The sectional curvature remains positive when taking quotients by certain nonfree actions

We study some cases when the sectional curvature remains positive under the taking of quotients by certain nonfree isometric actions of Lie groups. We consider the actions of the groups $S^1$ and $S^3$ such that the quotient space can be endowed with a smooth structure using the fibrations $S^3/S^1{\simeq}S^2$ and $S^7/S^3\simeq S^4$. We prove that the quotient space carries a metric of positive sectional curvature, provided that the original metric has positive sectional curvature on all 2-planes orthogonal to the orbits of the action.Comment: 26 pages, 1 figure. Changed the spelling of the author's nam

The ideology of managerialism in Russian social institutions: education, science, healthcare

The article is devoted to the consequences’ study of the managerial, management tools’ use in the social institutions of science, education, and health care. The study purpose is to substantiate the thesis that managerialism is a kind of a new ideology. To achieve the presented goal, methodological tools based on D. North’s neoinstitutional theory were used. The study revealed that managerialism as an efficiency ideology is based on institutional rules accepted by the state, it is applied considering informal restrictions established in society (values, attitudes, stereotypes, behavioral patterns, etc.) and relies on the Russian bureaucracy, which is the main beneficiary of the managerialist ideology. The negative consequences of managerialism are manifested as an increase in imitative practices; a decline in the level of employees’ professionalism of scientific, health care and educational organizations; a loss of the social purpose of social institutions, and the misuse of state resources

Tuning of tunneling current noise spectra singularities by localized states charging

We report the results of theoretical investigations of tunneling current noise spectra in a wide range of applied bias voltage. Localized states of individual impurity atoms play an important role in tunneling current noise formation. It was found that switching "on" and "off" of Coulomb interaction of conduction electrons with two charged localized states results in power law singularity of low-frequency tunneling current noise spectrum ($1/f^{\alpha}$) and also results on high frequency component of tunneling current spectra (singular peaks appear).Comment: 7 pages, 4 figure

Analysis of Implementation of the Requirements for Provision of Biological Safety at a Potentially Hazardous Facility

Discussed are the problems of implementation of requirements for the provision of biological safety at a potentially hazardous biological facility by the example of Federal Budgetary Institution of Science “State Scientific Center of Applied Microbiology and Biotechnology” of the Rospotrebnadzor. Identified are the necessary and sufficient organizational-andpreventive and control measures and procedures on management of works with microorganisms of the I-IV groups of pathogenicity (hazard) in isolated labs of the Center. Issues associated with exploitation of biological safety engineering systems and assessment of their protective efficiency, problems of medical support of the activities and response to the emergency situations of biological character with the involvement of doctors from a specialized medical wing of the Federal Medical-Biological Agency of the Russian Federation, serving the facility on a constant basis, are analyzed. Determined have been approaches to and principles of establishing the requirements for the system of biological safety at a potentially hazardous biological facility taking into account all the range of biological risks when working with microorganisms. Complex approach and realization of appropriate necessary measures in the sphere of biological safety provision, creating an environment for the reduction of biological risks up to acceptable level while working with pathogenic microorganisms, can be an effective solution of the problem on the whole

Optimization of the Process of Cholera Chemical Pelleted Vaccine Production Using Ultrafiltration Technology

Technology of O-antigen obtaining from Vibrio cholerae M41production strain, using the hollow fiber ultrafiltration modules, is developed and introduced into cholera vaccine manufacturing. Application of ultrafiltration makes it possible to obtain native high-activity O-antigen preparations which comply with the current regulatory requirements. Besides, it provides for economy (10-15-fold) of ammonium sulphate, used for antigen precipitation, reduces the duration of technological cycle (2 times), and the labor inputs. The technology of protective antigen concentrating is tested on V. cholerae strains MO45 and KM137 of O139 serogroup. Three series of experimental V. cholerae O139 vaccine are obtained

B-lymphocyte aggregation in the lung tissue is a pathogenic factor in experimental infection caused by Mycobacterium avium

When infecting the lungs with Mycobacterium avium of B6 line mice genetically susceptible to this infection the compact aggregates (follicles) of B-lymphocytes are formed with the peak at the 11-13th week after the infection. Physiological role of these cellular accumulations remained unclear. Having applied segregative genetic analysis to allele conglutination of Slc11a1 gene with two signs – quantity of mycobacteria and accumulation of B-cellular follicles to the F2 mice from crossing (В6 × I/St), one managed to find out that the quantity and size of follicles directly correlate with M. avium replication in the lungs. Thus this type of the lung tissue infiltration does not protect the host from infection and it is a pathogenic factor

Peculiarities of the Conjugative pSa Plasmid Transfer from <I>Escherichia coli</I> into <I>Francisella tularensis</I>

per a recipient cell). pSa′ plasmid molds several topological shapes with variable electrophoretic mobility in E. coli C600, while in tularemia microbe, this plasmid has only one shape. After the transfer of the plasmid from E. coli cells into F. tularensis cells each individual clone of tularemia microbe possesses a plasmid which differs in its electrophoretic mobility from plasmids of other clones

On the phenomenology of a Z' coupling only to third-family fermions

The phenomenology of an additional U(1) neutral gauge boson Z' coupled to the third family of fermions is discussed. One might expect such a particle to contribute to processes where taus, b and t quarks are produced. Precision data from LEP1 put severe constraints on the mixing and heavy-boson mass. We find that the effects of such a particle could not be observed at hadronic colliders, be it at the Tevatron or the LHC, because of the QCD background. At LEP2 and future e^+e^- linear colliders, one could instead hope to observe such effects, in particular for b\bar b final states.Comment: 36 pages, LaTeX, including 12 figure

Alteration of Effector Activity of T-Lymphocytes in Mice Immunized against Tularemia, Using <I>in vitro</I> Stimulation by Tularin

lymphocytes) isolated from mice, immunized against tularemia. Put forward is the proposition to use tularin in serological surveys and reactions in vitro for identification of postinfectious or postvaccinal immunity to tularemia