Electronic circuit detects left ventricular ejection events in cardiovascular system

Electronic circuit processes arterial blood pressure waveform to produce discrete signals that coincide with beginning and end of left ventricular ejection. Output signals provide timing signals for computers that monitor cardiovascular systems. Circuit operates reliably for heart rates between 50 and 200 beats per minute

Control system for an artificial heart

Inexpensive industrial pneumatic components are combined to produce control system to drive sac-type heart-assistance blood pump with controlled pulsatile pressure that makes pump rate of flow sensitive to venous /atrial/ pressure, while stroke is centered about set operating point and pump is synchronized with natural heart

Circuit for detecting initial systole and dicrotic notch

Circuitry is disclosed for processing an arterial pressure waveform to produce during any one cycle a pulse corresponding to the initial systole and a pulse corresponding to the dicrotic notch. In a first channel, an electrical analog of the arterial pressure waveform is filtered and then compared to the original waveform to produce an initial systole signal. In a second channel, the analog is differentiated, filtered, and fed through a gate controlled by pulses from the first channel to produce an electrical pulse corresponding to the dicrotic notch

Comment on "Limits on the Time Variation of the Electromagnetic Fine-Structure Constant in the Low Energy Limit from Absorption Lines in the Spectra of Distant Quasars"

In their Letter [Phys. Rev. Lett. 92, 121302 (2004)] (also [Astron. Astrophys. 417, 853 (2004)]), Srianand et al. analysed optical spectra of heavy-element species in 23 absorption systems along background quasar sight-lines, reporting limits on relative variations in the fine-structure constant: da/a=(-0.06+/-0.06) x 10^{-5}. Here we demonstrate basic flaws in their analysis, using the same data and absorption profile fits, which led to spurious values of da/a and significantly underestimated uncertainties. We conclude that these data and fits offer no stringent test of previous evidence for a varying alpha. In their Reply (arXiv:0711.1742) to this Comment, Srianand et al. state or argue several points regarding their original analysis and our new analysis. We discuss these points here, dismissing all of them because they are demonstrably incorrect or because they rely on a flawed application of simple statistical arguments.Comment: 1+2 pages, 1 EPS figure. Page 1 accepted as PRL Comment on arXiv:astro-ph/0402177 . Further details available in arXiv:astro-ph/0612407 . v2: Added critical discussion of Reply from Srianand et al. (arXiv:0711.1742

Time evolution of the fine structure constant

We present a short review of the current quasar (QSO) absorption line constraints on possible variation of the fine structure constant, alpha = e^2/(hbar*c). Particular attention is paid to recent optical Keck/HIRES spectra of 49 absorption systems which indicate a smaller alpha in the past (Murphy et al. 2001, Webb et al. 2001). Here we present new preliminary results from 128 absorption systems: da/a = (-0.57 +/- 0.10) x 10^{-5} over the redshift range 0.2 < z < 3.7, in agreement with the previous results. Known potential systematic errors cannot explain these results. We compare them with strong `local' constraints and discuss other (radio and millimetre-wave) QSO absorption line constraints on variations in alpha^2 * g_p and alpha^2 * g_p * m_e/m_p (g_p is the proton g-factor and m_e/m_p is the electron/proton mass ratio). Finally, we discuss future efforts to rule out or confirm the current 5.7 sigma optical detection.Comment: Invited review at the XXII Physics in Collision Conference (PIC02), Stanford, CA, USA, June 2002, 11 pages, LaTeX, 7 eps figures. PSN FRA T0

Keck constraints on a varying fine-structure constant: wavelength calibration errors

The Keck telescope's HIRES spectrograph has previously provided evidence for a smaller fine-structure constant, alpha, compared to the current laboratory value, in a sample of 143 quasar absorption systems: da/a=(-0.57+/-0.11)x10^{-5}. This was based on a variety of metal-ion transitions which, if alpha varies, experience different relative velocity shifts. This result is yet to be robustly contradicted, or confirmed, by measurements on other telescopes and spectrographs; it remains crucial to do so. It is also important to consider new possible instrumental systematic effects which may explain the Keck/HIRES results. Griest et al. (2009, arXiv:0904.4725v1) recently identified distortions in the echelle order wavelength scales of HIRES with typical amplitudes +/-250m/s. Here we investigate the effect such distortions may have had on the Keck/HIRES varying alpha results. We demonstrate that they cause a random effect on da/a from absorber to absorber because the systems are at different redshifts, placing the relevant absorption lines at different positions in different echelle orders. The typical magnitude of the effect on da/a is ~0.4x10^{-5} per absorber which, compared to the median error on da/a in the sample, ~1.9x10^{-5}, is relatively small. Consequently, the weighted mean value changes by less than 0.05x10^{-5} if the corrections we calculate are applied. Nevertheless, we urge caution, particularly for analyses aiming to achieve high precision da/a measurements on individual systems or small samples, that a much more detailed understanding of such intra-order distortions and their dependence on observational parameters is important if they are to be avoided or modelled reliably. [Abridged]Comment: 9 pages, 2 figures, 2 tables. Invited contribution to Proc. IAU XXVIIth General Assembly, Joint Discussion 9, "Are the fundamental constants varying with time?". To appear in P. Molaro, E. Vangioni-Flam, eds, Memorie della Societa Astronomica Italiana (MmSAIt), Vol. 80. Complete version of Table 1 available at http://astronomy.swin.edu.au/~mmurphy/pub.htm

Relativistic effects in Ni II and the search for variation of the fine structure constant

Theories unifying gravity and other interactions suggest the possibility of spatial and temporal variation of physical ``constants'' in the Universe. Detection of high redshift absorption systems intersecting the sight lines towards distant quasars provide a powerful tool for measuring these variations. In the present paper we demonstrate that high sensitivity to variation of the fine structure constant alpha can be obtained by comparing cosmic and laboratory spectra of the Ni II ion. Relativistic effects in Ni II reveal many interesting features. The Ni II spectrum exhibits avoided level crossing phenomenon under variation of alpha and the intervals between the levels have strong nonlinear dependencies on relativistic corrections. The values of the transition frequency shifts, due to the change of alpha, vary significantly from state to state including change of the sign. This enhances the sensitivity to the variation of alpha and reduces possible systematic errors. The calculations of alpha-dependence of the nickel ion spectral lines that are detectable in quasar absorption spectra have been performed using a relativistic configuration interaction method.Comment: 13 pages, 1 figure, accepted by Phys. Rev. A, typos corrected, acknowledgment adde