Assessment of the prognostic impact of the Epstein–Barr virus-encoded latent membrane protein-1 expression in Hodgkin's disease

We have examined expression of the Epstein–Barr virus (EBV) latent membrane protein-1 (LMP1) in the malignant Hodgkin and Reed–Sternberg (HRS) cells of Hodgkin's disease (HD) and its impact on response to treatment and on survival. Paraffin tissue from 100 adult immunocompetent patients with HD were analysed using immunohistochemistry to identify LMP1 expression. According to the Rye classification, 8% of patients had lymphocyte predominance (LP) subtype, 48% had nodular sclerosis (NS) disease, 37% were of the mixed cellularity (MC) subtype and 7% were of the lymphocyte depletion (LD) subtype. During the five year follow-up period 27 patients died and 74 patients achieved a complete remission. Patients with LD subtype were older (P = 0.03), less frequently achieved complete remission (P = 0.01), had shorter disease-free survival (P = 0.01) and overall survival (P = 0.002) compared with the other subtypes of HD. LMP1 expression was found in the tumour cells of 26% of cases of HD. LMP1 expression was less common in NS disease than in the other subtypes (P = 0.05), whereas an association between MC subtype and LMP1 expression was not found (P = 0.22). Using the log-rank test there were no differences in overall survival or disease-free survival based on EBV status either when all patients were analysed or when LD and LP subtypes were excluded. However, the presence of EBV was associated with significantly longer disease-free survival in the subgroup of patients ≤ 30 years old (P = 0.02) and in those patients ≤ 34 years old (P = 0.05). In contrast, there was a trend for shorter disease-free survival for EBV-positive patients in the subgroup > 35 years old, but this difference was not statistically significant (P = 0.11). A similar trend was observed in patients > 50 years old. Analysis of the impact of LMP1 expression in patients who had different stage and B symptoms status showed that expression of EBV was associated with longer disease-free survival (P = 0.019) in early stage (1 + 2) patients without B symptoms. Significant differences in the other subgroups based on EBV status was not found. Factors adversely affecting the likelihood to achieve a complete remission were: absence of LMP1 expression (OR 6.4, 95% Cl 1.07–38.5, P = 0.04), age (OR 1.68, 95%Cl 1.15–2.5, P = 0.007) and subtype of HD (OR 3.32, 95%Cl 1.11–9.94, P = 0.03). Age and subtype of HD had an independent impact on overall survival (P = 0.01). We conclude that expression of LMP1 in HRS cells has a favourable impact on prognosis for HD patients, but that this effect may be restricted to young adult patients and those with early stage disease. © 2001 Cancer Research Campaign http://www.bjcancer.co

Challenges of Misbehavior Detection in Industrial Wireless Networks

In recent years, wireless technologies are increasingly adopted in many application domains that were either unconnected before or exclusively used cable networks. This paradigm shift towards - often ad-hoc - wireless communication has led to significant benefits in terms of flexibility and mobility. Alongside with these benefits, however, arise new attack vectors, which cannot be mitigated by traditional security measures. Hence, mechanisms that are orthogonal to cryptographic security techniques are necessary in order to detect adversaries. In traditional networks, such mechanisms are subsumed under the term "intrusion detection system" and many proposals have been implemented for different application domains. More recently, the term "misbehavior detection" has been coined to encompass detection mechanisms especially for attacks in wireless networks. In this paper, we use industrial wireless networks as an exemplary application domain to discuss new directions and future challenges in detecting insider attacks. To that end, we review existing work on intrusion detection in mobile ad-hoc networks. We focus on physical-layer-based detection mechanisms as these are a particularly interesting research direction that had not been reasonable before widespread use of wireless technology.Peer Reviewe

Internet of things: where to be is to trust

[EN] Networks' creation is getting more and more required, anytime, anywhere. Devices that can participate on these networks can be quite different among them. Sensors, mobiles, home appliances, or other type of devices will have to collaborate to increase and improve the services provided to clients. In the same way, network configuration, security mechanisms establishment, and optimal performance control must be done by them. Some of these devices could have limited resources to work, sometimes even resources restriction not existing, they must work to optimize network traffic. In this article, we center our researching on spontaneous networks. We propose a secure spontaneous ad-hoc network, based on direct peer-to-peer interaction and communities' creation to grant a quick, easy, and secure access to users to surf the Web. Each device will have an identity in the network. Each community will also have an identity and will act as a unity on a world based on Internet connection. Security will be established in the moment they access to the network through the use of the trust chain generated by nodes. Trust is modified by each node on the basis of nodes behaviorLacuesta, R.; Palacios-Navarro, G.; Cetina Englada, C.; Peñalver Herrero, ML.; Lloret, J. (2012). Internet of things: where to be is to trust. EURASIP Journal on Wireless Communications and Networking. (203):1-16. doi:10.1186/1687-1499-2012-203S116203Lipnack J, Stamps J: Virtual Teams: Researching Across Space, Time, and Organizations with Technology. New York: John Wiley and Sons; 1997.Ahuja MK, Carley KN: Network structure in virtual organizations, organization science, Vol. 10, No. 6, Special Issue: Communication Processes for Virtual Organizations, November–December. 1999, 741-757.Mowshowitz A: Virtual organization. Commun ACM 1997, 40(9):30-37. 10.1145/260750.260759Preuß S: CH Cap, Overview of spontaneous networking-evolving concepts and technologies, in Rostocker Informatik-Berichte. Rostock: Fachbereich Informatik der Universit; 2000:113-123.Feeney LM, Ahlgren B, Westerlund A: Spontaneous networking: an application-oriented approach to ad hoc networking. IEEE Commun Mag 2001, 39(6):176-181. 10.1109/35.925687Latvakoski J, Pakkala D, Pääkkönen P: A communication architecture for spontaneous systems. IEEE Wirel Commun 2004, 11(3):36-42. 10.1109/MWC.2004.1308947Mani M, Nguyen A-M, Crespi N: SCOPE: a prototype for spontaneous P2P social networking. Proceedings of 8th IEEE International Conference on Pervasive Computing and Communications Workshops (PERCOM Workshops) 2010, 220-225.Legendre F, de Amorim MD, Fdida S: Implicit merging of overlapping spontaneous networks. Proceedings of Vehicular Technology Conference 2004, 3050-3054.Zarate Silva VH, De Cruz Salgado EI, Ramos Quintana F: AWISPA: an awareness framework for collaborative spontaneous networks. 36th Annual Frontiers in Education Conference 2006, 27-31.Perkins CE, Bhagwat P: Highly dynamic destination sequenced distance-vector routing (DSDV) for mobile computers. Proceedings of the Conference on Communications Architectures, Protocols and Applications (SIGCOMM’94 1994, 234-244.Johnson DB, Maltz DA, Broch J: DSR: The Dynamic Source Routing Protocol for Multihop Wireless Ad Hoc Networks. Boston, MA: Ad Hoc Networking (Addison-Wesley Longman Publishing; 2001.Perkins C, Belding-Royer E, Das S: Ad hoc on-demand distance vector (AODV) routing, RFC 3561. 2003.Park V, Corson MS: IETF MANET Internet Draft “draft-ietf-MANET-tora-spe03.txt”, November 2000. 2012. Accessed March http://tools.ietf.org/html/draft-ietf-manet-tora-spec-03Viana AC, De Amorim MD, Fdida S, de Rezende JF: Self-organization in spontaneous networks: the approach of DHT-based routing protocols. Ad Hoc Networks 2005, 3(5):589-606. 10.1016/j.adhoc.2004.08.006Lacuesta R, Peñalver L: IP addresses configuration in spontaneous networks. In Proceedings of the 9th WSEAS International Conference on Computers. Athens, Greece; 2005:1-6.Alvarez-Hamelin JI, Viana AC, de Amorim M Dias: Architectural considerations for a self-configuring routing scheme for spontaneous networks, Technical Report 1. 2005.Lacuesta R, Peñalver L: Automatic configuration of ad-hoc networks: establishing unique IP link-local addresses. In Proceedings of the International Conference on Emerging Security Information, Systems and Technologies (SECURWARE’07). Valencia, Spain; 2007:157-162.Foulks EF: Social network therapies and society: an overview. Contemp Fam Therapy 1985, 3(4):316-320.IBM: A Smarter Planet. 2012. http://www.ibm.com/smarterplanetMontenegro G, Kushalnagar N, Hui J, Culler D: RFC 4944: Transmission of IPv6 Packets over IEEE 802.15.4 Networks. 2007.Alcaraz C, Najera P, Lopez J, Roman R: Wireless Sensor Networks and the Internet of Things: Do We Need a Complete Integration?, 1st International workshop on the security of The internet of Things (SecIoT). tokyo (Japan); 2010. . Accessed January 2012 1er International Workshop on the Security of The Internet of Things (SecIoT 2010) http://www.nics.uma.es/seciot10/files/pdf/alcaraz_seciot10_paper.pdfFerscha A, Davies N, Schmidt A, Streitz N: Pervasive Socio-Technical Fabric. Procedia Computer Science 2011, 7: 88-91.Hubaux JP, Buttyán L, Capkun S: The quest for security in mobile ad-hoc networks, in Proceedings of the ACM Symposium on Mobile Ad-hoc Networking and Computing. 2001, 146-155.Wang Y, Varadharajan V: Interaction trust evaluation in decentralized environments, e-commerce and web technologies. In Proceedings of 5th International Conference on Electronic Commerce and Web Technologies, vol LNCS 3182. Springer; 2004:144-153.Jimin L, Junbao L, Aiguo A, Zhenpeng L: Two-way trust evaluation based on feedback. in Conference on Logistics Systems and Intelligent Management 2010, 3: 1910-1914.Daskapan S, Nurtanti I, Van den Berg J: Trust algorithms in P2P file sharing networks. Int J Internet Technol Secured Trans 2010, 2(1–2):174-200.Maña A, Koshutanski H, Pérez EJ: A trust negotiation based security framework for service provisioning in load-balancing clusters. Comput Secur 2012, 31(1):4-25. 10.1016/j.cose.2011.11.006Stajano F, Anderson R: The resurrecting duckling security issues for ad-hoc wireless networks. Security Protocols, 7th International Workshop Proceedings, Lecture notes in Computer Science, LNCS 1296 1999, 172-194.Balfanz D, Smetters DK, Stewart P, ChiWong H: Talking to strangers: authentication in ad-hoc wireless networks, in Symposium on Network and Distributed Systems Security (NDSS’02). San Diego, CA; 2002.Capkun S, Hubaux JP, Buttyán L: Mobility helps security in ad-hoc networks. In Proceedings of the 4th ACM international symposium on Mobile ad hoc networking & computing. MD, USA: Annapolis; 2003:46-56.Metzger MJ: Privacy, trust, and disclosure: exploring barriers to electronic commerce. J Comput-Mediat Commun 2004, 9(4). http://jcmc.indiana.edu/vol9/issue4/metzger.html 2004, 9(4)

A spontaneous ad hoc network to share www access

In this paper, we propose a secure spontaneous ad-hoc network, based on direct peer-to-peer interaction, to grant a quick, easy, and secure access to the users to surf the Web. The paper shows the description of our proposal, the procedure of the nodes involved in the system, the security algorithms implemented, and the designed messages. We have taken into account the security and its performance. Although some people have defined and described the main features of spontaneous ad-hoc networks, nobody has published any design and simulation until today. Spontaneous networking will enable a more natural form of wireless computing when people physically meet in the real world. We also validate the success of our proposal through several simulations and comparisons with a regular architecture, taking into account the optimization of the resources of the devices. Finally, we compare our proposal with other caching techniques published in the related literature. The proposal has been developed with the main objective of improving the communication and integration between different study centers of low-resource communities. That is, it lets communicate spontaneous networks, which are working collaboratively and which have been created on different physical places.Authors want to give thanks to the anonymous reviewers for their valuable suggestions, useful comments, and proofreading of this paper. This work was partially supported by the Ministerio de Educacion y Ciencia, Spain, under Grant no. TIN2008-06441-C02-01, and by the "Ayudas complementarias para proyectos de I+D para grupos de calidad de la Generalitat Valenciana" (ACOMP/2010/005).Lacuesta Gilaberte, R.; Lloret, J.; García Pineda, M.; Peñalver Herrero, ML. (2010). A spontaneous ad hoc network to share www access. EURASIP Journal on Wireless Communications and Networking. 2010:1-16. https://doi.org/10.1155/2010/232083S1162010Preuß S, Cap CH: Overview of spontaneous networking-evolving concepts and technologies. In Rostocker Informatik-Berichte. Volume 24. Fachbereich Informatik der Universit at Rostock; 2000:113-123.Gallo S, Galluccio L, Morabito G, Palazzo S: Rapid and energy efficient neighbor discovery for spontaneous networks. Proceedings of the 7th ACM International Symposium on Modeling, Analysis and Simulation of Wireless and Mobile Systems, October 2004, Venice, ItalyLatvakoski J, Pakkala D, Pääkkönen P: A communication architecture for spontaneous systems. IEEE Wireless Communications 2004, 11(3):36-42. 10.1109/MWC.2004.1308947Zarate Silva VH, De Cruz Salgado EI, Quintana FR: AWISPA: an awareness framework for collaborative spontaneous networks. Proceedings of the 36th ASEE/IEEE Frontiers in Education Conference (FIE '06), October 2006 1-6.Feeney LM, Ahlgren B, Westerlund A: Spontaneous networking: an application-oriented approach to ad hoc networking. IEEE Communications Magazine 2001, 39(6):176-181. 10.1109/35.925687Perkins CE, Bhagwat P: Highly dynamic destination-sequenced distance-vector routing (DSDV) for mobile computers. Proceedings of the Conference on Communications Architectures, Protocols and Applications (SIGCOMM '94), August 1994 234-244.Johnson DB, Maltz DA, Broch J: DSR: The Dynamic Source Routing Protocol for Multihop Wireless Ad Hoc Networks, Ad Hoc Networking. Addison-Wesley Longman Publishing, Boston, Mass, USA; 2001.Perkins C, Belding-Royer E, Das S: Ad hoc on-demand distance vector (AODV) routing. RFC 3561, July 2003Park V, Corson MS: IETF MANET Internet Draft "draft-ietf-MANET-tora-spe03.txt". Novemmer 2000.Viana AC, De Amorim MD, Fdida S, de Rezende JF: Self-organization in spontaneous networks: the approach of DHT-based routing protocols. Ad Hoc Networks 2005, 3(5):589-606.Gilaberte RL, Herrero LP: IP addresses configuration in spontaneous networks. Proceedings of the 9th WSEAS International Conference on Computers, July 2005, Athens, GreeceViana AC, Dias de Amorim M, Fdida S, de Rezende JF: Self-organization in spontaneous networks: the approach of DHT-based routing protocols. Ad Hoc Networks 2005, 3(5):589-606.Alvarez-Hamelin JI, Carneiro Viana A, Dias De Amorim M: Architectural considerations for a self-configuring routing scheme for spontaneous networks.,Tech. Rep. 1 October 2005.Lacuesta R, Peñalver L: Automatic configuration of ad-hoc networks: establishing unique IP link-local addresses. Proceedings of the International Conference on Emerging Security Information, Systems and Technologies (SECURWARE '07), October 2007, Valencia, SpainFoulks EF: Social network therapies and society: an overview. Contemporary Family Therapy 1985, 3(4):316-320.Wang Y, Wu H: DFT-MSN: the delay/fault-tolerant mobile sensor network for pervasive information gathering. Proceedings of the 25th IEEE International Conference on Computer Communications (INFOCOM '06), April 2006Kindberg T, Zhang K: Validating and securing spontaneous associations between wireless devices. In Proceedings of the 6th Information Security Conference (ISC '03), 2003. Springer; 44-53.Al-Jaroodi J: Routing security in open/dynamic mobile ad hoc networks. The International Arab Journal of Information Technology 2007, 4(1):17-25.Stajano F, Anderson RJ: The resurrecting duckling: security issues for ad-hoc wireless networks. Proceedings of the 7th International Workshop on Security Protocols, April 1999 172-194.Zhou L, Haas ZJ: Securing ad hoc networks. IEEE Network 1999, 13(6):24-30. 10.1109/65.806983Hauspie M, Simplot-Ryl I: Cooperation in ad hoc networks: enhancing the virtual currency based models. Proceedings of the 1st International Conference on Integrated Internet Ad Hoc and Sensor Networks (InterSense '06), May 2006, Nice, FranceWang X, Dai F, Qian L, Dong H: A way to solve the threat of selfish and malicious nodes for ad hoc networks. Proceedings of the International Symposium on Information Science and Engieering (ISISE '08), December 2008, Shanghai, China 1: 368-370.Kargl F, Klenk A, Weber M, Schlott S: Sensors for detection of misbehaving nodes in MANETs. Detection of Intrusion and Malware and Vulnerability Assessment (DIMVA '04), July 2004, Dortmund, Germany 83-97.Kargl F, Geiss A, Scholott S, Weber M: Secure dynamic source routing. Proceedings of the 38th Annual Hawaii International Conference on System Sciences (HICSS '05), January 2005, Big Island, Hawaii, USAGokhale S, Dasgupta P: Distributed authentication for peer-to-peer networks. Proceedings of the Symposium on Applications and the Internet Workshops, January 2003 347-353.Capkun S, Buttyán L, Hubaux J-P: Self-organized public-key management for mobile ad hoc networks. IEEE Transactions on Mobile Computing 2003, 2(1):52-64. 10.1109/TMC.2003.1195151Stajano F, Anderson R: The resurrecting duckling security issues for ad-hoc wireless networks. In Proceedings of the 7th International Workshop on Security Protocols, 1999, Berlin, Germany, Lecture Notes in Computer Science. Volume 1796. Springer; 172-194.Balfanz D, Smetters DK, Stewart P, Wong HC: Talking to strangers: authentication in ad-hoc wireless networks. Proceedings of the International Symposium on Network and Distributed Systems Security (NDSS '02), February 2002, San Diego, Calif, USABarbara D, Imielinski T: Sleepers and workaholics: caching strategies in mobile environments. Proceedings of the ACM SIGMOD International Conference on Management of Data, May 1994 1-12.Cao G: A scalable low-latency cache invalidation strategy for mobile environments. IEEE Transactions on Knowledge and Data Engineering 2003, 15(5):1251-1265. 10.1109/TKDE.2003.1232276Hu Q, Lee D: Cache algorithms based on adaptive invalidation reports for mobile environments. Cluster Computing 1998, 1(1):39-50. 10.1023/A:1019012927328Jing J, Elmagarmid A, Helal A, Alonso R: Bit-sequences: an adaptive cache invalidation method in mobile client/server environments. Mobile Networks and Applications 1997, 2(2):115-127. 10.1023/A:1013616213333Kahol A, Khurana S, Gupta S, Srimani P: An efficient cache management scheme for mobile environment. 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IEEE Transactions on Mobile Computing 2005, 4(1):68-83.Wessels D, Claffy K: Internet cache protocol (IC) v.2. http://www.ietf.org/rfc/rfc2186.txtFan L, Cao P, Almeida J, Broder AZ: Summary cache: a scalable wide-area web cache sharing protocol. IEEE/ACM Transactions on Networking 2000, 8(3):281-293. 10.1109/90.851975Dykes SG, Robbins KA: A viability analysis of cooperative proxy caching. Proceedings of the 20th Annual Joint Conference of the IEEE Computer and Communications Societies (INFOCOM '01), April 2001, Anchorage, Alaska, USA 3: 1205-1214.Wessels D, Claffy K: RFC 2186: Internet cache protocol (ICP), version 2. The Internet Engineering Taskforce, September 1997Wessels D, Claffy K: RFC 2187: application of internet cache protocol (ICP), version 2. The Internet Engineering Taskforce, September 1997Ren Q, Dunhan MH: Using semantic caching to manage location dependent data in mobile computing. 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Five essays on bankruptcy

Chapter 2 Bankruptcy Initiation In The New Era of Chapter 11 2.1 Abstract The bankruptcy act of 1978 placed corporate managers (as debtor in possession) in control of the bankruptcy process. Between 2000 and 2001 managers apparently lost this control to secured creditors. This study examines financial ratios of firms filing for bankruptcy between 1993 and 2004 and tests the hypothesis that the change from manager to creditor control created or exacerbated the managerial (and dominant creditor) incentive to delay bankruptcy filing. We find a clear deterioration in the financial conditions of firms filing after 2001. This is consistent with managers (or creditors who control them) delaying filing for bankruptcy. We also observe patterns of operating losses and liquidations that suggest adverse economic consequences from such delay. Chapter 3 Bankruptcy Resolution: Priority of Claims with the Secured Creditor in Control 3.1 Abstract We present new evidence on the violation of priority of claims in bankruptcy using a sample of 222 firms that tiled for Chapter 11 bankruptcy over the 1993-2004 period. Our study reveals a dramatic reduction in the violations of priority of claims compared to research on prior periods. These results are consistent with changes in both court practices and laws transferring power to the secured creditors over our sample period. We also find an increase in the time from the date of a bankruptcy filing to reaching plan confirmation where priority is not violated. Chapter 4 Bankruptcy Resolution: Speed, APR Violations and Delaware 4.1 Abstract We analyze speed of bankruptcy resolution on a sample of 294 US firms filing for bankruptcy in the 1993-2004 period. We find strong association between type of Chapter II filing and speed of bankruptcy resolution. We also find that violations to the absolute priority rule reduce the time from bankruptcy filing to plan confirmation. This is consistent with the hypothesis that creditors are willing to grant concessions in exchange for faster bankruptcy resolution. Furthermore, after controlling for the type of filing and violations to the absolute priority rule, we do not find any difference in the duration of the bankruptcy process for firms filing in Delaware, New York, or other bankruptcy districts. Chapter 5 Financial Distress and Corporate Control 5.1 Abstract We examine the replacement rates of directors and executives in 63 firms filing for bank ruptcy during the 1995-2002 period. We find that over 76% of directors and executives are replaced in the four year period from the year prior to the bankruptcy filing through three years after. These rates are higher than those found in prior research and is consistent with changes in bankruptcy procedures and practice (i.e. the increased secured creditors control over the process due to both DIP financing and changes in the Uniform Commercial Code) having a significant impact on the corporate governance of firms in financial distress. Chapter 6 Financial Statement Restatements: Decision to File for Bankruptcy 6.1 Abstract On a sample of 201 firms that restated their financial statements we analyze the process of regaining investor trust in a two year period after the restatement. We find that 20% of firms that restate their financial statements tile for bankruptcy or restructure out of court. Our results also indicate that the decisions to change auditor or management is correlated with a higher probability of failure. Increased media attention appears to partly explain the decision of firms to restructure their debt or tile for bankruptcy

Theory and Evidence on the Bankruptcy Initiation Problem.

The bankruptcy act of 1978 placed corporate managers (as debtor in possession) in control of the bankruptcy process. Between 2000 and 2001 managers lost such control to creditors. This study examines financial ratios of firms filing for bankruptcy between 1993 and 2004 and tests the hypothesis that the change from manager to creditor control created or exacerbated managerial (and dominant creditor) incentive to delay bankruptcy filing. We find a clear deterioration in the financial conditions of firms filing after 2001, which suggests that managers may now postpone filings to avoid creditor control. We also observe patterns of operating losses and liquidations that suggest adverse economic consequences from such delay