Efficacy, Safety, and Quality of Life (Qol) Data from the Eortc 18071 Phase III Trial of Ipilimumab (Ipi) Versus Placebo After Complete Resection of Stage III Melanoma

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Noninvasive Diagnosis of Visceral Leishmaniasis:Development and Evaluation of Two Urine-Based Immunoassays for Detection of Leishmania donovani Infection in India

Visceral leishmaniasis (VL), one of the most prevalent parasitic diseasesin the developing world causes serious health concerns. Post kala-azar dermal leishmaniasis (PKDL) is a skin disease which occurs after treatment as a sequel to VL. Parasitological diagnosis involves invasive tissue aspiration which is tedious and painful. Commercially available immunochromatographic rapid diagnostic test such as rK39-RDT is used for field diagnosis of VL, detects antibodiesin serum samples. Urine sample is however, much easier in collection,storage and handling than serum and would be a better alternative where collection of tissue aspirate or blood is impractical. In this study, we have developed and evaluated the performance of two urine-based diagnostic assays, ELISA and dipstick test, and compared the results with serologicalrK39-RDT. Our study shows the capability of urinebased tests in detecting anti-Leishmania antibodies effectively for both VL and PKDL diagnosis. The ability of dipstick test to demonstrate negative results after six months in 90% of the VL cases after treatment could be useful as a test of clinical cure. Urine-based tests can therefore replace the need for invasive practices and ensure better diagnosi

Performance of coriander under organic and chemical nutrient management practice

Coriander is one of the most important spice and fresh leaf vegetable which are used widely across the globe. Organic cultivation of this crop has wide scope as it is short duration and reduces the wastage of fertilizers as well as qualitative production. A field experiment was conducted at School of Agricultural Sciences and Forestry, RTU Bangalore in order to know the effective application rate of compost for economic production in comparison to chemical fertilizer. The research data reveals that, application of compost at 10t/ha produced significantly superior growth, yield parameters and herbage yield compared to control. But it was on par with RDF treatment. Thus application of compost at10t/ha might be an effective nutritional input in organic cultivation of coriander. &nbsp