8He Spectroscopy in Stopped Pion Absorption By 9Be

Level structure of 8He has been studied in the reaction of stopped pion absorption by 9Be nuclei. The missing mass spectrum in the range 0 MeV ≤ MM ≤ 10 MeV has been described by the superposition of phase-space distributions and the three states of 8He. Parameters of these states have been compared with data of other experimental and theoretical works

Monitoring of drug safety

The article presents recommendations for doctors, pharmacists, developers and manufacturers on how to prepare and report to the regulatory ofthe Russian Federation individual case safety reports of adverse drug reactions,unefficiency or adverse drug interaction

Cadmium-free Thin-Film Cu(In,Ga)Se2(In2S3) Heterophotoelements Fabrication and Properties

The method of heat treatment of metallic Cu–In–Ga layers in the N2 inert atmosphere in the presence of selenium and sulfur vapors was used to grow homogeneous films of Cu(In,Ga)(S,Se)2 alloys onto which the CdS or In2S3 films were deposited and, on the basis of these structures, the thin-film glass/Mo/p-Cu(In,Ga)(S,Se)2/n-(In2S3,CdS)/n-ZnO/Ni–Al photoelements were fabricated. The mechanisms of charge transport and the processes of photosensitivity in the obtained structures subjected to irradiation with natural and linearly polarized light are discussed. The broadband hotosensitivity of thin-film heterophotoelements and the induced photopleochroism were detected; these findings indicate that there is an interference-related blooming of the structures obtained. It is concluded that it is possible to use ecologically safe cadmium-free thin-film heterostructures as high-efficiency photoconverters of solar radiation

Comprehensive assessment of specific antibodies on infectious activity of tick-borne encephalitis virus

Vaccines for prophylactic immunization provide the most reliable and effective protection against the vast majority of infectious diseases. Tick-borne encephalitis (TBE) represents a high-priority medical issue at the territory of the Eurasian continent. Of great importance is assessing a role of distinct antibody titers especially low titers, observed quite often in vaccinated individuals, sometimes posing obstacles in determining a threshold of seropositivity as well as the level of specific protection against TBE virus. We aimed at obtaining data to assess antiviral activity of virus-specific antibodies with distinct titer levels based on the in vitro, ex vivo and in vivo experimental studies with a highly virulent Far-Eastern strain of tick-borne encephalitis virus. The in vitro, ex vivo and in vivo comprehensive experimental studies with a highly virulent Far-Eastern strain of tick-borne encephalitis virus (TBEV) were conducted and the dynamics of antiviral activity of virus-specific antibodies at variable titers (1:100–1:3200) was measured (timeframe ranged within 1–96 hours p.i.) to provide a rationale for evaluating the antiviral immune response. It was found that the in vitro experiments demonstrated that the IgG at 1:100 titer exerted a weak anti-TBEV neutralizing effect at all time-points examined. The IgG 1:400 titer caused a 2 log PFU/mL decline in TBEV Dal strain yield at 72 h post-infection, whereas at 1:3200 titer it completely suppressed TBEV replication throughout the observation period. The ex vivo experiments with blood serum obtained from vaccinated subjects demonstrating a range of TBEV antibody titers (sera from vaccinated individuals with varying anti-TBEV antibody titers) and in vivo (outinbred white mice) experiments revealed a delayed virus elimination for antibody titers at 1:100 and 1:200 as well as rapid virus elimination (1–2 days p.i.) for antibody titers greater than 1:400. Thus, antibody titer at 1:400 may be considered as the universal anti-TBEV protection threshold. In order to properly conclude regarding the revaccination schedule it is advised to start with testing blood serum for durability of anti-TBEV immune response. Subjects with TBEV antibody titers at 1:100 and 1:200 should be strongly recommended to undergo a mandatory revaccination. Such an approach is believed to be the most effective way toward enhancing efficacy of vaccine-mediated protection against TBE

Специалистическая модель в условиях непрерывного профессионального образования

Fundamental changes in the Russian economy determined by the increasing role of knowledge, the revolution in information and communication technologies, the formation of the global labor market, as well as political changes, dictate new requirements for professional training. The specialist model, professiogram, qualification characteristic, sociogram of profession, sociogram of professional identity is the view options of the ideal result of students’ training. The key competence is the defining competence because it corresponds to the conditions of implementation, which are neither limited, not too specific, but are to a certain extent universal. The essence of professional competence of a specialist is the integration of knowledge, skills, experience; personal qualities that provide professional development and self-realization of a specialist, i.e. personal opportunities that allow solving professional problems independently and effectively. The perspective direction of improvement of specialists training in professional education system is development of their models giving the chance to study more deeply problems of training and use of experts, to estimate quality of educational institutions work. In recent years, research aimed at developing a specialist model has covered not only the sphere of higher education; they are conducted in the systems of basic and secondary vocational education. One of the main means of rationing and assessing the quality of professional training of students is a competence model that allows getting the clearest information about the composition of competencies that must be formed in the future specialist in the learning process. The analysis of requirements to specialists training, the contents and technologies of educational process, methodology and practice of modern educational activity allows defining a number of principles and methods of formation of specialist model as bases of a component of the Federal State Educational Standard.Los cambios fundamentales en la economía rusa, determinados por el papel cada vez mayor del conocimiento, la revolución en las tecnologías de la información y la comunicación, la formación del mercado laboral mundial, así como los cambios políticos, dictan nuevos requisitos para la formación profesional. El modelo de especialista, el profesiograma, la característica de calificación, el sociograma de la profesión, el sociograma de la identidad profesional son las opciones de visualización del resultado ideal de la formación de los estudiantes. La competencia clave es la competencia definitoria porque corresponde a las condiciones de implementación, que no son limitadas, ni demasiado específicas, pero en cierta medida son universales. La esencia de la competencia profesional de un especialista es la integración de conocimientos, habilidades, experiencia; cualidades personales que proporcionan desarrollo profesional y autorrealización de un especialista, es decir, oportunidades personales que permiten resolver problemas profesionales de manera independiente y efectiva. La dirección de la perspectiva de mejora de la formación de especialistas en el sistema de educación profesional es el desarrollo de sus modelos que brinden la oportunidad de estudiar más profundamente los problemas de formación y uso de expertos, para estimar la calidad del trabajo de las instituciones educativas. En los últimos años, la investigación dirigida a desarrollar un modelo especializado ha cubierto no solo el ámbito de la educación superior; se llevan a cabo en los sistemas de educación vocacional básica y secundaria. Uno de los principales medios para racionar y evaluar la calidad de la formación profesional de los estudiantes es un modelo de competencia que permita obtener la información más clara sobre la composición de las competencias que deben formarse en el futuro especialista en el proceso de aprendizaje. El análisis de los requisitos para la capacitación de especialistas, los contenidos y las tecnologías del proceso educativo, la metodología y la práctica de la actividad educativa moderna permite definir una serie de principios y métodos de formación de modelos especializados como bases de un componente del Estándar Educativo del Estado Federal.Фундаментальные изменения в российской экономике, обусловленные растущей ролью знаний, революцией в информационных и коммуникационных технологиях, формированием мирового рынка труда, а также политическими изменениями, диктуют новые требования к профессиональной подготовке. Модель специалиста, профессиограмма, квалификационная характеристика, социограмма профессии, социограмма профессиональной идентичности - это варианты выбора идеального результата обучения студентов. Ключевой компетенцией является определяющая компетенция, поскольку она соответствует условиям реализации, которые не являются ни ограниченными, ни слишком конкретными, но в определенной степени универсальными. Суть профессиональной компетентности специалиста - интеграция знаний, навыков, опыта; личные качества, которые обеспечивают профессиональное развитие и самореализацию специалиста, то есть личные возможности, позволяющие самостоятельно и эффективно решать профессиональные проблемы. Перспективным направлением совершенствования подготовки специалистов в системе профессионального образования является разработка их моделей, позволяющих глубже изучить проблемы подготовки и использования специалистов, оценить качество работы учебных заведений. В последние годы исследования, направленные на разработку модели специалиста, охватывали не только сферу высшего образования; они ведутся в системах начального и среднего профессионального образования. Одним из основных средств нормирования и оценки качества профессиональной подготовки студентов является модель компетенций, позволяющая получить наиболее четкую информацию о составе компетенций, которые должны быть сформированы у будущего специалиста в процессе обучения. Анализ требований к подготовке специалистов, содержания и технологий учебного процесса, методологии и практики современной образовательной деятельности позволяет определить ряд принципов и методов формирования модели специалиста как основы компонента Федерального государственного образовательного стандарта

99.9% Spin‐Flip Efficiency in the Presence of a Strong Siberian Snake

We recently studied the spin‐flipping efficiency of an rf‐dipole magnet using a 120‐MeV horizontally polarized proton beam stored in the Indiana University Cyclotron Facility Cooler Ring, which contained a full Siberian snake. We flipped the spin by ramping the rf dipole’s frequency through an rf‐induced depolarizing resonance. By adiabatically turning on the rf dipole, we minimized the beam loss, while preserving almost all of the beam’s polarization. After optimizing the frequency ramp parameters, we used up to 400 multiple spin flips to measure a spin‐flip efficiency of 99.93 ± 0.02%. This result indicates that spin flipping should be possible in very‐high‐energy polarized storage rings, where Siberian snakes are certainly needed and only dipole rf‐flipper magnets are practical. © 2003 American Institute of PhysicsPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87684/2/776_1.pd

Status of the Michigan Ultra‐Cold Spin‐Polarized Hydrogen Jet

Progress on the Michigan ultra‐cold proton‐spin‐polarized atomic‐hydrogen Jet target is presented. We describe the present status of the Jet and some beam test results. © 2004 American Institute of PhysicsPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87591/2/639_1.pd

Cognitive Models of Loneliness in Women in Early and Middle Adulthood

The problem of loneliness is caused by a disunity and alienation of modern society, dissatisfaction with the basic social needs for acceptance and support. The fact that the subjective feeling of loneliness does not coincide with the real degree of social isolation determines the need to study the cognitive aspects. The aim of this study is to show the role of cognitive structures in loneliness in women. A survey of 144 women aged 26-55 years was conducted. Using the UCLA Loneliness Scale and the Differential Loneliness Experience Questionnaire, loneliness was measured as a global experience, positive and negative attitudes towards it. Cognitive models were studied using the Dysfunctional Attitude Scale, Young Schema Questionnaire, the author’s questionnaire that reveals cultural myths and gender stereotypes about loneliness. A comparative analysis of the groups showed no differences in the perception of loneliness among women with different family situations; it also does not depend on having children and their number. Age was found to be a significant determinant of perceptions of loneliness and family circumstances. Cognitive models influence women’s loneliness to a greater extent than family situation. The publication describes correlations between perceived loneliness and individual dysfunctional attitudes, and builds regression models of predictors of loneliness in different age groups. The study shows the prevalence of cultural stereotypes about the need for marriage and motherhood, and a special female vulnerability in relationships. The construct “tolerance to loneliness” is proposed and described, which reveals the positive potential of this experience for self-knowledge and self-development.</p

Risk factors for cardiovascular diseases and heart remodeling in sambo veterans

Introduction. The benefits of exercise for the cardiovascular system are apparent. However, the influence of predominantly strength exercises throughout life has not been sufficiently studied. This work details the studies around the structure and function of the heart in sambo veteran athletes residing in the Russian Federation (RF) and the Azerbaijan Republic (AR) as well as the frequency of risk factors for their cardiovascular system.Methods. We examined 55 male athletes aged 45.4 ± 8.3 yrs: 24 sambo veterans from RF (group “RF”), 10 sambo veterans from AR (group “AR”) and 21 persons representing control group (“CG”) (chess, bowling), RF. Questionnaires, analysis of ideal health factors, recording of electrocardiogram in 12 leads, echocardiography, stress test with oxygen analysis were carried out.Results. Maximum exercise power and peak oxygen consumption were higher in the “RF” and “AR” groups compared to the “CG” group. The main abnormalities were hypertrophy of interventricular septum (n = 11, 32.3 %) and left ventricular wall (n = 3, 8.8 %). Concentric left ventricular remodeling was predominant in the “AR” group (5 vs. 1, p &lt; 0.05) and greater left ventricular volume in the “RF” group (65.1 vs. 52.0 ml/m2, p &lt; 0.05). Lower physical performance and the presence of dyslipidemia were significantly associated with parameters reflecting concentric left ventricular remodeling (“AR” group). Various ideal health factors were absent in 10–80 % of the examinees. A total of 7 (20.6 %) veterans were found to have a high risk of cardiovascular diseases according to the questionnaire.Conclusion. Prolonged wrestling exercises allow veterans to maintain high aerobic capacity. Concentric remodeling of myocardium of the left ventricle is combined with higher indices of dyslipidemia in the group “AR” which may be connected to low physical activity and eating habits after sport practice