702 research outputs found
The consistency condition for the three-point function in dissipative single-clock inflation
We generalize the consistency condition for the three-point function in
single field inflation to the case of dissipative, multi-field, single-clock
models. We use the recently introduced extension of the effective field theory
of inflation that accounts for dissipative effects, to provide an explicit
proof to leading (non-trivial) order in the generalized slow roll parameters
and mixing with gravity scales. Our results illustrate the conditions necessary
for the validity of the consistency relation in situations with many degrees of
freedom relevant during inflation, namely that there is a preferred clock.
Departures from this condition in forthcoming experiments would rule out not
only single field but also a large class of multi-field models.Comment: 26+11 page
Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress.
The transmembrane protein neuropilin-1 (NRP1) promotes vascular endothelial growth factor (VEGF) and extracellular matrix signaling in endothelial cells (ECs). Although it is established that NRP1 is essential for angiogenesis, little is known about its role in EC homeostasis. Here, we report that NRP1 promotes mitochondrial function in ECs by preventing iron accumulation and iron-induced oxidative stress through a VEGF-independent mechanism in non-angiogenic ECs. Furthermore, NRP1-deficient ECs have reduced growth and show the hallmarks of cellular senescence. We show that a subcellular pool of NRP1 localizes in mitochondria and interacts with the mitochondrial transporter ATP-binding cassette B8 (ABCB8). NRP1 loss reduces ABCB8 levels, resulting in iron accumulation, iron-induced mitochondrial superoxide production, and iron-dependent EC senescence. Treatment of NRP1-deficient ECs with the mitochondria-targeted antioxidant compound mitoTEMPO or with the iron chelator deferoxamine restores mitochondrial activity, inhibits superoxide production, and protects from cellular senescence. This finding identifies an unexpected role of NRP1 in EC homeostasis
Transport Properties and Exponential n-values of Fe/MgB2 Tapes With Various MgB2 Particle Sizes
Fe/MgB2 tapes have been prepared starting with pre-reacted binary MgB2
powders. As shown by resistive and inductive measurements, the reduction of
particle size to a few microns by ball milling has little influence on Bc2,
while the superconducting properties of the individual MgB2 grains are
essentially unchanged. Reducing the particle size causes an enhancement of Birr
from 14 to 16 T, while Jc has considerably increased at high fields, its slope
Jc(B) being reduced. At 4.2K, values of 5.3*10^4 and 1.2*10^3 A/cm^2 were
measured at 3.5 and 10 T, respectively, suggesting a dominant role of the
conditions at the grain interfaces. A systematic variation of these conditions
at the interfaces is undertaken in order to determine the limit of transport
properties for Fe/MgB2 tapes. The addition of 5% Mg to MgB2 powder was found to
affect neither Jc nor Bc2. For the tapes with the highest Jc values, very high
exponential n factors were measured: n = 148, 89 and 17 at 3.5, 5 and 10T,
respectively and measurements of critical current versus applied strain have
been performed. The mechanism leading to high transport critical current
densities of filamentary Fe/MgB2 tapes based on MgB2 particles is discussed.Comment: Presented at ICMC 2003, 25-28 May 200
Strong enhancement of Jc in binary and alloyed in-situ MgB2 wires by a new approach: Cold high pressure densification
Cold high pressure densification (CHPD) is presented as a new way to
substantially enhance the critical current density of in situ MgB2 wires at 4.2
and 20 K at fields between 5 and 14 T. The results on two binary MgB2 wires and
an alloyed wire with 10 wt.% B4C are presented The strongest enhancement was
measured at 20K, where cold densification at 1.85 GPa on a binary Fe/MgB2 wire
raised both Jcpara and Jcperp by more than 300% at 5T, while Birr was enhanced
by 0.7 T. At 4.2K, the enhancement of Jc was smaller, but still reached 53% at
10 T. After applying pressures up to 6.5 GPa, the mass density dm of the
unreacted (B+Mg) mixture inside the filaments reached 96% of the theoretical
density. After reaction under atmospheric pressure, this corresponds to a
highest mass density df in the MgB2 filaments of 73%. After reaction, the
electrical resistance of wires submitted to cold densification was found to
decrease, reflecting an improved connectivity. A quantitative correlation
between filament mass density and the physical properties was established.
Monofilamentary rectangular wires with aspect ratios a/b < 1.25 based on low
energy ball milled powders exhibited very low anisotropy ratios, Gamma =
Jcpara/Jcperp being < 1.4 at 4.2 K and 10T. The present results can be
generalized to alloyed MgB2 wires, as demonstrated on a wire with B4C
additives. Based on the present data, it follows that cold densification has
the potential of further improving the highest Jcpara and Jcperp values
reported so far for in situ MgB2 tapes and wires with SiC and C additives.
Investigations are under work in our laboratory to determine whether the
densification method CHPD can be applied to longer wire or tape lengths.Comment: Submitted to Superconductors Science and Technolog
Excitonic condensation in a symmetric electron-hole bilayer
Using Diffusion Monte Carlo simulations we have investigated the ground state
of a symmetric electron-hole bilayer and determined its phase diagram at T=0.
We find clear evidence of an excitonic condensate, whose stability however is
affected by in-layer electronic correlation. This stabilizes the electron-hole
plasma at large values of the density or inter-layer distance, and the Wigner
crystal at low density and large distance. We have also estimated pair
correlation functions and low order density matrices, to give a microscopic
characterization of correlations, as well as to try and estimate the condensate
fraction.Comment: 4 pages, 3 figures, 2 table
Primordial non-Gaussianity in the Bispectrum of the Halo Density Field
The bispectrum vanishes for linear Gaussian fields and is thus a sensitive
probe of non-linearities and non-Gaussianities in the cosmic density field.
Hence, a detection of the bispectrum in the halo density field would enable
tight constraints on non-Gaussian processes in the early Universe and allow
inference of the dynamics driving inflation. We present a tree level derivation
of the halo bispectrum arising from non-linear clustering, non-linear biasing
and primordial non-Gaussianity. A diagrammatic description is developed to
provide an intuitive understanding of the contributing terms and their
dependence on scale, shape and the non-Gaussianity parameter fNL. We compute
the terms based on a multivariate bias expansion and the peak-background split
method and show that non-Gaussian modifications to the bias parameters lead to
amplifications of the tree level bispectrum that were ignored in previous
studies. Our results are in a good agreement with published simulation
measurements of the halo bispectrum. Finally, we estimate the expected signal
to noise on fNL and show that the constraint obtainable from the bispectrum
analysis significantly exceeds the one obtainable from the power spectrum
analysis.Comment: 34 pages, 15 figures, (v3): matches JCAP published versio
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