Multiple Andreev Reflections in Weak Links of Superfluid 3He-B

We calculate the current-pressure characteristics of a ballistic pinhole aperture between two volumes of B-phase superfluid 3He. The most important mechanism contributing to dissipative currents in weak links of this type is the process of multiple Andreev reflections. At low biases this process is significantly affected by relaxation due to inelastic quasiparticle-quasiparticle collisions. In the numerical calculations, suppression of the superfluid order parameter at surfaces is taken into account self-consistently. When this effect is neglected, the theory may be developed analytically like in the case of s-wave superconductors. A comparison with experimental results is presented.Comment: 12 pages, 9 figures, RevTeX

THE CHARACTERISTIC OF MICROCRYSTALLIZATION OF THE SALIVA AT THE ADULTS HAVING DISEASES OF SIALADENS

Questions of diagnosis and treatment of diseases of the salivary glands extensively researched the leading clinics of maxillofacial surgery and dentistry dental universities and medical academies. Features of a microcrystallization of oral liquid at adults of the different age groups having various chronic diseases of sialadens are studied. In work it is surveyed 246 (115 men and 134 women) aged from 25 till 82 years suffering from a chronic sialadenitis (sialodochitis), sialolithic illness (sialolithiasis), reactive and dystrophic diseases of sialadens (sialoses), radial and medicamental sialoadenopathia, and also good-quality and malignant neoplasms of sialadens. Dependence of crystallographic indicators of the saliva, both from a type of pathology of sialadens, and from age and the level of a comorbidity of adults is established

Anthropometric indices and their relationship with poor prognosis in patients with coronary artery disease and obesity

Aim. To assess the association of anthropometric indices in patients with coronary artery disease (CAD) and obesity and to study their predictive value in the development of adverse cardiovascular events.Material and methods. The study included 229 patients with CAD (median age, 55±7,56 years). Depending on the presence of obesity according to the World Health Organization criteria (1999), patients were divided into 2 groups. The 1st group included 107 obese patients, while the 2nd group — those without obesity (n=122). The groups were comparable in age. We measured waist (WC) and hip circumference (HC), followed by waist-to-hip ratio and body mass index calculation. The lipid profile parameters were determined by the enzymatic colorimetric method. During the study, the following indices were calculated: body mass index, visceral adiposity index, insulin resistance index, body shape index (BSI), fasting triglyceride (TG)/plasma glucose index, waist-to-height ratio, lipid accumulation product, TG-to-high density lipoprotein cholesterol ratio.Results. During the follow-up period, adverse cardiovascular events in the 1st group of patients were found in 37 (34,5%) patients, while in the 2nd group, the composite endpoint was revealed in 12,3% of patients. In order to develop a model for predicting the risk of an unfavorable CAD course in obese patients, we performed a logistic regression analysis, which showed that the following were the most significant predictors of unfavorable cardiovascular outcomes: TG/glucose index and BSI.Conclusion. Thus, of all the considered anthropometric indices, only two were associated with unfavorable CAD course — TG/glucose index and BSI. The data obtained indicate the validity of the search for novel useful obesity indicators with a good predictive value

Good Pharmacovigilance Practice in the United States and the European Union

The article presents the results of a comparative analysis of Goodpharmacovigilance practices (GVP), developed by experts of the regulatory bodiesof the European Union (EU) and the United States. It is shown that the EU GVP cover almost all possible aspects of pharmacovigilance. It is noted that the disadvantages of EU GVP are difficulties in the correct understanding and interpretation of certain definitions and processes, as well as the complexity of the implementation in practice of a number of provisions, mainly related to the organization of the quality management system, including audit and inspection. As the basis for development of the Russian Rules GVP is recommended to use the GVP E

SANITARY PROTECTION OF TERRITORIES FROM SEVERE ACUTE RESPIRATORY SYNDROME (SARS) IMPORTATION AND DISSEMINATION BY WATER AND AIR TRANSPORT AT FAR EASTERN REGION

The existing programs and plans of sanitary protection of territories and municipalities of Russian Federation are directed to prevention of importation and dissemination of quarantine and other known infectious diseases. Modern organizing-methodical papers of Ministry of Public Health of Russian Federation include both nosological and syndromic approaches to resolution of this problem. SARS epidemic situation in the world with an active focus at Asian-Pacific Ocean Region has tested the Russian sanitary protection system at Far Eastern Region. Data on organization and realization of the measures at the period of SARS epidemic troubles in the world are analyzed. The experience of State Surveillance Centers at water and air transport in Far Eastern Region in co-operation with all transport process participants to prevent importation and dissemination of early unknown especially dangerous infection (SARS) is summarized

The use of nitinol rods in stabilization of the lumbar spine for patients under 21 years

The outcomes of surgical treatment of 25 young patients with degenerative diseases of the lumbar spine in two groups were compared in patients with nitinol rods (dynamic stabilization) without spondylodesis and with rigid lumbar fixation of titanium rods. Men - 12, women - 13, the average age is 17.6 years (from 16 to 21 years). These patients are divided into 2 groups depending on the stabilization method. Clinical and radiological results were monitored at least 1 year after the operation. In our study we used nitinol rods of 2 standard sizes - 60 and 80 mm. The size and curvature of the bending of the rods is calculated from the average anatomical parameters characteristic of the lumbar spine and lumbosacral junction. In all groups, there were no statistically significant differences in preoperative values and in the control periods of observation of the VAS (for both the back and the lower limb), Oswestry and SF-36 between patients with nitinol and titanium rods (p> 0.05). In both cases (rigid and dynamic stabilization), statistically significant changes were noted in the postoperative period (p <0.01). In both groups, in comparison with preoperative values, improvement was observed in all control periods, which were highly statistically significant (p <0.01). When studying the mobility in stabilized segment with dynamic nitinol rods, it is determined that the mobility, which persists in 1 segment, averages 4.8°. This index is within the limits of measurement error (up to 5°), however, when measuring mobility in two segments, the mobility is 9.6°. Transpedicular fixation of the lumbosacral spine with the use of nitinol rods is an effective technology that allows to keep movements in the lumbosacral spine in combination with a stable fixation. Further study of this technology should continue, including with reference to deformations of the spine

On the safety of acetaminophen

Acetaminophen is one of the most commonly used analgesics /anti pyretics. However, taking into account the existing risk of hepatotoxicity,regulatory bodies of a number of the countries made additional adjustments tothe recommendations on the use of this drug. In the article the possible reasonsfor recourse to acetaminophen are discusse

Qualitative methods of benefit / risk assessment

In this article authors describe some existing methods of benefit / risk assessment

LOCAL ANESTHETIC MYOTOXICITY

The article presents the mechanisms of development and methods of correction of myotoxicity associated with use of local anesthetic