisin in a dose 10 mg/kg or reference drug nicotinic acid in a dose 25 mg/kg. Hyperlipidemia caused by single introduction of ethanol into the stomach in a dose 5 g/kg. In blood serum of tail vein measured the triacylglycerols, total cholesterol, high density and low density lipoproteins cholesterol, also the level of free fatty acids. Calculated the ratio of high density lipoproteins cholesterol to the amount of low density lipoproteins cholesterol and the index of atherogenicity.Results. A single dose of ethanol increased serum level of triacylglycerols in 1.9 times, free fatty acids β in 3.2 times, low density lipoproteins β on 44% in comparison with the intact animals indices. It shows the development of acute hyperlipidemia. Serum total cholesterol, high density lipoproteins cholesterol and the index of atherogenicity were not changed. Course sesquiterpene lactones grosshemin and grossmisin introduction against the background of acute hyperlipidemia was accompanied by a decrease in the serum of triacylglycerols levels respectively by 19.8% and 34.1%. Nicotinic acid lowered the content of triacylglycerols by 42.4%. Grosshemin and nicotinic acid reduced the increased level of free fatty acids in the blood serum by 60.7β67.9%. Grossmisin and nicotinic acid decreased by 14.6β17.2% of total cholesterol in the blood serum. In acute hyperlipidemia grosshemin and grossmisin reduced low density lipoproteins cholesterol by 17.6% and 20%, respectively, nicotinic acid β by 15.7%. Both of sesquiterpene lactone and nicotinic acid did not modify the content of high density lipoproteins cholesterol. When introduction grosshemin, grossmisin and nicotinic acid ratio of high density lipoproteins cholesterol to the amount of low density lipoproteins cholesterol significantly increased by 42.8%, 38,6% and 22.1% respectively.Conclusion. Sesquiterpene lactones grosshemin and grossmisin posses hypolipidemic effect in acute experimental hyperlipidemia caused by the ethanol introduction. Lactones normalize many indices of lipid metabolism, which can be caused by different biochemical targets of these molecules. Lactones, as nicotinic acid, in the model of acute hyperlipidemia decrease in blood serum triacylglycerols, total cholesterol, and low density lipoproteins cholesterol content. Grosshemin and nicotinic acid also reduce the free fatty acids level.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΈΠ·ΡΡΠΈΡΡ Π³ΠΈΠΏΠΎΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΠ΅ΡΠΊΠ²ΠΈΡΠ΅ΡΠΏΠ΅Π½ΠΎΠ²ΡΡ
Π»Π°ΠΊΡΠΎΠ½ΠΎΠ² Π³ΡΠΎΡΡΠ³Π΅ΠΌΠΈΠ½Π° ΠΈ Π³ΡΠΎΡΡΠΌΠΈΠ·ΠΈΠ½Π° ΠΏΡΠΈ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΎΡΡΡΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΠΈ, ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΡΠ°Π½ΠΎΠ»ΠΎΠΌ Ρ ΠΊΡΡΡ.ΠΡΡΡΠ°ΠΌ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 7 ΡΡΡ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ Π² ΠΆΠ΅Π»ΡΠ΄ΠΎΠΊ Π³ΡΠΎΡΡΠ³Π΅ΠΌΠΈΠ½ ΠΈ Π³ΡΠΎΡΡΠΌΠΈΠ·ΠΈΠ½ Π² Π΄ΠΎΠ·Π΅ 10 ΠΌΠ³/ΠΊΠ³ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° ΠΈΠ»ΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΡΡ ΠΊΠΈΡΠ»ΠΎΡΡ Π² Π΄ΠΎΠ·Π΅ 25 ΠΌΠ³/ΠΊΠ³ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π°. ΠΠΈΠΏΠ΅ΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΡ Ρ ΠΊΡΡΡ Π²ΡΠ·ΡΠ²Π°Π»ΠΈ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΡΠΌ Π²Π½ΡΡΡΠΈΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΡΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ ΡΡΠ°Π½ΠΎΠ»Π° Π² Π΄ΠΎΠ·Π΅ 5 Π³/ΠΊΠ³ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π°. Π ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ Ρ
Π²ΠΎΡΡΠΎΠ²ΠΎΠΉ Π²Π΅Π½Ρ ΠΈΠ·ΠΌΠ΅ΡΡΠ»ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΡΡΠΈΠ°ΡΠΈΠ»Π³Π»ΠΈΡΠ΅ΡΠΈΠ΄ΠΎΠ², ΠΎΠ±ΡΠ΅Π³ΠΎ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π°, Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° Π»ΠΈΠΏΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΎΠ² Π½ΠΈΠ·ΠΊΠΎΠΉ (ΠΠΠΠ) ΠΈ Π²ΡΡΠΎΠΊΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ (ΠΠΠΠ), ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΡ
ΠΆΠΈΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ. ΠΡΡΠΈΡΠ»ΡΠ»ΠΈ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΠΠΠ ΠΊ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Ρ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° ΠΠΠΠ ΠΈ ΠΈΠ½Π΄Π΅ΠΊΡ Π°ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΠΈ.ΠΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎΠ΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΡΡΠ°Π½ΠΎΠ»Π° ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π»ΠΎ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΡΡΠΎΠ²Π΅Π½Ρ ΡΡΠΈΠ°ΡΠΈΠ»Π³Π»ΠΈΡΠ΅ΡΠΈΠ΄ΠΎΠ² Π² 1,9 ΡΠ°Π·Π°, ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΡ
ΠΆΠΈΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ Π² 3,2 ΡΠ°Π·Π°, Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° ΠΠΠΠ β Π½Π° 44% ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΠΈΠ½ΡΠ°ΠΊΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. ΠΡΠΎ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΎΡΡΡΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΠΈ. Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΎΠ±ΡΠ΅Π³ΠΎ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π°, Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° ΠΠΠΠ ΠΈ ΠΈΠ½Π΄Π΅ΠΊΡ Π°ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΠΈ Π½Π΅ ΠΈΠ·ΠΌΠ΅Π½ΡΠ»ΠΈΡΡ.ΠΡΡΡΠΎΠ²ΠΎΠ΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΡΠ΅ΡΠΊΠ²ΠΈΡΠ΅ΡΠΏΠ΅Π½ΠΎΠ²ΡΡ
Π»Π°ΠΊΡΠΎΠ½ΠΎΠ² Π³ΡΠΎΡΡΠ³Π΅ΠΌΠΈΠ½Π° ΠΈ Π³ΡΠΎΡΡΠΌΠΈΠ·ΠΈΠ½Π° Π½Π° ΡΠΎΠ½Π΅ ΠΎΡΡΡΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΠΈ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π»ΠΎΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΡΡΠΎΠ²Π½Ρ ΡΡΠΈΠ°ΡΠΈΠ»Π³Π»ΠΈΡΠ΅ΡΠΈΠ΄ΠΎΠ² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ Π½Π° 19,8 ΠΈ 34,1%. ΠΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° ΡΠΌΠ΅Π½ΡΡΠ°Π»Π° ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΡΡΠΈΠ°ΡΠΈΠ»Π³Π»ΠΈΡΠ΅ΡΠΈΠ΄ΠΎΠ² Π½Π° 42,4%. ΠΡΠΎΡΡΠ³Π΅ΠΌΠΈΠ½ ΠΈ Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° ΡΠ½ΠΈΠΆΠ°Π»ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΡ
ΠΆΠΈΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΊΡΡΡ Π½Π° 60,7β67,9%. ΠΡΠΎΡΡΠΌΠΈΠ·ΠΈΠ½ ΠΈ Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° ΡΠΌΠ΅Π½ΡΡΠ°Π»ΠΈ Π½Π° 14,6β17,2% ΡΡΠΎΠ²Π΅Π½Ρ ΠΎΠ±ΡΠ΅Π³ΠΎ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π°.ΠΡΠΈ ΠΎΡΡΡΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΠΈ Π³ΡΠΎΡΡΠ³Π΅ΠΌΠΈΠ½ ΠΈ Π³ΡΠΎΡΡΠΌΠΈΠ·ΠΈΠ½ ΡΠ½ΠΈΠΆΠ°Π»ΠΈ ΡΡΠΎΠ²Π΅Π½Ρ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° ΠΠΠΠ Π½Π° 17,6β20,0%, Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° β Π½Π° 15,7%. ΠΠ±Π° ΡΠ΅ΡΠΊΠ²ΠΈΡΠ΅ΡΠΏΠ΅Π½ΠΎΠ²ΡΡ
Π»Π°ΠΊΡΠΎΠ½Π° ΠΈ Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° Π½Π΅ ΠΈΠ·ΠΌΠ΅Π½ΡΠ»ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° ΠΠΠΠ. ΠΡΠΈ ΠΊΡΡΡΠΎΠ²ΠΎΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ Π³ΡΠΎΡΡΠ³Π΅ΠΌΠΈΠ½Π°, Π³ΡΠΎΡΡΠΌΠΈΠ·ΠΈΠ½Π° ΠΈ Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° ΠΠΠΠ ΠΊ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Ρ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° ΠΠΠΠ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π»ΠΎΡΡ Π½Π° 42,8; 38,6 ΠΈ 22,1% ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎΠ‘Π΅ΡΠΊΠ²ΠΈΡΠ΅ΡΠΏΠ΅Π½ΠΎΠ²ΡΠ΅ Π»Π°ΠΊΡΠΎΠ½Ρ Π³ΡΠΎΡΡΠ³Π΅ΠΌΠΈΠ½ ΠΈ Π³ΡΠΎΡΡΠΌΠΈΠ·ΠΈΠ½ ΠΎΠ±Π»Π°Π΄Π°ΡΡ Π³ΠΈΠΏΠΎΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΠΏΡΠΈ ΠΎΡΡΡΠΎΠΉ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΠΈ, Π²ΡΠ·Π²Π°Π½Π½ΠΎΠΉ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ ΡΡΠ°Π½ΠΎΠ»Π°. ΠΠ°ΠΊΡΠΎΠ½Ρ Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·ΡΡΡ ΠΌΠ½ΠΎΠ³ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π»ΠΈΠΏΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°, ΡΡΠΎ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ ΡΠ°Π·Π½ΡΠΌΠΈ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΌΠΈΡΠ΅Π½ΡΠΌΠΈ Π΄Π»Ρ ΡΡΠΈΡ
ΠΌΠΎΠ»Π΅ΠΊΡΠ». ΠΠ°ΠΊΡΠΎΠ½Ρ, ΠΊΠ°ΠΊ ΠΈ Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ°, ΠΏΡΠΈ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΎΡΡΡΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΠΈ ΡΠ½ΠΈΠΆΠ°ΡΡ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΡΡΠΈΠ°ΡΠΈΠ»Π³Π»ΠΈΡΠ΅ΡΠΈΠ΄ΠΎΠ², ΠΎΠ±ΡΠ΅Π³ΠΎ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° ΠΈ Ρ
ΠΎΠ»Π΅ΡΡΠ΅ΡΠΈΠ½Π° ΠΠΠΠ. ΠΡΠΎΡΠ³Π΅ΠΌΠΈΠ½ ΠΈ Π½ΠΈΠΊΠΎΡΠΈΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° ΡΠ°ΠΊΠΆΠ΅ ΡΠΌΠ΅Π½ΡΡΠ°ΡΡ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΡ
ΠΆΠΈΡΠ½ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ
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