Atrial septal aneurysm in adult patients: spectrum of clinical, echocardiographic presentation and to propose a new classification on the basis of trans-thoracic-two-dimensional echocardiography

An atrial septal aneurysm is a rare but well recognized cardiac abnormality of uncertain clinical relevance. ASA is definitively associated with congenital and acquired heart diseases but also can be presented as an isolated and totally asymptomatic entity. On the basis of our TTE finding we are proposing a new classification of ASA. We have classified ASA in to two major types: (A) Localized, and (B) Generalized. Both major types are further Sub-classified into 5 possible types on the basis of movements of ASA. New classification of ASA is as follows (1) A/B Type 1R: if the bulging is in the RA only (2) A/B  Type 2L: if the bulging is in the LA only (3) A / B  Type 3RL : if the major excursion bulges to the RA and lesser excursion bulges toward LA (4) A/B Type 4LR: if the maximal excursion of the atrial septal aneurysm is toward the LA with a lesser excursion toward the RA (5) A / B Type 5: if the atrial septal aneurysm movement is bidirectional and equidistant to both atria during the cardiorespiratory cycle. We found higher prevalence (2.24%) of ASA. A/B Type 2L and A/B Type 4LR were most common types. All type of ASA had particular clinical and echocardiographic characteristics. Mobile ASA and ASA with >10 mm excursion are associated with a higher risk of stroke

Structural phase transitions in perovskite BaCeO3 with data mining and first-principles theoretical calculations

Several experiments conducted over decades have revealed that the perovskite-structured BaCeO3 goes through a series of temperature-induced structural phase transitions. However, it has been frequently observed that the number of phases and the sequence in which they appear as a function of temperature differ between experiments. Insofar as neutron diffraction and Raman spectroscopy experiments are concern, four structures are well characterized with three transitions: Pnma to Imma [563 K] to R-3c [673 K] to Pm-3m [1173 K]. In contrast, thermoanalytical methods showed multiple singularities corresponding to at-least three more structural transitions at around 830 K, 900 K, and 1030 K. In account of these conflicting experimental findings, we computed free energy phase diagram for BaCeO3 employing crystal structure data mining in conjunction with first principles electronic structure and phonon lattice dynamics. A total of 34 polymorphs have been predicted, the most stable of which follows the Glazer classification of the perovskite tilt system. It has been predicted that the Cmcm and P4/mbm phases surpass Pnma at 666 K and 1210 K, respectively. At any temperature, two alternate tetragonal phases (P42/nmc and I4/mcm) are also found to be 20 to 30 meV less favored than the Pnma. While the calculated stability order of the predicted polymorphs is in acceptable agreement with the results of neutron diffraction, the transitions observed in thermoanalytical studies could be ascribed to the development of four novel phases (Cmcm, P4/mbm, P42/nmc, and I4/mcm) at intermediate temperatures. However, we analyze that the R-3c phase predominantly stabilized over a broad temperature field, masking all subsequent phases up until the cubic Pm-3m. Consequently, the novel phases predicted to occur in thermoanalytical studies are only fleetingly metastable.Comment: 20 pages, 5 figures, 1 tabl

Impact of mothers’ knowledge and support for sustaining exclusive breastfeeding

Background: Breast milk is the best milk for the baby. It is beneficial for the baby as well as the mother, family, and nation. In spite of an established fact, still, a very low percentage (44.2%) is implementing it. Objective: The objective of this study was to find out the knowledge, concerns, and difficulties in breastfeeding and the obstacles in the practicing breastfeeding. Materials and Methods: A cross-sectional study was done at pediatric clinics in Warangal. A total of 1010 lactating mothers who were presenting for regular check-ups were enrolled. After taking oral consent, mothers were interviewed through a predesigned questionnaire containing 50 questions on pre- and post-natal counseling received, and knowledge of exclusive breastfeeding, importance of skin-to-skin contact (SSC), and their educational status and hygiene. The entire session of interview was carried out in the optimum privacy to create a favorable environment of acquiring the data. Results: Of 1010 mothers enrolled, only 25.4% had received antenatal counseling, 15.8% had received postnatal counseling regarding exclusive breastfeeding, 56.4% followed exclusive breastfeeding (EBF), and SSC was maintained by only 2%, after delivery which played an important role in breastfeeding, p=0.000003 for antenatal counseling and EBF. Conclusion: More attention should be given in educating mothers when they conceive, regarding breastfeeding, its problems and skills, during their first visit to health-care professionals

Investigating governance of tolerable and intolerable dark sides in B2B dyads in post pandemic emerging markets

The post-pandemic disruption of the global supply chain has caused severe stresses and conflicts in business-to-business dyadic relationships. Furthermore, intentions to dissolve extant relationships, motivated by opportunism, or actual terminations have aggravated the situation. Drawing on the dark side literature, we investigate the precise nature of the stress-inducing antecedents, the types of manifested conflicts and their outcomes on B2B dyadic exchanges. Using a proprietary survey data set of 487 dyadic conflicts collected from conciliation-arbitration cum legal experts in an emerging market, we provide insights into how tolerable and intolerable dark sides adversely affect short-term transactional and long-term relational B2B dyads, respectively. More importantly, we provide deep insights into specific and critical governance mechanisms invoked to attenuate/accentuate the respective dark side effects on B2B dyads. We contribute by providing an end-to-end spectrum of dark sides and their governance mechanism in B2B dyadic exchanges

Polypyrimidine tract binding protein functions as a negative regulator of feline calicivirus translation.

Positive strand RNA viruses rely heavily on host cell RNA binding proteins for various aspects of their life cycle. Such proteins interact with sequences usually present at the 5' or 3' extremities of the viral RNA genome, to regulate viral translation and/or replication. We have previously reported that the well characterized host RNA binding protein polypyrimidine tract binding protein (PTB) interacts with the 5'end of the feline calicivirus (FCV) genomic and subgenomic RNAs, playing a role in the FCV life cycle.We have demonstrated that PTB interacts with at least two binding sites within the 5'end of the FCV genome. In vitro translation indicated that PTB may function as a negative regulator of FCV translation and this was subsequently confirmed as the translation of the viral subgenomic RNA in PTB siRNA treated cells was stimulated under conditions in which RNA replication could not occur. We also observed that PTB redistributes from the nucleus to the cytoplasm during FCV infection, partially localizing to viral replication complexes, suggesting that PTB binding may be involved in the switch from translation to replication. Reverse genetics studies demonstrated that synonymous mutations in the PTB binding sites result in a cell-type specific defect in FCV replication.Our data indicates that PTB may function to negatively regulate FCV translation initiation. To reconcile this with efficient virus replication in cells, we propose a putative model for the function of PTB in the FCV life cycle. It is possible that during the early stages of infection, viral RNA is translated in the absence of PTB, however, as the levels of viral proteins increase, the nuclear-cytoplasmic shuttling of PTB is altered, increasing the cytoplasmic levels of PTB, inhibiting viral translation. Whether PTB acts directly to repress translation initiation or via the recruitment of other factors remains to be determined but this may contribute to the stimulation of viral RNA replication via clearance of ribosomes from viral RNA

Seed protectants for healthy exports

Dry formulations of three insecticides (chlorpyriphos, fenvalerate and carbaryl) were compared for their efficacy against rice moth, Corcyra cephalonica (Stainton) and groundnut bruchid Caryedon serratus Oliver, in the context of identifying a suitable alternative to aldrin. Fenvalerate 4 g/kg seed showed quick action and killed all the Corcyra eggs, and Caryedon grubs and adults, within 48 h. Chlorpyriphos and carbaryl were less effective, although the former showed high persistency. Fenvalerate and carbaryl were significantly superior to a range of rates of chlorpyriphos up to 180 DAT, and were on par with aldrin. For seed exports that require storage of 60 days or more, chlorpyriphos could be used as an effective replacement for aldrin. The chemicals tested hid no deleterious effects on seed viability of pearl millet and groundnut up to 180 days at ambient temperature during storag

Effect of Phosphine and Methyl Bromide Fumigation of Different Life Stages of Peanut Bruchid, Caryedon serratus Olivier

To ensure seed quality, peanut seeds received for export by the Plant Quarantine Unit of the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) were subjected to phosphine and methyl bromide fumigation. Effective control of eggs, larvae, and adults of Caryedon serratus Olivier was achieved with methyl bromide vacuum fumigation (16 g/m3 for 4 h exposure). Under normal atmospheric pressure (NAP), phosphine fumigation @ 0.5,1.0, and 2.0 g a.I./m3 for 24, and also with 0.25 g a.l. for 72 h gave effective control of eggs and larvae. Ph~phlne (1.0 g a.l./40 kg burlap bag) with bruchld Infested pods for 120 h resulted in 100% larval and 93% adult mortality. Both the fumigants did not impair the viability of peanut seeds. A dosage of 16 g/m3 of methyl bromide for 4 h under vacuum or 0.25 g a.l./m3 of phosphine for 72 h under NAP or placing 1.0 g a.l. of ph~phlne in dry pods stored in 40 kg burlap bag covered with polythene sheets for 120 h can satisfy the seed health requirements

Effect of Pasteurization Methods on Enzyme Activities, Microbial and Sensory Evaluations in Ready to Serve Watermelon Juice (Citrullus lanatus)

A comparative evaluation of the use of thermal, microwave and irradiation treatments for pasteurization of ready to serve watermelon juice was undertaken to study their relative impact on residual enzyme (polyphenol oxidase and peroxidase) activities microbial population, and sensorial changes during its refrigerated storage for a period of three months. Pasteurization using thermal and microwave treatments could effectively control the microbial load within the acceptable limit (<1 log cfu mL−1) over the entire three months of storage. Irradiation treatment of 0.5kGy resulted in the lowest residual polyphenol oxidase (RAPPO) activity followed by the microwave (1.56W/ml) and thermal treatments. However, maximum reduction in peroxidase activity (RAPOD) was achieved using thermal and microwave treatments. At the end of the three months storage, watermelon juice pasteurized using microwave energy was sensorially found to be the most acceptable product

Effect of phosphine and methyl bromide fumigation on eggs and larvae of rise moth corcyra cephalonica s. a common stored grain pest

Among the insect pests that attack stored groundnut, rice moth Corcyra ~ephalonica Stainton is most important- It is polyphagous in nature and cosmopolitan in distribution. .Its ability to develop at low humidities ( < 20 "/, RH) may account for its prevalence in the semi-arid tropics (SAT) over other stored product lep.idopterous pests (Dick, 1987)- The irifestation in groundnut results in both qualitative and quantitative losses. C. cephalonica is the most co.mrnon insect pest, often encountered during the visual examination of seed samples meant for export. Though this species is cosn~opolitan in distribution and has attained economic importance in several crops, very limited work has been done with respect to its control by fumigation. Hence this study was undertaken to evolve effective, easy, and economic fumigation schedule to control this pest to ensure better sanitation of outgoing seed