Reaction mechanisms involved in the production of neutron-rich isotopes

The reaction mechanisms best suited for the production of neutron-rich nuclei, fragmentation and fission, are discussed. Measurements of the production cross sections of reaction residues together with model calculations allow to conclude about the expected production rates of neutron-rich isotopes in future facilities.Comment: 9 pages, 8 figures Proceedings of the Third International Conference on Fission and Properties of Neutron-Rich Nuclei November 3-9, 2002, Sanibel Island, Florida, US

Dispersion of longitudinal momentum distributions induced in fragmentation reactions

On the basis of systematic measurements of fragmentation reactions, which provide a detailed overview on the velocity distributions of residual nuclei, an improved description of the kinematical properties of the fragmentation residues is established. This work is dedicated to the fluctuations of their momentum distributions. In contrast to previous investigations, limited to close-to-projectile fragments, we extended our study to the entire production range, down to the lightest observed fragments. In this context, beside the contribution of abrasion and evaporation processes, we considered the effect of the thermal break-up on the width of the momentum distributions. Using approximated theoretical descriptions of the different reaction stages, a new analytical formula for the variance of the momentum distribution is derived, which is well adapted to technical applications.Comment: 14 pages, 3 figures, background info. at http://www-wnt.gsi.de/charms

Experimental Indications for the Response of the Spectators to the Participant Blast

Precise momentum distributions of identified projectile fragments, formed in the reactions 238U + Pb and 238U + Ti at 1 A GeV, are measured with a high-resolution magnetic spectrometer. With increasing mass loss, the velocities first decrease as expected from previously established systematics, then level off, and finally increase again. Light fragments are on the average even faster than the projectiles. This finding is interpreted as the response of the spectators to the participant blast. The re-acceleration of projectile spectators is sensitive to the nuclear mean field and provides a new tool for investigating the equation of state of nuclear matter.Comment: 7 pages, 3 figures, background information on http://www-wnt.gsi.de/kschmidt

Biological aspects of mTOR in leukemia

The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival. Strong evidences have indicated that mTOR dysregulation is deeply implicated in leukemogenesis. This has led to growing interest in the development of modulators of its activity for leukemia treatment. This review intends to provide an outline of the principal biological and molecular functions of mTOR. We summarize the current understanding of how mTOR interacts with microRNAs, with components of cell metabolism, and with controllers of apoptotic machinery. Lastly, from a clinical/translational perspective, we recapitulate the therapeutic results in leukemia, obtained by using mTOR inhibitors as single agents and in combination with other compounds

Occupational risk factors in inflammatory bowel disease

Crohn's disease and ulcerative colitis are the two main forms of inflammatory bowel disease (IBD). Although the aetiology of IBD is not completely understood, an interaction between genetic and environmental factors has been proposed. In this context, however, environmental epidemiology lacks a comprehensive evaluation of the possible role of occupational exposures in IBD development and progression. Therefore, aim of our review was to evaluate how certain occupational risk factors may affect IBD pathogenesis, clinical history and severity of disease manifestations

Misure gravimetriche a L’Aquila. Confronto con i valori rilevati nel 1995

Nel febbraio 2010 si è dato inizio alla realizzazione di una rete gravimetrica a L’Aquila con l’istituzione di una stazione assoluta. La stazione è stata realizzata nel Palazzo Comunale della città di L’Aquila (Palazzo Margherita – foto a), nel centro della città, in un locale al piano terra (foto b). Sono state effettuata anche misure gravimetriche relative al fine di misurare il locale gradiente verticale della gravità (foto c) e riportare il valore assoluto ad una stazione satellite esterna all’edificio (foto d). Nel corso della campagna è stato anche effettuato il collegamento gravimetrico tra la nuova stazione e quella istituita nel 1995 nei laboratori sotterranei dei Laboratori Nazionali del Gran Sasso (LNGS) (foto e) dove è stato anche misurato il gradiente verticale. Tale punto fu allora istituito quale nodo fondamentale della costituenda “Rete Gravimetrica Nazionale di Ordine Zero”

Thirty years of precise gravity measurements at Mt. Vesuvius: an approach to detect underground mass movements

Since 1982, high precision gravity measurements have been routinely carried out on Mt. Vesuvius. The gravity network consists of selected sites most of them coinciding with, or very close to, leveling benchmarks to remove the effect of the elevation changes from gravity variations. The reference station is located in Napoli, outside the volcanic area. Since 1986, absolute gravity measurements have been periodically made on a station on Mt. Vesuvius, close to a permanent gravity station established in 1987, and at the reference in Napoli. The results of the gravity measurements since 1982 are presented and discussed. Moderate gravity changes on short-time were generally observed. On long-term significant gravity changes occurred and the overall fields displayed well defined patterns. Several periods of evolution may be recognized. Gravity changes revealed by the relative surveys have been confirmed by repeated absolute measurements, which also confirmed the long-term stability of the reference site. The gravity changes over the recognized periods appear correlated with the seismic crises and with changes of the tidal parameters obtained by continuous measurements. The absence of significant ground deformation implies masses redistribution, essentially density changes without significant volume changes, such as fluids migration at the depth of the seismic foci, i.e. at a few kilometers. The fluid migration may occur through pre-existing geological structures, as also suggested by hydrological studies, and/or through new fractures generated by seismic activity. This interpretation is supported by the analyses of the spatial gravity changes overlapping the most significant and recent seismic crises