281 research outputs found
Modeling Earthen Dike Stability: Sensitivity Analysis and Automatic Calibration of Diffusivities Based on Live Sensor Data
The paper describes concept and implementation details of integrating a
finite element module for dike stability analysis Virtual Dike into an early
warning system for flood protection. The module operates in real-time mode and
includes fluid and structural sub-models for simulation of porous flow through
the dike and for dike stability analysis. Real-time measurements obtained from
pore pressure sensors are fed into the simulation module, to be compared with
simulated pore pressure dynamics. Implementation of the module has been
performed for a real-world test case - an earthen levee protecting a sea-port
in Groningen, the Netherlands. Sensitivity analysis and calibration of
diffusivities have been performed for tidal fluctuations. An algorithm for
automatic diffusivities calibration for a heterogeneous dike is proposed and
studied. Analytical solutions describing tidal propagation in one-dimensional
saturated aquifer are employed in the algorithm to generate initial estimates
of diffusivities
Slope Instability of the Earthen Levee in Boston, UK: Numerical Simulation and Sensor Data Analysis
The paper presents a slope stability analysis for a heterogeneous earthen
levee in Boston, UK, which is prone to occasional slope failures under tidal
loads. Dynamic behavior of the levee under tidal fluctuations was simulated
using a finite element model of variably saturated linear elastic perfectly
plastic soil. Hydraulic conductivities of the soil strata have been calibrated
according to piezometers readings, in order to obtain correct range of
hydraulic loads in tidal mode. Finite element simulation was complemented with
series of limit equilibrium analyses. Stability analyses have shown that slope
failure occurs with the development of a circular slip surface located in the
soft clay layer. Both models (FEM and LEM) confirm that the least stable
hydraulic condition is the combination of the minimum river levels at low tide
with the maximal saturation of soil layers. FEM results indicate that in winter
time the levee is almost at its limit state, at the margin of safety (strength
reduction factor values are 1.03 and 1.04 for the low-tide and high-tide
phases, respectively); these results agree with real-life observations. The
stability analyses have been implemented as real-time components integrated
into the UrbanFlood early warning system for flood protection
Distributed simulation of city inundation by coupled surface and subsurface porous flow for urban flood decision support system
We present a decision support system for flood early warning and disaster
management. It includes the models for data-driven meteorological predictions,
for simulation of atmospheric pressure, wind, long sea waves and seiches; a
module for optimization of flood barrier gates operation; models for stability
assessment of levees and embankments, for simulation of city inundation
dynamics and citizens evacuation scenarios. The novelty of this paper is a
coupled distributed simulation of surface and subsurface flows that can predict
inundation of low-lying inland zones far from the submerged waterfront areas,
as observed in St. Petersburg city during the floods. All the models are
wrapped as software services in the CLAVIRE platform for urgent computing,
which provides workflow management and resource orchestration.Comment: Pre-print submitted to the 2013 International Conference on
Computational Scienc
Inference of the Russian drug community from one of the largest social networks in the Russian Federation
The criminal nature of narcotics complicates the direct assessment of a drug
community, while having a good understanding of the type of people drawn or
currently using drugs is vital for finding effective intervening strategies.
Especially for the Russian Federation this is of immediate concern given the
dramatic increase it has seen in drug abuse since the fall of the Soviet Union
in the early nineties. Using unique data from the Russian social network
'LiveJournal' with over 39 million registered users worldwide, we were able for
the first time to identify the on-line drug community by context sensitive text
mining of the users' blogs using a dictionary of known drug-related official
and 'slang' terminology. By comparing the interests of the users that most
actively spread information on narcotics over the network with the interests of
the individuals outside the on-line drug community, we found that the 'average'
drug user in the Russian Federation is generally mostly interested in topics
such as Russian rock, non-traditional medicine, UFOs, Buddhism, yoga and the
occult. We identify three distinct scale-free sub-networks of users which can
be uniquely classified as being either 'infectious', 'susceptible' or 'immune'.Comment: 12 pages, 11 figure
Reducing cross-flow vibrations of underflow gates: experiments and numerical studies
An experimental study is combined with numerical modelling to investigate new
ways to reduce cross-flow vibrations of hydraulic gates with underflow. A
rectangular gate section placed in a flume was given freedom to vibrate in the
vertical direction. Holes in the gate bottom enabled leakage flow through the
gate to enter the area directly under the gate which is known to play a key
role in most excitation mechanisms. For submerged discharge conditions with
small gate openings the vertical dynamic support force was measured in the
reduced velocity range 1.5 < Vr < 10.5 for a gate with and without holes. The
leakage flow through the holes significantly reduced vibrations. This
attenuation was most profound in the high stiffness region at 2 < Vr < 3.5.
Two-dimensional numerical simulations were performed with the Finite Element
Method to assess local velocities and pressures for both gate types. A moving
mesh covering both solid and fluid domain allowed free gate movement and
two-way fluid-structure interactions. Modelling assumptions and observed
numerical effects are discussed and quantified. The simulated added mass in
still water is shown to be close to experimental values. The spring stiffness
and mass factor were varied to achieve similar response frequencies at the same
dry natural frequencies as in the experiment. Although it was not possible to
reproduce the vibrations dominated by impinging leading edge vortices (ILEV) at
relatively low Vr, the simulations at high Vr showed strong vibrations with
movement-induced excitation (MIE). For the latter case, the simulated response
reduction of the ventilated gate agrees with the experimental results. The
numerical modelling results suggest that the leakage flow diminishes the
whipping effect of fluctuations at the trailing edge associated with the
streamwise pressure drop across the gate and the body's vertical oscillatory
motion.Comment: 27 pages, 15 figures, 2 table
Evolutionary Design of Numerical Methods: Generating Finite Difference and Integration Schemes by Differential Evolution
Classical and new numerical schemes are generated using evolutionary
computing. Differential Evolution is used to find the coefficients of finite
difference approximations of function derivatives, and of single and multi-step
integration methods. The coefficients are reverse engineered based on samples
from a target function and its derivative used for training. The Runge-Kutta
schemes are trained using the order condition equations. An appealing feature
of the evolutionary method is the low number of model parameters. The
population size, termination criterion and number of training points are
determined in a sensitivity analysis. Computational results show good agreement
between evolved and analytical coefficients. In particular, a new fifth-order
Runge-Kutta scheme is computed which adheres to the order conditions with a sum
of absolute errors of order 10^-14. Execution of the evolved schemes proved the
intended orders of accuracy. The outcome of this study is valuable for future
developments in the design of complex numerical methods that are out of reach
by conventional means.Comment: 19 pages, 7 figures, 10 tables, 4 appendice
Emergence of spatio-temporal variations in chemotherapeutic drug efficacy: in-vitro and in-Silico 3D tumour spheroid studies
Background: The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. We explore the emergence of spatially preferential drug efficacy resulting from variations in mechanisms of cell-drug interactions. Methods: 3D spheroids of HeLa-C3 cells were treated with drugs, cisplatin and paclitaxel. This was followed by sectioning and staining of the spheroids to track the spatio-temporal apoptotic effects of the drugs. A mechanistic drug-cell interaction model was developed and simulated to analyse the localized efficacy of these drugs. Results: The outcomes of drug actions on a local cell population was dependant on the interactions between cell repair probability, intracellular drug concentration and cell’s mitosis phase. In spheroids treated with cisplatin, drug induced apoptosis is found to be scattered throughout the volume of the spheroids. In contrast, effect of paclitaxel is found to be preferentially localized along the periphery of the spheroids. Combinatorial treatments of cisplatin and paclitaxel result in varying levels of cell apoptosis based on the scheduling strategy. Conclusions: The preferential action of paclitaxel can be attributed to the cell characteristics of the peripheral population. The model simulations and experimental data show that treatments initiated with paclitaxel are more efficacious due to the cascading of spatial effects of the drugs.Published versio
- …