A generative-oriented model-driven design environment for customizable video surveillance systems

To tackle the growing complexity and huge demand for tailored domestic video surveillance systems along with a high demanding time-to-market expectation, engineers at IVV Automação, LDAa are exploiting video surveillance domain as families of systems that can be developed following a pay-as-you-go fashion rather than developing an ex-nihilo new product. Several and different new functionalities are required for each new product’s hardware platforms (e.g., ranging from mobile phone, PDA to desktop PC) and operating systems (e.g., flavors of Linux, Windows and MAC OS X). Some of these functionalities have special economical constraints of development time and memory footprint. To better accommodate all the above listing requirements, a model-driven generative software development paradigm supported by mainstream tools is proposed to offer a significant leverage in hiding commonalities and configuring variabilities across families of video surveillance products while maintaining the new product quality.This work was funded through the Competitive Factors Operational Program COMPETE and through national funds though the Science and Technology Foundation - FCT, within the project: FCOMP-01-0124-FEDER-022674. This work was developed in cooperation with IVV Automation; all support and means provided by the company is acknowledged

Association of coronary calcification with prognosis of Covid-19 patients without known heart disease

Risk factors that determine the severity of Covid-19 have not been fully elucidated. The aim of this study was to evaluate the role of coronary artery calcification (CAC) as a risk factor for death or mechanical ventilation (MV) of patients without known heart disease infected with Covid-19. We analyzed 283 consecutive in-patients with acute respiratory symptoms with chest computed tomography (chest-CT), without previous heart disease, and criteria for Covid-19 (RT-PCR positive and/or typical clinical and chest-CT findings). CAC was classified by the number of coronary segments affected as absent (0), mild (1-3), and severe calcification (more than 3). The association between CAC, CAC severity, and death or MV due to severe respiratory failure was assessed by logistic regression. The mean age was 58.7 +/- 15.7 years and 54.1% were men. Patients with CAC were older, more likely to have hypertension, and less likely to be obese. CAC was present in 75 patients (26.5%), of which 42 had a mild calcification and 33 had severe calcification, and was associated with death (OR=2.35, 95%CI: 1.01-5.48) or MV (OR=2.72, 95%CI: 1.20-6.20) adjusted for multiple confounders, with significant and increased odds ratio for the severe form of CAC (death: OR=3.70, 95%CI: 1.20-11.42; MV: OR=3.30, 95%CI: 1.09-9.95). We concluded that CAC was an independent risk factor for death or MV in Covid-19 patients without previous heart disease, particularly for those with severe calcification. CAC can be easily visualized on common chest-CT, widely used in evaluation of moderate to severe Covid-19

Prevalence of asthma and rhinitis among adolescents living in urban or rural areas of different cities of Brazil

Universidade Federal de São Paulo, Escola Paulista Med, São Paulo, BrazilUniv Fed Santa Maria, BR-97119900 Santa Maria, RS, BrazilUniv Fed Pernambuco, BR-50000 Recife, PE, BrazilUniv Fed Pernambuco, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, São Paulo, BrazilWeb of Scienc

Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives

Submitted by Kamylla Nascimento ([email protected]) on 2018-09-13T12:01:52Z No. of bitstreams: 1 Immunological studies and in vitro schistosomicide action of new.pdf: 513006 bytes, checksum: 99dae120bb5aaddeedc985b1a17d2914 (MD5)Approved for entry into archive by Kamylla Nascimento ([email protected]) on 2018-09-13T12:27:26Z (GMT) No. of bitstreams: 1 Immunological studies and in vitro schistosomicide action of new.pdf: 513006 bytes, checksum: 99dae120bb5aaddeedc985b1a17d2914 (MD5)Made available in DSpace on 2018-09-13T12:27:26Z (GMT). No. of bitstreams: 1 Immunological studies and in vitro schistosomicide action of new.pdf: 513006 bytes, checksum: 99dae120bb5aaddeedc985b1a17d2914 (MD5) Previous issue date: 2011Fundação Federal de Pesquisa e Desenvolvimento (FINEP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de Pernambuco (UFPE). Departamento de Antibióticos. Laboratório de Desenho e Síntese de Fármacos. Recife, PE, Brasil.Universidade Federal de Pernambuco (UFPE). Departamento de Antibióticos. Laboratório de Desenho e Síntese de Fármacos. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Universidade Federal de Pernambuco (UFPE). Departamento de Antibióticos. Laboratório de Desenho e Síntese de Fármacos. Recife, PE, Brasil.Universidade Federal de Pernambuco (UFPE). Departamento de Antibióticos. Laboratório de Desenho e Síntese de Fármacos. Recife, PE, Brasil.Universidade Federal de Pernambuco (UFPE). Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil / Universidade Federal de Pernambuco (UFPE). Departamento de Medicina Tropical. Recife, PE, Brasil.Universidade Federal de Pernambuco (UFPE). Departamento de Antibióticos. Laboratório de Desenho e Síntese de Fármacos. Recife, PE, Brasil.Schistosomiasis is a major public health problem with 207 million people infected and more than 779 million at risk. The drug of choice for treating schistosomiasis is praziquantel (PZQ); however, it is inefficient against immature forms of schistosomes. The aim of this study was to test new imidazolidine derivatives LPSF/PT09 and LPSF/PT10 against adult Schistosoma mansoni worms. IC50, cytotoxicity, immune response and cell viability assays were also available for these imidazolidines. Different concentrations of imidazolidine, from 32 to 320 ¼M, promoted motor abnormalities in breeding and unpaired worms, and death in 24 hours at higher concentrations. Although LPSF/PT09 and LPSF/PT10 did not affect IFN-³ and IL-10 production, they induced nitric oxide production and showed a similar behavior to praziquantel on cell death test. Thus, these new imidazolidine derivatives should undergo further study to develop schistosomiasis drugs